Results 61 to 70 of about 10,043,563 (299)

Endosymbiont control through non-canonical immune signaling and gut metabolic remodeling

Cell Reports
Summary: Animals coexist with bacteria and need to keep these microorganisms under tight control. To achieve such control, pattern recognition receptors (PRRs) sense bacterial cues and induce the production of antimicrobials. Here, we uncover a metabolic
Sofie Burgmer, Fenja L. Meyer zu Altenschildesche, Akos Gyenis, Hyun Ju Lee, David Vilchez, Patrick Giavalisco, Arnaud Fichant, Mirka Uhlirova, Gilles Storelli   +8 more
doaj   +1 more source

Language, Culture, and Cancer: Qualitative Insights Into Communication Disparities Among Spanish‐Speaking Caregivers of Children With Cancer

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Latino children are projected to make up nearly one‐third of United States (US) children by 2060, and many of their caregivers speak Spanish. Prior survey research has documented communication difficulties for Spanish‐speaking caregivers of children with cancer, but contemporary qualitative data are limited.
Jenny Ruiz, Alejandra Curbelo‐Paz, Sonia Morales, Elizabeth Contreras, Amy Houtrow, Scott H. Maurer, Judy C. Chang   +6 more
wiley   +1 more source

DNL343 is an investigational CNS penetrant eukaryotic initiation factor 2B activator that prevents and reverses the effects of neurodegeneration caused by the integrated stress response

eLife
The integrated stress response (ISR) is a conserved pathway in eukaryotic cells that is activated in response to multiple sources of cellular stress.
Ernie Yulyaningsih, Jung H Suh, Melania Fanok, Roni Chau, Hilda Solanoy, Ryan Takahashi, Anna I Bakardjiev, Isabel Becerra, N Butch Benitez, Chi-Lu Chiu, Sonnet S Davis, William E Dowdle, Timothy Earr, Anthony A Estrada, Audrey Gill, Connie Ha, Patrick CG Haddick, Kirk R Henne, Martin Larhammar, Amy W-S Leung, Romeo Maciuca, Bahram Memarzadeh, Hoang N Nguyen, Alicia A Nugent, Maksim Osipov, Yingqing Ran, Kevin Rebadulla, Elysia Roche, Thomas Sandmann, Jing Wang, Joseph W Lewcock, Kimberly Scearce-Levie, Lesley A Kane, Pascal E Sanchez   +33 more
doaj   +1 more source

Parents of Youth With Cancer Report on Their Psychosocial Care: iSTEPPP Survey Finds Alignment and Gaps With Standards

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background The Standards for Psychosocial Care for Children with Cancer and Their Families guide the provision of comprehensive psychosocial care. Parallel to research characterizing implementation of the Standards from the perspective of providers, this study examines implementation of the Standards from the perspective of parents of youth ...
Emily M. Pariseau, Kimberly Buff, Michele A. Scialla, Kimberly S. Canter, Lori Wiener, Victoria Sardi‐Brown, Julia B. Tager, Kamyar Arasteh, Anne E. Kazak   +8 more
wiley   +1 more source

The Effects of Multivitamin Supplementation on Diurnal Cortisol Secretion and Perceived Stress [PDF]

, 2013
Recent evidence suggests that dietary intake of vitamins, in particular the B-vitamins including B6, B9 and B12 may have a number of positive effects on mood and stress.
White, David J., David Camfield, White, DJ, David White, Katherine Cox, Cox, Katherine, Cox, Katherine H., Kras, M, Erin Fogg, Stough, C, Marni Kras, Sali, Avni, Kras, Marni, Sali, A, Scholey, Andrew, Fogg, E, Sarris, Jerome (R18802), Avni Sali, Wetherell, Mark A., Sarris, Jerome, Pipingas, Andrew, Fogg, Erin, Camfield, DA, Jerome Sarris, Mark Wetherell, Con Stough, Camfield, David, Scholey, AB, White, David, Pipingas, A, Andrew Pipingas, Wetherell, Mark, Cox, KHM, Sarris, J, Scholey, Andrew B., Stough, Con K., Andrew Scholey, Stough, Con, Wetherell, MA   +38 more
core   +1 more source

Reovirus and the Host Integrated Stress Response: On the Frontlines of the Battle to Survive

Viruses, 2021
Cells are continually exposed to stressful events, which are overcome by the activation of a number of genetic pathways. The integrated stress response (ISR) is a large component of the overall cellular response to stress, which ultimately functions ...
Luke D. Bussiere, Cathy L. Miller
doaj   +1 more source

Exercise Capacity, Physical Activity, Fatigue, and Neurocognitive Function in Adult Survivors of Childhood Acute Lymphoblastic Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Adult survivors of childhood acute lymphoblastic leukemia (ALL) are at risk of reduced exercise capacity, decreased physical activity levels, persistent fatigue, and neurocognitive deficits. The aim was to investigate exercise capacity and physical activity levels of adult survivors of childhood ALL and their associations with ...
Laura Jess, Gustaf Glavå, Simon Skau, Hans‐Georg Kuhn, Maria Bäck, Marianne Jarfelt   +5 more
wiley   +1 more source

Transcriptomic analysis of the stress response to weaning at housing in bovine leukocytes using RNA-seq technology [PDF]

, 2012
peer-reviewedBackground: Weaning of beef calves is a necessary husbandry practice and involves separating the calf from its mother, resulting in numerous stressful events including dietary change, social reorganisation and the cessation of the maternal ...
David J Lynn, Lynn David J, McGee, Mark, O'Loughlin, Aran, Lynn, David J, McGee Mark, Matthew McCabe, McCabe, Matthew, O’Loughlin, Aran, Mark McGee, O’Loughlin Aran, Earley Bernadette, McCabe Matthew, Bernadette Earley, Doyle, Sean, Doyle Sean, Aran O’Loughlin, Sean Doyle, Earley, Bernadette, Lynn, David J.   +19 more
core   +1 more source

Integrated stress response as a therapeutic target for CNS injuries. [PDF]

, 2017
Central nervous system (CNS) injuries, caused by cerebrovascular pathologies or mechanical contusions (e.g., traumatic brain injury, TBI) comprise a diverse group of disorders that share the activation of the integrated stress response (ISR).
Nieto Sampedro, Manuel, Barreda Manso, Mª Asunción, Romero Ramírez, Lorenzo   +2 more
core   +2 more sources

HTRgene: a computational method to perform the integrated analysis of multiple heterogeneous time-series data: case analysis of cold and heat stress response signaling genes in Arabidopsis

BMC Bioinformatics, 2019
Background Integrated analysis that uses multiple sample gene expression data measured under the same stress can detect stress response genes more accurately than analysis of individual sample data.
Hongryul Ahn, Inuk Jung, Heejoon Chae, Dongwon Kang, Woosuk Jung, Sun Kim   +5 more
doaj   +1 more source