Results 11 to 20 of about 17,248,721 (282)

Role of activating transcription factor 4 in the hepatic response to amino acid depletion by asparaginase [PDF]

Scientific Reports, 2017
The anti-leukemic agent asparaginase activates the integrated stress response (ISR) kinase GCN2 and inhibits signaling via mechanistic target of rapamycin complex 1 (mTORC1).
Rana J. T. Al-Baghdadi, Inna A. Nikonorova, Emily T. Mirek, Yongping Wang, Jinhee Park, William J. Belden, Ronald C. Wek, Tracy G. Anthony   +7 more
doaj   +5 more sources

Role of Activating Transcription Factor 4 in Murine Choroidal Neovascularization Model [PDF]

International Journal of Molecular Sciences, 2021
Neovascular age-related macular degeneration (nAMD) featuring choroidal neovascularization (CNV) is the principal cause of irreversible blindness in elderly people in the world. Integrated stress response (ISR) is one of the intracellular signals to be adapted to various stress conditions including endoplasmic reticulum (ER) stress.
Masamitsu Shimazawa, Hideaki Hara, Shinsuke Nakamura   +2 more
exaly   +5 more sources

Activating transcription factor 4

The International Journal of Biochemistry & Cell Biology, 2008
Activating transcription factor 4 (ATF4) belongs to the ATF/CREB (activating transcription factor/cyclic AMP response element binding protein) family of basic region-leucine zipper (bZip) transcription factors, which have the consensus binding site cAMP responsive element (CRE). ATF4 has numerous dimerization partners. ATF4 is induced by stress signals
Ameri, K, Harris, A
openaire   +4 more sources

Activating transcription factor 4 regulates stearate-induced vascular calcification [PDF]

Journal of Lipid Research, 2012
Previously, we reported that stearate, a saturated fatty acid, promotes osteoblastic differentiation and mineralization of vascular smooth muscle cells (VSMC).
Masashi Masuda, Tabitha C. Ting, Moshe Levi, Sommer J. Saunders, Shinobu Miyazaki-Anzai, Makoto Miyazaki   +5 more
doaj   +3 more sources

Upregulation of the coagulation factor VII gene during glucose deprivation is mediated by activating transcription factor 4. [PDF]

PLoS ONE, 2012
BACKGROUND: Constitutive production of blood coagulation proteins by hepatocytes is necessary for hemostasis. Stressful conditions trigger adaptive cellular responses and delay processing of most proteins, potentially affecting plasma levels of proteins ...
Katherine R Cronin, Thomas P Mangan, Josephine A Carew   +2 more
doaj   +6 more sources

Epigallocatechin Gallate Ameliorates Granulosa Cell Developmental via the Eukaryotic Initiation Factor 2 Alpha/Activating Transcription Factor 4 Pathway in Hyperthyroid Female Rats [PDF]

Antioxidants
Follicular development is recognized as a highly complex biological process regulated by multiple factors. Thyroid hormone (TH) is considered one of the key regulators of female reproduction, and its dysregulation can significantly impair follicular ...
Ying Sun, Mingqi Wu, Haoyuan Feng, Yilin Yao, Rui Chen, Yanzhou Yang, Cheng Zhang   +6 more
doaj   +2 more sources

Pharmacological Disruption of Phosphorylated Eukaryotic Initiation Factor-2α/Activating Transcription Factor 4/Indian Hedgehog Protects Intervertebral Disc Degeneration via Reducing the Reactive Oxygen Species and Apoptosis of Nucleus Pulposus Cells [PDF]

Frontiers in Cell and Developmental Biology, 2021
Excessive reactive oxygen species (ROS) and apoptosis in nucleus pulposus (NP) cells accelerate the process of intervertebral disc degeneration (IDD). Here, we integrated pathological samples and in vitro and in vivo framework to investigate the impact ...
Junping Bao, Junping Bao, Zhanyang Qian, Zhanyang Qian, Lei Liu, Lei Liu, Xin Hong, Xin Hong, Hui Che, Xiaotao Wu, Xiaotao Wu   +10 more
doaj   +2 more sources

Regulation of cellular immunity by activating transcription factor 4. [PDF]

Immunol Lett, 2020
Activating transcription factor 4 (ATF4) is a DNA binding transcription factor belonging to the family of basic Leucine zipper proteins. ATF4 can be activated in response to multiple cellular stress signals including endoplasmic reticulum stress in the event of improper protein folding or oxidative stress because of mitochondrial dysfunction as well as
Mukherjee D, Bercz LS, Torok MA, Mace TA.   +3 more
europepmc   +4 more sources

Insulin inhibits melanoma tumor growth through the expression of activating transcription factor 4, without detectable expression of transcription factor CHOP: an in vivo model [PDF]

Anais Brasileiros de Dermatologia
Daniel do Prado, Marianna Boia-Ferreia, Hanna Camara da Justa, Andrea Senff-Ribeiro, Sérgio Lunardon Padilha   +4 more
doaj   +2 more sources

Activating transcription factor 4 regulates osteoclast differentiation in mice [PDF]

Journal of Clinical Investigation, 2010
Activating transcription factor 4 (ATF4) is a critical transcription factor for osteoblast (OBL) function and bone formation; however, a direct role in osteoclasts (OCLs) has not been established. Here, we targeted expression of ATF4 to the OCL lineage using the Trap promoter or through deletion of Atf4 in mice.
Huiling, Cao, Shibing, Yu, Zhi, Yao, Deborah L, Galson, Yu, Jiang, Xiaoyan, Zhang, Jie, Fan, Binfeng, Lu, Youfei, Guan, Min, Luo, Yumei, Lai, Yibei, Zhu, Noriyoshi, Kurihara, Kenneth, Patrene, G David, Roodman, Guozhi, Xiao   +15 more
openaire   +2 more sources