Results 101 to 110 of about 10,095,518 (284)

Stress granules in antiviral immunity and the integrated stress response

Adequate defense against microbial infection depends on the controlled activation of the immune system. This is particularly important for the RIG-I-like receptors (RLRs), which recognize viral dsRNA and initiate antiviral innate immune responses with ...
Paget, Max
core   +4 more sources

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Nuclear receptor LRH-1/NR5A2 is required and targetable for liver endoplasmic reticulum stress resolution [PDF]

, 2014
Chronic endoplasmic reticulum (ER) stress results in toxicity that contributes to multiple human disorders. We report a stress resolution pathway initiated by the nuclear receptor LRH-1 that is independent of known unfolded protein response (UPR ...
DeMayo, Fransesco J., San-Pin Wu, David D Moore, Moore, David D, Whitby, Richard J., Martin Wagner, Moore, David D., Peter J Stambrook, Whitby, Richard J, Sifers, Richard N, Ming-Jer Tsai, Francesco J DeMayo, Wu, San-pin, Mamrosh, Jennifer L, Jennifer L Mamrosh, Lee, Jae Man, Sifers, Richard N., Richard N Sifers, Richard J Whitby, Stambrook, Peter J, Stambrook, Peter J., Jae Man Lee, Wagner, Martin, Tsai, Ming-jer, Lee, Jae M., DeMayo, Francesco J, Mamrosh, Jennifer L.   +26 more
core   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Genetic integration of the stress response

, 2019
Abstract The stress response is a product of selection for an integrated suite of behavioural and physiological traits that facilitate coping with acute stressors. As such, genetic variation in the stress response is expected to reflect genetic variation in, and genetic covariation among, its behavioural and physiological components.
Houslay, T.M., Earley, R.L., White, S.J., Lammers, W., Grimmer, A.J., Travers, L.M., Johnson, E.L., Young, A.J., Wilson, A.J.   +8 more
openaire   +1 more source

Palmitate induces integrated stress response and lipoapoptosis in trophoblasts

Cell Death and Disease
Maternal obesity increases the risk of childhood obesity and programs the offspring to develop metabolic syndrome later in their life. Palmitate is the predominant saturated free fatty acid (FFA) that is transported across the placenta to the fetus.
Prakash Kumar Sahoo, Chandan Krishnamoorthy, Jennifer R. Wood, Corrine Hanson, Ann Anderson-Berry, Justin L. Mott, Sathish Kumar Natarajan   +6 more
doaj   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Translation of 5′ leaders is pervasive in genes resistant to eIF2 repression

eLife, 2015
Eukaryotic cells rapidly reduce protein synthesis in response to various stress conditions. This can be achieved by the phosphorylation-mediated inactivation of a key translation initiation factor, eukaryotic initiation factor 2 (eIF2).
Dmitry E Andreev, Patrick BF O'Connor, Ciara Fahey, Elaine M Kenny, Ilya M Terenin, Sergey E Dmitriev, Paul Cormican, Derek W Morris, Ivan N Shatsky, Pavel V Baranov   +9 more
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source