Results 41 to 50 of about 476,008 (241)
Activating transcription factor 4 and X box binding protein 1 of Litopenaeus vannamei transcriptional regulated white spot syndrome virus genes Wsv023 and Wsv083. [PDF]
PLoS ONE, 2013 In response to endoplasmic reticulum (ER) stress, the signaling pathway termed unfolded protein response (UPR) is activated. To investigate the role of UPR in Litopenaeus vannamei immunity, the activating transcription factor 4 (designated as LvATF4 ...
Xiao-Yun Li +7 more
doaj +1 more source
O-GlcNAc regulates the mitochondrial integrated stress response by regulating ATF4
Frontiers in Aging Neuroscience, 2023 BackgroundAccumulation of mitochondrial dysfunctional is a hallmark of age-related neurodegeneration including Alzheimer’s disease (AD). Impairment of mitochondrial quality control mechanisms leading to the accumulation of damaged mitochondria and ...
Ibtihal M. Alghusen +14 more
doaj +1 more source
Fibroblast growth factor 2 positively regulates expression of activating transcription factor 4 in osteoblasts [PDF]
Biochemical and Biophysical Research Communications, 2010 Our previous studies showed that basic fibroblast growth factor 2 (FGF2) null mice display markedly reduced bone mass and bone formation. However, the mechanism by which FGF2 regulates bone mass or bone formation is not fully defined. Activating transcription factor 4 (ATF4), one member of activating transcription factor/cAMP response element binding ...
Yurong, Fei +2 more
openaire +2 more sources
Phosphorylation of Serine 114 of the transcription factor ABSCISIC ACID INSENSITIVE 4 is essential for activity [PDF]
Plant Science, 2020 Abstract The transcription factor ABA-INSENSITIVE(ABI)4 has diverse roles in regulating plant growth, including inhibiting germination and reserve mobilization in response to ABA and high salinity, inhibiting seedling growth in response to high sugars, inhibiting lateral root growth, and repressing light-induced gene ...
Nadav Eisner +6 more
openaire +4 more sources
PLoS ONE, 2009 Parathyroid hormone (PTH) is a potent anabolic agent for the treatment of osteoporosis. However, its mechanism of action in osteoblast and bone is not well understood.
Shibing Yu +12 more
doaj +1 more source
Impact of activating transcription factor 4 signaling on lipogenesis in HepG2 cells
Molecular Medicine Reports, 2016 Non-alcoholic fatty liver disease (NAFLD) is a rapidly growing health threat that has previously been associated with lipogenesis. The direct effect of endoplasmic reticulum stress (ERS) inhibition on the induction of lipogenesis has not been investigated in hepatocytes in vitro.
Lu-Ping, Ren +7 more
openaire +3 more sources
Journal of Translational Medicine, 2021 Highlights 1. Gene transcript profiles in the elderly AML patients are different from those in young patients. 2. Statistical analysis reveals the down-regulation of protein processing in ER and pathways related to immunity in elderly patients. 3.
Jizhang Bao +15 more
doaj +1 more source
Cancer Treatment and Research Communications, 2022 Background: Previous studies showed that proline-rich polypeptide (PRP-1) is a ligand for innate immunity toll-like receptors (TLR), and an inhibitor of the mammalian target of rapamycin complex 1 (mTORC1) which induces the death of chondrosarcoma cancer
Karina Galoian +9 more
doaj +1 more source
Activating transcription factor 4 increases chemotherapeutics resistance of human hepatocellular carcinoma [PDF]
Cancer Biology & Therapy, 2012 It has been reported that activating transcription factor 4 (ATF4) increases the processes of tumor growth, metastasis and drug resistance. However, the role played by ATF4 in chemoresistance of hepatocellular carcinoma (HCC) remains unknown. Clarification of this role of ATF4 in HCC could greatly benefit the efficacy of clinical treatment of HCC.
Zhuhong, Zhang +13 more
openaire +2 more sources
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source