Results 21 to 30 of about 27,813 (194)

The eIF2α kinase HRI is responsible for ROS-induced eIF2α phosphorylation.

, 2020
(A) Representative immunoblots of phosphorylated eIF2α and total eIF2α in WT, 4KO and single eIF2α kinase-rescued 4KO MEF cells 1 h after 1 mM H2O2 treatment with or without 10 mM NAC. (B) Densitometry quantification of phosphorylated eIF2α normalized to
Yoshimasa Hamada (8555628), Shusuke Taniuchi (8555637), Yuji Furumoto (8555631), Kenji Teranishi (8555640), Akira Izutani (8555634), Masato Miyake (818680), Seiichi Oyadomari (623781), Miho Oyadomari (4170271), Naoyuki Shimomura (8555643)   +8 more
core   +1 more source

Xrp1 causes PERK-mediated phosphorylation of eIF2α.

, 2021
(A) Eye disc bearing eyFLP-induced MARCM clones of UAS-GFP cells stained with anti-phosphorylated eIF2α. (B) Eye disc bearing eyFLP-induced MARCM clones of PERK RNAi cells stained with anti-phosphorylated eIF2α.
Ryosuke Nakano (4557097), Tatsushi Igaki (10047238), Mai Nakamura (634579), Rina Nagata (11797964), Naotaka Ochi (11797961), Naoki Wakasa (11797967)   +5 more
core   +1 more source

PKR and GCN2 stress kinases promote an ER stress-independent eIF2α phosphorylation responsible for calreticulin exposure in melanoma cells

OncoImmunology, 2018
The immunogenic cell death (ICD) process represents a novel therapeutic approach to treat tumours, in which cytotoxic compounds promote both cancer cell death and the emission of damage-associated molecular patterns (DAMPs) from dying cells, to activate ...
Paola Giglio, Mara Gagliardi, Nicola Tumino, Fernanda Antunes, Soraya Smaili, Diego Cotella, Claudio Santoro, Roberta Bernardini, Maurizio Mattei, Mauro Piacentini, Marco Corazzari   +10 more
doaj   +1 more source

The eIF2α kinase HRI is responsible for nsPEF-induced eIF2α phosphorylation.

, 2020
(A) Various stressors phosphorylate eIF2α via activation of four eIF2α kinases, PERK, GCN2, HRI and PKR. (B) Representative immunoblots of phosphorylated eIF2α and total eIF2α in WT and 4KO MEF cells 1 h after nsPEF treatment (40 shots of 70-ns duration ...
Yoshimasa Hamada (8555628), Shusuke Taniuchi (8555637), Yuji Furumoto (8555631), Kenji Teranishi (8555640), Akira Izutani (8555634), Masato Miyake (818680), Seiichi Oyadomari (623781), Miho Oyadomari (4170271), Naoyuki Shimomura (8555643)   +8 more
core   +1 more source

Pharmacological Disruption of Phosphorylated Eukaryotic Initiation Factor-2α/Activating Transcription Factor 4/Indian Hedgehog Protects Intervertebral Disc Degeneration via Reducing the Reactive Oxygen Species and Apoptosis of Nucleus Pulposus Cells

Frontiers in Cell and Developmental Biology, 2021
Excessive reactive oxygen species (ROS) and apoptosis in nucleus pulposus (NP) cells accelerate the process of intervertebral disc degeneration (IDD). Here, we integrated pathological samples and in vitro and in vivo framework to investigate the impact ...
Junping Bao, Junping Bao, Zhanyang Qian, Zhanyang Qian, Lei Liu, Lei Liu, Xin Hong, Xin Hong, Hui Che, Xiaotao Wu, Xiaotao Wu   +10 more
doaj   +1 more source

Salubrinal Protects Against Cisplatin-Induced Cochlear Hair Cell Endoplasmic Reticulum Stress by Regulating Eukaryotic Translation Initiation Factor 2α Signalling

Frontiers in Molecular Neuroscience, 2022
ObjectiveCisplatin is a broad-spectrum anti-tumour drug commonly used in clinical practice. However, its ototoxicity greatly limits its clinical application, and no effective method is available to prevent this effect.
Wen Lu, Kun Ni, Kun Ni, Zhuangzhuang Li, Lili Xiao, Yini Li, Yumeng Jiang, Jincheng Zhang, Haibo Shi   +8 more
doaj   +1 more source

High glucose causes apoptosis of rabbit corneal epithelial cells involving activation of PERK-eIF2α-CHOP-caspase-12 signaling pathway [PDF]

International Journal of Ophthalmology, 2019
AIM: To investigate the effect of high concentration of glucose (HCG) on double stranded RNA-activated protein kinase-like ER kinase (PERK)-eukaryotic initiation factor-2α (eIF2α)-transcription factor C/EBP homologous protein (CHOP)-cysteine aspartate ...
Pan-Pan Yao, Min-Jie Sheng, Wen-Hao Weng, Yin Long, Hao Liu, Li Chen, Jia-Jun Lu, Ao Rong, Bing Li   +8 more
doaj   +1 more source

Pediatric glioblastoma cells are sensitive to drugs that inhibit eIF2α dephosphorylation and its phosphomimetic S51D variant

Frontiers in Oncology, 2022
We found that pediatric glioblastoma (PED-GBM) cell lines from diffuse intrinsic pontine glioma (DIPG) carrying the H3K27M mutation or from diffuse hemispheric glioma expressing the H3G34R mutation are sensitive to the combination of vorinostat (a ...
Karin Eytan, Ziv Versano, Ziv Versano, Roni Oren, Jasmine Jacob-Hirsch, Jasmine Jacob-Hirsch, Moshe Leitner, Alon Harmelin, Gideon Rechavi, Gideon Rechavi, Gideon Rechavi, Amos Toren, Amos Toren, Shoshana Paglin, Michal Yalon, Michal Yalon   +15 more
doaj   +1 more source

Regulation of G1 Arrest and Apoptosis in Hypoxia by PERK and GCN2-Mediated eIF2α Phosphorylation

Neoplasia: An International Journal for Oncology Research, 2010
Hypoxia is a common microenvironment in solid tumors and is correlated with tumor progression by regulating cancer cell survival. Recent studies suggest that activation of double-stranded RNA-dependent protein kinase-like endoplasmic reticulum-related ...
Yan Liu, Csaba László, Yi Liu, Wei Liu, Xiaozhuo Chen, Susan C. Evans, Shiyong Wu   +6 more
doaj   +1 more source

Polycystin-1 inhibits eIF2α phosphorylation and cell apoptosis through a PKR-eIF2α pathway. [PDF]

, 2017
Autosomal dominant polycystic kidney disease (ADPKD) is caused by mutations in PKD1 or PKD2 which encodes polycystin-1 (PC1) and polycystin-2, respectively.
Jingfeng Tang, Yan Tang, Wang Zheng, Xing-Zhen Chen, Richard Sandford, JungWoo Yang, Guanqing Wu, Di Chen, Zuocheng Wang   +8 more
core   +2 more sources