Results 21 to 30 of about 2,813,474 (315)

Porcine deltacoronavirus nucleocapsid protein inhibits RIG-I signaling pathway by suppressing G3BP1-mediated stress granules formation. [PDF]

Virulence
Guo M, Hu Y, Wang D, Tang Y, Yuan J, Shi C, Zu S, Wei Z.   +7 more
europepmc   +5 more sources

Functional amyloid protein FXR1 is recruited into neuronal stress granules

Prion
The FXR1 protein regulates the stability and translation of a number of RNA molecules and plays an important role in the regulation of cellular processes under normal conditions and stress.
Anna A. Valina, Tatyana A. Belashova, Anastasia K. Yuzman, Sergey P. Zadorsky, Evgeniy I. Sysoev, Vladimir A. Mitkevich, Alexander A. Makarov, Alexey P. Galkin   +7 more
doaj   +2 more sources

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation [PDF]

FEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima, Kotone WATANABE, Grigorii Sultanakhmetov, Aoi Fukuchi, Keiya Ito, Sawako Shimizu, Taro Saito, Akiko Asada, Kanae Ando   +8 more
openalex   +2 more sources

Biomimetic stress granules replenish lysosomal repair to reinstate macrophage immunometabolic antibacterial programs. [PDF]

Bioact Mater
Zhao S, Chen L, Shao Z, Sun Y, Mu X, Yao M, Chen J, Jin X, Wang F, Chai X, Xue Y, Yinwang E, Chen S, Mou H, Wang K, Hu X, Jin L, Lei J, Zhang S, Zhang Z, Yu X, Ye Z.   +21 more
europepmc   +2 more sources

The autophagy of stress granules

FEBS Letters, 2023
Our understanding of stress granule (SG) biology has deepened considerably in recent years, and with this, increased understanding of links has been made between SGs and numerous neurodegenerative diseases. One of the proposed mechanisms by which SGs and any associated protein aggregates may become pathological is based upon defects in their autophagic
Ryan, Laura, Rubinsztein, David C
openaire   +3 more sources

Mechanism and effect of stress granule formation in cancer and its potential roles in breast cancer therapy

Genes and Diseases, 2022
Stress granules are non-membranous cytoplasmic foci induced by various stress conditions. It is a protective strategy used by cells to suppress overall translation during stress. In cancer cells, it was thought that the formation of stress granules could
Taobo Hu, Wei Hou, Enhua Xiao, Mengping Long   +3 more
doaj   +1 more source

Localization to, and effects of Pbp1, Pbp4, Lsm12, Dhh1, and Pab1 on stress granules in Saccharomyces cerevisiae. [PDF]

PLoS ONE, 2010
The regulation of translation and mRNA degradation in eukaryotic cells involves the formation of cytoplasmic mRNP granules referred to as P-bodies and stress granules.
Kylie D Swisher, Roy Parker
doaj   +1 more source

Stress granules in the spinal muscular atrophy and amyotrophic lateral sclerosis: The correlation and promising therapy

Neurobiology of Disease, 2022
Increasing genetic and biochemical evidence has broadened our view of the pathomechanisms that lead to Spinal muscular atrophy (SMA) and Amyotrophic lateral sclerosis (ALS), two fatal neurodegenerative diseases with similar symptoms and causes.
LiDan Hu, Shanshan Mao, Li Lin, Guannan Bai, Bingjie Liu, Jianhua Mao   +5 more
doaj   +1 more source

Darinaparsin is a multivalent chemotherapeutic which induces incomplete stress response with disruption of microtubules and Shh signaling. [PDF]

PLoS ONE, 2011
Chemotherapeutics and other pharmaceuticals are common sources of cellular stress. Darinaparsin (ZIO-101) is a novel organic arsenical under evaluation as a cancer chemotherapeutic, but the drug's precise mechanism of action is unclear.
Twila A Mason, Elena Kolobova, Jiang Liu, Joseph T Roland, Chin Chiang, James R Goldenring   +5 more
doaj   +1 more source

DIAPH3 condensates formed by liquid-liquid phase separation act as a regulatory hub for stress-induced actin cytoskeleton remodeling

Cell Reports, 2023
Summary: Membraneless condensates, such as stress granules (SGs) and processing bodies (P-bodies), have attracted wide attention due to their unique feature of rapid response to stress without first requiring nuclear feedback.
Ke Zhang, Miaodan Huang, Ang Li, Jing Wen, Lingli Yan, Yunhao Li, Liman Guo, Kumaran Satyanarayanan Senthil, Yangyang Zhou, Guobing Chen, Yong Liu, Xiaofei Zhang, Xiaoli Yao, Dajiang Qin, Huanxing Su   +14 more
doaj   +1 more source