Brain-Derived Neurotrophic Factor Elevates Activating Transcription Factor 4 (ATF4) in Neurons and Promotes ATF4-Dependent Induction of Sesn2 [PDF]
Frontiers in Molecular Neuroscience, 2018 Activating transcription factor 4 (ATF4) plays important physiologic roles in the brain including regulation of learning and memory as well as neuronal survival and death.
Jin Liu +7 more
doaj +4 more sources
Activating Transcription Factor 4 (ATF4) Modulates Post-synaptic Development and Dendritic Spine Morphology [PDF]
Frontiers in Cellular Neuroscience, 2014 The ubiquitously expressed activating transcription factor 4 (ATF4) has been variably reported to either promote or inhibit neuronal plasticity and memory.
Jin eLiu +3 more
doaj +4 more sources
Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer. [PDF]
Mol OncolThis review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Yu M, Das P, Zhang X, Cheng X.
europepmc +2 more sources
Coordinated stimulation of axon regenerative and neurodegenerative transcriptional programs by ATF4 following optic nerve injury [PDF]
eLifeStress signaling is important for determining the fates of neurons following axonal insults. Previously, we showed that the stress-responsive kinase PERK contributes to injury-induced neurodegeneration (Larhammar et al., 2017).
Preethi Somasundaram +11 more
doaj +2 more sources
Biology of Activating Transcription Factor 4 (ATF4) and Its Role in Skeletal Muscle Atrophy [PDF]
Journal of Nutrition, 2022 Adrian Vella +2 more
exaly +2 more sources
Understanding of the functional role(s) of the Activating Transcription Factor 4(ATF4) in HIV regulation and production [PDF]
BMB Reports, 2018 Seong-Hyun Park
exaly +2 more sources
The loss of activating transcription factor 4 (ATF4) reduces bone toughness and fracture toughness [PDF]
Bone, 2014 Alexander Makowski +2 more
exaly +2 more sources
O-GlcNAc regulates the mitochondrial integrated stress response by regulating ATF4
Frontiers in Aging Neuroscience, 2023 BackgroundAccumulation of mitochondrial dysfunctional is a hallmark of age-related neurodegeneration including Alzheimer’s disease (AD). Impairment of mitochondrial quality control mechanisms leading to the accumulation of damaged mitochondria and ...
Ibtihal M. Alghusen +14 more
doaj +1 more source
ATF4 selectively regulates heat nociception and contributes to kinesin-mediated TRPM3 trafficking
Nature Communications, 2021 The molecular mechanisms mediating nociception are unclear. Here, the authors show that the Activating Transcription Factor 4 (ATF4) is important for the response to heat nociception in mice and ATF4 role in mediating protein trafficking in dorsal root ...
Man-Xiu Xie +10 more
doaj +1 more source
miRNA-1283 Regulates the PERK/ATF4 Pathway in Vascular Injury by Targeting ATF4. [PDF]
PLoS ONE, 2016 In our previous study, we found significant differences in the mRNA and microRNA (miRNA) levels among hypertensive patients with different degrees of vascular endothelial cells damage.
Ling He +5 more
doaj +1 more source