Results 41 to 50 of about 17,248,721 (282)

Fibroblast growth factor 2 positively regulates expression of activating transcription factor 4 in osteoblasts [PDF]

Biochemical and Biophysical Research Communications, 2010
Our previous studies showed that basic fibroblast growth factor 2 (FGF2) null mice display markedly reduced bone mass and bone formation. However, the mechanism by which FGF2 regulates bone mass or bone formation is not fully defined. Activating transcription factor 4 (ATF4), one member of activating transcription factor/cAMP response element binding ...
Yurong, Fei, Liping, Xiao, Marja M, Hurley   +2 more
openaire   +2 more sources

Effect of leucine on endoplasmic reticulum stress induced by early weaning in the liver of piglets

浙江大学学报. 农业与生命科学版, 2018
To investigate the effects of dietary leucine supplementation on endoplasmic reticulum (ER) stress in the liver of early-weaning piglets, we explored the morphology of liver cells, expression pattern of ER stress-associated proteins, and effects on ER ...
FAN Qiwen, CHEN Lingli, ZHAO Li, SHI Min, YAN Xianghua   +4 more
doaj   +1 more source

Activating transcription factor-4 promotes mineralization in vascular smooth muscle cells. [PDF]

JCI Insight, 2016
Emerging evidence indicates that upregulation of the ER stress–induced pro-osteogenic transcription factor ATF4 plays an important role in vascular calcification, a common complication in patients with aging, diabetes, and chronic kidney disease (CKD).
Masuda M, Miyazaki-Anzai S, Keenan AL, Shiozaki Y, Okamura K, Chick WS, Williams K, Zhao X, Rahman SM, Tintut Y, Adams CM, Miyazaki M.   +11 more
europepmc   +4 more sources

Krüppel-like factor 4, a novel transcription factor regulates microglial activation and subsequent neuroinflammation [PDF]

Journal of Neuroinflammation, 2010
Abstract Background Activation of microglia, the resident macrophages of the central nervous system (CNS), is the hallmark of neuroinflammation in neurodegenerative diseases and other pathological conditions associated with CNS infection.
Das Sulagna, Gupta Malvika, Kaushik Deepak K, Basu Anirban   +3 more
openaire   +3 more sources

Phosphorylation of Serine 114 of the transcription factor ABSCISIC ACID INSENSITIVE 4 is essential for activity [PDF]

Plant Science, 2020
Abstract The transcription factor ABA-INSENSITIVE(ABI)4 has diverse roles in regulating plant growth, including inhibiting germination and reserve mobilization in response to ABA and high salinity, inhibiting seedling growth in response to high sugars, inhibiting lateral root growth, and repressing light-induced gene ...
Nadav Eisner, Tzofia Maymon, Ester Cancho Sanchez, Dana Bar-Zvi, Sagie Brodsky, Ruth Finkelstein, Dudy Bar-Zvi   +6 more
openaire   +4 more sources

Function of the upstream activating factor in chromatin structure organization and transcriptional regulation at the yeast ribosomal DNA [PDF]

, 2010
Chromatin is the template of all processes involved in DNA metabolism in the eukaryotic cell. Accordingly, chromatin is a dynamic structure which changes in its composition and posttranslational modification correlating with the functional state of a ...
Götze, Hannah
core   +1 more source

Activating transcription factor 4 and X box binding protein 1 of Litopenaeus vannamei transcriptional regulated white spot syndrome virus genes Wsv023 and Wsv083. [PDF]

PLoS ONE, 2013
In response to endoplasmic reticulum (ER) stress, the signaling pathway termed unfolded protein response (UPR) is activated. To investigate the role of UPR in Litopenaeus vannamei immunity, the activating transcription factor 4 (designated as LvATF4 ...
Xiao-Yun Li, Li-Ran Pang, Yong-Gui Chen, Shao-Ping Weng, Hai-Tao Yue, Ze-Zhi Zhang, Yi-Hong Chen, Jian-Guo He   +7 more
doaj   +1 more source

Variable structure motifs for transcription factor binding sites [PDF]

, 2010
Background: Classically, models of DNA-transcription factor binding sites (TFBSs) have been based on relatively few known instances and have treated them as sites of fixed length using position weight matrices (PWMs).
Evans, Kenneth J., Dyer, N., Nigel Dyer, Ott Sascha, Reid, J.E., Lorenz Wernisch, Sascha Ott, Ott, S., Wernisch Lorenz, John E Reid, Evans Kenneth J, Wernisch, Lorenz, Reid, J. E. (John E.), Kenneth J Evans, Dyer, Nigel, Dyer Nigel, Ott, Sascha, Reid John E   +17 more
core   +6 more sources

O-GlcNAc regulates the mitochondrial integrated stress response by regulating ATF4

Frontiers in Aging Neuroscience, 2023
BackgroundAccumulation of mitochondrial dysfunctional is a hallmark of age-related neurodegeneration including Alzheimer’s disease (AD). Impairment of mitochondrial quality control mechanisms leading to the accumulation of damaged mitochondria and ...
Ibtihal M. Alghusen, Marisa S. Carman, Heather Wilkins, Heather Wilkins, Heather Wilkins, Sophiya John Ephrame, Amy Qiang, Wagner B. Dias, Halyna Fedosyuk, Aspin R. Denson, Russell H. Swerdlow, Russell H. Swerdlow, Russell H. Swerdlow, Chad Slawson, Chad Slawson   +14 more
doaj   +1 more source

An R2R3 MYB transcription factor associated with regulation of the anthocyanin biosynthetic pathway in Rosaceae [PDF]

, 2010
Background The control of plant anthocyanin accumulation is via transcriptional regulation of the genes encoding the biosynthetic enzymes. A key activator appears to be an R2R3 MYB transcription factor.
Wang, Kui-Lin, Kortstee, A.J., Tony K McGhie, McGhie Tony K, Hellens, R.P., Espley Richard V, Hellens Roger P, Grafton, Karryn, Espley, Richard V., Karryn Grafton, Karunairetnam, Sakuntala, Andrew C Allan, Kortstee, Anne, Roger P Hellens, Allan, A.C., Allan, Andrew C., McGhie, T.K., Richard V Espley, Kortstee Anne, Allan Andrew C, Espley, R.V., Sakuntala Karunairetnam, Karunairetnam Sakuntala, Grafton Karryn, McGhie, Tony K., Lin-Wang Kui, Bolitho, Karen, Karen Bolitho, Anne Kortstee, Bolitho Karen, Hellens, Roger P., Lin-Wang, Kui, Kui Lin-Wang   +32 more
core   +2 more sources