Results 21 to 30 of about 476,008 (241)

Glucagon and Insulin Cooperatively Stimulate Fibroblast Growth Factor 21 Gene Transcription by Increasing the Expression of Activating Transcription Factor 4. [PDF]

J Biol Chem, 2017
Previous studies have shown that glucagon cooperatively interacts with insulin to stimulate hepatic FGF21 gene expression. Here we investigated the mechanism by which glucagon and insulin increased FGF21 gene transcription in primary hepatocyte cultures.
Alonge KM, Meares GP, Hillgartner FB.
europepmc   +4 more sources

Insulin inhibits melanoma tumor growth through the expression of activating transcription factor 4, without detectable expression of transcription factor CHOP: an in vivo model [PDF]

Anais Brasileiros de Dermatologia
Daniel do Prado, Marianna Boia-Ferreia, Hanna Camara da Justa, Andrea Senff-Ribeiro, Sérgio Lunardon Padilha   +4 more
doaj   +2 more sources

High ATF4 Expression Is Associated With Poor Prognosis, Amino Acid Metabolism, and Autophagy in Gastric Cancer

Frontiers in Oncology, 2021
BackgroundThe role of activating transcription factor 4 (ATF4) underlying gastric cancer (GC) remains unclear. The purpose of this study was to investigate the expression levels and biological functions of ATF4 in GC.MethodsExpression of ATF4 was ...
Mingliang Wang, Yida Lu, Huizhen Wang, Youliang Wu, Xin Xu, Yongxiang Li   +5 more
doaj   +1 more source

Activating transcription factor 4 regulates osteoclast differentiation in mice [PDF]

Journal of Clinical Investigation, 2010
Activating transcription factor 4 (ATF4) is a critical transcription factor for osteoblast (OBL) function and bone formation; however, a direct role in osteoclasts (OCLs) has not been established. Here, we targeted expression of ATF4 to the OCL lineage using the Trap promoter or through deletion of Atf4 in mice.
Huiling, Cao, Shibing, Yu, Zhi, Yao, Deborah L, Galson, Yu, Jiang, Xiaoyan, Zhang, Jie, Fan, Binfeng, Lu, Youfei, Guan, Min, Luo, Yumei, Lai, Yibei, Zhu, Noriyoshi, Kurihara, Kenneth, Patrene, G David, Roodman, Guozhi, Xiao   +15 more
openaire   +2 more sources

Activating Transcription Factor 4 Is Translationally Regulated by Hypoxic Stress [PDF]

Molecular and Cellular Biology, 2004
Hypoxic stress results in a rapid and sustained inhibition of protein synthesis that is at least partially mediated by eukaryotic initiation factor 2alpha (eIF2alpha) phosphorylation by the endoplasmic reticulum (ER) kinase PERK. Here we show through microarray analysis of polysome-bound RNA in aerobic and hypoxic HeLa cells that a subset of ...
Jaime D, Blais, Vasilisa, Filipenko, Meixia, Bi, Heather P, Harding, David, Ron, Costas, Koumenis, Bradly G, Wouters, John C, Bell   +7 more
openaire   +2 more sources

Regulation of Vascular Endothelial Growth Factor A by Activating Transcription Factor 4 [PDF]

Circulation Research, 2008
To the Editor: In a recent article published in Circulation Research , Malabanan et al demonstrated that expression of vascular endothelial growth factor (VEGF)-A in response to fibroblast growth factor-2 is regulated by …
Steven F. Abcouwer, C. Nathaniel Roybal
openaire   +1 more source

Mitosin/CENP-F as a Negative Regulator of Activating Transcription Factor-4 [PDF]

Journal of Biological Chemistry, 2005
Mitosin/CENP-F is a human nuclear matrix protein with multiple leucine zipper motifs. Its accumulation in S-G2 phases and transient kinetochore localization in mitosis suggest a multifunctional protein for cell proliferation. Moreover, its murine and avian orthologs are implicated in myocyte differentiation.
Xubin, Zhou, Rong, Wang, Libin, Fan, Yan, Li, Li, Ma, Zhenye, Yang, Wei, Yu, Naihe, Jing, Xueliang, Zhu   +8 more
openaire   +2 more sources

MicroRNA-214 Suppresses Gluconeogenesis by Targeting Activating Transcriptional Factor 4 [PDF]

Journal of Biological Chemistry, 2015
Although the gluconeogenesis pathway is already a target for the treatment of type 2 diabetes, the potential role of microRNAs (miRNAs) in gluconeogenesis remains unclear. Here, we investigated the physiological functions of miR-214 in gluconeogenesis.
Kai, Li, Jin, Zhang, Junjie, Yu, Bin, Liu, Yajie, Guo, Jiali, Deng, Shanghai, Chen, Chunxia, Wang, Feifan, Guo   +8 more
openaire   +2 more sources

Activating transcription factor 4

The International Journal of Biochemistry & Cell Biology, 2008
Activating transcription factor 4 (ATF4) belongs to the ATF/CREB (activating transcription factor/cyclic AMP response element binding protein) family of basic region-leucine zipper (bZip) transcription factors, which have the consensus binding site cAMP responsive element (CRE). ATF4 has numerous dimerization partners. ATF4 is induced by stress signals
Ameri, K, Harris, A
openaire   +3 more sources

Time-resolved single-cell transcriptomics reveals the landscape and dynamics of hepatic cells in sepsis-induced acute liver dysfunction

JHEP Reports, 2023
Background & Aims: Sepsis-induced acute liver dysfunction often occurs early in sepsis and can exacerbate the pathology by triggering multiple organ dysfunction and increasing lethality.
Gan Chen, Chao Ren, Yao Xiao, Yujing Wang, Renqi Yao, Quan Wang, Guoxing You, Mingzi Lu, Shaoduo Yan, Xiaoyong Zhang, Jun Zhang, Yongming Yao, Hong Zhou   +12 more
doaj   +1 more source