Results 1 to 10 of about 77,443 (288)
Hypoxia-induced mitochondrial stress granules
Cell Death and Disease, 2023 Perturbations of mitochondrial proteostasis have been associated with aging, neurodegenerative diseases, and recently with hypoxic injury. While examining hypoxia-induced mitochondrial protein aggregation in C.
Chun-Ling Sun +2 more
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The Stress Granule Transcriptome Reveals Principles of mRNA Accumulation in Stress Granules [PDF]
Molecular Cell, 2017 Stress granules are mRNA-protein assemblies formed from nontranslating mRNAs. Stress granules are important in the stress response and may contribute to some degenerative diseases. Here, we describe the stress granule transcriptome of yeast and mammalian cells through RNA-sequencing (RNA-seq) analysis of purified stress granule cores and single ...
Anthony Khong +2 more
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N4-acetylcytidine (ac4C) promotes mRNA localization to stress granules [PDF]
EMBO ReportsStress granules are an integral part of the stress response that are formed from non-translating mRNAs aggregated with proteins. While much is known about stress granules, the factors that drive their mRNA localization are incompletely described ...
Pavel Kudrin +4 more
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Functional amyloid protein FXR1 is recruited into neuronal stress granules [PDF]
PrionThe FXR1 protein regulates the stability and translation of a number of RNA molecules and plays an important role in the regulation of cellular processes under normal conditions and stress.
Anna A. Valina +7 more
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Stress granules regulate paraspeckles: RNP granule continuum at work [PDF]
Cell Stress, 2019 Eukaryotic cells contain several types of RNA-protein membraneless macro-complexes – ribonucleoprotein (RNP) granules that form by liquid-liquid phase separation.
Haiyan An, Tatyana A. Shelkovnikova
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Cellular Stress Induces Nucleocytoplasmic Transport Deficits Independent of Stress Granules
Biomedicines, 2022 Stress granules are non-membrane bound granules temporarily forming in the cytoplasm in response to stress. Proteins of the nucleocytoplasmic transport machinery were found in these stress granules and it was suggested that stress granules contribute to ...
Joni Vanneste +5 more
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Translation landscape of stress granules. [PDF]
Sci AdvAbstract Stress granules, cytoplasmic assemblies of RNA-binding proteins and mRNAs formed during cellular stress, are implicated in translational control. However, their exact functions remain elusive. Here, we employed cryogenic correlative light and electron microscopy to visualize stress granules in their native environment and reconstructed
Wu Y +7 more
europepmc +4 more sources
Aspergillus oryzae AoSO is a novel component of stress granules upon heat stress in filamentous fungi. [PDF]
PLoS ONE, 2013 Stress granules are a type of cytoplasmic messenger ribonucleoprotein (mRNP) granule formed in response to the inhibition of translation initiation, which typically occurs when cells are exposed to stress.
Hsiang-Ting Huang +2 more
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Nature Precedings, 2010 AbstractOverexpressed EGFP-FMRP has been used as a substitute for endogenous fragile X mental retardation protein (FMRP) in protein-protein interaction studies, and in studies concerning the composition, the formation and the localization of neuronal granules.
Robert Denman, Robert Denman
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Sequestration of highly expressed mRNAs in cytoplasmic granules, P-bodies, and stress granules enhances cell viability. [PDF]
PLoS Genetics, 2012 Transcriptome analyses indicate that a core 10%-15% of the yeast genome is modulated by a variety of different stresses. However, not all the induced genes undergo translation, and null mutants of many induced genes do not show elevated sensitivity to ...
Anna Lavut, Dina Raveh
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