Results 51 to 60 of about 28,887 (200)

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

eIF2α-mediated translational control regulates the persistence of cocaine-induced LTP in midbrain dopamine neurons

eLife, 2016
Recreational drug use leads to compulsive substance abuse in some individuals. Studies on animal models of drug addiction indicate that persistent long-term potentiation (LTP) of excitatory synaptic transmission onto ventral tegmental area (VTA) dopamine
Andon N Placzek, Gonzalo Viana Di Prisco, Sanjeev Khatiwada, Martina Sgritta, Wei Huang, Krešimir Krnjević, Randal J Kaufman, John A Dani, Peter Walter, Mauro Costa-Mattioli   +9 more
doaj   +1 more source

In primary neurons, genetic reduction of eIF2α phosphorylation via eIF2α S51A knockin mutation does not inhibit BACE1 and APP elevation in response to Aβ42 oligomer treatment.

, 2014
Mixed cortical primary neurons were isolated from e15.5 mouse embryos that were either homozygous for the eIF2α S51A targeted replacement mutation (A/A) or heterozygous (S/A).
Pavel Osten (75265), William A. Eimer (592399), Robert Vassar (38951), Randal J. Kaufman (561534), Katherine R. Sadleir (592398)   +4 more
core   +1 more source

GCN2 is required neither for eIF2α phosphorylation nor cell competition.

, 2021
(A) Eye disc bearing eyFLP-induced MARCM clones of wolccp-28-/- + Gcn2-RNAi cells stained with anti-phosphorylated eIF2α. Quantification of the relative size of GFP-labeled clones or relative intensity of anti-phosphorylated eIF2α staining shown in A ...
Ryosuke Nakano (4557097), Tatsushi Igaki (10047238), Mai Nakamura (634579), Rina Nagata (11797964), Naotaka Ochi (11797961), Naoki Wakasa (11797967)   +5 more
core   +1 more source

Chemical Bond‐Orchestrated Energy Depletion to Augment Lung Cancer Chemo‐Immunotherapy

Advanced Science, EarlyView.
This study grafted dichloroacetic acid (DCA) into perylenediimide (PDI) skeleton via ionic or covalent bond to create novel metabolic agent PDIC‐AC and PDIC‐NAC, explicitly elaborated the underlying energy metabolism and therapeutic mechanism, and developed a promising strategy for energy metabolism‐targeting chemo‐immunotherapy by chemical bond ...
Xuejie Zhao, Yuting Liu, Xiao Huang, Liwen Zhao, Chunli Li, Yongwei Huang   +5 more
wiley   +1 more source

eIF2α phosphorylation is required to prevent hepatocyte death and liver fibrosis in mice challenged with a high fructose diet

Nutrition & Metabolism, 2017
Background Dietary fructose can rapidly cause fatty liver in animals through de novo lipogenesis (DNL) and contribute to the development and severity of nonalcoholic fatty liver disease (NAFLD).
Woo-Gyun Choi, Jaeseok Han, Ji-Hyeon Kim, Mi-Jeong Kim, Jae-Woo Park, Benbo Song, Hee-Jeong Cha, Hye-Seon Choi, Hun-Taeg Chung, In-Kyu Lee, Tae-Sik Park, Maria Hatzoglou, Hueng-Sik Choi, Hyun Ju Yoo, Randal J. Kaufman, Sung Hoon Back   +15 more
doaj   +1 more source

Genetic reduction of eIF2α phosphorylation via eIF2α S51A knockin mutation does not block amyloid-associated BACE1 elevation in 5XFAD brain.

, 2014
5XFAD mice were crossed with mice harboring the eIF2α S51A targeted replacement mutation to generate 5XFAD (+) or non-Tg (–) offspring that were either heterozygous for the eIF2α S51A knockin mutation (S/A) or wild-type (S/S). Mice were aged to 12 months,
Pavel Osten (75265), William A. Eimer (592399), Robert Vassar (38951), Randal J. Kaufman (561534), Katherine R. Sadleir (592398)   +4 more
core   +1 more source

Prion‐Like Protein LENG8‐Mediated Nucleation Drives Stress Granule Assembly

Advanced Science, EarlyView.
LENG8 is a newly identified stress granule (SG) nucleator required for SG assembly. Following stress, nuclear LENG8 granules disassemble, allowing LENG8 to translocate into the cytoplasm and form independent nucleation foci. These foci fuse with canonical early G3BP1/TIA1 seeds via LENG8‐TIA1 binding to drive SG maturation.
Mingxing Zhang, Xin Wang, Yilan Teng, Zhicheng Wu, Jing Fan, Hongwen Zhu, Peng Dai   +6 more
wiley   +1 more source

Translation of viral mRNA without active eIF2: the case of picornaviruses. [PDF]

PLoS ONE, 2011
Previous work by several laboratories has established that translation of picornavirus RNA requires active eIF2α for translation in cell free systems or after transfection in culture cells.
Ewelina Welnowska, Miguel Angel Sanz, Natalia Redondo, Luis Carrasco   +3 more
doaj   +1 more source

Guanabenz Downregulates Inflammatory Responses via eIF2α Dependent and Independent Signaling

, 2016
Integrated stress responses (ISR) may lead to cell death and tissue degeneration via eukaryotic translation initiation factor 2 α (eIF2α)-mediated signaling.
Andy Chen, Bai-Yan Li, Akihiro Sudo, Chen, Andy, Yokota, Hiroki, Shengzhi Liu, Takigawa, Shinya, Liu, Shengzhi, Hamamura, Kazunori, Kazunori Hamamura, Li, Bai-Yan, Shinya Takigawa, Hiroki Yokota, Nishimura, Akinobu, Sudo, Akihiro, Akinobu Nishimura   +15 more
core   +1 more source