Frontiers in Cellular Neuroscience, 2014 The ubiquitously expressed activating transcription factor 4 (ATF4) has been variably reported to either promote or inhibit neuronal plasticity and memory.
Jin eLiu +3 more
doaj +1 more source
Platelet-activating factor receptor plays a role in lung injury and death caused by influenza A in mice [PDF]
, 2010 Influenza A virus causes annual epidemics which affect millions of people worldwide. A recent Influenza pandemic brought new awareness over the health impact of the disease.
Sousa, Lirlandia P. +60 more
core +2 more sources
Basic and Clinical Neuroscience, 2021 Introduction: Diazinon is one of the most widely-used organophosphate pesticides in the world. This toxin enters the body in various ways and induces oxidative stress in various tissues.
Ali Esfandiarifar +3 more
doaj
ATF4 (activating transcription factor 4 (tax-responsive enhancer element B67)) [PDF]
, 2010 Review on ATF4 (activating transcription factor 4 (tax-responsive enhancer element B67)), with data on DNA, on the protein encoded, and where the gene is ...
AL Harris, Ameri, K, Harris, AL, K Ameri
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Inhibition of hepatocyte nuclear factor 4 transcriptional activity by the nuclear factor κB pathway [PDF]
Biochemical Journal, 2006 HNF-4 (hepatocyte nuclear factor 4) is a key regulator of liver-specific gene expression in mammals. We have shown previously that the activity of the human APOC3 (apolipoprotein C-III) promoter is positively regulated by the anti-inflammatory cytokine TGFβ (transforming growth factor β) and its effectors Smad3 (similar to mothers against ...
Varvara, Nikolaidou-Neokosmidou +2 more
openaire +2 more sources
ATF4 selectively regulates heat nociception and contributes to kinesin-mediated TRPM3 trafficking
Nature Communications, 2021 The molecular mechanisms mediating nociception are unclear. Here, the authors show that the Activating Transcription Factor 4 (ATF4) is important for the response to heat nociception in mice and ATF4 role in mediating protein trafficking in dorsal root ...
Man-Xiu Xie +10 more
doaj +1 more source
OPA1 deletion in brown adipose tissue improves thermoregulation and systemic metabolism via FGF21
eLife, 2021 Adrenergic stimulation of brown adipocytes alters mitochondrial dynamics, including the mitochondrial fusion protein optic atrophy 1 (OPA1). However, direct mechanisms linking OPA1 to brown adipose tissue (BAT) physiology are incompletely understood.
Renata O Pereira +18 more
doaj +1 more source
The Metabotropic GABAB Receptor Directly Interacts with the Activating Transcription Factor 4 [PDF]
Journal of Biological Chemistry, 2000 G protein-coupled receptors regulate gene expression by cellular signaling cascades that target transcription factors and their recognition by specific DNA sequences. In the central nervous system, heteromeric metabotropic gamma-aminobutyric acid type B (GABA(B)) receptors through adenylyl cyclase regulate cAMP levels, which may control transcription ...
Nehring, R. +8 more
openaire +3 more sources
Turnover and function of DNA methylation at transcription factor binding sites [PDF]
, 2014 Cell type identity is largely determined by regulatory networks consistent of various transcription factors. Transcription factor activity requires interaction with DNA and thus critically depends on the accessibility of binding motifs.
Feldmann, Angelika
core +1 more source
Activating transcription factor 4 confers a multidrug resistance phenotype to gastric cancer cells through transactivation of SIRT1 expression. [PDF]
PLoS ONE, 2012 BACKGROUND: Multidrug resistance (MDR) in gastric cancer remains a major challenge to clinical treatment. Activating transcription factor 4 (ATF4) is a stress response gene involved in homeostasis and cellular protection.
Hongwu Zhu +13 more
doaj +1 more source