Results 71 to 80 of about 27,813 (194)

Phosphorylation of eukaryotic initiation factor-2α (eIF2α) in autophagy

, 2020
International audienceThe integrated stress response is characterized by the phosphorylation of eukaryotic initiation factor-2α (eIF2α) on serine 51 by one out of four specific kinases (EIF2AK1 to 4).
Kepp, Oliver, Leduc, Marion, Cerrato, Giulia, Loos, Friedemann, Humeau, Juliette, Kroemer, Guido   +5 more
core   +1 more source

A Novel Pak1 Activator Ameliorates ER Stress for HFpEF Therapy

Advanced Science, EarlyView.
Chronic metabolic stress is a major contributor to HFpEF progression. Under prolonged metabolic stress, Pak1 activity becomes impaired, contributing to disrupted ER proteostasis, cardiomyocyte apoptosis, fibrosis, and diastolic dysfunction. Mechanistically, Pak1 overexpression activates the ERK1/2–MNK1–eIF4E signaling axis, promotes translational ...
Honglin Xu, Hongyuan Zhang, Tayyiba Azam, Susanne S. Hille, Yingjuan Liu, Min Zi, Jiaqing Lang, He Yu, Yujia Cao, Bernard D. Keavney, Tamer M. A. Mohamed, Jessica M. Miller, Riham R. E. Abouleisa, Ming Xu, Elizabeth J. Cartwright, Oliver J. Müller, Ming Lei, Xin Wang   +17 more
wiley   +1 more source

Characterization of Arabidopsis Eukaryotic Translation Initiation Factor 2α (eIF2α) Mutants [PDF]

, 2023
Plants are stationary organisms that are charged with overcoming a multitude of biotic and abiotic stresses. The eukaryotic translation initiation factor 2 (eIF2) is responsible for charging the P-site of the forming 80S ribosome with the initiator ...
Edens, Mark
core  

Chemical Bond‐Orchestrated Energy Depletion to Augment Lung Cancer Chemo‐Immunotherapy

Advanced Science, EarlyView.
This study grafted dichloroacetic acid (DCA) into perylenediimide (PDI) skeleton via ionic or covalent bond to create novel metabolic agent PDIC‐AC and PDIC‐NAC, explicitly elaborated the underlying energy metabolism and therapeutic mechanism, and developed a promising strategy for energy metabolism‐targeting chemo‐immunotherapy by chemical bond ...
Xuejie Zhao, Yuting Liu, Xiao Huang, Liwen Zhao, Chunli Li, Yongwei Huang   +5 more
wiley   +1 more source

Gefitinib and erlotinib activated eIF2α/ATF4 signaling.

, 2015
The effects of gefitinib and erlotinib (10 μM) on (A) eIF2α/ATF4 activation and (C) PERK migration in A549 cells were investigated. A549 cells were treated with gefitinib (10 μM) or erlotinib (10 μM) for indicated times and tunicamycin (0.005–10 μg/mL ...
Atsushi Yonezawa (784929), Shunsaku Nakagawa (430323), Ikuko Yano (784930), Kazuo Matsubara (647154), Tomohiro Omura (784928), Takayuki Nakagawa (202988), Satoshi Imai (124356), Satoshi Koyama (784927)   +7 more
core   +1 more source

CDK4/MERCs/PINK1 Axis Drives PFOA/HFPO‐TA‐Induced Cardiac Senescence via Mitophagy Defect and cGAS‐STING Activation: In Vitro Amelioration by Cycloastragenol

Advanced Science, EarlyView.
The present study demonstrated that PFOA and HFPO‐TA exposure suppressed CDK4, disrupted MERCs and impaired PINK1/Parkin‐mediated mitophagy, thereby accelerating cardiac senescence, whereas CAG effectively reversed these pathological changes in vitro. Our findings identify CDK4 as a critical regulator bridging mitophagy defects and cardiac senescence ...
Nuo‐Wa Li, Jun‐Ze Jiang, Ying‐Ying Liu, Tian‐Tian Zhang, Kanwar Kumar Malhi, Xin Yao, Jin‐Long Li   +6 more
wiley   +1 more source

Cannabinoid Modulation of Eukaryotic Initiation Factors (eIF2α and eIF2B1) and Behavioral Cross-Sensitization to Cocaine in Adolescent Rats

Cell Reports, 2018
Summary: Reduced eukaryotic Initiation Factor 2 (eIF2)α phosphorylation (p-eIF2α) enhances protein synthesis, memory formation, and addiction-like behaviors.
Philippe A. Melas, Johanna S. Qvist, Matteo Deidda, Chirag Upreti, Ya Bin Wei, Fabrizio Sanna, Walter Fratta, Maria Scherma, Paola Fadda, Denise B. Kandel, Eric R. Kandel   +10 more
doaj   +1 more source

Phase Separation, Material State, and Condensate Fate in Mammalian Autophagy

Advanced Science, EarlyView.
ABSTRACT Biomolecular phase separation has emerged as a key organizing principle in macroautophagy (hereafter autophagy). In mammalian cells, phase‐separated condensates not only serve as substrates for selective degradation, but also act as dynamic platforms for cargo recognition, signaling integration, and autophagosome assembly.
Yuanqiang Lin, Mingran Dai, Enyong Dai, Rui Kang, Daniel J. Klionsky, Daolin Tang, Yu Sun, Ningning Lv, Junnan Jiang   +8 more
wiley   +1 more source

Endoplasmic Reticulum Stress Mediated MDRV p10.8 Protein-Induced Cell Cycle Arrest and Apoptosis Through the PERK/eIF2α Pathway

Frontiers in Microbiology, 2018
In this study, the mechanism of Muscovy duck reovirus (MDRV) p10.8 protein-induced pathogenesis was investigated, with a focus on endoplasmic reticulum (ER) stress.
Quanxi Wang, Quanxi Wang, Xiaoqin Yuan, Xiaoqin Yuan, Yuan Chen, Yuan Chen, Qingli Zheng, Qingli Zheng, Lihui Xu, Yijian Wu   +9 more
doaj   +1 more source

Phosphorylation of eIF2α (p-eIF2α) and CHOP protein expression were up-regulated in Crif1-silenced cells.

, 2014
CRIF1 deficiency induced p-eIF2α and CHOP protein expression. p-eIF2α and CHOP protein expression levels were measured by Western blotting. p-eIF2α and CHOP protein expression levels were quantified by densitometric analysis (left panels).
Hee-Jung Song (573934), Sun Kwan Kwon (573932), Byeong Hwa Jeon (573935), Saet-byel Jung (4731324), Kaikobad Irani (346311), Cuk-Seong Kim (417673), Harsha Nagar (573931), Jung-Bum Park (573933), Minho Shong (92905)   +8 more
core   +1 more source