Results 1 to 10 of about 2,813,474 (315)

The Stress Granule Transcriptome Reveals Principles of mRNA Accumulation in Stress Granules [PDF]

Molecular Cell, 2017
Stress granules are mRNA-protein assemblies formed from nontranslating mRNAs. Stress granules are important in the stress response and may contribute to some degenerative diseases. Here, we describe the stress granule transcriptome of yeast and mammalian cells through RNA-sequencing (RNA-seq) analysis of purified stress granule cores and single ...
Anthony Khong, Joshua Wheeler, Roy Parker   +2 more
exaly   +5 more sources

Hypoxia-induced mitochondrial stress granules

Cell Death and Disease, 2023
Perturbations of mitochondrial proteostasis have been associated with aging, neurodegenerative diseases, and recently with hypoxic injury. While examining hypoxia-induced mitochondrial protein aggregation in C.
Chun-Ling Sun, Marc Van Gilst, C. Michael Crowder   +2 more
doaj   +4 more sources

N4-acetylcytidine (ac4C) promotes mRNA localization to stress granules [PDF]

EMBO Reports
Stress granules are an integral part of the stress response that are formed from non-translating mRNAs aggregated with proteins. While much is known about stress granules, the factors that drive their mRNA localization are incompletely described ...
Pavel Kudrin, Ankita Singh, David Meierhofer, Anna Kuśnierczyk, Ulf Andersson Vang Ørom   +4 more
doaj   +4 more sources

Translation landscape of stress granules. [PDF]

Sci Adv
Abstract Stress granules, cytoplasmic assemblies of RNA-binding proteins and mRNAs formed during cellular stress, are implicated in translational control. However, their exact functions remain elusive. Here, we employed cryogenic correlative light and electron microscopy to visualize stress granules in their native environment and reconstructed
Wu Y, Wang X, Meng L, Liao Z, Ji W, Zhang P, Lin J, Guo Q.   +7 more
europepmc   +4 more sources

Chronic stress antagonizes formation of stress granules. [PDF]

iScience
Abstract Chronic stress mediates cellular changes that can contribute to human disease. However, fluctuations in RNA metabolism caused by chronic stress have been largely neglected in the field. Stress granules (SGs) are cytoplasmic ribonucleoprotein condensates formed in response to stress-induced inhibition of mRNA translation and ...
Adachi Y, Williams AM, Masuda M, Taketani Y, Anderson PJ, Ivanov P.   +5 more
europepmc   +4 more sources

The p97 adaptor p47/NSFL1C is necessary for stress granule dissolution after heat stressThe p97 adaptor p47/NSFL1C is necessary for stress granule dissolution after heat stress [PDF]

Open Biology
Stress granules form in response to diverse cellular perturbations to sequester translation components until the stress is resolved. Stress granules are composed of RNA–protein assemblies in membrane-delimited structures and must be rapidly disassembled ...
Michelle A. Johnson, Richa Khanna, Sirisha Mukkavalli, Ly Nguyen, Malavika Raman   +4 more
doaj   +2 more sources

Cytoplasmic circular dsDNA is a key constituent of stress granules [PDF]

eLife
Stress granules are large cytoplasmic bodies formed in response to environmental insults by eukaryotic cells. Stress granule formation is key for post-stress recovery, and many diseases and infections are characterized by dysregulation of these ...
Natalia A Demeshkina, Adrian R Ferré-D'Amaré   +1 more
doaj   +2 more sources

TIA-1 Self-Multimerization, Phase Separation, and Recruitment into Stress Granules Are Dynamically Regulated by Zn2+

Cell Reports, 2018
Summary: Stress granules are non-membranous structures that transiently form in the cytoplasm during cellular stress, where they promote translational repression of non-essential RNAs and modulate cell signaling by sequestering key signal transduction ...
Joseph B. Rayman, Kevin A. Karl, Eric R. Kandel   +2 more
doaj   +3 more sources

Plant stress granules and mRNA processing bodies are distinct from heat stress granules [PDF]

Plant Journal, 2008
SummarySimilar to the situation in mammalian cells and yeast, messenger ribonucleo protein (mRNP) homeostasis in plant cells depends on rapid transitions between three functional states, i.e. translated mRNPs in polysomes, stored mRNPs and mRNPs under degradation.
Christian, Weber, Lutz, Nover, Markus, Fauth   +2 more
exaly   +3 more sources

Zinc increases stress granule formation by promoting RNA condensation

Cell Reports
Summary: During cellular stress, mRNAs are condensed into stress granules through the action of G3BP1 and G3BP2. How intracellular conditions affect RNA-protein condensation in stress granules is still unclear.
Luisa Macedo de Vasconcelos, Nina Ripin, Roy Parker   +2 more
doaj   +2 more sources