Central Activating Transcription Factor 4 (ATF4) Regulates Hepatic Insulin Resistance in Mice via S6K1 Signaling and the Vagus Nerve [PDF]
Diabetes, 2013 Recent studies have revealed that the central nervous system, particularly the hypothalamus, is critical for regulating insulin sensitivity in peripheral tissues. The aim of our current study is to investigate the possible involvement of hypothalamic activating transcription factor 4 (ATF4) in the regulation of insulin sensitivity in the liver.
Zhang, Qian +7 more
openaire +2 more sources
ATF4-mediated histone deacetylase HDAC1 promotes the progression of acute pancreatitis
Cell Death and Disease, 2021 Acute pancreatitis (AP), an acute inflammatory process, can be difficult to diagnose. Activating transcription factor 4 (ATF4) has been reported to participate in the pathogenesis of AP.
Xiaofeng Deng +3 more
doaj +1 more source
Cancer Treatment and Research Communications, 2022 Background: Previous studies showed that proline-rich polypeptide (PRP-1) is a ligand for innate immunity toll-like receptors (TLR), and an inhibitor of the mammalian target of rapamycin complex 1 (mTORC1) which induces the death of chondrosarcoma cancer
Karina Galoian +9 more
doaj +1 more source
Glucagon and Insulin Cooperatively Stimulate Fibroblast Growth Factor 21 Gene Transcription by Increasing the Expression of Activating Transcription Factor 4 [PDF]
, 2017 Previous studies have shown that glucagon cooperatively interacts with insulin to stimulate hepatic FGF21 gene expression. Here we investigated the mechanism by which glucagon and insulin increased FGF21 gene transcription in primary hepatocyte cultures.
Meares, Gordon P. +5 more
core +1 more source
ATF4 Is an Oxidative Stress–Inducible, Prodeath Transcription Factor in Neurons in Vitro and in Vivo [PDF]
, 2008 Oxidative stress is pathogenic in neurological diseases, including stroke. The identity of oxidative stress-inducible transcription factors and their role in propagating the death cascade are not well known.
Ratan, Rajiv +6 more
core +2 more sources
The Role of Sirtuin 1 in Palmitic Acid-Induced Endoplasmic Reticulum Stress in Cardiac Myoblasts
Life, 2022 Background: Lipotoxicity causes endoplasmic reticulum (ER) stress, leading to cell apoptosis. Sirtuin 1 (Sirt1) regulates gene transcription and cellular metabolism. In this study, we investigated the role of Sirt1 in palmitate-induced ER stress. Methods:
Hsiang-Yu Yang +8 more
doaj +1 more source
Effect of montelukast on platelet activating factor- and tachykinin induced mucus secretion in the rat [PDF]
, 2008 Background: Platelet activating factor and tachykinins (substance P, neurokinin A, neurokinin B) are important mediators contributing to increased airway secretion in the context of different types of respiratory diseases including acute and chronic ...
David A Groneberg +12 more
core +1 more source
iScience, 2023 Summary: Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with high metastasis and therapeutic resistance. Activating transcription factor 4 (ATF4), a master regulator of cellular stress, is exploited by cancer cells to survive.
Debasmita Mukherjee +18 more
doaj +1 more source
Frontiers in Pharmacology, 2020 Triple-negative breast cancer (TNBC) has a poor prognosis due to the lack of specific therapeutic targets. CCT020312, a selective eukaryotic translation initiation factor 2 alpha (eIF2α)/protein kinase RNA-like endoplasmic reticulum kinase (PERK ...
Xiaoli Li +16 more
doaj +1 more source
Up-Regulated ATF4 Expression Increases Cell Sensitivity to Apoptosis in Response to Radiation
Cellular Physiology and Biochemistry, 2017 Background/Aims: Activating transcription factor 4 (ATF4) is a member of the activating transcription factor family which regulates the expression of genes involved in amino acid metabolism, redox homeostasis and ER stress responses.
Ying Zong +4 more
doaj +1 more source