Results 81 to 90 of about 27,813 (194)

Xrp1-mediated phosphorylation of eIF2α commonly drives cell competition.

, 2021
(A-A”) Xrp1-lacZ/+ background wing disc bearing hsFLP-induced GFP-labeled clones of RpL14/+, salE>GFP cells stained with anti-β-gal. (B-B”) Wild-type background wing disc bearing hsFLP-induced GFP-labeled clones of RpL14/+, salE>GFP cells stained with ...
Ryosuke Nakano (4557097), Tatsushi Igaki (10047238), Mai Nakamura (634579), Rina Nagata (11797964), Naotaka Ochi (11797961), Naoki Wakasa (11797967)   +5 more
core   +1 more source

Recent Advances in Virus–Host Interactions, Antiviral Bioactive Compounds, and Breeding for Disease Resistance of Porcine Epidemic Diarrhea Virus

Animal Research and One Health, EarlyView.
Basic research on the PEDV infection cycle and virus–host interactions advances the development of anti‐PEDV drugs and disease‐resistant breeding and helps strengthen disease prevention and control while reducing economic losses in the swine industry.
Heyong Wu, Aosi Qi, Shuyu Zhong, Haozhen Du, Shimeng Guo, Hongsheng Ouyang, Hongming Yuan, Daxin Pang, Zicong Xie   +8 more
wiley   +1 more source

The phosphorylation of carboxyl-terminal eIF2α by SPA kinases contributes to enhanced translation efficiency during photomorphogenesis

Nature Communications
Light triggers an enhancement of global translation during photomorphogenesis in Arabidopsis, but little is known about the underlying mechanisms. The phosphorylation of the α-subunit of eukaryotic initiation factor 2 (eIF2α) at a conserved serine ...
Hui-Hsien Chang, Lin-Chen Huang, Karen S. Browning, Enamul Huq, Mei-Chun Cheng   +4 more
doaj   +1 more source

Increased eIF2α phosphorylation in response to radiation:

, 2013
a. MCF-7 and b. MDA-MB-231 cells were irradiated with the indicated radiation dose and processed for analysis of eIF2α phosphorylation at the noted time post-irradiation. c.
Liron Tuval-Kochen (476856), Charles Nakar (476859), Tamar Golani (476860), Shoshana Paglin (476857), Yaniv Lerenthal (476858), Joachim Yahalom (476861), Gilmor Keshet (247078), Yaacov Lawrence (476863), Raphael Pfeffer (476862), Amos Toren (267124)   +9 more
core   +1 more source

The Effects of Angiotensin Receptor Neprilysin Inhibitor on Endoplasmic Reticulum Stress in Doxorubicin‐Mediated Cardiomyopathy‐Associated Heart Failure Model in Rats

Journal of Applied Toxicology, EarlyView.
ABSTRACT One of the most serious complications associated with the use of the chemotherapeutic agent doxorubicin (DOX) is cardiomyopathy. Although cardioprotective drugs such as angiotensin receptor‐neprilysin inhibitors (ARNI) are used to prevent cardiomyopathy in DOX patients, no studies have reported the relationship between ARNI and endoplasmic ...
Mert Unvan, Meryem İlkay Karagül, Hatice Oruç Demirbağ, Ebru Balli   +3 more
wiley   +1 more source

Hypothalamic eIF2α Signaling Regulates Food Intake

Cell Reports, 2014
The reversible phosphorylation of the α subunit of eukaryotic initiation factor 2 (eIF2α) is a highly conserved signal implicated in the cellular adaptation to numerous stresses such as the one caused by amino acid limitation.
Anne-Catherine Maurin, Alexandre Benani, Anne Lorsignol, Xavier Brenachot, Laurent Parry, Valérie Carraro, Christophe Guissard, Julien Averous, Céline Jousse, Alain Bruhat, Cédric Chaveroux, Wafa B’chir, Yuki Muranishi, David Ron, Luc Pénicaud, Pierre Fafournoux   +15 more
doaj   +1 more source

DHT induces phosphorylation of eIF2α in an AR-dependent manner.

, 2013
A) Representative western blots indicating an increase in eIF2α-P in response to DHT addition in 22Rv1 cells. This effect was abrogated in PC3 cells, which do not express AR (right).
Christopher B. Geyer (279815), Vesna A. Chappell (279813), Thomas Green (279814), Adam S. Asch (196033), Maria J. Ruiz-Echevarría (279816), Ryan F. Overcash (279812)   +5 more
core   +1 more source

Bisphenol Analog‐Induced Cytotoxicity: Unraveling Endoplasmic Reticulum (ER) Stress and Apoptotic Pathways

Journal of Applied Toxicology, EarlyView.
ABSTRACT Bisphenol A (BPA) is increasingly replaced by structural analogs, yet their safety remains insufficiently characterized. This study investigated whether BPA and selected analogs, bisphenol AF (BPAF), bisphenol AP (BPAP), bisphenol P (BPP), and bisphenol E (BPE), induce cytotoxicity through activation of endoplasmic reticulum (ER) stress and ...
Rafia Afroze Rifa, Ramon Lavado
wiley   +1 more source

AGAP1-associated endolysosomal trafficking abnormalities link gene–environment interactions in neurodevelopmental disorders

Disease Models & Mechanisms, 2023
Sara A. Lewis, Somayeh Bakhtiari, Jacob Forstrom, Allan Bayat, Frédéric Bilan, Gwenaël Le Guyader, Ebba Alkhunaizi, Hilary Vernon, Sergio R. Padilla-Lopez, Michael C. Kruer   +9 more
doaj   +1 more source

Betacoronaviruses Differentially Activate the Integrated Stress Response to Optimize Viral Replication in Lung-Derived Cell Lines

Viruses
The betacoronavirus genus contains five of the seven human coronaviruses, making it a particularly critical area of research to prepare for future viral emergence. We utilized three human betacoronaviruses, one from each subgenus—HCoV-OC43 (embecovirus),
David M. Renner, Nicholas A. Parenti, Nicole Bracci, Susan R. Weiss   +3 more
doaj   +1 more source