Results 91 to 100 of about 10,095,518 (284)

Integrated Stress Responses to Bacterial Pathogenesis Patterns

Frontiers in Immunology, 2018
Activation of an appropriate innate immune response to bacterial infection is critical to limit microbial spread and generate cytokines and chemokines to instruct appropriate adaptive immune responses. Recognition of bacteria or bacterial products by pattern recognition molecules is crucial to initiate this response.
Rodrigues, Larissa O. C. P., Graça, Rodrigo S. F., Carneiro, Leticia A. M.   +2 more
openaire   +3 more sources

Monitoring integrated stress response in live Drosophila

, 2023
Summary Cells exhibit stress responses to various environmental changes. Among these responses, the integrated stress response (ISR) plays a pivotal role as a crucial stress signaling pathway. While extensive ISR research has been conducted on cultured cells, our understanding of its implications in multicellular organisms remains ...
Peter V. Lidsky, Jing Yuan, Kseniya A. Lashkevich, Sergey E. Dmitriev, Raul Andino   +4 more
openaire   +2 more sources

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

The role of sigma factor RpoH1 in the pH stress response of Sinorhizobium meliloti [PDF]

, 2010
de Lucena DK, Pühler A, Weidner S. The role of sigma factor RpoH1 in the pH stress response of Sinorhizobium meliloti. BMC Microbiology. 2010;10(1): 256.Background: Environmental pH stress constitutes a limiting factor for S.
Argandoña, Montserrat, Iglesias Guerra, Fernando, Jebbar Mohamed, Reina-Bueno Mercedes, Argandoña Montserrat, Mohamed Jebbar, Mercedes Reina-Bueno, Joaquín J Nieto, Reina Bueno, Mercedes, Argandoña Bertrán, Montserrat, Rodríguez-Moya, Javier, Vargas Macías, Carmen, Iglesias-Guerra Fernando, Jebbar, Mohamed, Nieto Joaquín J, Javier Rodríguez-Moya, Fernando Iglesias-Guerra, Vargas Carmen, de Lucena, Daniella Karine, Reina-Bueno, Mercedes, Rodríguez de Moya Vera, Javier, Pühler, Alfred ; https://orcid.org/, Iglesias-Guerra, Fernando, Weidner, Stefan, Nieto Gutiérrez, Joaquín José, Rodríguez-Moya Javier, Nieto, Joaquín J, Vargas, Carmen, Carmen Vargas, Montserrat Argandoña   +29 more
core   +1 more source

Homeostatic responses to amino acid insufficiency

Animal Nutrition, 2015
This article provides a brief overview describing how two key signaling pathways, namely the integrated stress response and the mammalian target of rapamycin complex 1, work together to facilitate cellular adaptation to dietary amino acid insufficiency ...
Tracy G. Anthony
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Impact of Abiotic Stress on Rice and the Role of DNA Methylation in Stress Response Mechanisms

With the intensification of global climate change and the increasing complexity of agricultural environments, the improvement of rice stress tolerance is an important focus of current breeding research. This review summarizes the current knowledge on the
Binying Fu, Yanfang Wang, Jianlong Xu, Ming Yin, Fan Zhang, Jie Lang, Zichao Li, Xiuqin Zhao, Yawei Liang, Ronghua Wei, Liying Zuo, Zekai Huang, Mingyue Huo, Shanwen Wang, Wensheng Wang   +14 more
core   +1 more source

The integrated stress response and proteotoxicity in cancer therapy [PDF]

Biochemical and Biophysical Research Communications, 2017
A variety of different forms of cellular stress can cause protein misfolding and aggregation and proteotoxicity. The cytoprotective response to proteotoxicity is termed the integrated stress response and involves 4 distinct serine/threonine protein kinases that converge on the translation initiation factor eIF2α, resulting in phosphorylation at S51 ...
openaire   +2 more sources