Results 61 to 70 of about 162,836 (295)

Atomic structures of TDP-43 LCD segments and insights into reversible or pathogenic aggregation. [PDF]

, 2018
The normally soluble TAR DNA-binding protein 43 (TDP-43) is found aggregated both in reversible stress granules and in irreversible pathogenic amyloid. In TDP-43, the low-complexity domain (LCD) is believed to be involved in both types of aggregation. To
A Jain, A Molliex, A Patel, A Saini, A Soragni, AE Conicella, AF Harrison, AJ McCoy, AK Chen, AK Walker, AWP Fitzpatrick, C Amador-Ortiz, C Colombrita, C Lagier-Tourenne, C Schwab, C Yang, C-H Chiang, CK Chang, CM Dewey, Collaborative Computational Project, Number 4., D Shi, DA Bosco, David R. Boyer, David S. Eisenberg, DS Eisenberg, DT Murray, Duilio Cascio, E Bentmann, E Buratti, E Kabashi, EB Lee, Elizabeth L. Guenther, EM Marcotte, F Meersman, GM Sheldrick, GN Murshudov, GS Pesiridis, H Nakashima-Yasuda, Hamilton Trinh, HB Schmidt, HJ Dyson, HJ Kim, HY Zoghbi, J Hattne, JA Rodriguez, Jiahui Lu, JJ Wiltzius, Jose A. Rodriguez, JP Ling, JR Wheeler, L Goldschmidt, L Lim, LC Reineke, LL Jiang, LL Jiang, LM Igaz, M Budini, M Cushman, M Hasegawa, M Kato, M Mompeán, M Neumann, M Xu, MA Gitcho, Masato Kato, MC Lawrence, MD Winn, Michael P. Hughes, Michael R. Sawaya, MP Hughes, MR Sawaya, N Gilks, N Kedersha, P Emsley, P Hackman, P-N Cheng, PD Adams, PJ Lukavsky, PM Seidler, PS Estes, Qin Cao, RA Fuentealba, S Higashi, S Xiang, SC Ling, TM Franzmann, TPJ Knowles, W Guo, W Kabsch, W Kabsch, Y Dang, Y Lin, Z Otwinowski, ZM March   +93 more
core   +1 more source

Viral modulation of stress granules

Virus Research, 2012
Following viral infection, the host responds by mounting a robust anti-viral response with the aim of creating an unfavorable environment for viral replication. As a countermeasure, viruses have elaborated mechanisms to subvert the host response in order to maintain viral protein synthesis and production.
Valiente-Echeverría, Fernando, Melnychuk, Luca, Mouland, Andrew J.   +2 more
openaire   +2 more sources

Stress granules, P-bodies and cancer [PDF]

Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2015
Cancer cells are exposed to adverse conditions in the tumor microenvironment, and utilize post-transcriptional control mechanisms to re-program gene expression in ways that enhance cell survival. Stress granules and processing bodies are RNA-containing granules that contribute to this process by modulating cellular signaling pathways, metabolic ...
Paul, Anderson, Nancy, Kedersha, Pavel, Ivanov   +2 more
openaire   +2 more sources

Detecting Stress Granules in Drosophila Neurons [PDF]

, 2022
Stress granules (SGs) are cytoplasmic ribonucleoprotein condensates that dynamically and reversibly assemble in response to stress. They are thought to contribute to the adaptive stress response by storing translationally inactive mRNAs as well as signaling molecules.
de Graeve, Fabienne, Formicola, Nadia, Pushpalatha, Kavya Vinayan, Nakamura, Akira, Debreuve, Eric, Descombes, Xavier, Besse, Florence   +6 more
openaire   +3 more sources

Regulation of Cellular Ribonucleoprotein Granules: From Assembly to Degradation via Post-translational Modification

Cells, 2022
Cells possess membraneless ribonucleoprotein (RNP) granules, including stress granules, processing bodies, Cajal bodies, or paraspeckles, that play physiological or pathological roles.
Pureum Jeon, Hyun-Ji Ham, Semin Park, Jin-A Lee   +3 more
doaj   +1 more source

Wet granulation in laboratory scale high shear mixers: Effect of binder properties [PDF]

, 2011
The effect of binder properties on torque curves, granule growth kinetics, wet mass consistency and dry granule strength has been investigated in this study.
Chitu, Toma Mihai, Hemati, Mehrdji, Oulahna, Driss   +2 more
core   +3 more sources

Neuron-Specific HuR-Deficient Mice Spontaneously Develop Motor Neuron Disease [PDF]

, 2018
Human Ag R (HuR) is an RNA binding protein in the ELAVL protein family. To study the neuron-specific function of HuR, we generated inducible, neuron-specific HuR-deficient mice of both sexes.
Bai, Ying, Chen, Xing, Hamilton, Thomas A., Herjan, Tomasz, Kokiko-Cochran, Olga N., Lamb, Bruce, Lee, Yu-Shang, Li, Xiao, Lin, Ching-Yi, Sun, Kevin, Zhou, Gao   +10 more
core   +1 more source

Promiscuous interactions and protein disaggregases determine the material state of stress-inducible RNP granules

eLife, 2015
RNA-protein (RNP) granules have been proposed to assemble by forming solid RNA/protein aggregates or through phase separation into a liquid RNA/protein phase. Which model describes RNP granules in living cells is still unclear.
Sonja Kroschwald, Shovamayee Maharana, Daniel Mateju, Liliana Malinovska, Elisabeth Nüske, Ina Poser, Doris Richter, Simon Alberti   +7 more
doaj   +1 more source

Population balance modelling for a flow induced phase inversion based granulation in a two-dimensional rotating agglomerator [PDF]

, 2010
A novel two-dimensional rotating agglomerator was developed to carry out the flow induced phase inversion (FIPI) based granulation. The process in this agglomerator shows that a continuous paste flow (mixed with liquid binder and primary particles) is ...
Akay, Akay, Akay, Akay, Bird, Ennis, G. Akay, Gaylord, German, Ghijsels, Hill, Hounslow, Hounslow, Hulbert, L. Liu, L. Tong, Lissant, Liu, Milewski, Nielsen, Paul, Ramkrishna, Randolph, Sastry, Van de Vegt, von Smoluchowski, Wildemuth   +26 more
core   +1 more source

Actin and microtubules position stress granules

PRX Life, 2023
AbstractMembraneless organelles, composed of protein and nucleic acids, alter the biochemical and physical landscape of the cell. While specific membraneless organelles are found in stereotypical locations, little is known about the physical mechanisms that guide their positioning.
Thomas J. Böddeker, Anja Rusch, Keno Leeners, Michael P. Murrell, Eric R. Dufresne   +4 more
openaire   +1 more source