Results 31 to 40 of about 495,141 (240)

Inhibition of hepatocyte nuclear factor 4 transcriptional activity by the nuclear factor κB pathway [PDF]

Biochemical Journal, 2006
HNF-4 (hepatocyte nuclear factor 4) is a key regulator of liver-specific gene expression in mammals. We have shown previously that the activity of the human APOC3 (apolipoprotein C-III) promoter is positively regulated by the anti-inflammatory cytokine TGFβ (transforming growth factor β) and its effectors Smad3 (similar to mothers against ...
Varvara, Nikolaidou-Neokosmidou, Vassilis I, Zannis, Dimitris, Kardassis   +2 more
openaire   +2 more sources

The Metabotropic GABAB Receptor Directly Interacts with the Activating Transcription Factor 4 [PDF]

Journal of Biological Chemistry, 2000
G protein-coupled receptors regulate gene expression by cellular signaling cascades that target transcription factors and their recognition by specific DNA sequences. In the central nervous system, heteromeric metabotropic gamma-aminobutyric acid type B (GABA(B)) receptors through adenylyl cyclase regulate cAMP levels, which may control transcription ...
Nehring, R., Horikawa, H., El Far, O., Kneussel, M., Brandstaetter, J., Stamm, S., Wischmeyer, E., Betz, H., Karschin, A.   +8 more
openaire   +3 more sources

ATF4 selectively regulates heat nociception and contributes to kinesin-mediated TRPM3 trafficking

Nature Communications, 2021
The molecular mechanisms mediating nociception are unclear. Here, the authors show that the Activating Transcription Factor 4 (ATF4) is important for the response to heat nociception in mice and ATF4 role in mediating protein trafficking in dorsal root ...
Man-Xiu Xie, Xian-Ying Cao, Wei-An Zeng, Ren-Chun Lai, Lan Guo, Jun-Chao Wang, Yi-Bin Xiao, Xi Zhang, Di Chen, Xian-Guo Liu, Xiao-Long Zhang   +10 more
doaj   +1 more source

OPA1 deletion in brown adipose tissue improves thermoregulation and systemic metabolism via FGF21

eLife, 2021
Adrenergic stimulation of brown adipocytes alters mitochondrial dynamics, including the mitochondrial fusion protein optic atrophy 1 (OPA1). However, direct mechanisms linking OPA1 to brown adipose tissue (BAT) physiology are incompletely understood.
Renata O Pereira, Alex Marti, Angela Crystal Olvera, Satya Murthy Tadinada, Sarah Hartwick Bjorkman, Eric Thomas Weatherford, Donald A Morgan, Michael Westphal, Pooja H Patel, Ana Karina Kirby, Rana Hewezi, William Bùi Trân, Luis Miguel García-Peña, Rhonda A Souvenir, Monika Mittal, Christopher M Adams, Kamal Rahmouni, Matthew J Potthoff, E Dale Abel   +18 more
doaj   +1 more source

Fibroblast growth factor 2 positively regulates expression of activating transcription factor 4 in osteoblasts [PDF]

Biochemical and Biophysical Research Communications, 2010
Our previous studies showed that basic fibroblast growth factor 2 (FGF2) null mice display markedly reduced bone mass and bone formation. However, the mechanism by which FGF2 regulates bone mass or bone formation is not fully defined. Activating transcription factor 4 (ATF4), one member of activating transcription factor/cAMP response element binding ...
Yurong, Fei, Liping, Xiao, Marja M, Hurley   +2 more
openaire   +2 more sources

Effect of leucine on endoplasmic reticulum stress induced by early weaning in the liver of piglets

浙江大学学报. 农业与生命科学版, 2018
To investigate the effects of dietary leucine supplementation on endoplasmic reticulum (ER) stress in the liver of early-weaning piglets, we explored the morphology of liver cells, expression pattern of ER stress-associated proteins, and effects on ER ...
FAN Qiwen, CHEN Lingli, ZHAO Li, SHI Min, YAN Xianghua   +4 more
doaj   +1 more source

Activating transcription factor 4 confers a multidrug resistance phenotype to gastric cancer cells through transactivation of SIRT1 expression. [PDF]

PLoS ONE, 2012
BACKGROUND: Multidrug resistance (MDR) in gastric cancer remains a major challenge to clinical treatment. Activating transcription factor 4 (ATF4) is a stress response gene involved in homeostasis and cellular protection.
Hongwu Zhu, Limin Xia, Yongguo Zhang, Honghong Wang, Wenjing Xu, Hao Hu, Jing Wang, Jing Xin, Yi Gang, Sumei Sha, Bin Xu, Daiming Fan, Yongzhan Nie, Kaichun Wu   +13 more
doaj   +1 more source

Activating transcription factor-4 promotes mineralization in vascular smooth muscle cells. [PDF]

JCI Insight, 2016
Emerging evidence indicates that upregulation of the ER stress–induced pro-osteogenic transcription factor ATF4 plays an important role in vascular calcification, a common complication in patients with aging, diabetes, and chronic kidney disease (CKD).
Masuda M, Miyazaki-Anzai S, Keenan AL, Shiozaki Y, Okamura K, Chick WS, Williams K, Zhao X, Rahman SM, Tintut Y, Adams CM, Miyazaki M.   +11 more
europepmc   +4 more sources

Krüppel-like factor 4, a novel transcription factor regulates microglial activation and subsequent neuroinflammation [PDF]

Journal of Neuroinflammation, 2010
Abstract Background Activation of microglia, the resident macrophages of the central nervous system (CNS), is the hallmark of neuroinflammation in neurodegenerative diseases and other pathological conditions associated with CNS infection.
Das Sulagna, Gupta Malvika, Kaushik Deepak K, Basu Anirban   +3 more
openaire   +3 more sources

Phosphorylation of Serine 114 of the transcription factor ABSCISIC ACID INSENSITIVE 4 is essential for activity [PDF]

Plant Science, 2020
Abstract The transcription factor ABA-INSENSITIVE(ABI)4 has diverse roles in regulating plant growth, including inhibiting germination and reserve mobilization in response to ABA and high salinity, inhibiting seedling growth in response to high sugars, inhibiting lateral root growth, and repressing light-induced gene ...
Nadav Eisner, Tzofia Maymon, Ester Cancho Sanchez, Dana Bar-Zvi, Sagie Brodsky, Ruth Finkelstein, Dudy Bar-Zvi   +6 more
openaire   +4 more sources