Activating transcription factor 4 drives the progression of diabetic cardiac fibrosis [PDF]
ESC Heart Failure, 2023 Aims Diabetic cardiomyopathy (DC) is one of serious complications of diabetic patients. This study investigated the biological function of activating transcription factor 4 (ATF4) in DC.
Yu Li +5 more
doaj +4 more sources
Activating transcription factor 4: a regulator of stress response in human cancers [PDF]
Frontiers in Cell and Developmental BiologyActivating transcription factor 4 (ATF4) is an adaptive response regulator of metabolic and oxidative homeostasis. In response to cellular stress, ATF4 is activated and functions as a regulator to promote cell adaptation for survival.
Di Wu, Jie Liang
doaj +4 more sources
Role of Activating Transcription Factor 4 in Metabolic, Neurologic, and Ocular Diseases [PDF]
CellsCells respond to metabolic and environmental challenges through the integrated stress response (ISR), a cellular process that maintains homeostasis under diverse stressors.
Minwoo Kwon +5 more
doaj +4 more sources
Activating transcription factor 4 plays a major role in shaping the transcriptional response to isoginkgetin in HCT116 cells [PDF]
Scientific ReportsActivating transcription factor 4 (ATF4) plays a central role in the integrated stress response (ISR) and one overlapping branch of the unfolded protein response (UPR).
Erin van Zyl +4 more
doaj +4 more sources
Role of activating transcription factor 4 in the hepatic response to amino acid depletion by asparaginase [PDF]
Scientific Reports, 2017 The anti-leukemic agent asparaginase activates the integrated stress response (ISR) kinase GCN2 and inhibits signaling via mechanistic target of rapamycin complex 1 (mTORC1).
Rana J. T. Al-Baghdadi +7 more
doaj +5 more sources
Activating transcription factor 4-dependent hsa-miR-663a transcription mediates mTORC1/p70S6K1 signaling underleucine deprivation [PDF]
Frontiers in Nutrition, 2022 The mechanistic target of rapamycin complex 1 (mTORC1) is involved in nutrient-induced signaling and is a master regulator of cell growth and metabolism.
Junki Yamamura +3 more
doaj +2 more sources
Regulation of cellular immunity by activating transcription factor 4. [PDF]
Immunol Lett, 2020 Activating transcription factor 4 (ATF4) is a DNA binding transcription factor belonging to the family of basic Leucine zipper proteins. ATF4 can be activated in response to multiple cellular stress signals including endoplasmic reticulum stress in the event of improper protein folding or oxidative stress because of mitochondrial dysfunction as well as
Mukherjee D +3 more
europepmc +4 more sources
Activating transcription factor 4 protects mice against sepsis-induced intestinal injury by regulating gut-resident macrophages differentiation [PDF]
Chinese Medical Journal, 2022 . Background:. Gut-resident macrophages (gMacs) supplemented by monocytes-to-gMacs differentiation play a critical role in maintaining intestinal homeostasis. Activating transcription factor 4 (ATF4) is involved in immune cell differentiation.
Zhenliang Wen +13 more
doaj +2 more sources
Activating transcription factor 4 mediates adaptation of human glioblastoma cells to hypoxia and temozolomide [PDF]
Scientific Reports, 2021 The integrated stress response (ISR) is a central cellular adaptive program that is activated by diverse stressors including ER stress, hypoxia and nutrient deprivation to orchestrate responses via activating transcription factor 4 (ATF4).
Nadja I. Lorenz +7 more
doaj +2 more sources
Activating transcription factor 4 regulates stearate-induced vascular calcification [PDF]
Journal of Lipid Research, 2012 Previously, we reported that stearate, a saturated fatty acid, promotes osteoblastic differentiation and mineralization of vascular smooth muscle cells (VSMC).
Masashi Masuda +5 more
doaj +3 more sources