Results 111 to 120 of about 28,887 (200)
Cancer Science, EarlyView.tRNA‐derived small RNAs (tsRNAs) function in digestive cancers across three scales: intracellular translational and metabolic control, extracellular vesicle–mediated immune remodeling, and systemic and host–microbe communication. This review organizes these mechanisms by evidence strength, from well‐established intracellular roles to emerging ...
Wang Xitan, Li Han
wiley +1 more source
, 2011 As phosphorylation of eukaryotic translation initiation factor 2α (eIF2α) on Ser51 inhibits protein synthesis, cells restrict this phosphorylation to the antiviral protein kinase PKR and related eIF2α kinases. In the crystal structure of the
John J. Li +7 more
core +1 more source
The FEBS Journal, EarlyView.RNA and DNA viruses can manipulate host cell death through various mechanisms. RNA viruses (H1N1, SARS‐CoV‐2) induce acute apoptosis, necroptosis, and pyroptosis to promote rapid viral transmission and epithelial barrier damage. In contrast, DNA viruses (HSV‐1, EBV) regulate these mechanisms to sustain a lytic‐latency cycle, evade immune response and ...
Panagiotis Keramidas +4 more
wiley +1 more source
PLoS Pathogens, 2016 Entamoeba histolytica is an enteric pathogen responsible for amoebic dysentery and liver abscess. It alternates between the host-restricted trophozoite form and the infective environmentally-stable cyst stage. Throughout its lifecycle E.
Holland M Hendrick +5 more
doaj +1 more source
, 2013 (A) Whole-cell lysates from K562 cells (ATCC) stably expressing myc-tagged eIF2α S51A (clone 3, 8) or a non-expressing control clone (clone 11) were subjected to Western blot analysis using antibodies reacting against the myc epitope or full-length eIF2α.
Hannes C. A. Drexler (375114)
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Advances in Cytosolic dsRNA Sensing of Viral Infections
Immunology &Cell Biology, EarlyView.Activation of cytosolic dsRNA sensors by viral infection generates multiple outcomes. dsRNA generated during viral infection, either of viral origin or from endogenous sources, can activate multiple cytosolic dsRNA sensors. Activation of PKR critically induces protein translation shutdown via phosphorylation of eukaryotic translation initiation factor ...
Sofia Maceratessi, Natalia G. Sampaio
wiley +1 more source
O-GlcNAcylation of eIF2α regulates the phospho-eIF2α-mediated ER stress response.
, 2015 O-GlcNAcylation is highly involved in cellular stress responses including the endoplasmic reticulum (ER) stress response. For example, glucosamine-induced flux through the hexosamine biosynthetic pathway can promote ER stress and ER stress inducers can ...
최현진, 김재우, 조진원
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Proteostasis in the regulation of pancreatic islet cell plasticity
Journal of Diabetes Investigation, EarlyView.Adaptive proteostasis integrates protein synthesis, folding, trafficking, and degradation through ISR, UPR, ER stress responses, autophagy, and proteasomal degradation. In pancreatic islet cells, this coordinated network preserves protein quality, secretory function, proliferation, and survival, enabling adaptation to metabolic stress and aging while ...
Jun Shirakawa
wiley +1 more source
생쥐 웅성생식세포에서 eIF2α kinases 발현연구 [PDF]
, 2013 학위논문 (석사)-- 서울대학교 대학원 : 생명과학부, 2013. 2. 이건수.The mammalian male germ cells should be maintained below the core body temperature for their successful development.
박교선
core
, 2013 S. cerevisiae W303-1b (WT) and mutant strain D4567 were grown up to stationary phase (A600 = 4.0) and the amount of phosphorylated and total eIF2α was estimated in total cell extracts resolved by SDS-PAGE.
Juan José Berlanga (125208) +3 more
core +1 more source