Results 21 to 30 of about 31,889 (263)

YBX1 Promotes Malignant Progression of HNSCC via Stabilizing NSUN2-m5C Modified ATF4 mRNA. [PDF]

Cancer Sci
The diagram depicts the core axis and the key finding: “Targeting YBX1/NSUN2 abrogates HNSCC progression”. Within left‐sided HNSCC cells, NSUN2 mediates m5C methylation on the CDS of ATF4 mRNA; YBX1 then specifically recognizes and binds this modified site, augmenting ATF4 mRNA stability, which ultimately promotes cancer cell proliferation, migration ...
Li Y, Li S, Li Y, Pan Z.
europepmc   +2 more sources

Regulation of Nrf2 by Mitochondrial Reactive Oxygen Species in Physiology and Pathology

Biomolecules, 2020
Reactive oxygen species (ROS) are byproducts of aerobic respiration and signaling molecules that control various cellular functions. Nrf2 governs the gene expression of endogenous antioxidant synthesis and ROS-eliminating enzymes in response to various ...
Shuya Kasai, Sunao Shimizu, Yota Tatara, Junsei Mimura, Ken Itoh   +4 more
doaj   +1 more source

A Novel Pak1 Activator Ameliorates ER Stress for HFpEF Therapy. [PDF]

Adv Sci (Weinh)
Chronic metabolic stress is a major contributor to HFpEF progression. Under prolonged metabolic stress, Pak1 activity becomes impaired, contributing to disrupted ER proteostasis, cardiomyocyte apoptosis, fibrosis, and diastolic dysfunction. Mechanistically, Pak1 overexpression activates the ERK1/2–MNK1–eIF4E signaling axis, promotes translational ...
Xu H, Zhang H, Azam T, Hille SS, Liu Y, Zi M, Lang J, Yu H, Cao Y, Keavney BD, Mohamed TMA, Miller JM, Abouleisa RRE, Xu M, Cartwright EJ, Müller OJ, Lei M, Wang X.   +17 more
europepmc   +2 more sources

ATF4-sensitive genes and biological pathways.

, 2023
(A) Gene ontology biological process enrichment analysis for genes with a TSS-proximal ATF4 peak called in ≥4 cell types (out of the 7 analyzed). One ChIP-Seq library was used to represent each cell type (the library with the most peaks called).
Tõnis Örd (234737), Tiit Örd (551518), Daima Örd (234734), Priit Adler (260134)   +3 more
core   +1 more source

ATF4- and NeuN-positive neurons in the corticolimbic system.

, 2021
Representative immunofluorescent images of 8-week-old OLETF and LETO rats in the anterior cingulate cortex (ACC; A, B, C and D), basolateral amygdala (BLA; E, F, G, and H), and hippocampal cornu ammonis area 3 (CA3; I, J, K, and L.
Hisao Nishijo (303632), Ryosuke Ochi (11419784), Son Tien Nguyen (11324552), Naoto Fujita (677910), Takaya Oshima (11324550), Susumu Urakawa (354542), Kaho Takaishi (11324547), Natsuki Goto (11324541)   +7 more
core   +1 more source

ATF4- and PV-positive neurons in the corticolimbic system.

, 2021
Representative immunofluorescent images of 8-week-old OLETF and LETO rats in the prelimbic cortex (PL; A, B, C and D), basolateral amygdala (BLA; E, F, G, and H), and hippocampal cornu ammonis area 3 (CA3; I, J, K, and L).
Hisao Nishijo (303632), Ryosuke Ochi (11419784), Son Tien Nguyen (11324552), Naoto Fujita (677910), Takaya Oshima (11324550), Susumu Urakawa (354542), Kaho Takaishi (11324547), Natsuki Goto (11324541)   +7 more
core   +1 more source

ATF4- and CCK-positive neurons in the corticolimbic system.

, 2021
Representative immunofluorescent images of 8-week-old OLETF and LETO rats in the anterior cingulate cortex (ACC; A, B, C, and D), basolateral amygdala (BLA; E, F, G, and H), and hippocampal cornu ammonis area 3 (CA3; I, J, K, and L).
Hisao Nishijo (303632), Ryosuke Ochi (11419784), Son Tien Nguyen (11324552), Naoto Fujita (677910), Takaya Oshima (11324550), Susumu Urakawa (354542), Kaho Takaishi (11324547), Natsuki Goto (11324541)   +7 more
core   +1 more source

High ATF4 Expression Is Associated With Poor Prognosis, Amino Acid Metabolism, and Autophagy in Gastric Cancer

Frontiers in Oncology, 2021
BackgroundThe role of activating transcription factor 4 (ATF4) underlying gastric cancer (GC) remains unclear. The purpose of this study was to investigate the expression levels and biological functions of ATF4 in GC.MethodsExpression of ATF4 was ...
Mingliang Wang, Yida Lu, Huizhen Wang, Youliang Wu, Xin Xu, Yongxiang Li   +5 more
doaj   +1 more source

ATF4 and HIF-1α in bone: An intriguing relationship [PDF]

Journal of Bone and Mineral Research, 2013
As occurs in any other vascularized organ, one of the essential functions of blood vessels in bone is to be a source of O2, nutrients, hormones and growth factors (1). However, additional roles for bone blood vessels are emerging. For example, osteoblast precursors have been recently identified within their wall (2,3), which suggests that blood vessels
Schipani, Ernestina, Mangiavini, Laura, Merceron, Christophe   +2 more
openaire   +3 more sources

Dynamic induction of drug resistance through a stress-responsive enhancer in acute myeloid leukemia

Molecular & Cellular Oncology, 2020
The drug efflux pump ABCB1 (ATP binding cassette subfamily B member 1) confers chemotherapy resistance in acute myeloid leukemia (AML). We recently identified an ABCB1 enhancer that is activated in response to a range of cellular stressors, including ...
Mark S. Williams, Tim C. P. Somervaille
doaj   +1 more source