Results 111 to 120 of about 10,095,518 (284)

Een waarderend en definitief archeologisch onderzoek door middel van proefsleuven en een archeologische begeleiding

, 2017
Een waarderend en definitief archeologisch onderzoek door middel van proefsleuven en een archeologische ...
EARTH Integrated Archaeology B.V.
core   +1 more source

Longitudinal trajectories of health-related quality of life and their predictors among community-dwelling older adults

Scientific Reports
The 36-item Short-Form Health Survey (SF-36) is widely used to assess health-related quality of life. However, only few studies have examined longitudinal SF-36 trajectories in general populations, and even fewer have explored their relationships with ...
Ryoga Oshima, Yuki Ohashi, Takuro Iwane, Yoshinori Tamada, Fumie Kinoshita, Tomoya Ito, Yuto Okumura, Tatsuya Mikami, Ken Itoh, Koichi Murashita, Masahiro Nakatochi   +10 more
doaj   +1 more source

Inhibiting the integrated stress response pathway prevents aberrant chondrocyte differentiation thereby alleviating chondrodysplasia

eLife, 2018
The integrated stress response (ISR) is activated by diverse forms of cellular stress, including endoplasmic reticulum (ER) stress, and is associated with diseases.
Cheng Wang, Zhijia Tan, Ben Niu, Kwok Yeung Tsang, Andrew Tai, Wilson C W Chan, Rebecca L K Lo, Keith K H Leung, Nelson W F Dung, Nobuyuki Itoh, Michael Q Zhang, Danny Chan, Kathryn Song Eng Cheah   +12 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Molecular Mechanisms of Gene Expression Regulation in Response to Heat Stress in Hemerocallis fulva

Hemerocallis fulva is one of the three major flowers in the world; its flower type and color are very rich, with high ornamental value and economic value. Heat stress severely limits the cultivation and geographical distribution of H. fulva.
Boyan Chu, Jinxia Li, Weixue Liu, Xiaofei Zhang, Ping Li   +4 more
core   +1 more source

Een inventariserend veldonderzoek door middel van boringen (IVO-O), verkennende fase

, 2017
Een inventariserend veldonderzoek door middel van boringen (IVO-O), verkennende ...
EARTH Integrated Archaeology B.V.
core   +1 more source

Cellular Responses to Flavivirus Infections: Stress Signaling at the Crossroads of Host Defense and Virus Infection

Viruses
Flaviviruses, encompassing notable pathogens, like Dengue, Zika, West Nile, and tick-borne encephalitis viruses, elicit complex cellular stress responses, involving pathways such as the unfolded protein response (UPR), integrated stress response (ISR ...
Pheonah Badu, Elianna T. Cruz González, Cara T. Pager   +2 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

The integrated stress response

, 2018
In response to diverse stress stimuli, eukaryotic cells activate a common adaptive pathway, termed the integrated stress response (ISR), to restore cellular homeostasis.
Koryga, Izabela, Ljujic, Mila, Mnich, Katarzyna, Gorman, Adrienne M., Pakos‐Zebrucka, Karolina, Samali, Afshin   +5 more
core  

Pharmacologic activation of integrated stress response kinases inhibits pathologic mitochondrial fragmentation

eLife
Excessive mitochondrial fragmentation is associated with the pathologic mitochondrial dysfunction implicated in the pathogenesis of etiologically diverse diseases, including many neurodegenerative disorders.
Kelsey R Baron, Samantha Oviedo, Sophia Krasny, Mashiat Zaman, Rama Aldakhlallah, Prerona Bora, Prakhyat Mathur, Gerald Pfeffer, Michael J Bollong, Timothy E Shutt, Danielle A Grotjahn, R Luke Wiseman   +11 more
doaj   +1 more source