Results 101 to 110 of about 10,043,563 (299)

Mutagenesis screen uncovers lifespan extension through integrated stress response inhibition without reduced mRNA translation

, 2021
Protein homeostasis is modulated by stress response pathways and its deficiency is a hallmark of aging. The integrated stress response (ISR) is a conserved stress-signaling pathway that tunes mRNA translation via phosphorylation of the translation ...
Wester, L., Denzel, M., Baddi, R., Derisbourg, M., Maxime J. Derisbourg, Laura E. Wester, Ruth Baddi, Martin S. Denzel   +7 more
core   +1 more source

Human Betacoronavirus OC43 Interferes with the Integrated Stress Response Pathway in Infected Cells

Viruses
Viruses evolve many strategies to ensure the efficient synthesis of their proteins. One such strategy is the inhibition of the integrated stress response—the mechanism through which infected cells arrest translation through the phosphorylation of the ...
Stacia M. Dolliver, Caleb Galbraith, Denys A. Khaperskyy   +2 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Integrated Stress Responses to Bacterial Pathogenesis Patterns

Frontiers in Immunology, 2018
Activation of an appropriate innate immune response to bacterial infection is critical to limit microbial spread and generate cytokines and chemokines to instruct appropriate adaptive immune responses. Recognition of bacteria or bacterial products by pattern recognition molecules is crucial to initiate this response.
Rodrigues, Larissa O. C. P., Graça, Rodrigo S. F., Carneiro, Leticia A. M.   +2 more
openaire   +3 more sources

Monitoring integrated stress response in live Drosophila

, 2023
Summary Cells exhibit stress responses to various environmental changes. Among these responses, the integrated stress response (ISR) plays a pivotal role as a crucial stress signaling pathway. While extensive ISR research has been conducted on cultured cells, our understanding of its implications in multicellular organisms remains ...
Peter V. Lidsky, Jing Yuan, Kseniya A. Lashkevich, Sergey E. Dmitriev, Raul Andino   +4 more
openaire   +2 more sources

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

The integrated stress response

, 2018
In response to diverse stress stimuli, eukaryotic cells activate a common adaptive pathway, termed the integrated stress response (ISR), to restore cellular homeostasis.
Koryga, Izabela, Ljujic, Mila, Mnich, Katarzyna, Gorman, Adrienne M., Pakos‐Zebrucka, Karolina, Samali, Afshin   +5 more
core  

Unveiling the Role of the Integrated Endoplasmic Reticulum Stress Response in Leishmania Infection – Future Perspectives [PDF]

, 2016
The integrated endoplasmic reticulum stress response (IERSR) is an evolutionarily conserved adaptive mechanism that ensures endoplasmic reticulum (ER) homeostasis and cellular survival in the presence of stress including nutrient deprivation, hypoxia ...
Lopes, U. G., Dias-Teixeira, K. L., J. S. Silva, N. Fasel, Pereira, R. M., Fasel, N., Pereira, R.M., K. L. Dias-Teixeira, R. M. Pereira, Silva, J.S., U. G. Lopes, Silva, J. S., Aktas, B. H., Aktas, B.H., B. H. Aktas, Dias-Teixeira, K.L., Lopes, U.G., Ulisses Gazos Lopes, Pereira RM, Dias-Teixeira KL, Silva JS, Aktas BH, Fasel N, Lopes UG   +23 more
core   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source