Results 101 to 110 of about 27,813 (194)

Guanabenz Downregulates Inflammatory Responses via eIF2α Dependent and Independent Signaling

, 2016
Integrated stress responses (ISR) may lead to cell death and tissue degeneration via eukaryotic translation initiation factor 2 α (eIF2α)-mediated signaling.
Andy Chen, Bai-Yan Li, Akihiro Sudo, Chen, Andy, Yokota, Hiroki, Shengzhi Liu, Takigawa, Shinya, Liu, Shengzhi, Hamamura, Kazunori, Kazunori Hamamura, Li, Bai-Yan, Shinya Takigawa, Hiroki Yokota, Nishimura, Akinobu, Sudo, Akihiro, Akinobu Nishimura   +15 more
core   +1 more source

eIF2α controls memory consolidation via excitatory and somatostatin neurons

, 2020
An important tenet of learning and memory is the notion of a molecular switch that promotes the formation of long-term memory1,2,3,4. The regulation of proteostasis is a critical and rate-limiting step in the consolidation of new memories5,6,7,8,9,10 ...
Cohen, Noah, Stokes, Matthew P., Hung, Tzu-Yu, Possemato, Anthony P., Eslamizade, Mohammad Javad, Khlaifia, Abdessattar, Quintana, Albert, Rosenblum, Kobi, Cuello, A. Claudio, Sanz, Elisenda, Lalzar, Maya, Lacaille, Jean-Claude, Sonenberg, Nahum, Abell, Kathryn, Sharma, Vijendra, Wang, Peng, Kaufman, Randal J., Khoutorsky, Arkady, Asgarihafshejani, Azam, Costa-Mattioli, Mauro, Truong, Vinh T., Lou, Danning, Kiniry, Stephen J., Sood, Rapita, Nader, Karim, Baranov, Pavel V., Gal-Ben-Ari, Shunit, Saffarzadeh, Fatemeh, Nelson, Alissa J., Yiannakas, Adonis   +29 more
core   +1 more source

TcALS knockdown accelerates metamorphosis via insulin signaling in Tribolium castaneum

Insect Science, EarlyView.
RNAi silencing of TcALS accelerates larva‐to‐pupa metamorphosis in Tribolium castaneum. Abstract Insect metamorphosis is an evolutionary adaptation precisely regulated by nutritional and hormonal cues. The red flour beetle Tribolium castaneum, a major stored‐product pest, serves as an excellent model for studying this process.
Min Li, Jie Chen, Zi‐Ye Wang, Fei‐Feng Wang, Lu‐Lu Dong, Jun Pan, Min‐Er Li, Lin Yu, Wen Sang   +8 more
wiley   +1 more source

Activation of the PERK/eIF2α axis is a pivotal prerequisite of taxanes to cancer cell apoptosis and renders synergism to overcome paclitaxel resistance in breast cancer cells

Cancer Cell International
Background Microtubule polymerization is usually considered as the upstream of apoptotic cell death induced by taxanes, but recently published studies provide more insights into the mechanisms responsible for the antineoplastic effect of taxanes. In this
Wanhua Cai, Dade Rong, Jiayu Ding, Xiaomei Zhang, Yuwei Wang, Ying Fang, Jing Xiao, Shulan Yang, Haihe Wang   +8 more
doaj   +1 more source

Inhibition of eIF2α dephosphorylation inhibits ErbB2-induced deregulation of mammary acinar morphogenesis

BMC Cell Biology, 2009
Background The ErbB2/Her2/Neu receptor tyrosine kinase is amplified in ~30% of human breast cancers. Phosphorylation of the translation initiation factor, eIF2α inhibits global protein synthesis and activates a stress signaling and growth suppressive ...
Avivar-Valderas Alvaro, Wen Huei, Sequeira Sharon J, Farias Eduardo F, Aguirre-Ghiso Julio A   +4 more
doaj   +1 more source

Lewy bodies are surrounded by granulovacuolar degeneration bodies in dementia with Lewy bodies

Brain Pathology, EarlyView.
Here, we report Lewy bodies (LBs) to be enriched for tau‐laden granulovacuolar degeneration bodies (GVBs), suggesting a potential mechanistic interface between α‐synuclein and tau pathology in dementia with Lewy bodies (DLB). Abstract Lewy bodies (LBs), composed primarily of aggregated α‐synuclein (α‐syn), are the pathological hallmark of Lewy body ...
Searlait Thom, Pawel Palmowski, Andrew Porter, Joe O'Neill, Johannes Attems, Laura A. Smith, Viktor I. Korolchuk, Daniel Erskine   +7 more
wiley   +1 more source

Pharmacological brake-release of mRNA translation enhances cognitive memory

eLife, 2013
Phosphorylation of the α-subunit of initiation factor 2 (eIF2) controls protein synthesis by a conserved mechanism. In metazoa, distinct stress conditions activate different eIF2α kinases (PERK, PKR, GCN2, and HRI) that converge on phosphorylating a ...
Carmela Sidrauski, Diego Acosta-Alvear, Arkady Khoutorsky, Punitha Vedantham, Brian R Hearn, Han Li, Karine Gamache, Ciara M Gallagher, Kenny K-H Ang, Chris Wilson, Voytek Okreglak, Avi Ashkenazi, Byron Hann, Karim Nader, Michelle R Arkin, Adam R Renslo, Nahum Sonenberg, Peter Walter   +17 more
doaj   +1 more source

Histone deacetylase inhibitors as venetoclax‐sensitising partners in acute myeloid leukaemia: Mechanisms, pharmacology and translational perspectives

British Journal of Pharmacology, EarlyView.
Abstract Venetoclax combined with hypomethylating agents has improved treatment for older or unfit patients with acute myeloid leukaemia (AML), but resistance and relapse remain common. This review analyses the rationale for combining venetoclax with inhibitors of histone deacetylase (HDAC).
Jaebok Lee, Marc Diederich
wiley   +1 more source

Involvement of eIF2α in salubrinal-driven Cyto-Src activity.

, 2014
(A, B) C28/I2 cells were cotransfected with Cyto-Src or Lyn-Src biosensor, and eIF2α or NC siRNA, and then treated with 10 µM salubrinal for 1 hour during imaging. (A) eIF2α siRNA blocks inhibitory effect of salubrinal on Cyto-Src activity.
Qiaoqiao Wan (621794), Sungsoo Na (262181), Jing-long Yan (621796), Wenxiao Xu (621795), Hiroki Yokota (507062)   +4 more
core   +1 more source

Phosphorylation of the Translation Initiation Factor eIF2α Increases BACE1 Levels and Promotes Amyloidogenesis [PDF]

, 2008
Summaryβ-site APP cleaving enzyme-1 (BACE1), the rate-limiting enzyme for β-amyloid (Aβ) production, is elevated in Alzheimer's disease (AD). Here, we show that energy deprivation induces phosphorylation of the translation initiation factor eIF2α (eIF2α ...
Sadleir, Katherine R., De Strooper, Bart, Vassar, Robert, Velliquette, Rodney A., O'Connor, Tracy, Haass, Christian, Bennett, David A., Eimer, William A., Hitt, Brian, Hébert, Sébastien, Lammich, Sven, Hébert, Sébastien S., Cole, Sarah L., Maus, Erika, Bembinster, Leslie A., Lichtenthaler, Stefan F., Zhao, Jie   +16 more
core   +1 more source