Results 131 to 140 of about 27,813 (194)
ER 스트레스에 노출된 eIF2α 인산화 결핍 세포에서의 Autophagy 역할 연구
, 2016 진핵세포에서 소포체 기능이상은 소포체 스트레스를 유발한다. 이때 세포는 UPR (unfolded protein response)이라 칭하는 반응을 통해 소포체 기능을 보호한다. UPR은 소포체 스트레스가 지속되는 동안 소포체에 축적된 미성숙 단백질(unfolded proteins)을 제거하기 위하여 autophagy와 proteasome같은 단백질 분해 시스템과 함께 작용한다.
김상아
core +1 more source
Cell Biochemistry and Function, Volume 44, Issue 9, September 2026.ABSTRACT Idiopathic pulmonary fibrosis (IPF) is a fatal interstitial lung disease of unknown cause, marked by excessive deposition of extracellular matrix (ECM) components such as collagen. This pathological accumulation results in progressive destruction of the lung architecture and ultimately leads to respiratory failure.
Yining Zhang +4 more
wiley +1 more source
Inhibition of eIF2α Kinases by Viral and Small Molecule Inhibitors
, 2016 Phosphorylation of the alpha subunit of the eukaryotic initiation factor 2 (eIF2α) on Ser51 is a key event in the eukaryotic stress response pathway.
Li, John Junyi
core +1 more source
Molecules and Cells: Eukaryotic translation initiation factor 2α (eIF2α) phosphorylation, which regulates all 3 unfolded protein response pathways, helps maintain cellular homeostasis and overcome endoplasmic reticulum (ER) stress through transcriptional and translational ...
Hien Thi Le +13 more
doaj +1 more source
Regulation of phosphorylated eIF2α levels by inhibition of its dephosphorylation.
, 2014 A) Guanabenz (Gz), at a relatively high concentration (100 µM), inhibits eIF2α dephosphorylation in untreated STHdhQ7/7 cells and also in those treated with Tun (5 µg/ml) up to 7h; this is also true in STHdhQ111/111 cells but only after very short ...
Marina Shenkman (529652) +6 more
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Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 9, September 2026.The graphical abstract represents the underlying neuroprotective potential of ICS II against Alzheimer's disease, Cerebral ischemia and Parkinson disease. ICS II downregulates ROS production, inflammation, mitochondrial dysfunction and apoptosis along with regulating their key signalling pathways.
Ashutosh Solanki +4 more
wiley +1 more source
Autoimmunity: Molecular Mechanisms, Biomarkers, and Therapeutic Opportunities
MedComm, Volume 7, Issue 9, September 2026.Major types of immunometabolism, epigenetics, posttranscriptional regulation, and functional reprogramming involved in autoimmune diseases. The roles of immunometabolism, epigenetics, posttranscriptional regulation, and functional reprogramming in autoimmune diseases have been a major research focus in recent years.
Jialong Kuang +10 more
wiley +1 more source
MedComm, Volume 7, Issue 9, September 2026.Mitochondria is the hub of apoptosis in various diseases. The disruption of mitochondrial structure (including membrane rupture, cristae remodeling, and mitochondrial membrane lipid redistribution), the imbalance of mitochondrial dynamics (including fusion and fission, autophagy), the release, disruption, and mutation of mitochondria DNA, as well as ...
Rubin Tan +9 more
wiley +1 more source
The response of eIF2α kinases to plant virus infection
, 2015 When the eukaryotic translation initiation factor 2 α (eIF2α) is phosphorylated in several eukaryotes, general mRNA translation is inhibited, but some mRNA species that contain an upstream open reading frame (uORF) are preferentially translated.
Immanuel, Tracey
core
Cell Death in Neurodegenerative Diseases: Molecular Mechanisms and Therapeutic Targets
MedComm, Volume 7, Issue 9, September 2026.Regulated cell death pathways, including apoptosis, necroptosis, pyroptosis, ferroptosis, and autophagy‐dependent cell death, interact with mitochondrial dysfunction, proteostasis failure, lysosomal stress, glial remodeling, and neuroinflammation across major neurodegenerative diseases.
Tianjiao Li +3 more
wiley +1 more source