Brain-Derived Neurotrophic Factor Elevates Activating Transcription Factor 4 (ATF4) in Neurons and Promotes ATF4-Dependent Induction of Sesn2 [PDF]
Frontiers in Molecular Neuroscience, 2018 Activating transcription factor 4 (ATF4) plays important physiologic roles in the brain including regulation of learning and memory as well as neuronal survival and death.
Jin Liu +7 more
doaj +6 more sources
Activating Transcription Factor 4 (ATF4) Modulates Post-synaptic Development and Dendritic Spine Morphology [PDF]
Frontiers in Cellular Neuroscience, 2014 The ubiquitously expressed activating transcription factor 4 (ATF4) has been variably reported to either promote or inhibit neuronal plasticity and memory.
Jin eLiu +3 more
doaj +7 more sources
Biology of Activating Transcription Factor 4 (ATF4) and Its Role in Skeletal Muscle Atrophy. [PDF]
Journal of Nutrition, 2022 Activating transcription factor 4 (ATF4) is a multifunctional transcription regulatory protein in the basic leucine zipper superfamily. ATF4 can be expressed in most if not all mammalian cell types, and it can participate in a variety of cellular responses to specific environmental stresses, intracellular derangements, or growth factors.
Adrian Vella +2 more
exaly +5 more sources
The loss of activating transcription factor 4 (ATF4) reduces bone toughness and fracture toughness [PDF]
Bone, 2014 Even though age-related changes to bone tissue affecting fracture risk are well characterized, only a few matrix-related factors have been identified as important to maintaining fracture resistance. As a gene critical to osteoblast differentiation, activating transcription factor 4 (ATF4) is possibly one of these important factors.
Alexander Makowski +2 more
exaly +8 more sources
miRNA-1283 Regulates the PERK/ATF4 Pathway in Vascular Injury by Targeting ATF4. [PDF]
PLoS ONE, 2016 In our previous study, we found significant differences in the mRNA and microRNA (miRNA) levels among hypertensive patients with different degrees of vascular endothelial cells damage.
Ling He +5 more
doaj +2 more sources
Elevated Expression of Selenoprotein Synthesis Enzyme SEPHS2 Driven by ATF4 Promotes the Resistance to Ferroptosis in Prostate Cancer [PDF]
MedCommWhile it has been reported that antioxidant selenoproteins are crucial for anti‐ferroptosis in tumors, it remains unclear whether and how biosynthetic dysregulation of selenoproteins promotes resistance to ferroptosis.
Shijia Bao +9 more
doaj +2 more sources
O-GlcNAc regulates the mitochondrial integrated stress response by regulating ATF4
Frontiers in Aging Neuroscience, 2023 BackgroundAccumulation of mitochondrial dysfunctional is a hallmark of age-related neurodegeneration including Alzheimer’s disease (AD). Impairment of mitochondrial quality control mechanisms leading to the accumulation of damaged mitochondria and ...
Ibtihal M. Alghusen +14 more
doaj +1 more source
ATF4 selectively regulates heat nociception and contributes to kinesin-mediated TRPM3 trafficking
Nature Communications, 2021 The molecular mechanisms mediating nociception are unclear. Here, the authors show that the Activating Transcription Factor 4 (ATF4) is important for the response to heat nociception in mice and ATF4 role in mediating protein trafficking in dorsal root ...
Man-Xiu Xie +10 more
doaj +1 more source
ATF4 Responds to Metabolic Stress in Drosophila
Frontiers in Bioscience-Landmark, 2023 Background: Activating transcription factor 4 (ATF4) is a fundamental basic-leucine zipper transcription factor that plays a pivotal role in numerous stress responses, including endoplasmic reticulum (ER) stress and the integrated stress response.
Soonhyuck Ok +5 more
doaj +1 more source
Frontiers in Oncology, 2021 BackgroundThe role of activating transcription factor 4 (ATF4) underlying gastric cancer (GC) remains unclear. The purpose of this study was to investigate the expression levels and biological functions of ATF4 in GC.MethodsExpression of ATF4 was ...
Mingliang Wang +5 more
doaj +1 more source