Understanding of the functional role(s) of the Activating Transcription Factor 4(ATF4) in HIV regulation and production. [PDF]
BMB Rep, 2018 The activating transcription factor (ATF) 4 belongs to the ATF/CREB (cAMP Response Element Binding bZIP [Basic Leucine Zipper]) transcription factor family, and plays a central role in the UPR (Unfolded Protein Response) process in cells. The induction of ATF4 expression has previously been shown to increase the replication of HIV-1.
Lee SD +5 more
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miR-1283 Contributes to Endoplasmic Reticulum Stress in the Development of Hypertension Through the Activating Transcription Factor-4 (ATF4)/C/EBP-Homologous Protein (CHOP) Signaling Pathway. [PDF]
Med Sci Monit, 2021 BACKGROUND Hypertension-related microRNA(miR)-1283 and its target gene, activating transcription factor-4 (ATF4), can regulate vascular endothelial dysfunction. This study aimed to explore whether miR-1283 prevents hypertension through targeting ATF4. MATERIAL AND METHODS Transcriptome sequencing was performed after overexpression or inhibition of miR ...
Chen W +7 more
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Activating Transcription Factor 4 (ATF4) modulates Rho GTPase levels and function via regulation of RhoGDIα. [PDF]
Sci Rep, 2016 AbstractIn earlier studies, we showed that ATF4 down-regulation affects post-synaptic development and dendritic spine morphology in neurons through increased turnover of the Rho GTPase Cell Division Cycle 42 (Cdc42) protein. Here, we find that ATF4 down-regulation in both hippocampal and cortical neuron cultures reduces protein and message levels of ...
Pasini S +5 more
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Deletion of the transcription factor ATF4 in a model of clear cell renal cell carcinoma
Neoplasia: An International Journal for Oncology ResearchClear cell renal cell carcinoma (ccRCC) is the most common form of kidney cancer in adults. We generated TRAnsgenic of Cancer of the Kidney (TRACK) mice that express a triple-mutant (P402A, P564A, and N803A) human HIF1α construct specifically in their ...
Yuling Chi +6 more
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Endoplasmic Reticulum Stress Induces miR-706, A Pro-Cell Death microRNA, in A Protein Kinase RNA-Like ER Kinase (PERK) and Activating Transcription Factor 4 (ATF4) Dependent Manner. [PDF]
Cell J, 2020 Endoplasmic reticulum (ER) stress causes an adaptive response initiated by protein kinase RNA-like ER kinase (PERK), Ire1 and ATF6. It has been reported that these upstream regulators induce microRNAs. The current study was designed to find a novel microRNA that mediates ER stress components and finally contributes to cell fate decision.In this ...
Wang X, Han Y, Hu G, Guo J, Chen H.
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, 2013 Previous results from our group demonstrate that human herpesvirus 8 (HHV-8) triggers proangiogenic behavior in endothelial cells by promoting transcriptional activation and secretion of monocyte chemoattractant protein 1 (MCP-1), through activation of Nuclear Factor κB (NF-κB).
Grigolato, Jessica
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Clinical and Translational Medicine, 2021 Chemoresistance remains a major obstacle to successful cancer therapy, especially for advanced cancers. It used to be recognised as a stable outcome resulting from genetic changes.
Lifeng Feng +12 more
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Functional interaction of the HTLV-1 transactivator Tax with activating transcription factor-4 (ATF4) [PDF]
Oncogene, 1997 The Tax protein of the Human T-cell Leukemia Virus (HTLV) activates the expression of viral mRNA through a three 21 bp repeat enhancer located within the HTLV-1 LTR. Since Tax does not bind to the 21 bp DNA repeats directly, it has been speculated that Tax interacts with cellular protein(s) which mediate binding to the enhancer.
T R, Reddy +3 more
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Cell Death and Disease, 2021 Cancer-associated fibroblasts (CAFs) contribute to malignant progression and chemoresistance in pancreatic ductal adenocarcinoma (PDAC). However, little is known about the underlying mechanism.
Lusheng Wei +7 more
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Lysosomes mediate the mitochondrial UPR via mTORC1-dependent ATF4 phosphorylation
Cell Discovery, 2023 Lysosomes are central platforms for not only the degradation of macromolecules but also the integration of multiple signaling pathways. However, whether and how lysosomes mediate the mitochondrial stress response (MSR) remain largely unknown.
Terytty Yang Li +7 more
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