Results 111 to 120 of about 30,346 (252)

ATF4 in cardiovascular diseases: an emerging therapeutic target

Biochemical Pharmacology
Activating transcription factor 4 (ATF4), as a core regulatory factor of the activating transcription factor (ATF)/cAMP-response element binding protein (CREB) family, governs cell fate determination through endoplasmic reticulum stress(ERS), autophagy, and redox networks.
Luning, Qin, Ruolan, Chen, Chao, Huang, Xuezhe, Wang, Qinghang, Song, Zhaoqing, Li, Xiaojian, Xu, Zhijun, Liu, Banghui, Wang, Bing, Li, Xian-Ming, Chu   +10 more
openaire   +2 more sources

Combinatorial control of ATF4‐dependent gene transcription in osteoblasts

Annals of the New York Academy of Sciences, 2011
Osteoblast‐specific gene transcription requires interaction between bone cell–specific transcription factors and more widely expressed transcriptional regulators. This is particularly evident for the basic domain‐leucine zipper factor activating transcription factor 4 (ATF4), whose activity can be enhanced or inhibited through interaction with other ...
René, St-Arnaud, Bahareh, Hekmatnejad
openaire   +3 more sources

Exploring the Role of ATF4 in Circadian Photic Phase Shifting

, 2018
The phenotypic role of activation transcription factor 4 (ATF4) in the mammalian circadian system has yet to be characterized. Previous research has provided evidence that ATF4 may play a key role in modulating molecular circadian activity, and it has ...
Chan, Ryan K.
core   +1 more source

Endoplasmic reticulum stress increases LECT2 expression via ATF4

, 2021
Non-alcoholic fatty liver disease (NAFLD) is frequently associated with obesity, insulin resistance, and endoplasmic reticulum (ER) stress. Elevated circulating levels of the hepatokine leukocyte cell-derived chemotaxin-2 (LECT2) have also been noted in ...
최한석, 정지훈, 박찬윤, 최경철, 박혜순, 김지민, 김동욱, 이슬기, 한성림, 장연진   +9 more
core   +1 more source

Air Pollution Quinones Impair Intestinal Barrier Integrity and Endoplasmic Reticulum in Differentiated Caco‐2 Cells

Journal of Applied Toxicology, EarlyView.
ABSTRACT Particulate matter (PM) is a major global health threat, linked to millions of deaths annually. Beyond inhalation, PM components reach the gastrointestinal tract through the mucociliary escalator or contaminated food and water. Among PM's organic fraction, redox‐active quinones such as 1,2‐naphthoquinone (NQ) and 9,10‐phenanthrenequinone (PQ ...
Franco Cervellati, Giulia Trinchera, Alice Casoni, Alessandra Pecorelli, Mascia Benedusi, Maria Chiara Pietrogrande, Giuseppe Valacchi   +6 more
wiley   +1 more source

Oncogenic KRAS Rewires Stress Granule Dynamics: Mechanisms and Therapeutic Opportunities

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Stress granules (SGs) are dynamic, membrane‐less structures that form in response to various cellular stresses, including metabolic, oxidative, and therapeutic challenges. They function as adaptive hubs and reorganize protein synthesis and signaling networks to help cells survive under stress. In cancer, these condensates are often hijacked to
Msimisi Ndzinisa, Birhanetensay Masresha Altaye, Yuh‐Pyng Sher   +2 more
wiley   +1 more source

DDX3 regulates endoplasmic reticulum stress-induced ATF4 expression

, 2017
Accumulation of unfolded and potentially toxic proteins in the endoplasmic reticulum (ER) activates a cell stress adaptive response, which involves a reprogramming of general gene expression.
Valérie Grenier St-Sauveur, Edouard W. Khandjian, Pauline Adjibade, Rachid Mazroui, Jonathan Bergeman, Marc-Etienne Huot   +5 more
core   +1 more source

ATF4 promotes renal tubulointerstitial fibrosis through hexokinase II-mediated glycolysis

Frontiers in Immunology
BackgroundRenal tubulointerstitial fibrosis is a reliable predictor of progressive chronic kidney disease (CKD). Activating transcription factor 4 (ATF4) has recently emerged as a pivotal player in multiple pathophysiologic processes, particularly the ...
Songtao Feng, Songtao Feng, Yueming Gao, Zheng Wang, Weijie Ni, Yan Zhou, Mingyue Yuan, Jinyang Ge, Lu Sun, Bicheng Liu, Hui Qian, Zuolin Li   +11 more
doaj   +1 more source

Toxicity Differences Between Microplastics and Nanoplastics in Organs: From Molecular Mechanisms to Potential Therapeutic Strategies

Med Research, EarlyView.
This review systematically compares the size‐dependent toxicity of microplastics and nanoplastics in the intestine, liver, kidney, lung, and brain. Particle size determines bioavailability, barrier penetration, and injury mechanisms. Because of their small size and high surface reactivity, NPs readily cross the intestinal epithelium and blood–brain ...
Yixian Cheng, Junjie Chen, Rui Fu, Jiawei Zhang, Jianguang Jia, Wei Wang, Zheng Zhang, Peng Zhang, Haosong Chen, Huake Cao, Gang Li, Weiwei Sheng, Ting Li, Bo Chen, Guodong Cao   +14 more
wiley   +1 more source

Function of Atf4 in Endochondral Bone Formation

, 2011
Activating transcription factor 4 (Atf4) is a leucine zip transcription factor. Atf4 mutant (Atf4-/-) mice show severe low bone mass and short stature phenotype. Atf4 is expressed in growth plate chondrocytes.
Wang, Weiguang
core