Results 141 to 150 of about 28,887 (200)

Harnessing Terminalia arjuna in Next Generation Phytomedicine: Cutting Edge Nutraceutical Trends Shaping Food and Health

open access: yesFood Science &Nutrition, Volume 14, Issue 10, October 2026.
This graphical abstract illustrates the complete translational pipeline of Terminalia arjuna in modern phytomedicine and functional food development. It is rich in key bioactive compounds like arjunolic acid, arjungenin, flavonoids, and tannins which serve as the foundation for the plant's versatile medicinal uses and offers broad therapeutic benefits ...
Ishani Banerjee   +5 more
wiley   +1 more source

Electrical Pulse Stimulation Partially Restores Insulin Signaling in Palmitate‐Induced Insulin‐Resistant Skeletal Muscle Cells via Mitochondrial Remodeling and Contractile Activity‐Dependent Secretome

open access: yesJournal of Cellular Physiology, Volume 241, Issue 10, October 2026.
ABSTRACT Lipid oversupply induces insulin resistance in skeletal muscle (SkM), partly by altering mitochondrial function and dynamics. Although electrical pulse stimulation (EPS) improves insulin signaling in myotubes, the mechanisms contributing to this effect under lipotoxic conditions remain unclear.
Alessandro Falcone   +9 more
wiley   +1 more source

Cancer Cell Metastasis: From Molecular Mechanisms to Therapeutic Strategies

open access: yesMedComm, Volume 7, Issue 10, October 2026.
The schematic representation of intrinsic and extrinsic influences of cancer cell metastasis. Genomic evolution of metastatic tumor cells (MTCs) promotes their metastatic phenotypes and reconstruct the primary tumor microenvironment. During MTCs migration along different routes (blood circulation, lymphatic vessels, and perineuronal spaces), the ...
Yupeng Zhao   +7 more
wiley   +1 more source

Carbon Quantum Dots: From Mechanisms to Biomedical Applications

open access: yesMedComm, Volume 7, Issue 10, October 2026.
Carbon quantum dots (CQDs) are promising carbon‐based nanomaterials with broad biomedical applications, including bioimaging, drug delivery, biosensing, and tissue regeneration. This Review summarizes the biological mechanisms of CQDs in tissue regeneration, focusing on their regulation of cellular functions, immune responses, and redox balance.
Bingxin Fan   +7 more
wiley   +1 more source

Universal and Lineage‐Specific Patterns in the Distribution of ECOD Domain Homology Groups Across Superkingdoms

open access: yesProteins: Structure, Function, and Bioinformatics, Volume 94, Issue 10, Page 1644-1657, October 2026.
ABSTRACT Proteins are built from modular domains that serve as fundamental units of structure and evolution. While individual domains have been extensively cataloged, their collective distribution across the lineages of life has remained poorly resolved.
Rui Guo   +5 more
wiley   +1 more source

The Pathological Roles of Cationic Amino Acid Transporters (CATs) in Cancer

open access: yesCancer Science, Volume 117, Issue 10, Page 2636-2643, October 2026.
CAT family transporters (SLC7A1–SLC7A4) coordinate arginine allocation within the tumor microenvironment, thereby regulating cancer metabolism, mTORC1 signaling, immune responses, and metastatic progression. Emerging evidence supports context‐dependent roles for SLC7A1–SLC7A3, whereas the physiological and pathological functions of SLC7A4 remain poorly
Thant Thant Myo Oo, Yasuhiro Saito
wiley   +1 more source

The Unfolded Protein Response as a Modulator of Cancer‐Immune Cell Communication in the Tumour Microenvironment

open access: yesJournal of Cellular and Molecular Medicine, Volume 30, Issue 19, October 2026.
ABSTRACT The tumour microenvironment (TME) comprises a dynamic network of structural, cellular, and signalling components that interact to influence tumour development. Immune cells play a key role in recognizing and eliminating cancer cells through detection of tumour‐derived membrane and secreted proteins processed in the endoplasmic reticulum (ER ...
Yew Hwang Chee   +4 more
wiley   +1 more source

Cell-type-specific role of eiF2α pathway human Alzheimer’s disease brains

open access: yes
Protein synthesis is required for the consolidation of short-term memory into long-term memory, and it is regulated by various signaling pathways including the eIF2α pathway. The eIF2α pathway bidirectionally regulates the initiation of protein synthesis
Olotu , Samuel O.A.
core  

Cartilage Extracellular Matrix Homeostasis in Knee Osteoarthritis: Pathomechanisms and Therapeutic Targeting

open access: yesJournal of Cellular and Molecular Medicine, Volume 30, Issue 19, October 2026.
ABSTRACT Knee osteoarthritis (KOA) is a degenerative joint disease primarily driven by the disruption of homeostasis in the chondrocyte extracellular matrix (CECM). This review systematically examines the central role of CECM homeostasis in KOA pathogenesis and summarizes recent advances in this field.
Chao Du   +8 more
wiley   +1 more source

Transcriptomics Implicates the G3BP1–SG Axis in Cochlear Hair‐Cell Pyroptosis During Age‐Related Hearing Loss

open access: yesJournal of Cellular and Molecular Medicine, Volume 30, Issue 19, October 2026.
ABSTRACT Age‐related hearing loss (ARHL) is a degenerative change in the auditory system, but its underlying mechanism remains unclear. In this study, using RNA sequencing technology, we analysed the expression profiles of mRNAs in the cochlear tissues of ARHL‐susceptible C57BL/6J (C57) mice and relatively resistant CBA/CaJ (CBA) mice.
Chen Li   +11 more
wiley   +1 more source

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