Results 11 to 20 of about 162,836 (295)
Stress granules and neurodegeneration [PDF]
Nature Reviews Neuroscience, 2019 Recent advances suggest that the response of RNA metabolism to stress has an important role in the pathophysiology of neurodegenerative diseases, particularly amyotrophic lateral sclerosis, frontotemporal dementias and Alzheimer disease. RNA-binding proteins (RBPs) control the utilization of mRNA during stress, in part through the formation of ...
Benjamin Wolozin, Pavel Ivanov
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The Stress Granule Transcriptome Reveals Principles of mRNA Accumulation in Stress Granules [PDF]
Molecular Cell, 2017 Stress granules are mRNA-protein assemblies formed from nontranslating mRNAs. Stress granules are important in the stress response and may contribute to some degenerative diseases. Here, we describe the stress granule transcriptome of yeast and mammalian cells through RNA-sequencing (RNA-seq) analysis of purified stress granule cores and single ...
Anthony, Khong +5 more
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Principles and Properties of Stress Granules [PDF]
Trends in Cell Biology, 2016 Stress granules are assemblies of untranslating messenger ribonucleoproteins (mRNPs) that form from mRNAs stalled in translation initiation. Stress granules form through interactions between mRNA-binding proteins that link together populations of mRNPs. Interactions promoting stress granule formation include conventional protein-protein interactions as
David S W, Protter, Roy, Parker
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Localization to, and effects of Pbp1, Pbp4, Lsm12, Dhh1, and Pab1 on stress granules in Saccharomyces cerevisiae. [PDF]
PLoS ONE, 2010 The regulation of translation and mRNA degradation in eukaryotic cells involves the formation of cytoplasmic mRNP granules referred to as P-bodies and stress granules.
Kylie D Swisher, Roy Parker
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Aspergillus oryzae AoSO is a novel component of stress granules upon heat stress in filamentous fungi. [PDF]
PLoS ONE, 2013 Stress granules are a type of cytoplasmic messenger ribonucleoprotein (mRNP) granule formed in response to the inhibition of translation initiation, which typically occurs when cells are exposed to stress.
Hsiang-Ting Huang +2 more
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Neurobiology of Disease, 2022 Increasing genetic and biochemical evidence has broadened our view of the pathomechanisms that lead to Spinal muscular atrophy (SMA) and Amyotrophic lateral sclerosis (ALS), two fatal neurodegenerative diseases with similar symptoms and causes.
LiDan Hu +5 more
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Darinaparsin is a multivalent chemotherapeutic which induces incomplete stress response with disruption of microtubules and Shh signaling. [PDF]
PLoS ONE, 2011 Chemotherapeutics and other pharmaceuticals are common sources of cellular stress. Darinaparsin (ZIO-101) is a novel organic arsenical under evaluation as a cancer chemotherapeutic, but the drug's precise mechanism of action is unclear.
Twila A Mason +5 more
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Cell Reports, 2023 Summary: Membraneless condensates, such as stress granules (SGs) and processing bodies (P-bodies), have attracted wide attention due to their unique feature of rapid response to stress without first requiring nuclear feedback.
Ke Zhang +14 more
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mRNPs meet stress granules [PDF]
FEBS Letters, 2017 Stress granules are cytoplasmic structures that form in response to a variety of cellular stresses. They contain mRNAs and many proteins including numerous types of RNA‐binding proteins, and have been studied in connection to major cellular events such as protein synthesis as well as disease. Despite the well‐known fact that stress granules encapsulate
Jonathan Sheinberger, Yaron Shav‐Tal
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Applied Sciences, 2021 Divalent cations were known to alleviate salinity stress on anammox bacteria. Understanding the mechanism of reducing the salinity stress on anammox granules is essential for the application of the anammox process for saline wastewater treatment. In this
Yeonju Kim +9 more
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