Results 21 to 30 of about 23,537 (152)

Regulation of G1 Arrest and Apoptosis in Hypoxia by PERK and GCN2-Mediated eIF2α Phosphorylation

Neoplasia: An International Journal for Oncology Research, 2010
Hypoxia is a common microenvironment in solid tumors and is correlated with tumor progression by regulating cancer cell survival. Recent studies suggest that activation of double-stranded RNA-dependent protein kinase-like endoplasmic reticulum-related ...
Yan Liu, Csaba László, Yi Liu, Wei Liu, Xiaozhuo Chen, Susan C. Evans, Shiyong Wu   +6 more
doaj   +1 more source

Pediatric glioblastoma cells are sensitive to drugs that inhibit eIF2α dephosphorylation and its phosphomimetic S51D variant

Frontiers in Oncology, 2022
We found that pediatric glioblastoma (PED-GBM) cell lines from diffuse intrinsic pontine glioma (DIPG) carrying the H3K27M mutation or from diffuse hemispheric glioma expressing the H3G34R mutation are sensitive to the combination of vorinostat (a ...
Karin Eytan, Ziv Versano, Ziv Versano, Roni Oren, Jasmine Jacob-Hirsch, Jasmine Jacob-Hirsch, Moshe Leitner, Alon Harmelin, Gideon Rechavi, Gideon Rechavi, Gideon Rechavi, Amos Toren, Amos Toren, Shoshana Paglin, Michal Yalon, Michal Yalon   +15 more
doaj   +1 more source

Extracellular arginine availability modulates eIF2α O-GlcNAcylation and heme oxygenase 1 translation for cellular homeostasis

Journal of Biomedical Science, 2023
Background Nutrient limitations often lead to metabolic stress during cancer initiation and progression. To combat this stress, the enzyme heme oxygenase 1 (HMOX1, commonly known as HO-1) is thought to play a key role as an antioxidant. However, there is
Yu-Wen Hung, Ching Ouyang, Xiaoli Ping, Yue Qi, Yi-Chang Wang, Hsing-Jien Kung, David K. Ann   +6 more
doaj   +1 more source

Duck Hepatitis A Virus Type 1 Induces eIF2α Phosphorylation-Dependent Cellular Translation Shutoff via PERK/GCN2

Frontiers in Microbiology, 2021
Duck hepatitis A virus type 1 (DHAV-1) is one of the most deadly pathogens that endanger the duck industry. Most viruses usually turn off host translation after infection to facilitate viral replication and translation.
Yuanzhi Liu, Yuanzhi Liu, Yuanzhi Liu, Anchun Cheng, Anchun Cheng, Anchun Cheng, Mingshu Wang, Mingshu Wang, Mingshu Wang, Sai Mao, Sai Mao, Sai Mao, Xumin Ou, Xumin Ou, Xumin Ou, Qiao Yang, Qiao Yang, Qiao Yang, Ying Wu, Ying Wu, Ying Wu, Qun Gao, Qun Gao, Qun Gao, Mafeng Liu, Mafeng Liu, Mafeng Liu, Shaqiu Zhang, Shaqiu Zhang, Shaqiu Zhang, Juan Huang, Juan Huang, Juan Huang, Renyong Jia, Renyong Jia, Renyong Jia, Dekang Zhu, Dekang Zhu, Shun Chen, Shun Chen, Shun Chen, Xinxin Zhao, Xinxin Zhao, Xinxin Zhao, Yanling Yu, Yanling Yu, Yanling Yu, Yunya Liu, Yunya Liu, Yunya Liu, Ling Zhang, Ling Zhang, Ling Zhang, Bin Tian, Bin Tian, Leichang Pan, Leichang Pan   +56 more
doaj   +1 more source

Translational control by eIF2α phosphorylation regulates vulnerability to the synaptic and behavioral effects of cocaine

eLife, 2016
Adolescents are especially prone to drug addiction, but the underlying biological basis of their increased vulnerability remains unknown. We reveal that translational control by phosphorylation of the translation initiation factor eIF2α (p-eIF2α ...
Wei Huang, Andon N Placzek, Gonzalo Viana Di Prisco, Sanjeev Khatiwada, Carmela Sidrauski, Krešimir Krnjević, Peter Walter, John A Dani, Mauro Costa-Mattioli   +8 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Endoplasmic reticulum stress and autophagy in cerebral ischemia/reperfusion injury: PERK as a potential target for intervention

Neural Regeneration Research
Several studies have shown that activation of unfolded protein response and endoplasmic reticulum (ER) stress plays a crucial role in severe cerebral ischemia/reperfusion injury. Autophagy occurs within hours after cerebral ischemia, but the relationship
Ju Zheng, Yixin Li, Ting Zhang, Yanlin Fu, Peiyan Long, Xiao Gao, Zhengwei Wang, Zhizhong Guan, Xiaolan Qi, Wei Hong, Yan Xiao   +10 more
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Research Progress of Endoplasmic Reticulum Stress PERK-eIF2α-AFT4-CHOP Signaling Pathway in Hematological Malignancies

Zhongliu Fangzhi Yanjiu
The biosynthesis and maturation of proteins are primarily regulated by the endoplasmic reticulum in its physiological state. Thus, the disruption of physiological homeostasis initiates the buildup of unfolded and misfolded proteins in the endoplasmic ...
HE Mengke, XU Zizhen, LI Junmin
doaj   +1 more source

eIF2α-mediated translational control regulates the persistence of cocaine-induced LTP in midbrain dopamine neurons

eLife, 2016
Recreational drug use leads to compulsive substance abuse in some individuals. Studies on animal models of drug addiction indicate that persistent long-term potentiation (LTP) of excitatory synaptic transmission onto ventral tegmental area (VTA) dopamine
Andon N Placzek, Gonzalo Viana Di Prisco, Sanjeev Khatiwada, Martina Sgritta, Wei Huang, Krešimir Krnjević, Randal J Kaufman, John A Dani, Peter Walter, Mauro Costa-Mattioli   +9 more
doaj   +1 more source