Results 11 to 20 of about 16,783,083 (225)

ATF4 (activating transcription factor 4 (tax-responsive enhancer element B67)) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011
Review on ATF4 (activating transcription factor 4 (tax-responsive enhancer element B67)), with data on DNA, on the protein encoded, and where the gene is implicated.
Ameri, K, Harris, AL
openaire   +4 more sources

Sestrin2 Regulates Endoplasmic Reticulum Stress-Dependent Ferroptosis to Engage Pulmonary Fibrosis by Nuclear Factor Erythroid 2-Related Factor 2/Activating Transcription Factor 4 (NRF2/ATF4)

Journal of Immunology Research, 2023
Pulmonary fibrosis (PF) can lead to chronic inflammation, the destruction of alveoli and irreversible lung damage. Sestrin2 is a highly protective stress-inducible protein that is involved in the cell response to various stress factors and the regulation of homeostasis and has a certain protective effect against PF.
Zhaoxing Dong, Ting Li, Cenli Wang, Yong Zhou, Zhongkai Tong, Xuekui Du   +5 more
openaire   +4 more sources

Activating transcription factor 4: a regulator of stress response in human cancers [PDF]

Frontiers in Cell and Developmental Biology
Activating transcription factor 4 (ATF4) is an adaptive response regulator of metabolic and oxidative homeostasis. In response to cellular stress, ATF4 is activated and functions as a regulator to promote cell adaptation for survival.
Di Wu, Jie Liang
doaj   +2 more sources

Activating transcription factor 4 (ATF4) is upregulated by human herpesvirus 8 infection, increases virus replication and promotes proangiogenic properties

Archives of Virology, 2011
Human herpesvirus 8 (HHV-8) triggers proangiogenic behaviour in endothelial cells by inducing monocyte chemoattractant protein 1 (MCP-1) through activation of Nuclear Factor κB (NF-κB). However, NF-κB inhibition still results in partial MCP-1 induction and consequent angiogenesis, suggesting the involvement of another transcriptional pathway.
CASELLI, Elisabetta, BENEDETTI, Sabrina, GRIGOLATO, Jessica, Caruso A., DI LUCA, Dario   +4 more
openaire   +4 more sources

Critical role of activating transcription factor 4 in the anabolic actions of parathyroid hormone in bone. [PDF]

PLoS ONE, 2009
Parathyroid hormone (PTH) is a potent anabolic agent for the treatment of osteoporosis. However, its mechanism of action in osteoblast and bone is not well understood.
Shibing Yu, Renny T Franceschi, Min Luo, Jie Fan, Di Jiang, Huiling Cao, Tae-Geon Kwon, Yumei Lai, Jian Zhang, Kenneth Patrene, Kurt Hankenson, G David Roodman, Guozhi Xiao   +12 more
doaj   +2 more sources

Regulation of Activating Transcription Factor 4 (ATF4) Expression by Fat Mass and Obesity-Associated (FTO) in Mouse Hepatocyte Cells. [PDF]

Acta Endocrinol (Buchar), 2021
Abnormally increased hepatic glucose production contributes to hyperglycemia in diabetes. Interventions that suppress hepatic gluconeogenesis should be beneficial in improving glycemic control in patients with diabetes.It has been suggested that hepatic FTO is involved in glycemic control by regulating gluconeogenesis.
Mizuno TM, Lew PS.
europepmc   +4 more sources

Activating transcription factor 4 (ATF4) promotes skeletal muscle atrophy by forming a heterodimer with the transcriptional regulator C/EBPβ. [PDF]

J Biol Chem, 2020
Skeletal muscle atrophy is a highly-prevalent and debilitating condition that remains poorly understood at the molecular level. Previous work found that aging, fasting, and immobilization promote skeletal muscle atrophy via expression of activating transcription factor 4 (ATF4) in skeletal muscle fibers.
Ebert SM, Bullard SA, Basisty N, Marcotte GR, Skopec ZP, Dierdorff JM, Al-Zougbi A, Tomcheck KC, DeLau AD, Rathmacher JA, Bodine SC, Schilling B, Adams CM.   +12 more
europepmc   +4 more sources

Activating Transcription Factor 4 (ATF4) Regulates Neuronal Activity by Controlling GABA_BR Trafficking. [PDF]

J Neurosci, 2018
Activating Transcription Factor 4 (ATF4) has been postulated as a key regulator of learning and memory. We previously reported that specific hippocampal ATF4 downregulation causes deficits in synaptic plasticity and memory and reduction of glutamatergic functionality. Here we extend our studies to address ATF4's role in neuronal excitability.
Corona C, Pasini S, Liu J, Amar F, Greene LA, Shelanski ML.   +5 more
europepmc   +4 more sources

Estudio de ATF4 (Activating Transcription Factor 4) como biomarcador de agresividad en cáncer de mama triple negativo [PDF]

, 2020
Breast cancer is one of the most frequently diagnosed tumors and has a significant health impact on the female population due to its high incidence and associated mortality rate. Among the different subtypes that exist, depending on the presence or absence of hormonal receptors for estrogen, progesterone and HER2 (Human Epidermal growth factor Receptor
González González, Adrián
core   +3 more sources

miR-1283 Contributes to Endoplasmic Reticulum Stress in the Development of Hypertension Through the Activating Transcription Factor-4 (ATF4)/C/EBP-Homologous Protein (CHOP) Signaling Pathway. [PDF]

Med Sci Monit, 2021
BACKGROUND Hypertension-related microRNA(miR)-1283 and its target gene, activating transcription factor-4 (ATF4), can regulate vascular endothelial dysfunction. This study aimed to explore whether miR-1283 prevents hypertension through targeting ATF4. MATERIAL AND METHODS Transcriptome sequencing was performed after overexpression or inhibition of miR ...
Chen W, Liu T, Liang Q, Chen X, Tao W, Fang M, Xiao Y, Chen L.   +7 more
europepmc   +4 more sources