Results 61 to 70 of about 31,889 (263)
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
ATF4-dependent Regulation of the JMJD3 Gene during Amino Acid Deprivation Can Be Rescued in Atf4-deficient Cells by Inhibition of Deacetylation [PDF]
Journal of Biological Chemistry, 2012 Following amino acid deprivation, the amino acid response (AAR) induces transcription from specific genes through a collection of signaling mechanisms, including the GCN2-eIF2-ATF4 pathway. The present report documents that the histone demethylase JMJD3 is an activating transcription factor 4 (ATF4)-dependent target gene.
Jixiu, Shan +4 more
openaire +2 more sources
O-GlcNAc regulates the mitochondrial integrated stress response by regulating ATF4
Frontiers in Aging Neuroscience, 2023 BackgroundAccumulation of mitochondrial dysfunctional is a hallmark of age-related neurodegeneration including Alzheimer’s disease (AD). Impairment of mitochondrial quality control mechanisms leading to the accumulation of damaged mitochondria and ...
Ibtihal M. Alghusen +14 more
doaj +1 more source
ATF4-sensitive (putatively ATF4-activated) genes based on gene expression profiling studies.
, 2023 FC, fold change; KO, knock-out; WT, wild type. (XLSX)
Tõnis Örd (234737) +3 more
core +1 more source
Molecular Oncology, EarlyView.This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu +3 more
wiley +1 more source
(A, top) Sagittal sections of ATF4 (left) and ATF4 (right) brains stained with cresyl violet
, 2011 Bar, 3,000 μm. (A, middle) Ventral view of large cerebral blood vessels of representative ATF4 (left) and ATF4 (right) mice that were perfused with India ink. Note the higher degree of tortuosity of the MCA in the brain from the ATF4 mouse. Bar, 3,000 μm.
Tim M. Townes (46696) +7 more
core +1 more source
Systematic analysis of ATF4 binding sites in the human genome.
, 2023 (A) Number of peaks called in ATF4 ChIP-Seq experiments in human cell types. Data from published experiments was reprocessed from raw reads using a uniform pipeline. To obtain a common peak set across all cell types, overlapping peak regions were merged.
Tõnis Örd (234737) +3 more
core +1 more source
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
Cell Death and Disease, 2021 Cancer-associated fibroblasts (CAFs) contribute to malignant progression and chemoresistance in pancreatic ductal adenocarcinoma (PDAC). However, little is known about the underlying mechanism.
Lusheng Wei +7 more
doaj +1 more source
Advanced Healthcare Materials, EarlyView.A GSH‐responsive AIE nanoplatform (TSH NPs) with RGD‐mediated tumor targeting co‐delivers a photosensitizer (TPA) and HCPT for extrahepatic cholangiocarcinoma. The system synergistically enhances PDT and chemotherapy by suppressing HIF‐1α/VEGF‐driven hypoxic adaptation, effectively overcoming PDT resistance.
Yong Qu +19 more
wiley +1 more source