Results 61 to 70 of about 30,346 (252)
EXtENDINg β cell survival by UPRegulating ATF4 translation [PDF]
Cell Metabolism, 2006 In this issue of Cell Metabolism, Daniel Drucker and colleagues (Yusta et al., 2006) explore how the incretin mimetic exendin-4 improves beta cell function and survival during ER stress. Their findings suggest that protein kinase A signaling elicited by GLP-1 receptor activation differentially modulates one arm of the unfolded protein response (UPR ...
Wek, Ronald C., Anthony, Tracy G.
openaire +2 more sources
PLOS Genetics, 2023 Activating Transcription Factor 4 (ATF4) is an important regulator of gene expression in stress responses and developmental processes in many cell types. Here, we catalogued ATF4 binding sites in the human genome and identified overlaps with trait-associated genetic variants.
Tiit Örd +3 more
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Profiles of Patients with ATF4-Positive or ATF4-Negative ESCCs.
, 2014 Profiles of Patients with ATF4-Positive or ATF4-Negative ESCCs.
Xiong Chen (555744) +6 more
core +1 more source
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
ATF4‐amino acid circuits: a recipe for resistance in melanoma [PDF]
The EMBO Journal, 2018 Lactate dehydrogenase A (LDHA) has appropriately received attention as a therapeutic target for the treatment of a broad spectrum of tumor types, yet little is known regarding intrinsic resistance to LDHA inhibitors. Pathria et al (2018) now establish that ATF4‐dependent control of enzymes that direct amino acid metabolism confers resistance to LDHA ...
Mario R, Fernandez, John L, Cleveland
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Systematic analysis of ATF4 binding sites in the human genome.
, 2023 (A) Number of peaks called in ATF4 ChIP-Seq experiments in human cell types. Data from published experiments was reprocessed from raw reads using a uniform pipeline. To obtain a common peak set across all cell types, overlapping peak regions were merged.
Tõnis Örd (234737) +3 more
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Zhongliu Fangzhi YanjiuThe biosynthesis and maturation of proteins are primarily regulated by the endoplasmic reticulum in its physiological state. Thus, the disruption of physiological homeostasis initiates the buildup of unfolded and misfolded proteins in the endoplasmic ...
HE Mengke, XU Zizhen, LI Junmin
doaj +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
(A, top) Sagittal sections of ATF4 (left) and ATF4 (right) brains stained with cresyl violet
, 2011 Bar, 3,000 μm. (A, middle) Ventral view of large cerebral blood vessels of representative ATF4 (left) and ATF4 (right) mice that were perfused with India ink. Note the higher degree of tortuosity of the MCA in the brain from the ATF4 mouse. Bar, 3,000 μm.
Tim M. Townes (46696) +7 more
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Scientific Reports, 2021 UTX/KDM6A encodes a major histone H3 lysine 27 (H3K27) demethylase, and is frequently mutated in various types of human cancers. Although UTX appears to play a crucial role in oncogenesis, the mechanisms involved are still largely unknown.
Shojiro Kitajima +8 more
doaj +1 more source