Results 101 to 110 of about 32,812 (263)
ATF4 inhibits tumor development and mediates p-GCN2/ASNS upregulation in colon cancer
Scientific ReportsColon cancer (CC) is a highly malignant tumor with a high incidence and poor prognosis. This study aimed to explore the function and molecular mechanisms of activating transcription factor 4 (ATF4) in CC.
Jiawei Chen +3 more
doaj +1 more source
Role of ATF4 in dietary sulfur amino acid restriction
, 2018 Dietary sulfur amino acid restriction (SAAR) increases food intake and energy expenditure and improves body composition. Dietary SAAR activates the integrated stress response (ISR), which orchestrates transcriptional changes through activating ...
core +1 more source
Advanced Science, EarlyView.This study established a one‐step method inducing pro‐spermatogonia‐like (activating SOX17) and oogonia‐like (activating SOX17/TFAP2C) cells from porcine pgEpiSCs with a NANOS3‐tdTomato reporter. EGF activates the core PGC program and supports survival; BMP4 further induces NANOS3 and DDX4 expression; IWR1 enhances PGCLC efficiency by suppressing ...
Pengcheng He +14 more
wiley +1 more source
Role of Activating Transcription Factor 4 in Metabolic, Neurologic, and Ocular Diseases
CellsCells respond to metabolic and environmental challenges through the integrated stress response (ISR), a cellular process that maintains homeostasis under diverse stressors.
Minwoo Kwon +5 more
doaj +1 more source
Frontiers in Cellular Neuroscience, 2014 The ubiquitously expressed activating transcription factor 4 (ATF4) has been variably reported to either promote or inhibit neuronal plasticity and memory.
Jin eLiu +3 more
doaj +1 more source
Endoplasmic reticulum stress increases LECT2 expression via ATF4
, 2021 Non-alcoholic fatty liver disease (NAFLD) is frequently associated with obesity, insulin resistance, and endoplasmic reticulum (ER) stress. Elevated circulating levels of the hepatokine leukocyte cell-derived chemotaxin-2 (LECT2) have also been noted in ...
최한석 +9 more
core +1 more source
Animal Models and Experimental Medicine, EarlyView.Due to the complex pathophysiology of aortic valve disease (AVD) and the resulting lack of effective pharmacotherapy, existing animal models are valuable research tools, but each has its own strengths and limitations. This review systematically surveys the major AVD models, compares their induction methods, pathological features, advantages and ...
Liya Hou +4 more
wiley +1 more source
DDX3 regulates endoplasmic reticulum stress-induced ATF4 expression
, 2017 Accumulation of unfolded and potentially toxic proteins in the endoplasmic reticulum (ER) activates a cell stress adaptive response, which involves a reprogramming of general gene expression.
Valérie Grenier St-Sauveur +5 more
core +1 more source
Animal Models and Experimental Medicine, EarlyView.Animal models enable mechanistic testing of how ischemic injury disrupts neurovascular trafficking and drives cognitive vulnerability after stroke. Complementary models capture distinct vascular, cellular, white matter, and cognitive features of PSCI.
Pratchaya Kaewkaen
wiley +1 more source
Scientific Reports, 2017 The anti-leukemic agent asparaginase activates the integrated stress response (ISR) kinase GCN2 and inhibits signaling via mechanistic target of rapamycin complex 1 (mTORC1).
Rana J. T. Al-Baghdadi +7 more
doaj +1 more source