Results 61 to 70 of about 28,887 (200)
Spatial Au+ Mapping Reveals a Self‐Amplifying Anti‐Tumor Immunity Loop Driven by Au(I) Complexes
Advanced Science, EarlyView.The first report of spatial Au+ mapping of a representative gold complex (Au9). Macrophages, DCs, and tumor cells ranked as the top three in Au+ enrichment after Au9 treatment. Interestingly, Au9 treatment could induce ferroptosis and suppress cellular cholesterol, further eliciting a self‐amplifying anti‐tumor immunity loop.
Zhongren Xu +5 more
wiley +1 more source
ECTV- and VACV-induced phosphorylation of eIF2α in RK13 cells.
, 2015 (A) Wild-type RK13 or RK13+E3L+K3L cells were mock infected or infected with the indicated VACV strains at an MOI of 5. Cell lysates were collected 6 hours post infection and subjected to SDS-PAGE and immunoblot analysis. Membranes were first probed with
Stefan Rothenburg (66518) +4 more
core +1 more source
Advanced Science, EarlyView.Salvianolic acid A (SAA) selectively induces senescent vascular smooth muscle cell apoptosis, alleviating atherosclerosis. Mechanistically, SAA targets heat shock protein 90 alpha (HSP90α) to disrupt the protein inase B (AKT)‐PRKR‐Like Endoplasmic Reticulum Kinase (PERK) scaffold, driving ubiquitin‐proteasome‐dependent AKT degradation.
Xiuya Guan +8 more
wiley +1 more source
, 2014 (A) Western blots showing the elevated level of p-eIF2α by salubrinal and guanabenz. (B) Staining intensity of p-eIF2α, normalized by intensity of eIF2α. * p7 cells.
Qiaoqiao Wan (621794) +4 more
core +1 more source
Advanced Science, EarlyView.An injectable bimodal TCPD nanodepot disrupts glutaminolysis and TCA metabolism, sensitizing large tumors to spatially complementary sono‐thermal ablation for complete treatment coverage. This intervention induces mitochondrial and endoplasmic reticulum dysfunction, genotoxicity, and NAD+ depletion, converging to trigger PANoptosome assembly and ...
Yi‐Ming Liu +10 more
wiley +1 more source
eIF2α kinases regulate development through the BzpR transcription factor in Dictyostelium discoideum. [PDF]
PLoS ONE, 2012 A major mechanism of translational regulation in response to a variety of stresses is mediated by phosphorylation of eIF2α to reduce delivery of initiator tRNAs to scanning ribosomes.
Charles K Singleton +3 more
doaj +1 more source
Bridging Energy Need and Feeding Behavior: The Impact of eIF2α Phosphorylation in AgRP Neurons
, 2023 Eukaryotic translation initiation factor 2α (eIF2α) is a key mediator of the endoplasmic reticulum (ER) stress-induced unfolded protein response (UPR).
Dasol Kang +27 more
core +1 more source
Advanced Science, EarlyView.This Review outlines the biological framework of entry, maintenance, and awakening in dormant minimal residual disease across gynecologic cancers. By mapping critical biological dependencies—from metabolic plasticity to microenvironment interactions—it evaluates novel interception concepts and presents a translational framework combining single‐cell ...
Shih‐Hsuan Cheng +7 more
wiley +1 more source
, 2013 (A) Cells of yeast strains W303-1b (WT), D45, D45p (transformed with pFL36), D45p2α (transformed with pFL36 P2α) and D45p2β (transformed with pFL36 P2β) growing in the mid-exponential phase (A600 = 0.6) were harvested and the levels of eIF2α-P, eIF2α and
Juan José Berlanga (125208) +3 more
core +1 more source
The eIF2α kinase HRI is responsible for ROS-induced eIF2α phosphorylation.
, 2020 (A) Representative immunoblots of phosphorylated eIF2α and total eIF2α in WT, 4KO and single eIF2α kinase-rescued 4KO MEF cells 1 h after 1 mM H2O2 treatment with or without 10 mM NAC. (B) Densitometry quantification of phosphorylated eIF2α normalized to
Yoshimasa Hamada (8555628) +8 more
core +1 more source