Results 91 to 100 of about 32,812 (263)
Early Atf4 activity drives airway club and goblet cell differentiation
Life Science AlliancePERK/Atf4 drives airway epithelial differentiation, impacting secretory cell numbers, revealing ATF4’s role in respiratory tract regeneration. Activating transcription factor 4 (Atf4), which is modulated by the protein kinase RNA-like ER kinase (PERK ...
Juan F Barrera-Lopez +10 more
doaj +1 more source
(A) ATF4 (♦) and ATF4 (▴) cortical neurons were treated with 10 mM HCA
, 2011 At the indicated time points, cells were trypsinized, washed, and pelleted. Reduced glutathione (GSH) was determined in the cell pellets using HPLC electrochemical detection.
Giovanni Coppola (624423) +7 more
core +1 more source
Advanced Science, EarlyView.This Review outlines the biological framework of entry, maintenance, and awakening in dormant minimal residual disease across gynecologic cancers. By mapping critical biological dependencies—from metabolic plasticity to microenvironment interactions—it evaluates novel interception concepts and presents a translational framework combining single‐cell ...
Shih‐Hsuan Cheng +7 more
wiley +1 more source
, 2018 Activating transcription factor 4 (ATF4) plays important physiologic roles in the brain including regulation of learning and memory as well as neuronal survival and death.
Jin Liu +7 more
core +1 more source
Degradation of transcriptional repressor ATF4 during long-term synaptic plasticity
, 2020 Maintenance of long-term synaptic plasticity requires gene expression mediated by cAMP-responsive element binding protein (CREB). Gene expression driven by CREB can commence only if the inhibition by a transcriptional repressor activating transcription ...
Haynes, Kathryn A. +5 more
core +1 more source
Advanced Science, EarlyView.HIV preferentially infects microglia, activating IL‐17A‐driven IFN‐γ/STAT1, CEBPB, and NF‐κB signaling that converges with cGAS‐STING and Notch–NEURL1 pathways, promoting neuroinflammation, mitochondrial dysfunction, and synaptic impairment. cART suppresses viral replication, attenuates inflammatory signaling, and at least partially restores ...
Karthick Chennakesavan +7 more
wiley +1 more source
Exploring the Role of ATF4 in Circadian Photic Phase Shifting
, 2018 The phenotypic role of activation transcription factor 4 (ATF4) in the mammalian circadian system has yet to be characterized. Previous research has provided evidence that ATF4 may play a key role in modulating molecular circadian activity, and it has ...
Chan, Ryan K.
core +1 more source
Advanced Science, EarlyView.SLC25A4high hepatocytes drive metabolic‐associated steatotic liver disease (MASLD) remission by recruiting lipid‐eating macrophages. The hepatocyte Slc25a4/PANX1/ATP/P2ry12 axis mediates find‐me signaling that triggers macrophage recruitment and efferocytosis, while recruited macrophages secrete GDF15 to activate hepatocyte PPARα and promote fatty acid
Yiting Qian +8 more
wiley +1 more source
ATF4 in cardiovascular diseases: an emerging therapeutic target
Biochemical PharmacologyActivating transcription factor 4 (ATF4), as a core regulatory factor of the activating transcription factor (ATF)/cAMP-response element binding protein (CREB) family, governs cell fate determination through endoplasmic reticulum stress(ERS), autophagy, and redox networks.
Luning, Qin +10 more
openaire +2 more sources
Advanced Science, EarlyView.This study identifies reduced taurine availability as a mediator of intermittent fasting in colorectal cancer and shows that taurine interacts with GRP78 to maintain PERK abundance post‐transcriptionally. It further shows that taurine depletion destabilizes PERK, induces immunogenic paraptosis, remodels the tumor microenvironment toward a CD8+ T cell ...
Baohui Song +11 more
wiley +1 more source