Results 41 to 50 of about 27,813 (194)

Increased eIF2α phosphorylation in response to rapamycin:

, 2013
a. Cells were incubated for 24 hours with 50 nM rapamycin, harvested and processed for determination of changes in eIF2α phosphorylation b. Mean ± SEM fold change relative to control of eIF2α (e), p-eIF2α (p) and the ratio p-eIF2α/eIF2α (p/e) in ...
Liron Tuval-Kochen (476856), Charles Nakar (476859), Tamar Golani (476860), Shoshana Paglin (476857), Yaniv Lerenthal (476858), Joachim Yahalom (476861), Gilmor Keshet (247078), Yaacov Lawrence (476863), Raphael Pfeffer (476862), Amos Toren (267124)   +9 more
core   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Impact of eIF2α phosphorylation on the translational landscape of mouse embryonic stem cells

Cell Reports
Summary: The integrated stress response (ISR) is critical for cell survival under stress. In response to diverse environmental cues, eIF2α becomes phosphorylated, engendering a dramatic change in mRNA translation.
Mehdi Amiri, Stephen J. Kiniry, Anthony P. Possemato, Niaz Mahmood, Tayebeh Basiri, Catherine R. Dufour, Negar Tabatabaei, Qiyun Deng, Michael A. Bellucci, Keerthana Harwalkar, Matthew P. Stokes, Vincent Giguère, Randal J. Kaufman, Yojiro Yamanaka, Pavel V. Baranov, Soroush Tahmasebi, Nahum Sonenberg   +16 more
doaj   +1 more source

Cross Talk between eIF2α and eEF2 Phosphorylation Pathways Optimizes Translational Arrest in Response to Oxidative Stress

iScience, 2019
Summary: The cellular stress response triggers a cascade of events leading to transcriptional reprogramming and a transient inhibition of global protein synthesis, which is thought to be mediated by phosphorylation of eukaryotic initiation factor-2α ...
Marisa Sanchez, Yingying Lin, Chih-Cheng Yang, Philip McQuary, Alexandre Rosa Campos, Pedro Aza Blanc, Dieter A. Wolf   +6 more
doaj   +1 more source

The role of PKR/eIF2α signaling pathway in prognosis of non-small cell lung cancer. [PDF]

PLoS ONE, 2011
In this study, we investigated whether PKR protein expression is correlated with mRNA levels and also evaluated molecular biomarkers that are associated with PKR, such as phosphorylated PKR (p-PKR) and phosphorylated eIF2α (p-eIF2α).We determined the ...
Yong He, Arlene M Correa, Maria Gabriela Raso, Wayne L Hofstetter, Bingliang Fang, Carmen Behrens, Jack A Roth, Yihong Zhou, Liping Yu, Ignacio I Wistuba, Stephen G Swisher, Apar Pataer   +11 more
doaj   +1 more source

Scheme of PERK dependent eIF2α phosphorylation and the principle of LanthaScreen detection of p-eIF2α.

, 2015
Scheme of PERK dependent eIF2α phosphorylation and the principle of LanthaScreen detection of p-eIF2α.
William E. Wixted (703659), Wensheng Xie (703657), Roberto Solari (112167), Alan Diehl (703666), Maggie Truong (703662), Hu Li (130600), Yolanda Sanchez (213896), Christina Pao (703663), James Callahan (703665), Robert S. Ames (703664), Nilesh Chitnis (703660), Marie Pariollaud (703658), Yan Liu (25061), James Fornwald (703661)   +13 more
core   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Translational control of auditory imprinting and structural plasticity by eIF2α

eLife, 2016
The formation of imprinted memories during a critical period is crucial for vital behaviors, including filial attachment. Yet, little is known about the underlying molecular mechanisms.
Gervasio Batista, Jennifer Leigh Johnson, Elena Dominguez, Mauro Costa-Mattioli, Jose L Pena   +4 more
doaj   +1 more source

ROS-activated HRI phosphorylates eIF2α during nsPEF treatment.

, 2020
(A) Representative immunoblots of phosphorylated eIF2α and total eIF2α in WT, 4KO and single eIF2α kinase-rescued 4KO MEF cells 1 h after nsPEF treatment (40 shots of 70-ns duration and 30-kV/cm electric fields) with or without 10 mM NAC.
Yoshimasa Hamada (8555628), Shusuke Taniuchi (8555637), Yuji Furumoto (8555631), Kenji Teranishi (8555640), Akira Izutani (8555634), Masato Miyake (818680), Seiichi Oyadomari (623781), Miho Oyadomari (4170271), Naoyuki Shimomura (8555643)   +8 more
core   +1 more source

생쥐 웅성생식세포에서 eIF2α kinases 발현연구 [PDF]

, 2013
학위논문 (석사)-- 서울대학교 대학원 : 생명과학부, 2013. 2. 이건수.The mammalian male germ cells should be maintained below the core body temperature for their successful development.
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