Results 91 to 100 of about 27,813 (194)

Absence of IMPACT increases eIF2α phosphorylation in the hypothalamus.

, 2019
(A) Western blot of extracts of the cortex (Cx), remaining brain parts (B), heart (H) and liver (L) of wild-type (WT) and Impact-/- animals (Imp-KO), using antibodies against IMPACT (upper panel). The Ponceau stained membrane is shown in the bottom panel
Bruna B. Brandão (6804050), Claudio M. Queiroz (6804053), Raissa G. Ludwig (6804056), Beatriz M. Longo (6804062), Catia M. Pereira (746544), Debora Hipolide (6804059), Luiz E. Mello (265667), Renato Filev (801652), Francisco P. Dubiela (6804047), Marcelo A. Mori (135344), Beatriz A. Castilho (195975)   +10 more
core   +1 more source

Air Pollution Quinones Impair Intestinal Barrier Integrity and Endoplasmic Reticulum in Differentiated Caco‐2 Cells

Journal of Applied Toxicology, EarlyView.
ABSTRACT Particulate matter (PM) is a major global health threat, linked to millions of deaths annually. Beyond inhalation, PM components reach the gastrointestinal tract through the mucociliary escalator or contaminated food and water. Among PM's organic fraction, redox‐active quinones such as 1,2‐naphthoquinone (NQ) and 9,10‐phenanthrenequinone (PQ ...
Franco Cervellati, Giulia Trinchera, Alice Casoni, Alessandra Pecorelli, Mascia Benedusi, Maria Chiara Pietrogrande, Giuseppe Valacchi   +6 more
wiley   +1 more source

ER stress-induced eIF2-alpha phosphorylation underlies sensitivity of striatal neurons to pathogenic huntingtin.

PLoS ONE, 2014
A hallmark of Huntington's disease is the pronounced sensitivity of striatal neurons to polyglutamine-expanded huntingtin expression. Here we show that cultured striatal cells and murine brain striatum have remarkably low levels of phosphorylation of ...
Julia Leitman, Boaz Barak, Ron Benyair, Marina Shenkman, Uri Ashery, F Ulrich Hartl, Gerardo Z Lederkremer   +6 more
doaj   +1 more source

Improving protein secretion with autophagy‐inhibiting or proteasome‐activating small molecules

Journal of Chemical Technology &Biotechnology, EarlyView.
Abstract BACKGROUND Therapeutic proteins are produced frequently by mammalian cells in large‐scale bioreactors. As a result, producer cells are exposed to a chemically (nutrients, gas exchange, target protein overexpression) and physically (shear due to mixing) stressful environment, which can lead to endoplasmic reticulum (ER) stress and loss of ...
R Chauncey Splichal, Christina Chan, S Patrick Walton   +2 more
wiley   +1 more source

Deficiency of heme-regulated eIF2α kinase decreases hepcidin expression and splenic iron in HFE−/− mice

Haematologica, 2008
Heme-regulated eIF2α kinase (HRI) is essential for regulating globin translation in iron deficiency and in β-thalassemia. We investigated the role of heme-regulated eIF2α kinase in hemoglobin and red blood cell production as well as in iron homeostasis ...
Sijin Liu, Rajasekhar N.V.S. Suragani, Anping Han, Wanting Zhao, Nancy C. Andrews, Jane-Jane Chen   +5 more
doaj   +1 more source

Bridging Energy Need and Feeding Behavior: The Impact of eIF2α Phosphorylation in AgRP Neurons

, 2023
 Eukaryotic translation initiation factor 2α (eIF2α) is a key mediator of the endoplasmic reticulum (ER) stress–induced unfolded protein response (UPR).
Kwang Kon Kim (511710), Tae Hwan Lee (16618590), Sungho Jin (769987), Byung Ju Lee (192404), Bora Jeong (8707581), Dasol Kang (16618592), Byong Seo Park (192390), Jin Woo Kim (16618598), Sung Hoon Back (512790), Han Rae Kim (511708), Jeong Woo Park (192399), Jae Geun Kim (192389), Dong Hee Kim (16618595), Hye Rim Yang (16618599)   +13 more
core   +1 more source

Oncogenic KRAS Rewires Stress Granule Dynamics: Mechanisms and Therapeutic Opportunities

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Stress granules (SGs) are dynamic, membrane‐less structures that form in response to various cellular stresses, including metabolic, oxidative, and therapeutic challenges. They function as adaptive hubs and reorganize protein synthesis and signaling networks to help cells survive under stress. In cancer, these condensates are often hijacked to
Msimisi Ndzinisa, Birhanetensay Masresha Altaye, Yuh‐Pyng Sher   +2 more
wiley   +1 more source

Toxicity Differences Between Microplastics and Nanoplastics in Organs: From Molecular Mechanisms to Potential Therapeutic Strategies

Med Research, EarlyView.
This review systematically compares the size‐dependent toxicity of microplastics and nanoplastics in the intestine, liver, kidney, lung, and brain. Particle size determines bioavailability, barrier penetration, and injury mechanisms. Because of their small size and high surface reactivity, NPs readily cross the intestinal epithelium and blood–brain ...
Yixian Cheng, Junjie Chen, Rui Fu, Jiawei Zhang, Jianguang Jia, Wei Wang, Zheng Zhang, Peng Zhang, Haosong Chen, Huake Cao, Gang Li, Weiwei Sheng, Ting Li, Bo Chen, Guodong Cao   +14 more
wiley   +1 more source

In primary neurons, genetic reduction of eIF2α phosphorylation via eIF2α S51A knockin mutation does not inhibit BACE1 and APP elevation in response to Aβ42 oligomer treatment.

, 2014
Mixed cortical primary neurons were isolated from e15.5 mouse embryos that were either homozygous for the eIF2α S51A targeted replacement mutation (A/A) or heterozygous (S/A).
Pavel Osten (75265), William A. Eimer (592399), Robert Vassar (38951), Randal J. Kaufman (561534), Katherine R. Sadleir (592398)   +4 more
core   +1 more source

Twenty‐Five Years of the Environmental Stress Response and the Enduring Power of Yeast in Stress Biology

Yeast, EarlyView.
ABSTRACT All organisms must be able to sense and respond to adverse environments, especially those that threaten cellular integrity. The age of genomics clarified the breadth and specificity of cellular stress responses, including in free‐living microbes directly exposed to a changing environment.
Audrey P. Gasch
wiley   +1 more source