Results 11 to 20 of about 476,008 (241)

Role of Activating Transcription Factor 4 in Murine Choroidal Neovascularization Model. [PDF]

Int J Mol Sci, 2021
Neovascular age-related macular degeneration (nAMD) featuring choroidal neovascularization (CNV) is the principal cause of irreversible blindness in elderly people in the world. Integrated stress response (ISR) is one of the intracellular signals to be adapted to various stress conditions including endoplasmic reticulum (ER) stress.
Yasuda H, Tanaka M, Nishinaka A, Nakamura S, Shimazawa M, Hara H.   +5 more
europepmc   +4 more sources

The dual role of activating transcription factor 4: from cellular stress sentinel to cardiovascular disease intervention [PDF]

PeerJ
As the master orchestrator of integrated stress response, activating transcription factor 4 (ATF4) operates as a central molecular switch that directs cellular fate toward survival or death by regulating genes associated with oxidative stress ...
Yaping Wang, Jie Yuan, Feifan Wang, Hong Ma   +3 more
doaj   +3 more sources

Sestrin2 Regulates Endoplasmic Reticulum Stress-Dependent Ferroptosis to Engage Pulmonary Fibrosis by Nuclear Factor Erythroid 2-Related Factor 2/Activating Transcription Factor 4 (NRF2/ATF4) [PDF]

Journal of Immunology Research, 2023
Pulmonary fibrosis (PF) can lead to chronic inflammation, the destruction of alveoli and irreversible lung damage. Sestrin2 is a highly protective stress-inducible protein that is involved in the cell response to various stress factors and the regulation
Zhaoxing Dong, Ting Li, Cenli Wang, Yong Zhou, Zhongkai Tong, Xuekui Du   +5 more
doaj   +2 more sources

Activating transcription factor 4-dependent lactate dehydrogenase activation as a protective response to amyloid beta toxicity. [PDF]

Brain Commun, 2021
Abstract Accumulation of amyloid beta peptides is thought to initiate the pathogenesis of Alzheimer's disease. However, the precise mechanisms mediating their neurotoxicity are unclear. Our microarray analyses show that, in Drosophila models of amyloid beta 42 toxicity, genes involved in the unfolded protein response and metabolic ...
Niccoli T, Kerr F, Snoeren I, Fabian D, Aleyakpo B, Ivanov D, Sofola-Adesakin O, Cryar A, Adcott J, Thornton J, Partridge L.   +10 more
europepmc   +7 more sources

Brain-Derived Neurotrophic Factor Elevates Activating Transcription Factor 4 (ATF4) in Neurons and Promotes ATF4-Dependent Induction of Sesn2 [PDF]

Frontiers in Molecular Neuroscience, 2018
Activating transcription factor 4 (ATF4) plays important physiologic roles in the brain including regulation of learning and memory as well as neuronal survival and death.
Jin Liu, Fatou Amar, Carlo Corona, Raphaella W. L. So, Stuart J. Andrews, Peter L. Nagy, Michael L. Shelanski, Lloyd A. Greene   +7 more
doaj   +2 more sources

Epigallocatechin Gallate Ameliorates Granulosa Cell Developmental via the Eukaryotic Initiation Factor 2 Alpha/Activating Transcription Factor 4 Pathway in Hyperthyroid Female Rats [PDF]

Antioxidants
Follicular development is recognized as a highly complex biological process regulated by multiple factors. Thyroid hormone (TH) is considered one of the key regulators of female reproduction, and its dysregulation can significantly impair follicular ...
Ying Sun, Mingqi Wu, Haoyuan Feng, Yilin Yao, Rui Chen, Yanzhou Yang, Cheng Zhang   +6 more
doaj   +2 more sources

Upregulation of the coagulation factor VII gene during glucose deprivation is mediated by activating transcription factor 4. [PDF]

PLoS ONE, 2012
BACKGROUND: Constitutive production of blood coagulation proteins by hepatocytes is necessary for hemostasis. Stressful conditions trigger adaptive cellular responses and delay processing of most proteins, potentially affecting plasma levels of proteins ...
Katherine R Cronin, Thomas P Mangan, Josephine A Carew   +2 more
doaj   +6 more sources

Pharmacological Disruption of Phosphorylated Eukaryotic Initiation Factor-2α/Activating Transcription Factor 4/Indian Hedgehog Protects Intervertebral Disc Degeneration via Reducing the Reactive Oxygen Species and Apoptosis of Nucleus Pulposus Cells [PDF]

Frontiers in Cell and Developmental Biology, 2021
Excessive reactive oxygen species (ROS) and apoptosis in nucleus pulposus (NP) cells accelerate the process of intervertebral disc degeneration (IDD). Here, we integrated pathological samples and in vitro and in vivo framework to investigate the impact ...
Junping Bao, Junping Bao, Zhanyang Qian, Zhanyang Qian, Lei Liu, Lei Liu, Xin Hong, Xin Hong, Hui Che, Xiaotao Wu, Xiaotao Wu   +10 more
doaj   +2 more sources

Activating transcription factor-4 promotes mineralization in vascular smooth muscle cells. [PDF]

JCI Insight, 2016
Emerging evidence indicates that upregulation of the ER stress–induced pro-osteogenic transcription factor ATF4 plays an important role in vascular calcification, a common complication in patients with aging, diabetes, and chronic kidney disease (CKD).
Masuda M, Miyazaki-Anzai S, Keenan AL, Shiozaki Y, Okamura K, Chick WS, Williams K, Zhao X, Rahman SM, Tintut Y, Adams CM, Miyazaki M.   +11 more
europepmc   +4 more sources

Activating Transcription Factor 4 (ATF4) Regulates Neuronal Activity by Controlling GABA_BR Trafficking. [PDF]

J Neurosci, 2018
Activating Transcription Factor 4 (ATF4) has been postulated as a key regulator of learning and memory. We previously reported that specific hippocampal ATF4 downregulation causes deficits in synaptic plasticity and memory and reduction of glutamatergic functionality. Here we extend our studies to address ATF4's role in neuronal excitability.
Corona C, Pasini S, Liu J, Amar F, Greene LA, Shelanski ML.   +5 more
europepmc   +4 more sources