Results 61 to 70 of about 32,812 (263)
ATF4-dependent Regulation of the JMJD3 Gene during Amino Acid Deprivation Can Be Rescued in Atf4-deficient Cells by Inhibition of Deacetylation [PDF]
Journal of Biological Chemistry, 2012 Following amino acid deprivation, the amino acid response (AAR) induces transcription from specific genes through a collection of signaling mechanisms, including the GCN2-eIF2-ATF4 pathway. The present report documents that the histone demethylase JMJD3 is an activating transcription factor 4 (ATF4)-dependent target gene.
Jixiu, Shan +4 more
openaire +2 more sources
Axonally Synthesized ATF4 Transmits a Neurodegenerative Signal across Brain Regions [PDF]
, 2014 SummaryIn Alzheimer’s disease (AD) brain, exposure of axons to Aβ causes pathogenic changes that spread retrogradely by unknown mechanisms, affecting the entire neuron.
Crary, John F. +6 more
core +1 more source
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
Scientific Reports, 2021 UTX/KDM6A encodes a major histone H3 lysine 27 (H3K27) demethylase, and is frequently mutated in various types of human cancers. Although UTX appears to play a crucial role in oncogenesis, the mechanisms involved are still largely unknown.
Shojiro Kitajima +8 more
doaj +1 more source
ATF4-sensitive (putatively ATF4-activated) genes based on gene expression profiling studies.
, 2023 FC, fold change; KO, knock-out; WT, wild type. (XLSX)
Tõnis Örd (234737) +3 more
core +1 more source
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
(A, top) Sagittal sections of ATF4 (left) and ATF4 (right) brains stained with cresyl violet
, 2011 Bar, 3,000 μm. (A, middle) Ventral view of large cerebral blood vessels of representative ATF4 (left) and ATF4 (right) mice that were perfused with India ink. Note the higher degree of tortuosity of the MCA in the brain from the ATF4 mouse. Bar, 3,000 μm.
Tim M. Townes (46696) +7 more
core +1 more source
Systematic analysis of ATF4 binding sites in the human genome.
, 2023 (A) Number of peaks called in ATF4 ChIP-Seq experiments in human cell types. Data from published experiments was reprocessed from raw reads using a uniform pipeline. To obtain a common peak set across all cell types, overlapping peak regions were merged.
Tõnis Örd (234737) +3 more
core +1 more source
A Novel Pak1 Activator Ameliorates ER Stress for HFpEF Therapy
Advanced Science, EarlyView.Chronic metabolic stress is a major contributor to HFpEF progression. Under prolonged metabolic stress, Pak1 activity becomes impaired, contributing to disrupted ER proteostasis, cardiomyocyte apoptosis, fibrosis, and diastolic dysfunction. Mechanistically, Pak1 overexpression activates the ERK1/2–MNK1–eIF4E signaling axis, promotes translational ...
Honglin Xu +17 more
wiley +1 more source
Cell Reports, 2023 ATF4 is a master transcriptional regulator of the integrated stress response leading cells towards adaptation or death. ATF4's induction under stress was thought to be mostly due to delayed translation reinitiation, where the reinitiation-permissive uORF1 plays a key role.
Anna M. Smirnova +14 more
openaire +5 more sources