Results 21 to 30 of about 17,248,721 (282)

High ATF4 Expression Is Associated With Poor Prognosis, Amino Acid Metabolism, and Autophagy in Gastric Cancer

Frontiers in Oncology, 2021
BackgroundThe role of activating transcription factor 4 (ATF4) underlying gastric cancer (GC) remains unclear. The purpose of this study was to investigate the expression levels and biological functions of ATF4 in GC.MethodsExpression of ATF4 was ...
Mingliang Wang, Yida Lu, Huizhen Wang, Youliang Wu, Xin Xu, Yongxiang Li   +5 more
doaj   +1 more source

Activating Transcription Factor 4 Is Translationally Regulated by Hypoxic Stress [PDF]

Molecular and Cellular Biology, 2004
Hypoxic stress results in a rapid and sustained inhibition of protein synthesis that is at least partially mediated by eukaryotic initiation factor 2alpha (eIF2alpha) phosphorylation by the endoplasmic reticulum (ER) kinase PERK. Here we show through microarray analysis of polysome-bound RNA in aerobic and hypoxic HeLa cells that a subset of ...
Jaime D, Blais, Vasilisa, Filipenko, Meixia, Bi, Heather P, Harding, David, Ron, Costas, Koumenis, Bradly G, Wouters, John C, Bell   +7 more
openaire   +2 more sources

Activating transcription factor 4-dependent lactate dehydrogenase activation as a protective response to amyloid beta toxicity. [PDF]

Brain Commun, 2021
Abstract Accumulation of amyloid beta peptides is thought to initiate the pathogenesis of Alzheimer's disease. However, the precise mechanisms mediating their neurotoxicity are unclear. Our microarray analyses show that, in Drosophila models of amyloid beta 42 toxicity, genes involved in the unfolded protein response and metabolic ...
Niccoli T, Kerr F, Snoeren I, Fabian D, Aleyakpo B, Ivanov D, Sofola-Adesakin O, Cryar A, Adcott J, Thornton J, Partridge L.   +10 more
europepmc   +7 more sources

Regulation of Vascular Endothelial Growth Factor A by Activating Transcription Factor 4 [PDF]

Circulation Research, 2008
To the Editor: In a recent article published in Circulation Research , Malabanan et al demonstrated that expression of vascular endothelial growth factor (VEGF)-A in response to fibroblast growth factor-2 is regulated by …
Steven F. Abcouwer, C. Nathaniel Roybal
openaire   +1 more source

MicroRNA-214 Suppresses Gluconeogenesis by Targeting Activating Transcriptional Factor 4 [PDF]

Journal of Biological Chemistry, 2015
Although the gluconeogenesis pathway is already a target for the treatment of type 2 diabetes, the potential role of microRNAs (miRNAs) in gluconeogenesis remains unclear. Here, we investigated the physiological functions of miR-214 in gluconeogenesis.
Kai, Li, Jin, Zhang, Junjie, Yu, Bin, Liu, Yajie, Guo, Jiali, Deng, Shanghai, Chen, Chunxia, Wang, Feifan, Guo   +8 more
openaire   +2 more sources

Lipopolysaccharide induces nitric oxide synthase expression and platelet-activating factor increases nitric oxide production in human fetal membranes in culture [PDF]

, 2004
Platelet-activating factor and nitric oxide may be involved in the initiation of human labour as inflammatory mediators. The aim of this study was to test whether platelet-activating factor and lipopolysaccharide were able to induce nitric oxide synthase
Damian J Murphy, Dunmore, Simon J., Murphy Damian J, Carson Ray J, Rodrigo, Nalinda, Seyffarth Gunter, Nelson, Paul N., Dunmore Simon J, Simon J Dunmore, Nalinda Rodrigo, Carson, Ray J., Seyffarth, Gunther, Rodrigo Nalinda, Paul N Nelson, Murphy, Damian J., Nelson Paul N, Gunter Seyffarth, Ray J Carson   +17 more
core   +1 more source

DNA binding and transcription activation specificity of hepatocyte nuclear factor 4 [PDF]

Nucleic Acids Research, 1998
Hepatocyte nuclear factor 4 (HNF-4) is an orphan intracellular receptor that appears to be a key factor in the regulation of energy metabolism. In order to gain greater understanding of the binding and activation requirements of HNF-4, we performed genetic analysis of the apoCIII promoter, a promoter that has previously been shown to be highly ...
J D, Fraser, V, Martinez, R, Straney, M R, Briggs   +3 more
openaire   +2 more sources

Effect of montelukast on platelet activating factor- and tachykinin induced mucus secretion in the rat [PDF]

, 2008
Background: Platelet activating factor and tachykinins (substance P, neurokinin A, neurokinin B) are important mediators contributing to increased airway secretion in the context of different types of respiratory diseases including acute and chronic ...
David A Groneberg, Groneberg, David A., Wagner, Ulrich, Groneberg, Jan David Alexander, Groneberg David A, Staats Petra, Schmidt Rene, Ulrich Wagner, Schmidt, Rene, Petra Staats, Staats, Petra, Rene Schmidt, Wagner Ulrich   +12 more
core   +1 more source

Time-resolved single-cell transcriptomics reveals the landscape and dynamics of hepatic cells in sepsis-induced acute liver dysfunction

JHEP Reports, 2023
Background & Aims: Sepsis-induced acute liver dysfunction often occurs early in sepsis and can exacerbate the pathology by triggering multiple organ dysfunction and increasing lethality.
Gan Chen, Chao Ren, Yao Xiao, Yujing Wang, Renqi Yao, Quan Wang, Guoxing You, Mingzi Lu, Shaoduo Yan, Xiaoyong Zhang, Jun Zhang, Yongming Yao, Hong Zhou   +12 more
doaj   +1 more source

Mitosin/CENP-F as a Negative Regulator of Activating Transcription Factor-4 [PDF]

Journal of Biological Chemistry, 2005
Mitosin/CENP-F is a human nuclear matrix protein with multiple leucine zipper motifs. Its accumulation in S-G2 phases and transient kinetochore localization in mitosis suggest a multifunctional protein for cell proliferation. Moreover, its murine and avian orthologs are implicated in myocyte differentiation.
Xubin, Zhou, Rong, Wang, Libin, Fan, Yan, Li, Li, Ma, Zhenye, Yang, Wei, Yu, Naihe, Jing, Xueliang, Zhu   +8 more
openaire   +2 more sources