Brain-Derived Neurotrophic Factor Elevates Activating Transcription Factor 4 (ATF4) in Neurons and Promotes ATF4-Dependent Induction of Sesn2 [PDF]
Frontiers in Molecular Neuroscience, 2018 Activating transcription factor 4 (ATF4) plays important physiologic roles in the brain including regulation of learning and memory as well as neuronal survival and death.
Fatou Amar +2 more
exaly +4 more sources
Activating transcription factor 4 drives the progression of diabetic cardiac fibrosis [PDF]
ESC Heart Failure, 2023 Aims Diabetic cardiomyopathy (DC) is one of serious complications of diabetic patients. This study investigated the biological function of activating transcription factor 4 (ATF4) in DC.
Yu Li +5 more
doaj +2 more sources
Activating transcription factor 4-dependent hsa-miR-663a transcription mediates mTORC1/p70S6K1 signaling underleucine deprivation [PDF]
Frontiers in Nutrition, 2022 The mechanistic target of rapamycin complex 1 (mTORC1) is involved in nutrient-induced signaling and is a master regulator of cell growth and metabolism.
Junki Yamamura +3 more
doaj +2 more sources
Activating transcription factor 4 protects mice against sepsis-induced intestinal injury by regulating gut-resident macrophages differentiation [PDF]
Chinese Medical Journal, 2022 . Background:. Gut-resident macrophages (gMacs) supplemented by monocytes-to-gMacs differentiation play a critical role in maintaining intestinal homeostasis. Activating transcription factor 4 (ATF4) is involved in immune cell differentiation.
Zhenliang Wen +13 more
doaj +2 more sources
Role of Activating Transcription Factor 4 in Metabolic, Neurologic, and Ocular Diseases [PDF]
CellsCells respond to metabolic and environmental challenges through the integrated stress response (ISR), a cellular process that maintains homeostasis under diverse stressors.
Minwoo Kwon +5 more
doaj +2 more sources
Activating transcription factor 4 mediates adaptation of human glioblastoma cells to hypoxia and temozolomide [PDF]
Scientific Reports, 2021 The integrated stress response (ISR) is a central cellular adaptive program that is activated by diverse stressors including ER stress, hypoxia and nutrient deprivation to orchestrate responses via activating transcription factor 4 (ATF4).
Nadja I. Lorenz +7 more
doaj +2 more sources
Activating transcription factor 4: a regulator of stress response in human cancers [PDF]
Frontiers in Cell and Developmental BiologyActivating transcription factor 4 (ATF4) is an adaptive response regulator of metabolic and oxidative homeostasis. In response to cellular stress, ATF4 is activated and functions as a regulator to promote cell adaptation for survival.
Di Wu, Jie Liang
doaj +2 more sources
The dual role of activating transcription factor 4: from cellular stress sentinel to cardiovascular disease intervention [PDF]
PeerJAs the master orchestrator of integrated stress response, activating transcription factor 4 (ATF4) operates as a central molecular switch that directs cellular fate toward survival or death by regulating genes associated with oxidative stress ...
Yaping Wang +3 more
doaj +3 more sources
Sestrin2 Regulates Endoplasmic Reticulum Stress-Dependent Ferroptosis to Engage Pulmonary Fibrosis by Nuclear Factor Erythroid 2-Related Factor 2/Activating Transcription Factor 4 (NRF2/ATF4) [PDF]
Journal of Immunology Research, 2023 Pulmonary fibrosis (PF) can lead to chronic inflammation, the destruction of alveoli and irreversible lung damage. Sestrin2 is a highly protective stress-inducible protein that is involved in the cell response to various stress factors and the regulation
Zhaoxing Dong +5 more
doaj +2 more sources
Activating transcription factor 4 plays a major role in shaping the transcriptional response to isoginkgetin in HCT116 cells [PDF]
Scientific ReportsActivating transcription factor 4 (ATF4) plays a central role in the integrated stress response (ISR) and one overlapping branch of the unfolded protein response (UPR).
Erin van Zyl +4 more
doaj +2 more sources