Results 71 to 80 of about 162,836 (295)

The pestivirus N terminal protease N(pro) redistributes to mitochondria and peroxisomes suggesting new sites for regulation of IRF3 by N(pro.) [PDF]

, 2014
The N-terminal protease of pestiviruses, N(pro) is a unique viral protein, both because it is a distinct autoprotease that cleaves itself from the following polyprotein chain, and also because it binds and inactivates IRF3, a central regulator of ...
C Achmüller, C Castanier, CA Benedict, D Hoepfner, E Dixit, E Peterhans, F Hou, HW Platta, Irina Mohorianu, JC Martinou, JE Vince, Karen L. Mossman, KE Taylor, KV Mohan, Matthew Jefferson, Matthew Whelband, MJ Killip, MR Szymanski, N Ruggli, N Zemirli, O Bauhofer, PB Lazarow, Penny P. Powell, R Higgs, RB Seth, RE Lloyd, S Chattopadhyay, S Paz, S Sharma, SA La Rocca, SM Belgnaoui, SW Tait, T Wolff, TJ Ettema, V Doceul, V Moennig, Y Li   +36 more
core   +5 more sources

Who Regulates Whom? An Overview of RNA Granules and Viral Infections

Viruses, 2016
After viral infection, host cells respond by mounting an anti-viral stress response in order to create a hostile atmosphere for viral replication, leading to the shut-off of mRNA translation (protein synthesis) and the assembly of RNA granules.
Natalia Poblete-Durán, Yara Prades-Pérez, Jorge Vera-Otarola, Ricardo Soto-Rifo, Fernando Valiente-Echeverría   +4 more
doaj   +1 more source

Dance with the Devil: Stress Granules and Signaling in Antiviral Responses

Viruses, 2020
Cells have evolved highly specialized sentinels that detect viral infection and elicit an antiviral response. Among these, the stress-sensing protein kinase R, which is activated by double-stranded RNA, mediates suppression of the host translation ...
Nina Eiermann, Katharina Haneke, Zhaozhi Sun, Georg Stoecklin, Alessia Ruggieri   +4 more
doaj   +1 more source

TIA1 Mutations in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Promote Phase Separation and Alter Stress Granule Dynamics. [PDF]

, 2017
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are age-related neurodegenerative disorders with shared genetic etiologies and overlapping clinical and pathological features. Here we studied a novel ALS/FTD family and identified the
Annu, Kavya, Baker, Matt, Bigio, Eileen, Boylan, Kevin B., Caselli, Richard J., Dickson, Dennis W., Finger, Elizabeth, Fryer, John D., Graff-Radford, Neill R., Hirsch-Reinshagen, Veronica, Hsiung, Ging-Yuek R., Kato, Masato, Keith, Julia, Kim, Hong Joo, Krieger, Charles, Kurti, Aishe, Lacomis, David, Lippa, Carol, Mackenzie, Ian R., Matchett, Billie J., Messing, James, Mesulam, Marsel, Mittag, Tanja, Murray, Melissa E., Nicholson, Alexandra M., Perkerson, Ralph B., Petersen, Ronald C., Petrucelli, Leonard, Pottier, Cyril, Purice, Maria D., Rademakers, Rosa, Rogaeva, Ekaterina, Roos, Raymond P., Sarkar, Mohona, Stewart, Heather, Taylor, J. Paul, Temirov, Jamshid, Weintraub, Sandra, Wszolek, Zbigniew K., Zinman, Lorne, Zivkovic, Sasha A., Züchner, Stephan   +41 more
core   +2 more sources

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Rheology, granule growth and granule strength: Application to the wet granulation of lactose–MCC mixtures [PDF]

, 2011
This study aims at better understanding the wet granulation process of a binary mixture composed of microcrystalline cellulose (water insoluble) and lactose (water soluble).
Chitu, Toma Mihai, Hemati, Mehrdji, Oulahna, Driss   +2 more
core   +3 more sources

Stress Granule Assembly Disrupts Nucleocytoplasmic Transport [PDF]

Cell, 2018
Defects in nucleocytoplasmic transport have been identified as a key pathogenic event in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) mediated by a GGGGCC hexanucleotide repeat expansion in C9ORF72, the most common genetic cause of ALS/FTD.
Ke, Zhang, J Gavin, Daigle, Kathleen M, Cunningham, Alyssa N, Coyne, Kai, Ruan, Jonathan C, Grima, Kelly E, Bowen, Harsh, Wadhwa, Peiguo, Yang, Frank, Rigo, J Paul, Taylor, Aaron D, Gitler, Jeffrey D, Rothstein, Thomas E, Lloyd   +13 more
openaire   +2 more sources

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Method for Particle Size Control During the Drying and Granulation in Fluidized Bed [PDF]

, 2001
The fluidized bed process presented in this paper is suitable for recovery of solids from solutions in the form of granules. The solution is sprayed into the bed and as solvent evaporates, solid material is deposited on the surface of fluidizing ...
Dencs, B., Gyenis, János, Tardos, I. G.
core