Results 51 to 60 of about 27,813 (194)
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw +5 more
wiley +1 more source
Phosphorylation of eIF2α during glucose deprivation.
, 2012 Western blots of extracts from HepG2 cells incubated for 6 hr in media having either 0 mM or 5 mM glucose, and without (-) or with (+) 10 µM Sal003 as shown above lanes.
Josephine A. Carew (146600) +2 more
core +1 more source
Advanced Science, EarlyView.RT promotes VG161 replication in BC and its immunostimulatory transgenes expression, which is mediated by the upregulation of GADD34 and HVEM caused by RT. The combination therapy with VG161 and RT increases the abundances of tumor‐infiltrating lymphocytes and elicits potent systemic antitumor immunity, thereby effectively inhibiting local tumors and ...
Lijuan Lyu +13 more
wiley +1 more source
Titration of GFP-eIF2α BacMam.
, 2015 (A) U-2 OS cells were mixed with different amount of GFP-eIF2α BacMam and plated to a 384 well culture plate for overnight. Cells were then treated with either DMSO or 2 μM Tg for 1 h at 37°C 5% CO2.
William E. Wixted (703659) +13 more
core +1 more source
Mechanistic Link between PKR Dimerization, Autophosphorylation, and eIF2α Substrate Recognition [PDF]
, 2005 SummaryThe antiviral protein kinase PKR inhibits protein synthesis by phosphorylating the translation initiation factor eIF2α on Ser51. Binding of double-stranded RNA to the regulatory domains of PKR promotes dimerization, autophosphorylation, and the ...
Sicheri, Frank +6 more
core +1 more source
Advanced Science, EarlyView.This study uncovers that quercetin naturally targets mitochondria. By coordinating quercetin with Fe3+, we engineer an ultrasmall cascade nanozyme (MCN) with superoxide dismutase‐catalase activities. MCN crosses the damaged blood–brain barrier, scavenges mitochondrial ROS, prevents mitochondrial DNA leakage, and blocks the cGAS‐STING pathway, thereby ...
Wenxuan Zheng +14 more
wiley +1 more source
Translation of viral mRNA without active eIF2: the case of picornaviruses. [PDF]
PLoS ONE, 2011 Previous work by several laboratories has established that translation of picornavirus RNA requires active eIF2α for translation in cell free systems or after transfection in culture cells.
Ewelina Welnowska +3 more
doaj +1 more source
Advanced Science, EarlyView.Inhibition of KDELR2 in a small fraction of tumor cells generates sustainable immunogenic cell death conditions within the tumor microenvironment. These conditions promote the regression of tumors in a T cell independent manner. During regression, macrophages prime T cells that subsequently provide systemic protection against recurrence. The potency of
Shakti P Pattanayak +6 more
wiley +1 more source
Nutrition & Metabolism, 2017 Background Dietary fructose can rapidly cause fatty liver in animals through de novo lipogenesis (DNL) and contribute to the development and severity of nonalcoholic fatty liver disease (NAFLD).
Woo-Gyun Choi +15 more
doaj +1 more source
, 2014 5XFAD mice were crossed with mice harboring the eIF2α S51A targeted replacement mutation to generate 5XFAD (+) or non-Tg (–) offspring that were either heterozygous for the eIF2α S51A knockin mutation (S/A) or wild-type (S/S). Mice were aged to 12 months,
Pavel Osten (75265) +4 more
core +1 more source