Results 41 to 50 of about 28,887 (200)
Molecular Oncology, EarlyView.Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both +7 more
wiley +1 more source
Increased eIF2α phosphorylation in response to radiation:
, 2013 a. MCF-7 and b. MDA-MB-231 cells were irradiated with the indicated radiation dose and processed for analysis of eIF2α phosphorylation at the noted time post-irradiation. c.
Liron Tuval-Kochen (476856) +9 more
core +1 more source
iScience, 2019 Summary: The cellular stress response triggers a cascade of events leading to transcriptional reprogramming and a transient inhibition of global protein synthesis, which is thought to be mediated by phosphorylation of eukaryotic initiation factor-2α ...
Marisa Sanchez +6 more
doaj +1 more source
eIF2α controls memory consolidation via excitatory and somatostatin neurons
, 2020 An important tenet of learning and memory is the notion of a molecular switch that promotes the formation of long-term memory1,2,3,4. The regulation of proteostasis is a critical and rate-limiting step in the consolidation of new memories5,6,7,8,9,10 ...
Cohen, Noah +59 more
core +1 more source
CHANGES IN eIF2α PHOSPHORYLATION IN RESPONSE TO NUTRIENT DEFICIENCY AND OTHER STRESSORS IN FISH [PDF]
, 2015 The present study investigates the response of two teleost species to stressors as measured by phosphorylation of the α-subunit of the translational initiation factor, eIF2.
Liu, Chieh-lun
core +1 more source
FEBS Open Bio, EarlyView.Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya +2 more
wiley +1 more source
Translational control of auditory imprinting and structural plasticity by eIF2α
eLife, 2016 The formation of imprinted memories during a critical period is crucial for vital behaviors, including filial attachment. Yet, little is known about the underlying molecular mechanisms.
Gervasio Batista +4 more
doaj +1 more source
Titration of GFP-eIF2α BacMam.
, 2015 (A) U-2 OS cells were mixed with different amount of GFP-eIF2α BacMam and plated to a 384 well culture plate for overnight. Cells were then treated with either DMSO or 2 μM Tg for 1 h at 37°C 5% CO2.
William E. Wixted (703659) +13 more
core +1 more source
The role of PKR/eIF2α signaling pathway in prognosis of non-small cell lung cancer. [PDF]
PLoS ONE, 2011 In this study, we investigated whether PKR protein expression is correlated with mRNA levels and also evaluated molecular biomarkers that are associated with PKR, such as phosphorylated PKR (p-PKR) and phosphorylated eIF2α (p-eIF2α).We determined the ...
Yong He +11 more
doaj +1 more source
Phosphorylation of eIF2α along the cell cycle.
, 2015 Exponentially growing wild type (MSY-WT2) and yih1Δ (MSY-Y2) cells were arrested in G1 with α-factor and released into fresh SD media. Samples were collected at the indicated time intervals.
Richard C. Silva (130526) +5 more
core +1 more source