Results 71 to 80 of about 32,812 (263)

ATF4 siRNA blocks basal F7 expression. A.

, 2012
siRNA directed to either the 5' UTR (ATF4 si#1, white bars) or the 3' UTR (ATF4 si#2, striped bars) of the human ATF4 gene were introduced into HepG2 cells cultured in media with 5 mM glucose.
Josephine A. Carew (146600), Katherine R. Cronin (146594), Thomas P. Mangan (146597)   +2 more
core   +1 more source

Cancer-associated fibroblasts-mediated ATF4 expression promotes malignancy and gemcitabine resistance in pancreatic cancer via the TGF-β1/SMAD2/3 pathway and ABCC1 transactivation

Cell Death and Disease, 2021
Cancer-associated fibroblasts (CAFs) contribute to malignant progression and chemoresistance in pancreatic ductal adenocarcinoma (PDAC). However, little is known about the underlying mechanism.
Lusheng Wei, Qing Lin, Yanan Lu, Guolin Li, Leyi Huang, Zhiqiang Fu, Rufu Chen, Quanbo Zhou   +7 more
doaj   +1 more source

Polystyrene Nanoplastics Drive β‐Cell Dedifferentiation Through Dendritic Cell‐Intrinsic MHC‐I‐Dependent Inflammatory Crosstalk

Advanced Science, EarlyView.
Polystyrene nanoplastics disrupt pancreatic immune–endocrine homeostasis by promoting MHC‐I‐associated dendritic cell activation and inflammatory crosstalk with β cells. This immune remodeling drives β‐cell dedifferentiation, impairs insulin secretion, and aggravates metabolic dysfunction, revealing a previously unrecognized immunometabolic mechanism ...
Conghui Qiao, Yuqing Song, Fang Yang, Menghui Guo, Libin Jiang, Xiaoyue Quan, Wei Wei, Xinyang Wang, Tianshu Han, Mingyuan Liu, Wenbo Jiang   +10 more
wiley   +1 more source

Atf4 Regulates Obesity, Glucose Homeostasis, and Energy Expenditure [PDF]

Diabetes, 2009
OBJECTIVE We evaluate a potential role of activating transcription factor 4 (Atf4) in invertebrate and mammalian metabolism. RESEARCH DESIGN AND METHODS With two parallel approaches—a fat body–specific green fluorescent protein enhancer trap screen ...
Seo, J Seo, Jin, Fortuno, ES Fortuno, Edgardo S., III, Suh, JM Suh, Jae Myoung, Stenesen, D Stenesen, Drew, Tang, W Tang, Wei, Parks, EJ Parks, Elizabeth J., Adams, CM Adams, Christopher M., Townes, T Townes, Tim, Graff, JM Graff, Jonathan M.   +8 more
openaire   +3 more sources

Programmable Paracrine‐Mimetic Microneedle System for Temporal Regulation of Cardiac Repair

Advanced Science, EarlyView.
Temporal signaling is encoded into a programmable paracrine‐mimetic microneedle patch via tris(2,2'‐bipyridyl)dichlororuthenium(II) hexahydrate/sodium persulfate‐tuned hydrogel microparticles that deliver TGF‐β, IGF‐1, and VEGF over phase‐matched 7‐, 14‐, and 28‐day windows.
Yichen Dai, Pengchong Du, Zhaoyang Wang, Surilige, Rangga Fokta, Renjian Tan, Xiqing Zhao, Shuoyi Zhang, Yuecheng Wang, Yixin Zhang, Ziliang Fu, Rui Gong, Cheng Jiang, Yisheng He, Qiguang Wang, Renke Li, Khoon Lim, Junnan Tang, Xiaolin Cui   +18 more
wiley   +1 more source

DDIT4 is essential for DINP-induced autophagy of ovarian granulosa cells

Ecotoxicology and Environmental Safety, 2023
As one of the most important phthalates, di-isononyl phthalate (DINP) has been widely used as a common plasticizer in the food and personal care products sectors.
Yijing Wang, Si Yang, Chaoju Hao, Jiaxiang Chen, Jinglei Wang, Linlin Xu   +5 more
doaj   +1 more source

Chemical Bond‐Orchestrated Energy Depletion to Augment Lung Cancer Chemo‐Immunotherapy

Advanced Science, EarlyView.
This study grafted dichloroacetic acid (DCA) into perylenediimide (PDI) skeleton via ionic or covalent bond to create novel metabolic agent PDIC‐AC and PDIC‐NAC, explicitly elaborated the underlying energy metabolism and therapeutic mechanism, and developed a promising strategy for energy metabolism‐targeting chemo‐immunotherapy by chemical bond ...
Xuejie Zhao, Yuting Liu, Xiao Huang, Liwen Zhao, Chunli Li, Yongwei Huang   +5 more
wiley   +1 more source

Activating transcription factor 4 regulates stearate-induced vascular calcification

Journal of Lipid Research, 2012
Previously, we reported that stearate, a saturated fatty acid, promotes osteoblastic differentiation and mineralization of vascular smooth muscle cells (VSMC).
Masashi Masuda, Tabitha C. Ting, Moshe Levi, Sommer J. Saunders, Shinobu Miyazaki-Anzai, Makoto Miyazaki   +5 more
doaj   +1 more source

The Role of Sirtuin 1 in Palmitic Acid-Induced Endoplasmic Reticulum Stress in Cardiac Myoblasts

Life, 2022
Background: Lipotoxicity causes endoplasmic reticulum (ER) stress, leading to cell apoptosis. Sirtuin 1 (Sirt1) regulates gene transcription and cellular metabolism. In this study, we investigated the role of Sirt1 in palmitate-induced ER stress. Methods:
Hsiang-Yu Yang, Jhao-Ying Chen, Yen-Nien Huo, Pei-Ling Yu, Pei-Zhen Lin, Shih-Che Hsu, Shih-Ming Huang, Chien-Sung Tsai, Chih-Yuan Lin   +8 more
doaj   +1 more source

In vivo ATF4 reporter, tub-ATF4.5′UTR>dsRed responds to protein misfolding.

, 2015
(A) The structure of the ATF4 translational activation reporter, tub-ATF4.5′UTR>dsRed. The dsRed ORF replaces that of ATF4, thereby reporting ATF4′s translation. (B-E) Validation of the reporter response in vivo.
Hyung Don Ryoo (440989), Min-Ji Kang (464343), Jee-Hyun Yoon (491218), Kwonyoon Kang (740150), Jung-Eun Park (480566)   +4 more
core   +1 more source