Results 131 to 140 of about 10,043,563 (299)

Gene regulation during stress response transcription in Saccharomyces Cerevisiae [PDF]

, 2013
DYNAMIC TRANSCRIPTOME ANALYSIS MEASURES RATES OF MRNA SYNTHESIS AND DECAY IN YEAST To obtain rates of mRNA synthesis and decay in yeast, we established dynamic transcriptome analysis (DTA).
Miller, Christian
core  

Thematische collectie: EARTH Integrated Archaeology

, 2015
Overzicht van de in het e-depot gearchiveerde projecten van EARTH Integrated ...
EARTH Integrated Archaeology
core   +1 more source

Pharmacologic activation of integrated stress response kinases inhibits pathologic mitochondrial fragmentation

eLife
Excessive mitochondrial fragmentation is associated with the pathologic mitochondrial dysfunction implicated in the pathogenesis of etiologically diverse diseases, including many neurodegenerative disorders.
Kelsey R Baron, Samantha Oviedo, Sophia Krasny, Mashiat Zaman, Rama Aldakhlallah, Prerona Bora, Prakhyat Mathur, Gerald Pfeffer, Michael J Bollong, Timothy E Shutt, Danielle A Grotjahn, R Luke Wiseman   +11 more
doaj   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Ribosome-free L3 targets E2F pathway: a new p53 independent mechanism linking ribosomal stress to cancer cell proliferation

, 2018
Our previous data demonstrated that ribosomal stress induced by anticancer drugs in colon cancer cells devoid of p53 leads to the activation of ribosomal protein L3 as inhibitor of cell cycle.
Di Stefano Ilaria, Russo Annapina, Esposito Olindo G., Di Domenico R., Pecoraro Annalisa., Russo Giulia   +5 more
core  

The integrated stress response in metabolic adaptation

Journal of Biological Chemistry
The integrated stress response (ISR) refers to signaling pathways initiated by stress-activated eIF2α kinases. Distinct eIF2α kinases respond to different stress signals, including amino acid deprivation and mitochondrial stress. Such stress-induced eIF2α phosphorylation attenuates general mRNA translation and, at the same time, stimulates the ...
openaire   +2 more sources

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

The central role of the glutamate system in stress response and anxiety

, 2013
The 9th symposium on ‘Systems Neuropsychiatry’, we will discuss integrative concepts of ‘Stress, Anxiety and Addiction’. Here, we would like to present integrated functional knowledge of circuits of stress and anxiety which are interconnected with ...
M. Popoli
core  

Activating transcription factor 4 plays a major role in shaping the transcriptional response to isoginkgetin in HCT116 cells

Scientific Reports
Activating transcription factor 4 (ATF4) plays a central role in the integrated stress response (ISR) and one overlapping branch of the unfolded protein response (UPR).
Erin van Zyl, John D. H. Stead, Claire Peneycad, Carole L. Yauk, Bruce C. McKay   +4 more
doaj   +1 more source