Results 81 to 90 of about 31,889 (263)

MiR-552 is a target gene of ATF4 in VSMCs.

, 2022
(A) qRT-PCR assay was conducted to assess the expression level of the top five TFs expression. (Student’s t test) (B) The impact of ATF4 elevation on SKI in HBVSMCs and mVSMCs was tested with western blot assay.
Wenxian Tu (13124235), Meina Feng (13124232), Yunfeng Wang (290822), Kang Xu (708915), Yuanmin Du (1721401), Qin Zhou (239082)   +5 more
core   +1 more source

An Integrative Strategy Delineates Modular Metabolic Remodeling and Potential Therapeutic Targets Across Metabolic Diseases

Advanced Science, EarlyView.
An integrative single‐cell atlas across multiple metabolic diseases reveals coordinated metabolic modules and disease‐shared versus disease‐specific pathway activities. By systematically comparing scoring strategies, a robust RankAve framework is established. Coupled with network analysis and drug‐target prediction, this resource uncovers cross‐disease
Kuan Yang, Congxue Hu, Hang Zhao, Xiao Peng, Yiming Yan, Jiasi Wang, Wenqi Jiang, Depeng Mu, Yan Cao, Xia Li, Yunpeng Zhang   +10 more
wiley   +1 more source

Pre-print data on ATF4 paper

, 2023
BWA and MACS2 data from the article about ATF4 regulation of tracheal epithelial differentiation.
Angel Carlos Roman (12077375)
core   +1 more source

Molecular and Cellular Hallmarks of Age‐Related Vestibular Hair Cell Degeneration

Advanced Science, EarlyView.
This study utilizes single‐cell RNA‐seq transcriptomes, advanced imaging, and electrophysiology to examine universal and cell‐type‐specific aging signatures of vestibular hair cells. The study shows that impaired hair bundle function is a key driver of age‐related vestibular dysfunction.
Samadhi Kulasooriya, Huizhan Liu, Sarath Vijayakumar, Celia Bloom, Zhenhang Xu, Shu Tu, Benjamin J. Borgmeier, Mi Zhou, Litao Tao, Bechara Kachar, David Z. He   +10 more
wiley   +1 more source

Inhibition of signaling protein ERN1 increases the sensitivity of serine synthesis gene expressions to glucose and glutamine deprivations in U87MG glioblastoma cells

Endocrine Regulations
Objective. Glucose and glutamine supply as well as serine synthesis and endoplasmic reticulum (ER) stress are important factors of glioblastoma growth. Previous studies showed that the knockdown of ERN1 (ER to nucleus signaling 1) suppressed glioblastoma
Minchenko Oleksandr H., Sliusar Myroslava Y., Khita Olena O., Minchenko Dmytro O., Viletska Yuliia M., Halkin Oleh V., Levadna Liudmyla O., Cherednychenko Anastasiia A., Khikhlo Yevgen P.   +8 more
doaj   +1 more source

ATF4 primer information table.

, 2016
ATF4 primer information table.
Jing Yuan (217967), Meixia Fang (747684), Qingyun Xu (2574106), Ruixue Chen (3045180), Liguo Chen (3045183), Ling He (282204)   +5 more
core   +1 more source

miR-320a activates ATF4 during ER stress.

, 2021
(A) RT-qPCR quantification of spliced(s)-XBP1, BiP, and CHOP mRNA in HCT116 cells transfected with miR-320a mimic. Data are shown as the average of three biological replicates with a standard deviation and individual data points.
Tongjun Gu (177923), Nicholas M. Hiers (11846090), Peike Sheng (381106), Tianqi Li (1335987), Michael S. Kilberg (11846096), Lauren Gay (8196042), Lu Li (14069), Taha Huda (11846093), Jiang Bian (662830), Rolf Renne (30420), Mingyi Xie (9954031), Christopher J. Fields (11834393), Jixiu Shan (285719)   +12 more
core   +1 more source

QRICH1 Disrupts Endoplasmic Reticulum Homeostasis and Amplifies NF‐κB Signaling in Periodontal Ligament Stem Cells to Exacerbate Diabetic Periodontitis

Advanced Science, EarlyView.
QRICH1 has been established as a key factor contributing to impaired osteogenic potential and accelerated apoptosis of PDLSCs in diabetic periodontitis. QRICH1 not only significantly enhances UPR‐associated apoptotic signaling but also amplifies NF‐κB‐mediated inflammatory responses. Its inhibition restores osteogenic capacity and reduces alveolar bone
Han Li, Xiaoyu Yang, He Wang, Yunchun Kuang, Yiyao Hu, Houxuan Li, Shuhong Li, Deping Zeng, Jie Li, Jinlin Song   +9 more
wiley   +1 more source

Aberrant GRP78 Phase Transition Sustains Endothelial IRE1α Signaling and Drives Blood–Brain Barrier Failure in Cerebral Amyloid Angiopathy

Advanced Science, EarlyView.
Vascular Aβ40 corrupts GRP78 phase behavior in brain endothelial cells, sustaining IRE1α–TRAF2–JNK signaling and driving apoptosis, tight junction loss, and blood–brain barrier failure in cerebral amyloid angiopathy. Pharmacological IRE1α inhibition restores vascular integrity, reduces leakage, and improves functional outcomes, revealing a targetable ...
Honglin Zheng, Qiang Li, Haiyang Luo, Yapei Yuan, Na Zhang, Yongting Lu, Suying Duan, Jieshi Zhong, Hang Zhang, Chenyang Liu, Yaochong Zhang, Wenzhuo Zhao, Yaxuan Song, Tuo Wang, Si Yan, Yapeng Li, Han Liu, Yuan Gao, Zongping Xia, Yuming Xu   +19 more
wiley   +1 more source

Early Atf4 activity drives airway club and goblet cell differentiation

Life Science Alliance
PERK/Atf4 drives airway epithelial differentiation, impacting secretory cell numbers, revealing ATF4’s role in respiratory tract regeneration. Activating transcription factor 4 (Atf4), which is modulated by the protein kinase RNA-like ER kinase (PERK ...
Juan F Barrera-Lopez, Guadalupe Cumplido-Laso, Marcos Olivera-Gomez, Sergio Garrido-Jimenez, Selene Diaz-Chamorro, Clara M Mateos-Quiros, Dixan A Benitez, Francisco Centeno, Sonia Mulero-Navarro, Angel C Roman, Jose M Carvajal-Gonzalez   +10 more
doaj   +1 more source