Results 31 to 40 of about 16,783,083 (225)

Lysosomes mediate the mitochondrial UPR via mTORC1-dependent ATF4 phosphorylation

Cell Discovery, 2023
Lysosomes are central platforms for not only the degradation of macromolecules but also the integration of multiple signaling pathways. However, whether and how lysosomes mediate the mitochondrial stress response (MSR) remain largely unknown.
Terytty Yang Li, Qi Wang, Arwen W. Gao, Xiaoxu Li, Yu Sun, Adrienne Mottis, Minho Shong, Johan Auwerx   +7 more
doaj   +1 more source

The Role of Activating Transcription Factor 4 (ATF4) in the Physiological Response to Dietary Sulfur Amino Acid Restriction (OR27-01-19) [PDF]

Curr Dev Nutr, 2019
Dietary restriction of the sulfur amino acids (SAAs) improves metabolic health in part via hepatic production of fibroblast growth factor 21 (FGF21). Transcriptional control of Fgf21includes regulation by ATF4 during low protein feeding. Therefore, we aimed to determine the impact of Atf4 deletion on FGF21 levels and associated metabolic outcomes in ...
Jonsson W, Margolies N, Mirek E, Gettys T, Anthony T.   +4 more
europepmc   +3 more sources

Lipopolysaccharide induces nitric oxide synthase expression and platelet-activating factor increases nitric oxide production in human fetal membranes in culture [PDF]

, 2004
Platelet-activating factor and nitric oxide may be involved in the initiation of human labour as inflammatory mediators. The aim of this study was to test whether platelet-activating factor and lipopolysaccharide were able to induce nitric oxide synthase
Damian J Murphy, Dunmore, Simon J., Murphy Damian J, Carson Ray J, Rodrigo, Nalinda, Seyffarth Gunter, Nelson, Paul N., Dunmore Simon J, Simon J Dunmore, Nalinda Rodrigo, Carson, Ray J., Seyffarth, Gunther, Rodrigo Nalinda, Paul N Nelson, Murphy, Damian J., Nelson Paul N, Gunter Seyffarth, Ray J Carson   +17 more
core   +1 more source

ATF4- and NeuN-positive neurons in the corticolimbic system.

, 2021
Representative immunofluorescent images of 8-week-old OLETF and LETO rats in the anterior cingulate cortex (ACC; A, B, C and D), basolateral amygdala (BLA; E, F, G, and H), and hippocampal cornu ammonis area 3 (CA3; I, J, K, and L.
Hisao Nishijo (303632), Ryosuke Ochi (11419784), Son Tien Nguyen (11324552), Naoto Fujita (677910), Takaya Oshima (11324550), Susumu Urakawa (354542), Kaho Takaishi (11324547), Natsuki Goto (11324541)   +7 more
core   +1 more source

PRMT5 regulates ATF4 transcript splicing and oxidative stress response

Redox Biology, 2022
Protein methyltransferase 5 (PRMT5) symmetrically dimethylates arginine residues leading to regulation of transcription and splicing programs. Although PRMT5 has emerged as an attractive oncology target, the molecular determinants of PRMT5 dependency in ...
Magdalena M. Szewczyk, Genna M. Luciani, Victoria Vu, Alex Murison, David Dilworth, Samir H. Barghout, Mathieu Lupien, Cheryl H. Arrowsmith, Mark D. Minden, Dalia Barsyte-Lovejoy   +9 more
doaj   +1 more source

Activating transcription factor 4 regulates hypoxia inducible factor 1α in chronic hypoxia in pancreatic cancer cells [PDF]

, 2022
Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive and difficult to treat cancers with tumors typically exhibiting high levels of chronic hypoxia.
Brothers, Shaun P., Welford, Scott, Carriere, Candace H., Chee, Nancy T., Miller, Zachary   +4 more
core   +1 more source

Pharmacological Disruption of Phosphorylated Eukaryotic Initiation Factor-2α/Activating Transcription Factor 4/Indian Hedgehog Protects Intervertebral Disc Degeneration via Reducing the Reactive Oxygen Species and Apoptosis of Nucleus Pulposus Cells

Frontiers in Cell and Developmental Biology, 2021
Excessive reactive oxygen species (ROS) and apoptosis in nucleus pulposus (NP) cells accelerate the process of intervertebral disc degeneration (IDD). Here, we integrated pathological samples and in vitro and in vivo framework to investigate the impact ...
Junping Bao, Junping Bao, Zhanyang Qian, Zhanyang Qian, Lei Liu, Lei Liu, Xin Hong, Xin Hong, Hui Che, Xiaotao Wu, Xiaotao Wu   +10 more
doaj   +1 more source

SIRT1 Suppresses Activating Transcription Factor 4 (ATF4) Expression in Response to Proteasome Inhibition

Journal of Microbiology and Biotechnology, 2013
The synthetic machinery of ATF4 (activating transcription factor 4) is activated in response to various stress conditions involved in nutrient restriction, endoplasmic reticulum homeostasis, and oxidation. Stress-induced inhibition of proteasome activity triggers the unfolded protein response and endoplasmic reticulum stress, where ATF4 is crucial for ...
Seon Rang, Woo, Jeong-Eun, Park, Yang Hyun, Kim, Yeun-Jin, Ju, Hyun-Jin, Shin, Hyun-Yoo, Joo, Eun-Ran, Park, Sung Hee, Hong, Gil Hong, Park, Kee-Ho, Lee   +9 more
openaire   +2 more sources

ATF4- and PV-positive neurons in the corticolimbic system.

, 2021
Representative immunofluorescent images of 8-week-old OLETF and LETO rats in the prelimbic cortex (PL; A, B, C and D), basolateral amygdala (BLA; E, F, G, and H), and hippocampal cornu ammonis area 3 (CA3; I, J, K, and L).
Hisao Nishijo (303632), Ryosuke Ochi (11419784), Son Tien Nguyen (11324552), Naoto Fujita (677910), Takaya Oshima (11324550), Susumu Urakawa (354542), Kaho Takaishi (11324547), Natsuki Goto (11324541)   +7 more
core   +1 more source

ATF4- and CCK-positive neurons in the corticolimbic system.

, 2021
Representative immunofluorescent images of 8-week-old OLETF and LETO rats in the anterior cingulate cortex (ACC; A, B, C, and D), basolateral amygdala (BLA; E, F, G, and H), and hippocampal cornu ammonis area 3 (CA3; I, J, K, and L).
Hisao Nishijo (303632), Ryosuke Ochi (11419784), Son Tien Nguyen (11324552), Naoto Fujita (677910), Takaya Oshima (11324550), Susumu Urakawa (354542), Kaho Takaishi (11324547), Natsuki Goto (11324541)   +7 more
core   +1 more source