Results 41 to 50 of about 2,813,474 (315)
Activation of Gαq sequesters specific transcripts into Ago2 particles
Scientific Reports, 2022 The Gαq/phospholipase Cβ1 (PLCβ1) signaling system mediates calcium responses from hormones and neurotransmitters. While PLCβ1 functions on the plasma membrane, there is an atypical cytosolic population that binds Argonaute 2 (Ago2) and other proteins ...
Lela Jackson +3 more
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, 2020 The capacity of cells to organize complex biochemical reactions in intracellular space is a fundamental organizational principle of life. Key to this organization is the compartmentalization of the cytoplasm into distinct organelles, which is frequently achieved through intracellular membranes.
Min-Seok, Song, Elda, Grabocka
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PARP10 is critical for stress granule initiation
Life Science Alliance, 2023 Stress granules (SGs) are cytoplasmic biomolecular condensates enriched with RNA and translation factors. They form in response to stress, in part through phosphorylation of the translation initiation factor eIF2α, and are implicated in viral infection, tumorigenesis, and neurodegeneration. Although ADP-ribosylation plays a key role in SG assembly, the
Aravinth Kumar Jayabalan +2 more
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Biochemistry and Biophysics Reports, 2021 Pesticides entering our body, either directly or indirectly, are known to increase the risk of developing neurodegenerative disorders. The pesticide-induced animal models of Parkinson's disease and Alzheimer's disease recapitulates many of the ...
Pratibha Bhadauriya +2 more
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Principles and Properties of Stress Granules [PDF]
Trends in Cell Biology, 2016 Stress granules are assemblies of untranslating messenger ribonucleoproteins (mRNPs) that form from mRNAs stalled in translation initiation. Stress granules form through interactions between mRNA-binding proteins that link together populations of mRNPs. Interactions promoting stress granule formation include conventional protein-protein interactions as
David S W, Protter, Roy, Parker
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MSGP: the first database of the protein components of the mammalian stress granules [PDF]
, 2019 In response to different stress stimuli, cells transiently form stress granules (SGs) in order to protect themselves and re-establish homeostasis. Besides these important cellular functions, SGs are now being implicated in different human diseases, such ...
Mestre, Isa +5 more
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Editorial: Biology of Stress Granules in Plants
Frontiers in Plant Science, 2022 Eukaryotic cells have developed sophisticated mechanisms to survive under ever-changing environments which include compartmentalization of translationally arrested mRNA molecules and proteins into a type of membraneless cytoplasmic foci called stress granules (SGs).
Monika Chodasiewicz +3 more
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Frontiers in Molecular Biosciences, 2022 Stress granules are non-membrane bound RNA-protein granules essential for survival during acute cellular stress. TIA-1 is a key protein in the formation of stress granules that undergoes liquid-liquid phase separation by association with specific RNAs ...
Danella L. West +7 more
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Development of a novel light-up probe for detection of G-quadruplexes in stress granules
Scientific Reports, 2022 G-quadruplexes (G4s) regulate various biological processes in cells. However, cellular imaging of dynamically forming G4s in biomolecular condensates using small molecules has been poorly investigated. Herein, we present a fluorescent light-up probe with
Keisuke Iida +4 more
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Stress Granules in the Post-transcriptional Regulation of Immune Cells
Frontiers in Cell and Developmental Biology, 2021 Immune cell activation triggers transcriptional and translational programs eliciting cellular processes, such as differentiation or proliferation, essential for an efficient immune response.
Nicolas Curdy +18 more
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