Results 71 to 80 of about 31,889 (263)
Cell Reports, 2023 ATF4 is a master transcriptional regulator of the integrated stress response leading cells towards adaptation or death. ATF4's induction under stress was thought to be mostly due to delayed translation reinitiation, where the reinitiation-permissive uORF1 plays a key role.
Anna M. Smirnova +14 more
openaire +5 more sources
ATF4 siRNA blocks basal F7 expression. A.
, 2012 siRNA directed to either the 5' UTR (ATF4 si#1, white bars) or the 3' UTR (ATF4 si#2, striped bars) of the human ATF4 gene were introduced into HepG2 cells cultured in media with 5 mM glucose.
Josephine A. Carew (146600) +2 more
core +1 more source
Advanced Science, EarlyView.This study uncovers that quercetin naturally targets mitochondria. By coordinating quercetin with Fe3+, we engineer an ultrasmall cascade nanozyme (MCN) with superoxide dismutase‐catalase activities. MCN crosses the damaged blood–brain barrier, scavenges mitochondrial ROS, prevents mitochondrial DNA leakage, and blocks the cGAS‐STING pathway, thereby ...
Wenxuan Zheng +14 more
wiley +1 more source
DDIT4 is essential for DINP-induced autophagy of ovarian granulosa cells
Ecotoxicology and Environmental Safety, 2023 As one of the most important phthalates, di-isononyl phthalate (DINP) has been widely used as a common plasticizer in the food and personal care products sectors.
Yijing Wang +5 more
doaj +1 more source
Spatiotemporal Targeting Randle Cycle and Immune Checkpoint for Potent Antitumor Therapy
Advanced Science, EarlyView.A glucose oxidase‐based nanogel (GOX‐NG) system using catechol‐functionalized alginate, exhibits enhanced tumor penetration, prolonged retention, and sustained glucose depletion in the tumor microenvironment. When combined with a fatty acid oxidation inhibitor, it implements dual metabolic suppression, thereby enhancing ROS‐induced immunogenic cell ...
Yuan Gao +11 more
wiley +1 more source
Atf4 Regulates Obesity, Glucose Homeostasis, and Energy Expenditure [PDF]
Diabetes, 2009 OBJECTIVE We evaluate a potential role of activating transcription factor 4 (Atf4) in invertebrate and mammalian metabolism. RESEARCH DESIGN AND METHODS With two parallel approaches—a fat body–specific green fluorescent protein enhancer trap screen ...
Seo, J Seo, Jin +8 more
openaire +3 more sources
The Role of Sirtuin 1 in Palmitic Acid-Induced Endoplasmic Reticulum Stress in Cardiac Myoblasts
Life, 2022 Background: Lipotoxicity causes endoplasmic reticulum (ER) stress, leading to cell apoptosis. Sirtuin 1 (Sirt1) regulates gene transcription and cellular metabolism. In this study, we investigated the role of Sirt1 in palmitate-induced ER stress. Methods:
Hsiang-Yu Yang +8 more
doaj +1 more source
Advanced Science, EarlyView.Inhibition of KDELR2 in a small fraction of tumor cells generates sustainable immunogenic cell death conditions within the tumor microenvironment. These conditions promote the regression of tumors in a T cell independent manner. During regression, macrophages prime T cells that subsequently provide systemic protection against recurrence. The potency of
Shakti P Pattanayak +6 more
wiley +1 more source
Activating transcription factor 4 regulates stearate-induced vascular calcification
Journal of Lipid Research, 2012 Previously, we reported that stearate, a saturated fatty acid, promotes osteoblastic differentiation and mineralization of vascular smooth muscle cells (VSMC).
Masashi Masuda +5 more
doaj +1 more source
In vivo ATF4 reporter, tub-ATF4.5′UTR>dsRed responds to protein misfolding.
, 2015 (A) The structure of the ATF4 translational activation reporter, tub-ATF4.5′UTR>dsRed. The dsRed ORF replaces that of ATF4, thereby reporting ATF4′s translation. (B-E) Validation of the reporter response in vivo.
Hyung Don Ryoo (440989) +4 more
core +1 more source