ATF4 links ER stress with reticulophagy in glioblastoma cells [PDF]
Autophagy, 2020 Selective degradation of the endoplasmic reticulum (ER; reticulophagy) is a type of autophagy involved in the removal of ER fragments. So far, amino acid starvation as well as ER stress have been described as inducers of reticulophagy, which in turn restores cellular energy levels and ER homeostasis.
Svenja Zielke +11 more
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Vitamin D receptor attenuate ischemia-reperfusion kidney injury via inhibiting ATF4
Cell Death Discovery, 2023 Activating transcription factor 4 (ATF4) is one of the key effectors of endoplasmic reticulum stress (ERS), ATF4/CHOP pathway-mediated ERS plays an important role in the progression of acute kidney disease (AKI).
Shiqi Tang +10 more
doaj +1 more source
Shared Gene Targets of the ATF4 and p53 Transcriptional Networks
Molecular and Cellular Biology, 2023 Abstract The master tumor suppressor p53 regulates multiple cell fate decisions, like cell cycle arrest and apoptosis, via transcriptional control of a broad gene network. Dysfunction in the p53 network is common in cancer, often through mutations that inactivate p53 or other members of the pathway.
Gabriele Baniulyte +3 more
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Nuclear protein 1 induced by ATF4 in response to various stressors acts as a positive regulator on the transcriptional activation of ATF4 [PDF]
IUBMB Life, 2009 AbstractNuclear protein 1 (NUPR1) was originally identified as p8, a member of the family of HMG‐I/Y transcription factors induced in response to various cellular stressors. However, the signaling pathway underlying NUPR1 induction by cellular stresses remains to be established.
Hyeon-Ok, Jin +6 more
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Genetic variants that are located in ATF4 binding regions and alter ATF4 binding motifs.
, 2023 Genetic variants that are located in ATF4 binding regions and alter ATF4 binding motifs.
Tõnis Örd (234737) +3 more
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ATF4 DNA binding activity in nuclear extracts of ATF4-293 cells.
, 2023 Cells were untreated (-) or treated with tetracycline (+) to induce ATF4 overexpression from a stably integrated tetracycline-upregulated expression construct. (A) ATF4 protein level in nuclear extracts (20 μg per line) determined using Western blotting.
Tõnis Örd (234737) +3 more
core +1 more source
ATF4-mediated histone deacetylase HDAC1 promotes the progression of acute pancreatitis
Cell Death and Disease, 2021 Acute pancreatitis (AP), an acute inflammatory process, can be difficult to diagnose. Activating transcription factor 4 (ATF4) has been reported to participate in the pathogenesis of AP.
Xiaofeng Deng +3 more
doaj +1 more source
Investigation of Nrf2, AhR and ATF4 Activation in Toxicogenomic Databases [PDF]
Frontiers in Genetics, 2018 Toxicological responses to chemical insult are largely regulated by transcriptionally activated pathways that may be independent, correlated and partially or fully overlapping. Investigating the dynamics of the interactions between stress responsive transcription factors from toxicogenomic data and defining the signature of each of them is an ...
Zgheib +9 more
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Cancer Biology & MedicineObjective: Tumor cell radio-resistance and radiation-induced fibrosis of normal tissues hinder the efficacy of radiotherapy. Nintedanib, a promising therapeutic agent for radiation-induced pulmonary fibrosis and solid tumors, has yet to be investigated ...
Chunya Li +8 more
doaj +1 more source
ATF4-sensitive (putatively ATF4-activated) genes based on gene expression profiling studies.
, 2023 FC, fold change; KO, knock-out; WT, wild type. (XLSX)
Tõnis Örd (234737) +3 more
core +1 more source