Results 131 to 140 of about 28,887 (200)
Advanced Science, Volume 13, Issue 56, 9 October 2026.QRICH1 has been established as a key factor contributing to impaired osteogenic potential and accelerated apoptosis of PDLSCs in diabetic periodontitis. QRICH1 not only significantly enhances UPR‐associated apoptotic signaling but also amplifies NF‐κB‐mediated inflammatory responses. Its inhibition restores osteogenic capacity and reduces alveolar bone
Han Li +9 more
wiley +1 more source
A Novel Pak1 Activator Ameliorates ER Stress for HFpEF Therapy
Advanced Science, Volume 13, Issue 60, 28 October 2026.Chronic metabolic stress is a major contributor to HFpEF progression. Under prolonged metabolic stress, Pak1 activity becomes impaired, contributing to disrupted ER proteostasis, cardiomyocyte apoptosis, fibrosis, and diastolic dysfunction. Mechanistically, Pak1 overexpression activates the ERK1/2–MNK1–eIF4E signaling axis, promotes translational ...
Honglin Xu +17 more
wiley +1 more source
Advanced Science, Volume 13, Issue 56, 9 October 2026.The present study demonstrated that PFOA and HFPO‐TA exposure suppressed CDK4, disrupted MERCs and impaired PINK1/Parkin‐mediated mitophagy, thereby accelerating cardiac senescence, whereas CAG effectively reversed these pathological changes in vitro. Our findings identify CDK4 as a critical regulator bridging mitophagy defects and cardiac senescence ...
Nuo‐Wa Li +6 more
wiley +1 more source
, 2014 Insulinoma cells were treated with palmitate (500 µM) alone or together with metformin (10 µM, 100 µM) at 70–80% confluence. Cell lysates were prepared after 8 h and the phosphorylation and expression level of eIF2α were assessed by Western blot analysis
Márton Kokas (572560) +4 more
core +1 more source
CNS Neuroscience &Therapeutics, Volume 32, Issue 10, October 2026.We identified endoplasmic reticulum (ER) stress modulation as a convergent transcription signature across fentanyl and multiple substance use disorder (SUD)‐relevant treatments. Key ER stress genes, including TRIB3, XBP1, and DDIT3, were downregulated, while CEBPB emerged as a shared upstream regulator linked to ER stress–related proteins.
Cheng Zhang, Hu Li, Ming‐Fen Ho
wiley +1 more source
Bioactive peptides in cancer and inflammation: Mechanisms, model systems and clinical translation
Clinical and Translational Discovery, Volume 6, Issue 5, October 2026.Bioactive peptides (BAPs) derived from host, marine, insect, plant and synthetic sources share cationic, amphipathic structures adopting α‐helical, β‐sheet or cyclic conformations. These features underlie anti‐cancer effects, including membrane disruption, apoptosis and cell‐cycle arrest, anti‐metastatic activity, reduced invasion and migration, and ...
Najwa Doha +4 more
wiley +1 more source
Combined treatment of salubrinal and Vorinostat increases eIF2α phosphorylation:
, 2013 a. Cells were harvested 48 hours following application of the vehicle (D), 4.5 µM salubrinal (S), 0.75 µM Vorinostat (V) or both (V+S) and processed for Western blot analysis of eIF2α phosphorylation. b. Mean fold change relative to control of eIF2α (e),
Liron Tuval-Kochen (476856) +9 more
core +1 more source
Recalibrating the apoptotic threshold: Ubiquitin‐regulated ER stress signalling in colorectal cancer
Clinical and Translational Discovery, Volume 6, Issue 5, October 2026.Ubiquitin‐dependent turnover of ER‐stress sensors, proteostasis factors, and apoptotic regulators can recalibrate the apoptotic threshold in colorectal cancer, balancing adaptive survival against terminal cell death. Defining these context‐dependent vulnerabilities may enable strategies that overcome stress adaptation and restore apoptotic competence ...
Jing Hu, Shanliang Zheng, Ying Hu
wiley +1 more source
Molecules and Cells: Eukaryotic translation initiation factor 2α (eIF2α) phosphorylation, which regulates all 3 unfolded protein response pathways, helps maintain cellular homeostasis and overcome endoplasmic reticulum (ER) stress through transcriptional and translational ...
Hien Thi Le +13 more
doaj +1 more source
Phosphorylated eIF2α and eIF4G in mESCs and hESCs.
, 2015 (A) mESCs were cultured either with LIF (mESCs +LIF) or without LIF for 24 h (mESCs–LIF). Increasing amounts of cell lysate (indicated by triangles) were separated by 4–12% gradient SDS-PAGE and indicated proteins visualized by western blot.
Kyle Friend (799951) +4 more
core +1 more source