Results 21 to 30 of about 32,812 (263)
Developmental Cell, 2003 Multiple intracellular stress pathways converge on a single event--phosphorylation of the translation initiation factor eIF2alpha and subsequent translational activation of the transcription factor ATF4. Exploring the consequences of this event has highlighted the ways in which stress is sensed and responded to via many distinct pathways.
Rutkowski, D.Thomas, Kaufman, Randal J
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Regulation of Nrf2 by Mitochondrial Reactive Oxygen Species in Physiology and Pathology
Biomolecules, 2020 Reactive oxygen species (ROS) are byproducts of aerobic respiration and signaling molecules that control various cellular functions. Nrf2 governs the gene expression of endogenous antioxidant synthesis and ROS-eliminating enzymes in response to various ...
Shuya Kasai +4 more
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ATF4-sensitive genes and biological pathways.
, 2023 (A) Gene ontology biological process enrichment analysis for genes with a TSS-proximal ATF4 peak called in ≥4 cell types (out of the 7 analyzed). One ChIP-Seq library was used to represent each cell type (the library with the most peaks called).
Tõnis Örd (234737) +3 more
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ATF4- and NeuN-positive neurons in the corticolimbic system.
, 2021 Representative immunofluorescent images of 8-week-old OLETF and LETO rats in the anterior cingulate cortex (ACC; A, B, C and D), basolateral amygdala (BLA; E, F, G, and H), and hippocampal cornu ammonis area 3 (CA3; I, J, K, and L.
Hisao Nishijo (303632) +7 more
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ATF4- and PV-positive neurons in the corticolimbic system.
, 2021 Representative immunofluorescent images of 8-week-old OLETF and LETO rats in the prelimbic cortex (PL; A, B, C and D), basolateral amygdala (BLA; E, F, G, and H), and hippocampal cornu ammonis area 3 (CA3; I, J, K, and L).
Hisao Nishijo (303632) +7 more
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ATF4- and CCK-positive neurons in the corticolimbic system.
, 2021 Representative immunofluorescent images of 8-week-old OLETF and LETO rats in the anterior cingulate cortex (ACC; A, B, C, and D), basolateral amygdala (BLA; E, F, G, and H), and hippocampal cornu ammonis area 3 (CA3; I, J, K, and L).
Hisao Nishijo (303632) +7 more
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Frontiers in Oncology, 2021 BackgroundThe role of activating transcription factor 4 (ATF4) underlying gastric cancer (GC) remains unclear. The purpose of this study was to investigate the expression levels and biological functions of ATF4 in GC.MethodsExpression of ATF4 was ...
Mingliang Wang +5 more
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ATF4 and HIF-1α in bone: An intriguing relationship [PDF]
Journal of Bone and Mineral Research, 2013 As occurs in any other vascularized organ, one of the essential functions of blood vessels in bone is to be a source of O2, nutrients, hormones and growth factors (1). However, additional roles for bone blood vessels are emerging. For example, osteoblast precursors have been recently identified within their wall (2,3), which suggests that blood vessels
Schipani, Ernestina +2 more
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Dynamic induction of drug resistance through a stress-responsive enhancer in acute myeloid leukemia
Molecular & Cellular Oncology, 2020 The drug efflux pump ABCB1 (ATP binding cassette subfamily B member 1) confers chemotherapy resistance in acute myeloid leukemia (AML). We recently identified an ABCB1 enhancer that is activated in response to a range of cellular stressors, including ...
Mark S. Williams, Tim C. P. Somervaille
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Cell Death Discovery, 2022 AbstractProliferating cancer cells are dependent on glutamine metabolism for survival when challenged with oxidative stresses caused by reactive oxygen species, hypoxia, nutrient deprivation and matrix detachment. ATF4, a key stress responsive transcription factor, is essential for cancer cells to sustain glutamine metabolism when challenged with these
Ruizhi Li +2 more
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