Results 21 to 30 of about 16,783,083 (225)

Activating Transcription Factor 4 (ATF4) modulates Rho GTPase levels and function via regulation of RhoGDIα. [PDF]

Sci Rep, 2016
AbstractIn earlier studies, we showed that ATF4 down-regulation affects post-synaptic development and dendritic spine morphology in neurons through increased turnover of the Rho GTPase Cell Division Cycle 42 (Cdc42) protein. Here, we find that ATF4 down-regulation in both hippocampal and cortical neuron cultures reduces protein and message levels of ...
Pasini S, Liu J, Corona C, Peze-Heidsieck E, Shelanski M, Greene LA.   +5 more
europepmc   +4 more sources

Deletion of the transcription factor ATF4 in a model of clear cell renal cell carcinoma

Neoplasia: An International Journal for Oncology Research
Clear cell renal cell carcinoma (ccRCC) is the most common form of kidney cancer in adults. We generated TRAnsgenic of Cancer of the Kidney (TRACK) mice that express a triple-mutant (P402A, P564A, and N803A) human HIF1α construct specifically in their ...
Yuling Chi, Shireen Chikara, Eduardo Mere Del Aguila, Tuo Zhang, Jacob B. Geri, David M. Nanus, Lorraine J. Gudas   +6 more
doaj   +2 more sources

Endoplasmic Reticulum Stress Induces miR-706, A Pro-Cell Death microRNA, in A Protein Kinase RNA-Like ER Kinase (PERK) and Activating Transcription Factor 4 (ATF4) Dependent Manner. [PDF]

Cell J, 2020
Endoplasmic reticulum (ER) stress causes an adaptive response initiated by protein kinase RNA-like ER kinase (PERK), Ire1 and ATF6. It has been reported that these upstream regulators induce microRNAs. The current study was designed to find a novel microRNA that mediates ER stress components and finally contributes to cell fate decision.In this ...
Wang X, Han Y, Hu G, Guo J, Chen H.
europepmc   +3 more sources

ACTIVATING TRANSCRIPTION FACTOR 4 (ATF4) IS UPREGULATED BY HUMAN HERPESVIRUS 8 INFECTION, INCREASES VIRUS REPLICATION AND PROMOTES VIRUS PROANGIOGENIC PROPERTIES

, 2013
Previous results from our group demonstrate that human herpesvirus 8 (HHV-8) triggers proangiogenic behavior in endothelial cells by promoting transcriptional activation and secretion of monocyte chemoattractant protein 1 (MCP-1), through activation of Nuclear Factor κB (NF-κB).
Grigolato, Jessica
openaire   +2 more sources

ATF4 Responds to Metabolic Stress in Drosophila

Frontiers in Bioscience-Landmark, 2023
Background: Activating transcription factor 4 (ATF4) is a fundamental basic-leucine zipper transcription factor that plays a pivotal role in numerous stress responses, including endoplasmic reticulum (ER) stress and the integrated stress response.
Soonhyuck Ok, Jung-Eun Park, Seunghee Byun, Kwonyoon Kang, Jaekyoung Son, Min-Ji Kang   +5 more
doaj   +1 more source

High ATF4 Expression Is Associated With Poor Prognosis, Amino Acid Metabolism, and Autophagy in Gastric Cancer

Frontiers in Oncology, 2021
BackgroundThe role of activating transcription factor 4 (ATF4) underlying gastric cancer (GC) remains unclear. The purpose of this study was to investigate the expression levels and biological functions of ATF4 in GC.MethodsExpression of ATF4 was ...
Mingliang Wang, Yida Lu, Huizhen Wang, Youliang Wu, Xin Xu, Yongxiang Li   +5 more
doaj   +1 more source

CK1δ stimulates ubiquitination‐dependent proteasomal degradation of ATF4 to promote chemoresistance in gastric Cancer

Clinical and Translational Medicine, 2021
Chemoresistance remains a major obstacle to successful cancer therapy, especially for advanced cancers. It used to be recognised as a stable outcome resulting from genetic changes.
Lifeng Feng, Muchun Li, Xinyang Hu, Yiling Li, Liyuan Zhu, Miaoqin Chen, Qi Wei, Wenxia Xu, Qiyin Zhou, Weikai Wang, Dingwei Chen, Xian Wang, Hongchuan Jin   +12 more
doaj   +1 more source

Functional interaction of the HTLV-1 transactivator Tax with activating transcription factor-4 (ATF4) [PDF]

Oncogene, 1997
The Tax protein of the Human T-cell Leukemia Virus (HTLV) activates the expression of viral mRNA through a three 21 bp repeat enhancer located within the HTLV-1 LTR. Since Tax does not bind to the 21 bp DNA repeats directly, it has been speculated that Tax interacts with cellular protein(s) which mediate binding to the enhancer.
T R, Reddy, H, Tang, X, Li, F, Wong-Staal   +3 more
openaire   +2 more sources

Identification and Small Molecule Inhibition of an Activating Transcription Factor 4 (ATF4)-dependent Pathway to Age-related Skeletal Muscle Weakness and Atrophy. [PDF]

J Biol Chem, 2015
Aging reduces skeletal muscle mass and strength, but the underlying molecular mechanisms remain elusive. Here, we used mouse models to investigate molecular mechanisms of age-related skeletal muscle weakness and atrophy as well as new potential interventions for these conditions.
Ebert SM, Dyle MC, Bullard SA, Dierdorff JM, Murry DJ, Fox DK, Bongers KS, Lira VA, Meyerholz DK, Talley JJ, Adams CM.   +10 more
europepmc   +4 more sources

Cancer-associated fibroblasts-mediated ATF4 expression promotes malignancy and gemcitabine resistance in pancreatic cancer via the TGF-β1/SMAD2/3 pathway and ABCC1 transactivation

Cell Death and Disease, 2021
Cancer-associated fibroblasts (CAFs) contribute to malignant progression and chemoresistance in pancreatic ductal adenocarcinoma (PDAC). However, little is known about the underlying mechanism.
Lusheng Wei, Qing Lin, Yanan Lu, Guolin Li, Leyi Huang, Zhiqiang Fu, Rufu Chen, Quanbo Zhou   +7 more
doaj   +1 more source