Results 21 to 30 of about 495,141 (240)

Activating Transcription Factor 4 Is Translationally Regulated by Hypoxic Stress [PDF]

Molecular and Cellular Biology, 2004
Hypoxic stress results in a rapid and sustained inhibition of protein synthesis that is at least partially mediated by eukaryotic initiation factor 2alpha (eIF2alpha) phosphorylation by the endoplasmic reticulum (ER) kinase PERK. Here we show through microarray analysis of polysome-bound RNA in aerobic and hypoxic HeLa cells that a subset of ...
Jaime D, Blais, Vasilisa, Filipenko, Meixia, Bi, Heather P, Harding, David, Ron, Costas, Koumenis, Bradly G, Wouters, John C, Bell   +7 more
openaire   +2 more sources

Activating transcription factor 4-dependent lactate dehydrogenase activation as a protective response to amyloid beta toxicity. [PDF]

Brain Commun, 2021
Abstract Accumulation of amyloid beta peptides is thought to initiate the pathogenesis of Alzheimer's disease. However, the precise mechanisms mediating their neurotoxicity are unclear. Our microarray analyses show that, in Drosophila models of amyloid beta 42 toxicity, genes involved in the unfolded protein response and metabolic ...
Niccoli T, Kerr F, Snoeren I, Fabian D, Aleyakpo B, Ivanov D, Sofola-Adesakin O, Cryar A, Adcott J, Thornton J, Partridge L.   +10 more
europepmc   +7 more sources

Regulation of Vascular Endothelial Growth Factor A by Activating Transcription Factor 4 [PDF]

Circulation Research, 2008
To the Editor: In a recent article published in Circulation Research , Malabanan et al demonstrated that expression of vascular endothelial growth factor (VEGF)-A in response to fibroblast growth factor-2 is regulated by …
Steven F. Abcouwer, C. Nathaniel Roybal
openaire   +1 more source

MicroRNA-214 Suppresses Gluconeogenesis by Targeting Activating Transcriptional Factor 4 [PDF]

Journal of Biological Chemistry, 2015
Although the gluconeogenesis pathway is already a target for the treatment of type 2 diabetes, the potential role of microRNAs (miRNAs) in gluconeogenesis remains unclear. Here, we investigated the physiological functions of miR-214 in gluconeogenesis.
Kai, Li, Jin, Zhang, Junjie, Yu, Bin, Liu, Yajie, Guo, Jiali, Deng, Shanghai, Chen, Chunxia, Wang, Feifan, Guo   +8 more
openaire   +2 more sources

Activating transcription factor 4

The International Journal of Biochemistry & Cell Biology, 2008
Activating transcription factor 4 (ATF4) belongs to the ATF/CREB (activating transcription factor/cyclic AMP response element binding protein) family of basic region-leucine zipper (bZip) transcription factors, which have the consensus binding site cAMP responsive element (CRE). ATF4 has numerous dimerization partners. ATF4 is induced by stress signals
Ameri, K, Harris, A
openaire   +3 more sources

DNA binding and transcription activation specificity of hepatocyte nuclear factor 4 [PDF]

Nucleic Acids Research, 1998
Hepatocyte nuclear factor 4 (HNF-4) is an orphan intracellular receptor that appears to be a key factor in the regulation of energy metabolism. In order to gain greater understanding of the binding and activation requirements of HNF-4, we performed genetic analysis of the apoCIII promoter, a promoter that has previously been shown to be highly ...
J D, Fraser, V, Martinez, R, Straney, M R, Briggs   +3 more
openaire   +2 more sources

Time-resolved single-cell transcriptomics reveals the landscape and dynamics of hepatic cells in sepsis-induced acute liver dysfunction

JHEP Reports, 2023
Background & Aims: Sepsis-induced acute liver dysfunction often occurs early in sepsis and can exacerbate the pathology by triggering multiple organ dysfunction and increasing lethality.
Gan Chen, Chao Ren, Yao Xiao, Yujing Wang, Renqi Yao, Quan Wang, Guoxing You, Mingzi Lu, Shaoduo Yan, Xiaoyong Zhang, Jun Zhang, Yongming Yao, Hong Zhou   +12 more
doaj   +1 more source

Mitosin/CENP-F as a Negative Regulator of Activating Transcription Factor-4 [PDF]

Journal of Biological Chemistry, 2005
Mitosin/CENP-F is a human nuclear matrix protein with multiple leucine zipper motifs. Its accumulation in S-G2 phases and transient kinetochore localization in mitosis suggest a multifunctional protein for cell proliferation. Moreover, its murine and avian orthologs are implicated in myocyte differentiation.
Xubin, Zhou, Rong, Wang, Libin, Fan, Yan, Li, Li, Ma, Zhenye, Yang, Wei, Yu, Naihe, Jing, Xueliang, Zhu   +8 more
openaire   +2 more sources

Activating Transcription Factor 4 (ATF4) Modulates Post-synaptic Development and Dendritic Spine Morphology

Frontiers in Cellular Neuroscience, 2014
The ubiquitously expressed activating transcription factor 4 (ATF4) has been variably reported to either promote or inhibit neuronal plasticity and memory.
Jin eLiu, Silvia ePasini, Michael L Shelanski, Lloyd A Greene   +3 more
doaj   +1 more source

The Effect of Resistance Training and Berberine Chloride on the Apoptosis-related Unfolded Protein Response Signaling Pathway in the Hippocampus of Diazinon-poisoned Rats

Basic and Clinical Neuroscience, 2021
Introduction: Diazinon is one of the most widely-used organophosphate pesticides in the world. This toxin enters the body in various ways and induces oxidative stress in various tissues.
Ali Esfandiarifar, Mohammad Ali Azarbayjani, Maghsood Peeri, Seyed Behnamedin Jameie   +3 more
doaj