Results 141 to 150 of about 27,813 (194)

Hypericin Suppresses Liver Cancer Through Autophagic Degradation of AKT and Eliciting Antitumor Immune Response

Cancer Science, Volume 117, Issue 9, Page 2567-2585, September 2026.
Hypericin induces autophagic AKT degradation by promoting AKT‐HSPA5 interaction in an S473 phosphorylation‐dependent manner, suppressing HCC growth. It enhances CD8+ T cell‐mediated antitumor immunity and synergizes with anti‐PD‐L1 therapy, showing favorable safety for HCC treatment. ABSTRACT Hepatocellular carcinoma (HCC) is the most prevalent primary
Sien Ma, Qianqian Xu, Mengjuan Zhu, Xianming Ge, Jian Xu, Yan Pan, Mengli Wang, Yuting Zhu, Aoxuan Xu, Hanmeng Liu, GuangHai Xiang, Weipeng Gong, Bao Zhao   +12 more
wiley   +1 more source

Huachansu triggers mitochondrial apoptosis and ER stress to inhibit hepatocellular carcinoma progression. [PDF]

Saudi Pharm J
Li X, Yan Q, Wu Q, Dong D, Zhang R, Meng Q, Xu C, Lai Y, Tan J, Yu C, Li L, Shen W, Chen Q, Cheng H, Sun D.   +14 more
europepmc   +1 more source

Etomidate Prevents Homocysteine‑Induced Endothelial Dysfunction by Suppressing PERK‑eIF2α‑ATF4 Signaling, Oxidative Stress, Mitochondrial Injury, and Autophagic Dysregulation. [PDF]

J Biochem Mol Toxicol
Song M, Tang H.
europepmc   +1 more source

Cepharanthine inhibits tick‑borne encephalitis virus infection through modulation of the stress and inflammation response. [PDF]

Int J Mol Med
Tang WD, Zhao LJ.
europepmc   +1 more source

Mechanism of eIF2α Kinase Inhibition by Viral Pseudokinase PK2

, 2011
Phosphorylation of eukaryotic translation initiation factor 2α (eIF2α) is a conserved eukaryotic mechanism to limit protein synthesis under stress conditions. Baculovirus PK2, which resembles the C-terminal half of a protein kinase domain, inhibits eIF2α
Li, John
core  

Translational resistance to amino acid starvation in breast cancer cells revealed by ribosome profiling. [PDF]

iScience
Li F, Zhang S, Duan H, Wolf DA, Yang X.
europepmc   +1 more source

牙鲆eIF2α激酶基因HRI和PKR的克隆、表达及功能分析

, 2006
当真核细胞面临各种外界压力时，可通过磷酸化真核翻译起始因子eIF2α的Ser51位点来调节蛋白的合成。目前发现了四种磷酸化eIF2α的丝氨酸/苏氨酸蛋白激酶，分别是HRI(the heme-regulated initiation factor 2α kinase)、PKR（the interferon inducible double-stranded RNA dependent protein kinase）、GCN2（the general control nonderepressible 2 ...
朱蓉
core  

CRM-1 Aggravates Stroke Injury by Promoting BANF1-Mediated Unfolded Protein Response Through Inducing Nuclear Export of ALKBH5. [PDF]

FASEB J
Liu C, Li C, Hu T, Duan W, Zheng L, Li A.   +5 more
europepmc   +1 more source

2-O-Methylhonokiol Suppresses 3T3-L1 Adipogenesis Through Metabolic Stress Signaling and Early Cell Cycle Restriction. [PDF]

Int J Mol Sci
Fu M, Singh MK, Kim G, Yoon KS, Kim SS, Ha J, Kang I, Choe W.   +7 more
europepmc   +1 more source

EIF2α-ATF4-CHAC1 Signalling Links ER Stress to Ferroptosis in Human Aortic Smooth Muscle Cells: Mechanistic Insights and Therapeutic Implications. [PDF]

J Cell Mol Med
Fang C, Du X, Wang Y, Jin Y, Wang W.
europepmc   +1 more source