Results 41 to 50 of about 495,141 (240)

Activating transcription factor 4 and X box binding protein 1 of Litopenaeus vannamei transcriptional regulated white spot syndrome virus genes Wsv023 and Wsv083. [PDF]

PLoS ONE, 2013
In response to endoplasmic reticulum (ER) stress, the signaling pathway termed unfolded protein response (UPR) is activated. To investigate the role of UPR in Litopenaeus vannamei immunity, the activating transcription factor 4 (designated as LvATF4 ...
Xiao-Yun Li, Li-Ran Pang, Yong-Gui Chen, Shao-Ping Weng, Hai-Tao Yue, Ze-Zhi Zhang, Yi-Hong Chen, Jian-Guo He   +7 more
doaj   +1 more source

O-GlcNAc regulates the mitochondrial integrated stress response by regulating ATF4

Frontiers in Aging Neuroscience, 2023
BackgroundAccumulation of mitochondrial dysfunctional is a hallmark of age-related neurodegeneration including Alzheimer’s disease (AD). Impairment of mitochondrial quality control mechanisms leading to the accumulation of damaged mitochondria and ...
Ibtihal M. Alghusen, Marisa S. Carman, Heather Wilkins, Heather Wilkins, Heather Wilkins, Sophiya John Ephrame, Amy Qiang, Wagner B. Dias, Halyna Fedosyuk, Aspin R. Denson, Russell H. Swerdlow, Russell H. Swerdlow, Russell H. Swerdlow, Chad Slawson, Chad Slawson   +14 more
doaj   +1 more source

Impact of activating transcription factor 4 signaling on lipogenesis in HepG2 cells

Molecular Medicine Reports, 2016
Non-alcoholic fatty liver disease (NAFLD) is a rapidly growing health threat that has previously been associated with lipogenesis. The direct effect of endoplasmic reticulum stress (ERS) inhibition on the induction of lipogenesis has not been investigated in hepatocytes in vitro.
Lu-Ping, Ren, Xian, Yu, Guang-Yao, Song, Pu, Zhang, Li-Na, Sun, Shu-Chun, Chen, Zhi-Juan, Hu, Xue-Mei, Zhang   +7 more
openaire   +3 more sources

Critical role of activating transcription factor 4 in the anabolic actions of parathyroid hormone in bone.

PLoS ONE, 2009
Parathyroid hormone (PTH) is a potent anabolic agent for the treatment of osteoporosis. However, its mechanism of action in osteoblast and bone is not well understood.
Shibing Yu, Renny T Franceschi, Min Luo, Jie Fan, Di Jiang, Huiling Cao, Tae-Geon Kwon, Yumei Lai, Jian Zhang, Kenneth Patrene, Kurt Hankenson, G David Roodman, Guozhi Xiao   +12 more
doaj   +1 more source

Activating transcription factor 4 increases chemotherapeutics resistance of human hepatocellular carcinoma [PDF]

Cancer Biology & Therapy, 2012
It has been reported that activating transcription factor 4 (ATF4) increases the processes of tumor growth, metastasis and drug resistance. However, the role played by ATF4 in chemoresistance of hepatocellular carcinoma (HCC) remains unknown. Clarification of this role of ATF4 in HCC could greatly benefit the efficacy of clinical treatment of HCC.
Zhuhong, Zhang, Jing, Yin, Chunyan, Zhang, Ning, Liang, Nan, Bai, Antao, Chang, Yanhua, Liu, Zongjin, Li, Xiaoyue, Tan, Na, Li, Dan, Lv, Rong, Xiang, Yaping, Tian, Chenghu, Liu   +13 more
openaire   +2 more sources

Platelet transcriptome profiles provide potential therapeutic targets for elderly acute myelocytic leukemia patients

Journal of Translational Medicine, 2021
Highlights 1. Gene transcript profiles in the elderly AML patients are different from those in young patients. 2. Statistical analysis reveals the down-regulation of protein processing in ER and pathways related to immunity in elderly patients. 3.
Jizhang Bao, Xinhua Zhao, Jiahui Lu, Zhaoyang Hu, Minghui Hu, Xiaoxia Hu, Libing Wang, Qi Hu, Weiling Sun, Jie Wang, Hailin Chen, Hao Lu, Changgui Li, Jing Xu, Yongming Zhou, Wenwei Zhu   +15 more
doaj   +1 more source

Effect of DFPP on Ferroptosis in Peripheral Blood CD14+ Monocytes of Hyperlipidemic Patients Involving the ACSL4/LPCAT3/ALOX5 Pathway

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Hyperlipidemia is a major risk factor for atherosclerotic cardiovascular disease (ASCVD). Although statins are the cornerstone of lipid‐lowering therapy, their use may be limited in some patients by adverse effects. This study evaluated the possible impact of non‐drug treatment using double‐filtration plasmapheresis (DFPP) on CD14+
Yun Cheng, Lan Li, Qingmei Yang, Meipeng Wu   +3 more
wiley   +1 more source

PRP-1, a toll-like receptor ligand, upregulates the unfolded protein response in human chondrosarcoma cells

Cancer Treatment and Research Communications, 2022
Background: Previous studies showed that proline-rich polypeptide (PRP-1) is a ligand for innate immunity toll-like receptors (TLR), and an inhibitor of the mammalian target of rapamycin complex 1 (mTORC1) which induces the death of chondrosarcoma cancer
Karina Galoian, Victoria Dahl, Andres Perez, Carina Denny, Beatrice Becker, Anil Sedani, Alexandra Moran, Daniel Martinez, Aaron Hoyt, Jeffrey Brown   +9 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Activating Transcription Factor 4 (ATF4) Regulates Neuronal Activity by Controlling GABA_BR Trafficking. [PDF]

J Neurosci, 2018
Activating Transcription Factor 4 (ATF4) has been postulated as a key regulator of learning and memory. We previously reported that specific hippocampal ATF4 downregulation causes deficits in synaptic plasticity and memory and reduction of glutamatergic functionality. Here we extend our studies to address ATF4's role in neuronal excitability.
Corona C, Pasini S, Liu J, Amar F, Greene LA, Shelanski ML.   +5 more
europepmc   +4 more sources