تأثیر شش هفته تمرین هوازی بر بیان ژن‌های استرس اکسیداتیو شبکه آندوپلاسمی (X-box Binding Protein-1 و Eukaryotic Initiation Factor-2α) در بافت قلب موش‌های صحرایی نر دیابتی شده با استرپتوزوتوسین [PDF]
مجله دانشکده پزشکی اصفهان, 2022 مقدمه: هدف از انجام پژوهش حاضر، بررسی تأثیر شش هفته تمرین هوازی بر بیان ژن‌های استرس اکسیداتیو شبکه‌ی آندوپلاسمی (Endoplasmic reticulum یا ER) شامل عامل شروع‌کننده‌ی ترجمه‌ی یوکاریوتی 2 (Eukaryotic Initiation Factor-2α یا eIF2α) و پروتئین ...
معصومه حسین‌زاده +1 more
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Modulation of GCN2 activity under excess light stress by osmoprotectants and amino acids
Plant Signaling & Behavior, 2022 The protein kinase GCN2 (General Control Nonderepressible2) and its phosphorylation target, the eukaryotic translation initiation factor (eIF)2α represent the core module of the plant’s integrated stress response, a signaling pathway widely conserved in ...
Ansul Lokdarshi +2 more
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GCN2 upregulates autophagy in response to short-term deprivation of a single essential amino acid
Autophagy Reports, 2022 The ability to adapt the proteolysis rates based on fluctuations in essential amino acid (EAA) availability is essential for life. The GCN2-eIF2α-ATF4 signaling pathway is involved in the adaptive response to EAA deprivations.
Anne-Catherine Maurin +14 more
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Embryonic Stem Cell Growth Factors Regulate eIF2α Phosphorylation. [PDF]
PLoS ONE, 2015 Growth factors and transcription factors are well known to regulate pluripotent stem cells, but less is known about translational control in stem cells.
Kyle Friend +4 more
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Eukaryotic initiation factor 2α--a downstream effector of mammalian target of rapamycin--modulates DNA repair and cancer response to treatment. [PDF]
PLoS ONE, 2013 In an effort to circumvent resistance to rapamycin--an mTOR inhibitor--we searched for novel rapamycin-downstream-targets that may be key players in the response of cancer cells to therapy.
Liron Tuval-Kochen +9 more
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Veterinary Research, 2021 Viruses have evolved multiple strategies to manipulate their host’s translational machinery for the synthesis of viral proteins. A common viral target is the alpha subunit of eukaryotic initiation factor 2 (eIF2α).
Ting Zhu +6 more
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Journal of Marine Science and Engineering, 2022 The present study investigates the response of the marine fish cobia, Rachycentron canadum, to stressors as measured by phosphorylation of the α-subunit of the translational initiation factor, eIF2.
Chieh Lun Liu +4 more
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6-Shogaol induces apoptosis in human hepatocellular carcinoma cells and exhibits anti-tumor activity in vivo through endoplasmic reticulum stress. [PDF]
PLoS ONE, 2012 6-Shogaol is an active compound isolated from Ginger (Zingiber officinale Rosc). In this work, we demonstrated that 6-shogaol induces apoptosis in human hepatocellular carcinoma cells in relation to caspase activation and endoplasmic reticulum (ER ...
Rong Hu +10 more
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PLoS ONE, 2020 The integrated stress response (ISR) is one of the most important cytoprotective mechanisms and is integrated by phosphorylation of the α subunit of eukaryotic translation initiation factor 2 (eIF2α).
Yoshimasa Hamada +8 more
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Viruses, 2019 Sindbis virus (SINV) infection induces eIF2α phosphorylation, which leads to stress granule (SG) assembly. SINV infection also stimulates autophagy, which has an important role in controlling the innate immune response.
Matthew Jefferson +3 more
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