Results 11 to 20 of about 77,443 (288)

Getting stress out of stressed‐out stress granules [PDF]

The EMBO Journal, 2017
Amyotrophic lateral sclerosis (ALS) pathology is linked to the aberrant aggregation of specific proteins, including TDP‐43, FUS, and SOD1, but it is not clear why these aggregation events cause ALS. In this issue of The EMBO Journal , Mateju et al (2017) report a direct link between misfolded proteins accumulating in stress granules and the phase ...
Pratibha Siwach, Daniel Kaganovich
openaire   +4 more sources

Chronic stress antagonizes formation of stress granules. [PDF]

iScience
Abstract Chronic stress mediates cellular changes that can contribute to human disease. However, fluctuations in RNA metabolism caused by chronic stress have been largely neglected in the field. Stress granules (SGs) are cytoplasmic ribonucleoprotein condensates formed in response to stress-induced inhibition of mRNA translation and ...
Adachi Y, Williams AM, Masuda M, Taketani Y, Anderson PJ, Ivanov P.   +5 more
europepmc   +4 more sources

Stress granules and neurodegeneration [PDF]

Nature Reviews Neuroscience, 2019
Recent advances suggest that the response of RNA metabolism to stress has an important role in the pathophysiology of neurodegenerative diseases, particularly amyotrophic lateral sclerosis, frontotemporal dementias and Alzheimer disease. RNA-binding proteins (RBPs) control the utilization of mRNA during stress, in part through the formation of ...
Benjamin Wolozin, Pavel Ivanov, Wolozin Benjamin   +2 more
exaly   +3 more sources

Stress‐induced mRNP granules: Form and function of processing bodies and stress granules [PDF]

WIREs RNA, 2019
In response to stress, cells must quickly reprogram gene expression to adapt and survive. This is achieved in part by altering levels of mRNAs and their translation into proteins. Recently, the formation of two stress‐induced messenger ribonucleoprotein (mRNP) assemblies named stress granules and processing bodies has been postulated to directly impact
Anna R. Guzikowski, Yang S. Chen, Brian M. Zid   +2 more
openaire   +6 more sources

Stress Granules and Virus Replication [PDF]

Future Virology, 2011
Viruses are dependent on the cellular translation machinery for protein synthesis. Part of the innate immune response to infection is activation of the stress kinase PKR which phosphorylates the alpha subunit of the initiation factor eIF2. This results in inhibition of translation and is intended to block virus replication.
Cathy L Miller
openaire   +3 more sources

Ribonucleoprotein Granules: Between Stress and Transposable Elements

Biomolecules, 2023
Transposable elements (TEs) are DNA sequences that can transpose and replicate within the genome, leading to genetic changes that affect various aspects of host biology.
Sungjin Moon, Sim Namkoong
doaj   +2 more sources

Stress Granules in the Post-transcriptional Regulation of Immune Cells

Frontiers in Cell and Developmental Biology, 2021
Immune cell activation triggers transcriptional and translational programs eliciting cellular processes, such as differentiation or proliferation, essential for an efficient immune response.
Nicolas Curdy, Nicolas Curdy, Nicolas Curdy, Olivia Lanvin, Olivia Lanvin, Olivia Lanvin, Sarah Cadot, Sarah Cadot, Sarah Cadot, Camille Laurent, Camille Laurent, Camille Laurent, Camille Laurent, Jean-Jacques Fournié, Jean-Jacques Fournié, Jean-Jacques Fournié, Don-Marc Franchini, Don-Marc Franchini, Don-Marc Franchini   +18 more
doaj   +2 more sources

Rim4-seeded stress granules connect temperature sensing to meiotic regulation

Nature Communications
Meiosis is more vulnerable to heat than mitosis in many species including humans. In Saccharomyces cerevisiae, we discovered that stress granule formation halts meiosis at high temperatures. Meiotic stress granules appear at lower temperatures (33–42 °C)
Rudian Zhang, Shunjin Li, Wenzhi Feng, Suhong Qian, Akshay John Chellappa, Fei Wang   +5 more
doaj   +2 more sources

RNA Granules and Stress Granules in Virus Systems

Journal of Bacteriology and Virology, 2012
Viruses initiate a number of cellular stress responses and modulate gene regulation and compartmentalization of RNA upon infection to be successful parasites. Virus infections may induce or impair stress granule (SG) formation to maximize replication efficiency.
Kim, K
openaire   +2 more sources

The autophagy of stress granules

FEBS Letters, 2023
Our understanding of stress granule (SG) biology has deepened considerably in recent years, and with this, increased understanding of links has been made between SGs and numerous neurodegenerative diseases. One of the proposed mechanisms by which SGs and any associated protein aggregates may become pathological is based upon defects in their autophagic
Ryan, Laura, Rubinsztein, David C
openaire   +3 more sources