Results 21 to 30 of about 162,836 (295)
Cell Cycle, 2012 Cell growth and proliferation are fundamental processes in living organisms and are dynamically controlled by environmental cues. TOR complex 1 (TORC1) is a central protein kinase involved in the regulation of cell growth in response to a wide variety of cellular states and is the target of the immunosuppressant and anticancer drug rapamycin.
Takahara, Terunao, Maeda, Tatsuya
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Frontiers in Plant Science, 2021 During the energy crisis associated with submergence stress, plants restrict mRNA translation and rapidly accumulate stress granules that act as storage hubs for arrested mRNA complexes. One of the proteins associated with hypoxia-induced stress granules
Sterling Field +2 more
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Aberrant Stress Granule Dynamics and Aggrephagy in ALS Pathogenesis
Cells, 2021 Stress granules are conserved cytosolic ribonucleoprotein (RNP) compartments that undergo dynamic assembly and disassembly by phase separation in response to stressful conditions.
Yi Zhang, Jiayu Gu, Qiming Sun
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Getting stress out of stressed‐out stress granules [PDF]
The EMBO Journal, 2017 Amyotrophic lateral sclerosis (ALS) pathology is linked to the aberrant aggregation of specific proteins, including TDP‐43, FUS, and SOD1, but it is not clear why these aggregation events cause ALS. In this issue of The EMBO Journal , Mateju et al (2017) report a direct link between misfolded proteins accumulating in stress granules and the phase ...
Pratibha Siwach, Daniel Kaganovich
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The autophagy of stress granules
FEBS Letters, 2023 Our understanding of stress granule (SG) biology has deepened considerably in recent years, and with this, increased understanding of links has been made between SGs and numerous neurodegenerative diseases. One of the proposed mechanisms by which SGs and any associated protein aggregates may become pathological is based upon defects in their autophagic
Ryan, Laura, Rubinsztein, David C
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Biology Open, 2016 Stress granules are cytoplasmic foci that directly respond to the protein synthesis status of the cell. Various environmental insults, such as oxidative stress or extreme heat, block protein synthesis; consequently, mRNA will stall in translation, and ...
Cecilia Zampedri +6 more
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Drug-induced stress granule formation protects sensory hair cells in mouse cochlear explants during ototoxicity [PDF]
, 2019 Stress granules regulate RNA translation during cellular stress, a mechanism that is generally presumed to be protective, since stress granule dysregulation caused by mutation or ageing is associated with neurodegenerative disease.
Dawson, Sally J. +6 more
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The Journal of Cell Biology, 2004 Nuclear stress granules are subnuclear compartments that form in response to heat shock and other stress stimuli. Although many components of nuclear stress granules have been identified, including HSF1 and pre-mRNA processing factors, their function remains a mystery. A paper in this issue describes the stress-induced transcriptional activation of one
Anton Sandqvist, Lea Sistonen
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Role of the RNA-binding protein Nrd1 in stress granule formation and its implication in the stress response in fission yeast. [PDF]
PLoS ONE, 2012 We have previously identified the RNA recognition motif (RRM)-type RNA-binding protein Nrd1 as an important regulator of the posttranscriptional expression of myosin in fission yeast.
Ryosuke Satoh +10 more
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Methodology of mechanical characterization of coated spherical materials [PDF]
, 2008 The aim of this work was to develop a methodology for the mechanical characterization of catalyst beads with a core-shell structure and more especially for coated spherical granules.
Celse, Benoit +3 more
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