Results 81 to 90 of about 32,812 (263)

MiR-552 is a target gene of ATF4 in VSMCs.

, 2022
(A) qRT-PCR assay was conducted to assess the expression level of the top five TFs expression. (Student’s t test) (B) The impact of ATF4 elevation on SKI in HBVSMCs and mVSMCs was tested with western blot assay.
Wenxian Tu (13124235), Meina Feng (13124232), Yunfeng Wang (290822), Kang Xu (708915), Yuanmin Du (1721401), Qin Zhou (239082)   +5 more
core   +1 more source

GPR68 Inhibition Induces Ferroptosis in Atypical Teratoid Rhabdoid Tumors [PDF]

Cancer Rep (Hoboken)
ABSTRACT Background Atypical teratoid/rhabdoid tumors (ATRTs) are aggressive pediatric CNS malignancies with < 30% 5‐year survival despite multimodal therapy. No prior studies have explored ferroptosis induction in ATRT. Aims To determine whether GPR68 inhibition by ogremorphin (OGM) induces ATF4‐dependent ferroptosis in ATRT cell lines and whether ...
Neitzel L, Hong C.
europepmc   +2 more sources

Pre-print data on ATF4 paper

, 2023
BWA and MACS2 data from the article about ATF4 regulation of tracheal epithelial differentiation.
Angel Carlos Roman (12077375)
core   +1 more source

Expanding Genetic Code to Generate Human Brain Organoids with Both Vasculature and Microglia‐Like Cells

Advanced Science, EarlyView.
Using genetic code expansion, we engineered vascularized human cerebral organoids (vhCOs) with microglia‐like cells and blood‐brain barrier features. vhCOs recapitulate neurovascular interactions, regional identities, and neuronal subtypes resembling the fetal brain.
Haishuang Lin, Yaqing Wang, Hu Du, Yuxin Qin, Haoyu Zhang, Peng Wang, Lin Wei, Jianhua Qin   +7 more
wiley   +1 more source

Inhibition of signaling protein ERN1 increases the sensitivity of serine synthesis gene expressions to glucose and glutamine deprivations in U87MG glioblastoma cells

Endocrine Regulations
Objective. Glucose and glutamine supply as well as serine synthesis and endoplasmic reticulum (ER) stress are important factors of glioblastoma growth. Previous studies showed that the knockdown of ERN1 (ER to nucleus signaling 1) suppressed glioblastoma
Minchenko Oleksandr H., Sliusar Myroslava Y., Khita Olena O., Minchenko Dmytro O., Viletska Yuliia M., Halkin Oleh V., Levadna Liudmyla O., Cherednychenko Anastasiia A., Khikhlo Yevgen P.   +8 more
doaj   +1 more source

ATF4 primer information table.

, 2016
ATF4 primer information table.
Jing Yuan (217967), Meixia Fang (747684), Qingyun Xu (2574106), Ruixue Chen (3045180), Liguo Chen (3045183), Ling He (282204)   +5 more
core   +1 more source

miR-320a activates ATF4 during ER stress.

, 2021
(A) RT-qPCR quantification of spliced(s)-XBP1, BiP, and CHOP mRNA in HCT116 cells transfected with miR-320a mimic. Data are shown as the average of three biological replicates with a standard deviation and individual data points.
Tongjun Gu (177923), Nicholas M. Hiers (11846090), Peike Sheng (381106), Tianqi Li (1335987), Michael S. Kilberg (11846096), Lauren Gay (8196042), Lu Li (14069), Taha Huda (11846093), Jiang Bian (662830), Rolf Renne (30420), Mingyi Xie (9954031), Christopher J. Fields (11834393), Jixiu Shan (285719)   +12 more
core   +1 more source

High‐Density Type I Collagen Promotes IFN‐γ+ CD8+ T Cell Exhaustion via SAT1‐ASS1‐Mediated Glutamine Accumulation and Ferroptosis in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
High‐density type I collagen promotes glutamine (Gln) accumulation–related ferroptosis of TNBC cells via the spermidine/spermine N1‐acetyltransferase 1 (SAT1)‐ argininosuccinate synthase (ASS1) signaling pathway, thus depriving immune cells of Gln supply and inducing IFN‐γ+ CD8+ T cell exhaustion in the TME.
Jinyan Wang, Shuangyue Pan, Lu Bai, Bin Li, Tiantian Liu, Jianing Cao, Mengdi Yang, Heda Zhang, Duancheng Guo, Wenxiang Zhi, Zhonghua Tao, Xichun Hu   +11 more
wiley   +1 more source

Salvianolic Acid a Disrupts the HSP90α‐AKT‐PERK Ternary Complex to Alleviate Atherosclerosis by Activating Endoplasmic Reticulum Stress of Senescent Vascular Smooth Muscle Cells

Advanced Science, EarlyView.
Salvianolic acid A (SAA) selectively induces senescent vascular smooth muscle cell apoptosis, alleviating atherosclerosis. Mechanistically, SAA targets heat shock protein 90 alpha (HSP90α) to disrupt the protein inase B (AKT)‐PRKR‐Like Endoplasmic Reticulum Kinase (PERK) scaffold, driving ubiquitin‐proteasome‐dependent AKT degradation.
Xiuya Guan, Mengkai Lu, Xinhai Cui, Dawei Zhang, Lei Zhang, Lin Lin, Yuan Li, Yuanlong Hu, Chao Li   +8 more
wiley   +1 more source

Glutaminolysis Blockade‐Empowered Bimodal Nanodepot for Spatially Complementary Sono‐Thermal Ablation via PANoptosis and STING Activation Against Large Tumors

Advanced Science, EarlyView.
An injectable bimodal TCPD nanodepot disrupts glutaminolysis and TCA metabolism, sensitizing large tumors to spatially complementary sono‐thermal ablation for complete treatment coverage. This intervention induces mitochondrial and endoplasmic reticulum dysfunction, genotoxicity, and NAD+ depletion, converging to trigger PANoptosome assembly and ...
Yi‐Ming Liu, Juan Qin, Si‐Yuan Wu, Xue‐Zhen Zhu, Yun‐Fei Cai, Pei‐Yao Sun, Hao Yang, Xing‐Yue Wang, Shu Li, Duo Wang, Hai‐Dong Zhu   +10 more
wiley   +1 more source