Results 21 to 30 of about 28,887 (200)

Pharmacological Disruption of Phosphorylated Eukaryotic Initiation Factor-2α/Activating Transcription Factor 4/Indian Hedgehog Protects Intervertebral Disc Degeneration via Reducing the Reactive Oxygen Species and Apoptosis of Nucleus Pulposus Cells

Frontiers in Cell and Developmental Biology, 2021
Excessive reactive oxygen species (ROS) and apoptosis in nucleus pulposus (NP) cells accelerate the process of intervertebral disc degeneration (IDD). Here, we integrated pathological samples and in vitro and in vivo framework to investigate the impact ...
Junping Bao, Junping Bao, Zhanyang Qian, Zhanyang Qian, Lei Liu, Lei Liu, Xin Hong, Xin Hong, Hui Che, Xiaotao Wu, Xiaotao Wu   +10 more
doaj   +1 more source

Structural and Functional Analysis of the GADD34:PP1 eIF2α Phosphatase

Cell Reports, 2015
The attenuation of protein synthesis via the phosphorylation of eIF2α is a major stress response of all eukaryotic cells. The growth-arrest- and DNA-damage-induced transcript 34 (GADD34) bound to the serine/threonine protein phosphatase 1 (PP1) is the ...
Meng S. Choy, Permeen Yusoff, Irene C. Lee, Jocelyn C. Newton, Catherine W. Goh, Rebecca Page, Shirish Shenolikar, Wolfgang Peti   +7 more
doaj   +1 more source

Pediatric glioblastoma cells are sensitive to drugs that inhibit eIF2α dephosphorylation and its phosphomimetic S51D variant

Frontiers in Oncology, 2022
We found that pediatric glioblastoma (PED-GBM) cell lines from diffuse intrinsic pontine glioma (DIPG) carrying the H3K27M mutation or from diffuse hemispheric glioma expressing the H3G34R mutation are sensitive to the combination of vorinostat (a ...
Karin Eytan, Ziv Versano, Ziv Versano, Roni Oren, Jasmine Jacob-Hirsch, Jasmine Jacob-Hirsch, Moshe Leitner, Alon Harmelin, Gideon Rechavi, Gideon Rechavi, Gideon Rechavi, Amos Toren, Amos Toren, Shoshana Paglin, Michal Yalon, Michal Yalon   +15 more
doaj   +1 more source

Regulation of G1 Arrest and Apoptosis in Hypoxia by PERK and GCN2-Mediated eIF2α Phosphorylation

Neoplasia: An International Journal for Oncology Research, 2010
Hypoxia is a common microenvironment in solid tumors and is correlated with tumor progression by regulating cancer cell survival. Recent studies suggest that activation of double-stranded RNA-dependent protein kinase-like endoplasmic reticulum-related ...
Yan Liu, Csaba László, Yi Liu, Wei Liu, Xiaozhuo Chen, Susan C. Evans, Shiyong Wu   +6 more
doaj   +1 more source

Scheme of PERK dependent eIF2α phosphorylation and the principle of LanthaScreen detection of p-eIF2α.

, 2015
Scheme of PERK dependent eIF2α phosphorylation and the principle of LanthaScreen detection of p-eIF2α.
William E. Wixted (703659), Wensheng Xie (703657), Roberto Solari (112167), Alan Diehl (703666), Maggie Truong (703662), Hu Li (130600), Yolanda Sanchez (213896), Christina Pao (703663), James Callahan (703665), Robert S. Ames (703664), Nilesh Chitnis (703660), Marie Pariollaud (703658), Yan Liu (25061), James Fornwald (703661)   +13 more
core   +1 more source

Polycystin-1 inhibits eIF2α phosphorylation and cell apoptosis through a PKR-eIF2α pathway. [PDF]

, 2017
Autosomal dominant polycystic kidney disease (ADPKD) is caused by mutations in PKD1 or PKD2 which encodes polycystin-1 (PC1) and polycystin-2, respectively.
Jingfeng Tang, Yan Tang, Wang Zheng, Xing-Zhen Chen, Richard Sandford, JungWoo Yang, Guanqing Wu, Di Chen, Zuocheng Wang   +8 more
core   +2 more sources

High glucose causes apoptosis of rabbit corneal epithelial cells involving activation of PERK-eIF2α-CHOP-caspase-12 signaling pathway [PDF]

International Journal of Ophthalmology, 2019
AIM: To investigate the effect of high concentration of glucose (HCG) on double stranded RNA-activated protein kinase-like ER kinase (PERK)-eukaryotic initiation factor-2α (eIF2α)-transcription factor C/EBP homologous protein (CHOP)-cysteine aspartate ...
Pan-Pan Yao, Min-Jie Sheng, Wen-Hao Weng, Yin Long, Hao Liu, Li Chen, Jia-Jun Lu, Ao Rong, Bing Li   +8 more
doaj   +1 more source

Salubrinal Protects Against Cisplatin-Induced Cochlear Hair Cell Endoplasmic Reticulum Stress by Regulating Eukaryotic Translation Initiation Factor 2α Signalling

Frontiers in Molecular Neuroscience, 2022
ObjectiveCisplatin is a broad-spectrum anti-tumour drug commonly used in clinical practice. However, its ototoxicity greatly limits its clinical application, and no effective method is available to prevent this effect.
Wen Lu, Kun Ni, Kun Ni, Zhuangzhuang Li, Lili Xiao, Yini Li, Yumeng Jiang, Jincheng Zhang, Haibo Shi   +8 more
doaj   +1 more source

Increased eIF2α phosphorylation in response to rapamycin:

, 2013
a. Cells were incubated for 24 hours with 50 nM rapamycin, harvested and processed for determination of changes in eIF2α phosphorylation b. Mean ± SEM fold change relative to control of eIF2α (e), p-eIF2α (p) and the ratio p-eIF2α/eIF2α (p/e) in ...
Liron Tuval-Kochen (476856), Charles Nakar (476859), Tamar Golani (476860), Shoshana Paglin (476857), Yaniv Lerenthal (476858), Joachim Yahalom (476861), Gilmor Keshet (247078), Yaacov Lawrence (476863), Raphael Pfeffer (476862), Amos Toren (267124)   +9 more
core   +1 more source

Salubrinal enhances radiation induced eIF2α phosphorylation:

, 2013
a. Cells were processed for analysis of eIF2α phosphorylation 48 hours post-addition of salubrinal (Sal). b. Mean ± SEM fold change relative to control of eIF2α (e), p-eIF2α (p) and of the ratio p-eIF2α/eIF2α (p/e) in salubrinal (Sal) treated cells.
Liron Tuval-Kochen (476856), Charles Nakar (476859), Tamar Golani (476860), Shoshana Paglin (476857), Yaniv Lerenthal (476858), Joachim Yahalom (476861), Gilmor Keshet (247078), Yaacov Lawrence (476863), Raphael Pfeffer (476862), Amos Toren (267124)   +9 more
core   +1 more source