Results 1 to 10 of about 23,537 (152)

Roles of eIF2α kinases in the pathogenesis of Alzheimer’s disease [PDF]

Frontiers in Molecular Neuroscience, 2014
Cell signaling in response to an array of diverse stress stimuli converges on the phosphorylation of eukaryotic initiation factor-2α (eIF2α). Evidence is accumulating that persistent eIF2α phosphorylation at Ser51 through prolonged overactivation of ...
Masuo eOhno, Masuo eOhno
doaj   +3 more sources

تأثیر شش هفته تمرین هوازی بر بیان ژن‌های استرس اکسیداتیو شبکه آندوپلاسمی (X-box Binding Protein-1 و Eukaryotic Initiation Factor-2α) در بافت قلب موش‌های صحرایی نر دیابتی شده با استرپتوزوتوسین [PDF]

مجله دانشکده پزشکی اصفهان, 2022
مقدمه: هدف از انجام پژوهش حاضر، بررسی تأثیر شش هفته تمرین هوازی بر بیان ژن‌های استرس اکسیداتیو شبکه‌ی آندوپلاسمی (Endoplasmic reticulum یا ER) شامل عامل شروع‌کننده‌ی ترجمه‌ی یوکاریوتی 2 (Eukaryotic Initiation Factor-2α یا eIF2α) و پروتئین ...
معصومه حسین‌زاده, اسماء طاهری   +1 more
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Modulation of GCN2 activity under excess light stress by osmoprotectants and amino acids

Plant Signaling & Behavior, 2022
The protein kinase GCN2 (General Control Nonderepressible2) and its phosphorylation target, the eukaryotic translation initiation factor (eIF)2α represent the core module of the plant’s integrated stress response, a signaling pathway widely conserved in ...
Ansul Lokdarshi, Albrecht G von Arnim, Teressa K Akuoko   +2 more
doaj   +1 more source

GCN2 upregulates autophagy in response to short-term deprivation of a single essential amino acid

Autophagy Reports, 2022
The ability to adapt the proteolysis rates based on fluctuations in essential amino acid (EAA) availability is essential for life. The GCN2-eIF2α-ATF4 signaling pathway is involved in the adaptive response to EAA deprivations.
Anne-Catherine Maurin, Laurent Parry, Wafa B’chir, Valérie Carraro, Cécile Coudy-Gandilhon, Ghita Chaouki, Cédric Chaveroux, Sylvie Mordier, Brigitte Martinie, Vanessa Reinhardt, Céline Jousse, Alain Bruhat, Patrice Codogno, Julien Averous, Pierre Fafournoux   +14 more
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Endoplasmic reticulum stress mediates radiation-induced autophagy by perk-eIF2α in caspase-3/7-deficient cells [PDF]

Oncogene, 2010
As apoptosis defects limit efficacy of anticancer agents, autophagy has been proposed as a novel strategy for radiotherapy enhancement. We previously showed that caspase-3/7 inhibition induces autophagy and promotes radiosensitivity in vitro and in vivo. Therefore, we further investigated the mechanism by which radiation triggers autophagy in caspase-3/
Kim, Kwang Woon, Moretti, Luigi, Mitchell, L.R., Jung, D.K., Lu, Bo   +4 more
openaire   +3 more sources

Glucose-stimulated Protein Synthesis in Pancreatic β-Cells Parallels an Increase in the Availability of the Translational Ternary Complex (eIF2-GTP·Met-tRNAi) and the Dephosphorylation of eIF2α [PDF]

Journal of Biological Chemistry, 2004
In pancreatic beta-cells, glucose causes a rapid increase in the rate of protein synthesis. However, the mechanism by which this occurs is poorly understood. In this report, we demonstrate, in the pancreatic beta-cell line MIN6, that glucose stimulates the recruitment of ribosomes onto the mRNA, indicative of an increase in the rate of the initiation ...
E. Gomez, M.L. Powell, I.C. Greenman, Terence Herbert   +3 more
openaire   +4 more sources

Embryonic Stem Cell Growth Factors Regulate eIF2α Phosphorylation. [PDF]

PLoS ONE, 2015
Growth factors and transcription factors are well known to regulate pluripotent stem cells, but less is known about translational control in stem cells.
Kyle Friend, Hunter A Brooks, Nicholas E Propson, James A Thomson, Judith Kimble   +4 more
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Eukaryotic initiation factor 2α--a downstream effector of mammalian target of rapamycin--modulates DNA repair and cancer response to treatment. [PDF]

PLoS ONE, 2013
In an effort to circumvent resistance to rapamycin--an mTOR inhibitor--we searched for novel rapamycin-downstream-targets that may be key players in the response of cancer cells to therapy.
Liron Tuval-Kochen, Shoshana Paglin, Gilmor Keshet, Yaniv Lerenthal, Charles Nakar, Tamar Golani, Amos Toren, Joachim Yahalom, Raphael Pfeffer, Yaacov Lawrence   +9 more
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GADD34-mediated dephosphorylation of eIF2α facilitates pseudorabies virus replication by maintaining de novo protein synthesis

Veterinary Research, 2021
Viruses have evolved multiple strategies to manipulate their host’s translational machinery for the synthesis of viral proteins. A common viral target is the alpha subunit of eukaryotic initiation factor 2 (eIF2α).
Ting Zhu, Xueli Jiang, Hangkuo Xin, Xiaohui Zheng, Xiaonuan Xue, Ji-Long Chen, Baomin Qi   +6 more
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eIF2α Phosphorylation in Response to Nutritional Deficiency and Stressors in the Aquaculture Fish, Rachycentron canadum

Journal of Marine Science and Engineering, 2022
The present study investigates the response of the marine fish cobia, Rachycentron canadum, to stressors as measured by phosphorylation of the α-subunit of the translational initiation factor, eIF2.
Chieh Lun Liu, Erica A. Dasi, Aaron M. Watson, Allen R. Place, Rosemary Jagus   +4 more
doaj   +1 more source