Results 111 to 120 of about 32,812 (263)

Function of Atf4 in Endochondral Bone Formation

, 2011
Activating transcription factor 4 (Atf4) is a leucine zip transcription factor. Atf4 mutant (Atf4-/-) mice show severe low bone mass and short stature phenotype. Atf4 is expressed in growth plate chondrocytes.
Wang, Weiguang
core  

ATF4 Regulates CD4+ T Cell Immune Responses through Metabolic Reprogramming

, 2018
Summary: T cells are strongly regulated by oxidizing environments and amino acid restriction. How T cells reprogram metabolism to adapt to these extracellular stress situations is not well understood.
Danielle Obando, Yibei Zhu, Changping Wu, Wenwen Du, Rui Xia, Jingting Jiang, Qianting Yang, Xiaojuan Chen, Xi Yang, Huiling Cao, Jon Piganelli, Cuihua Yue, Yu Jiang, Peter Wipf, Xinchun Chen, Wensi Zhai, Guozhi Xiao, Binfeng Lu, Jane-Jane Chen   +18 more
core   +1 more source

Harnessing ferroptosis from multilayer defense networks to nanoplatforms for specific cancer therapy

BMEMat, EarlyView.
Nanomaterials target metabolically‐regulated ferroptosis for cancer therapy. Iron‐based or alternative nanoplatforms integrate ferroptosis with chemotherapy, immunotherapy, or radiotherapy. They enable stimulus‐responsive therapies (photothermal, photodynamic, sonodynamic) activated by near‐infrared, light, or ultrasound, achieving potent synergistic ...
Xinyue Xu, Xuejian Wang, Wenyan Jiang, Wan Hairul Anuar Kamaruddin, Chunyan Fang, Pengfei Zhang   +5 more
wiley   +1 more source

ATF4 promotes renal tubulointerstitial fibrosis through hexokinase II-mediated glycolysis

Frontiers in Immunology
BackgroundRenal tubulointerstitial fibrosis is a reliable predictor of progressive chronic kidney disease (CKD). Activating transcription factor 4 (ATF4) has recently emerged as a pivotal player in multiple pathophysiologic processes, particularly the ...
Songtao Feng, Songtao Feng, Yueming Gao, Zheng Wang, Weijie Ni, Yan Zhou, Mingyue Yuan, Jinyang Ge, Lu Sun, Bicheng Liu, Hui Qian, Zuolin Li   +11 more
doaj   +1 more source

ER‐Localized Deadenylase PNLDC1 Suppresses Colorectal Cancer Progression by Targeting the mRNA Decay of TUBB4B

Exploration, EarlyView.
The deficiency of PNLDC1 exacerbates the advancement of CRC. PNLDC1 interacts with TUBB4B mRNA to regulate the p53–p21–CDK2–cyclin E2 pathway, thereby influencing the G2/M phase of the cell cycle. ABSTRACT Colorectal cancer (CRC) remains a leading cause of cancer‐related mortality, highlighting the urgent need for novel therapeutic strategies.
Lexin Liu, Yuelin Guan, Yuzhou Qin, Guiping Chen, Guozhen Wang, Xiang Yan, Xue Li, Lei Sun, Wei Yu, Shi Ouyang, Zhichao Ma, Zihao Xu, Zhongkai Cao, Fan Yu, Tong Zhou, Ziyou Luo, Xiangjun Chen, Yongbin Yan, Lidan Hu   +18 more
wiley   +1 more source

ATF4 ChIP-Seq datasets used in the study.

, 2023
Activating Transcription Factor 4 (ATF4) is an important regulator of gene expression in stress responses and developmental processes in many cell types.
Tõnis Örd (234737), Tiit Örd (551518), Daima Örd (234734), Priit Adler (260134)   +3 more
core   +1 more source

Human biomarker navigator

iMeta, EarlyView.
The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li, Qian Zhang, Zijie Wang, Zeping Gui, Jing Liu, Jingda Li, Maojun Jiang, Zukang Chang, Qingqing Han, Bendong Yang, Tariq Saeed, Jun Li, Jinghan Jia, Chenghu Song, Tong Shao, Tianhuan Peng, Xueying Zhang, Pingping Guo, Jun Luo, Gangao Yang, Yuan Wan, Gokhan Zengin, Quan Yuan, Lingru Li, Xiaohui Fan, Yang Luo, Lvyun Zhu, Yanfei Zheng, Wenjun Mao, Wenlong Sun   +29 more
wiley   +1 more source

The Effects of Angiotensin Receptor Neprilysin Inhibitor on Endoplasmic Reticulum Stress in Doxorubicin‐Mediated Cardiomyopathy‐Associated Heart Failure Model in Rats

Journal of Applied Toxicology, EarlyView.
ABSTRACT One of the most serious complications associated with the use of the chemotherapeutic agent doxorubicin (DOX) is cardiomyopathy. Although cardioprotective drugs such as angiotensin receptor‐neprilysin inhibitors (ARNI) are used to prevent cardiomyopathy in DOX patients, no studies have reported the relationship between ARNI and endoplasmic ...
Mert Unvan, Meryem İlkay Karagül, Hatice Oruç Demirbağ, Ebru Balli   +3 more
wiley   +1 more source

ATF4 promotes glutaminolysis and glycolysis in colorectal cancer by transcriptionally inducing SLC1A5

Acta Biochimica et Biophysica Sinica
Glutaminolysis and glycolysis promote the malignant progression of colorectal cancer. The role of activating transcription factor 4 (ATF4) in solute carrier family 1 member 5 (SLC1A5)-mediated glutaminolysis and ...
Zhou Zengli, Ye Shufang, Chen Jingyu, Dai Fei, Chen Luyi, Ye Ran, Zhang Jianmei, Chen Gefei, Wang Yanjiao, Liu Yangyang   +9 more
doaj   +1 more source

Bisphenol Analog‐Induced Cytotoxicity: Unraveling Endoplasmic Reticulum (ER) Stress and Apoptotic Pathways

Journal of Applied Toxicology, EarlyView.
ABSTRACT Bisphenol A (BPA) is increasingly replaced by structural analogs, yet their safety remains insufficiently characterized. This study investigated whether BPA and selected analogs, bisphenol AF (BPAF), bisphenol AP (BPAP), bisphenol P (BPP), and bisphenol E (BPE), induce cytotoxicity through activation of endoplasmic reticulum (ER) stress and ...
Rafia Afroze Rifa, Ramon Lavado
wiley   +1 more source