Results 141 to 150 of about 28,887 (200)
This graphical abstract illustrates the complete translational pipeline of Terminalia arjuna in modern phytomedicine and functional food development. It is rich in key bioactive compounds like arjunolic acid, arjungenin, flavonoids, and tannins which serve as the foundation for the plant's versatile medicinal uses and offers broad therapeutic benefits ...
Ishani Banerjee +5 more
wiley +1 more source
ABSTRACT Lipid oversupply induces insulin resistance in skeletal muscle (SkM), partly by altering mitochondrial function and dynamics. Although electrical pulse stimulation (EPS) improves insulin signaling in myotubes, the mechanisms contributing to this effect under lipotoxic conditions remain unclear.
Alessandro Falcone +9 more
wiley +1 more source
Cancer Cell Metastasis: From Molecular Mechanisms to Therapeutic Strategies
The schematic representation of intrinsic and extrinsic influences of cancer cell metastasis. Genomic evolution of metastatic tumor cells (MTCs) promotes their metastatic phenotypes and reconstruct the primary tumor microenvironment. During MTCs migration along different routes (blood circulation, lymphatic vessels, and perineuronal spaces), the ...
Yupeng Zhao +7 more
wiley +1 more source
Carbon Quantum Dots: From Mechanisms to Biomedical Applications
Carbon quantum dots (CQDs) are promising carbon‐based nanomaterials with broad biomedical applications, including bioimaging, drug delivery, biosensing, and tissue regeneration. This Review summarizes the biological mechanisms of CQDs in tissue regeneration, focusing on their regulation of cellular functions, immune responses, and redox balance.
Bingxin Fan +7 more
wiley +1 more source
ABSTRACT Proteins are built from modular domains that serve as fundamental units of structure and evolution. While individual domains have been extensively cataloged, their collective distribution across the lineages of life has remained poorly resolved.
Rui Guo +5 more
wiley +1 more source
The Pathological Roles of Cationic Amino Acid Transporters (CATs) in Cancer
CAT family transporters (SLC7A1–SLC7A4) coordinate arginine allocation within the tumor microenvironment, thereby regulating cancer metabolism, mTORC1 signaling, immune responses, and metastatic progression. Emerging evidence supports context‐dependent roles for SLC7A1–SLC7A3, whereas the physiological and pathological functions of SLC7A4 remain poorly
Thant Thant Myo Oo, Yasuhiro Saito
wiley +1 more source
ABSTRACT The tumour microenvironment (TME) comprises a dynamic network of structural, cellular, and signalling components that interact to influence tumour development. Immune cells play a key role in recognizing and eliminating cancer cells through detection of tumour‐derived membrane and secreted proteins processed in the endoplasmic reticulum (ER ...
Yew Hwang Chee +4 more
wiley +1 more source
Cell-type-specific role of eiF2α pathway human Alzheimer’s disease brains
Protein synthesis is required for the consolidation of short-term memory into long-term memory, and it is regulated by various signaling pathways including the eIF2α pathway. The eIF2α pathway bidirectionally regulates the initiation of protein synthesis
Olotu , Samuel O.A.
core
ABSTRACT Knee osteoarthritis (KOA) is a degenerative joint disease primarily driven by the disruption of homeostasis in the chondrocyte extracellular matrix (CECM). This review systematically examines the central role of CECM homeostasis in KOA pathogenesis and summarizes recent advances in this field.
Chao Du +8 more
wiley +1 more source
ABSTRACT Age‐related hearing loss (ARHL) is a degenerative change in the auditory system, but its underlying mechanism remains unclear. In this study, using RNA sequencing technology, we analysed the expression profiles of mRNAs in the cochlear tissues of ARHL‐susceptible C57BL/6J (C57) mice and relatively resistant CBA/CaJ (CBA) mice.
Chen Li +11 more
wiley +1 more source

