Results 31 to 40 of about 162,836 (295)
Stress granules regulate stress-induced paraspeckle assembly [PDF]
Journal of Cell Biology, 2019 Eukaryotic cells contain a variety of RNA-protein macrocomplexes termed RNP granules. Different types of granules share multiple protein components; however, the crosstalk between spatially separated granules remains unaddressed. Paraspeckles and stress granules (SGs) are prototypical RNP granules localized exclusively in the nucleus and cytoplasm ...
Haiyan An +2 more
openaire +3 more sources
Activation of Gαq sequesters specific transcripts into Ago2 particles
Scientific Reports, 2022 The Gαq/phospholipase Cβ1 (PLCβ1) signaling system mediates calcium responses from hormones and neurotransmitters. While PLCβ1 functions on the plasma membrane, there is an atypical cytosolic population that binds Argonaute 2 (Ago2) and other proteins ...
Lela Jackson +3 more
doaj +1 more source
Biochemistry and Biophysics Reports, 2021 Pesticides entering our body, either directly or indirectly, are known to increase the risk of developing neurodegenerative disorders. The pesticide-induced animal models of Parkinson's disease and Alzheimer's disease recapitulates many of the ...
Pratibha Bhadauriya +2 more
doaj +1 more source
To translate, or not to translate: viral and host mRNA regulation by interferon-stimulated genes. [PDF]
, 2015 Type I interferon (IFN) is one of the first lines of cellular defense against viral pathogens. As a result of IFN signaling, a wide array of IFN-stimulated gene (ISG) products is upregulated to target different stages of the viral life cycle.
Li, Melody MH +2 more
core +1 more source
Impact of Weather Conditions and Farming Systems on Size Distribution of Starch Granules and Flour Yield of Winter Wheat [PDF]
, 2020 The size distribution of wheat-grain starch granules has an impact on the yield of finne flour. The aim of the study was to compare the impact of conventional (mineral fertilizers, pesticides) and organic farming treatments (cover crops, composted cattle
Alaru, Maarika +8 more
core +2 more sources
Plant Stress Granules: Trends and Beyond [PDF]
Frontiers in Plant Science, 2021 Stress granules (SGs) are dynamic membrane-less condensates transiently assembled through liquid–liquid phase separation (LLPS) in response to stress. SGs display a biphasic architecture constituted of core and shell phases. The core is a conserved SG fraction fundamental for its assembly and consists primarily of proteins with intrinsically disordered
Maruri Lopez, Israel +3 more
openaire +4 more sources
, 2020 The capacity of cells to organize complex biochemical reactions in intracellular space is a fundamental organizational principle of life. Key to this organization is the compartmentalization of the cytoplasm into distinct organelles, which is frequently achieved through intracellular membranes.
Min-Seok, Song, Elda, Grabocka
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Sequestration of highly expressed mRNAs in cytoplasmic granules, P-bodies, and stress granules enhances cell viability. [PDF]
PLoS Genetics, 2012 Transcriptome analyses indicate that a core 10%-15% of the yeast genome is modulated by a variety of different stresses. However, not all the induced genes undergo translation, and null mutants of many induced genes do not show elevated sensitivity to ...
Anna Lavut, Dina Raveh
doaj +1 more source
Background-deflection Brillouin microscopy reveals altered biomechanics of intracellular stress granules by ALS protein FUS [PDF]
, 2018 Altered cellular biomechanics have been implicated as key photogenic triggers in age-related diseases. An aberrant liquid-to-solid phase transition, observed in in vitro reconstituted droplets of FUS protein, has been recently proposed as a possible ...
Antonacci, Giuseppe +3 more
core +3 more sources
Cell Reports, 2018 Summary: Stress granules are non-membranous structures that transiently form in the cytoplasm during cellular stress, where they promote translational repression of non-essential RNAs and modulate cell signaling by sequestering key signal transduction ...
Joseph B. Rayman +2 more
doaj +1 more source