Results 81 to 90 of about 30,346 (252)

Atf4 Regulates Obesity, Glucose Homeostasis, and Energy Expenditure [PDF]

Diabetes, 2009
OBJECTIVE We evaluate a potential role of activating transcription factor 4 (Atf4) in invertebrate and mammalian metabolism. RESEARCH DESIGN AND METHODS With two parallel approaches—a fat body–specific green fluorescent protein enhancer trap screen ...
Seo, J Seo, Jin, Fortuno, ES Fortuno, Edgardo S., III, Suh, JM Suh, Jae Myoung, Stenesen, D Stenesen, Drew, Tang, W Tang, Wei, Parks, EJ Parks, Elizabeth J., Adams, CM Adams, Christopher M., Townes, T Townes, Tim, Graff, JM Graff, Jonathan M.   +8 more
openaire   +3 more sources

ATF4 siRNA blocks basal F7 expression. A.

, 2012
siRNA directed to either the 5' UTR (ATF4 si#1, white bars) or the 3' UTR (ATF4 si#2, striped bars) of the human ATF4 gene were introduced into HepG2 cells cultured in media with 5 mM glucose.
Josephine A. Carew (146600), Katherine R. Cronin (146594), Thomas P. Mangan (146597)   +2 more
core   +1 more source

MiR-552 is a target gene of ATF4 in VSMCs.

, 2022
(A) qRT-PCR assay was conducted to assess the expression level of the top five TFs expression. (Student’s t test) (B) The impact of ATF4 elevation on SKI in HBVSMCs and mVSMCs was tested with western blot assay.
Wenxian Tu (13124235), Meina Feng (13124232), Yunfeng Wang (290822), Kang Xu (708915), Yuanmin Du (1721401), Qin Zhou (239082)   +5 more
core   +1 more source

The Role of Sirtuin 1 in Palmitic Acid-Induced Endoplasmic Reticulum Stress in Cardiac Myoblasts

Life, 2022
Background: Lipotoxicity causes endoplasmic reticulum (ER) stress, leading to cell apoptosis. Sirtuin 1 (Sirt1) regulates gene transcription and cellular metabolism. In this study, we investigated the role of Sirt1 in palmitate-induced ER stress. Methods:
Hsiang-Yu Yang, Jhao-Ying Chen, Yen-Nien Huo, Pei-Ling Yu, Pei-Zhen Lin, Shih-Che Hsu, Shih-Ming Huang, Chien-Sung Tsai, Chih-Yuan Lin   +8 more
doaj   +1 more source

Caveolin‐1 Stabilizes SERCA2 to Counteract Acute Kidney Injury via Suppression of Ca2+‐Dependent Endoplasmic Reticulum Stress in Distal Tubules

Advanced Science, EarlyView.
In AKI, initial kidney injury upregulates the expression of Cav‐1, which subsequently binds to and stabilizes SERCA2 via its scaffolding domain and through deubiquitination, thereby regulating Ca2+ homeostasis and ER stress. Conversely, Cav‐1 deficiency accelerates SERCA2 degradation, triggering Ca2+ overload and ER stress, and ultimately exacerbating ...
Yan Zhang, Xin He, Hao Huang, Rong Lu, Xin Lv, Shenglan Li, Sijue Zou, Jiawei Cheng, Yiwei Xiong, Zhenghao Deng, Qiongjing Yuan, Yanyun Xie, Ling Huang, Jiaxi Pu, Shao Liu, Qianbin Li, Jie Meng, Huixiang Yang, Lijian Tao, Zhangzhe Peng   +19 more
wiley   +1 more source

Intrinsically Mitochondria‐Targeting Nanozyme via Coordination‐Assembly of Natural Quercetin for Cascade Antioxidant Therapy of Cerebral Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
This study uncovers that quercetin naturally targets mitochondria. By coordinating quercetin with Fe3+, we engineer an ultrasmall cascade nanozyme (MCN) with superoxide dismutase‐catalase activities. MCN crosses the damaged blood–brain barrier, scavenges mitochondrial ROS, prevents mitochondrial DNA leakage, and blocks the cGAS‐STING pathway, thereby ...
Wenxuan Zheng, Zhicheng Wang, Xin Zhou, Shuya Wang, Xiaojing Shi, Tingli Xiong, Ruishi Li, Yuting Lin, Zhen Chen, Jiawen Wei, Fei Li, Jinwen Ge, Kelong Ai, Chong Liu, Guiming Deng   +14 more
wiley   +1 more source

Activating transcription factor 4 regulates stearate-induced vascular calcification

Journal of Lipid Research, 2012
Previously, we reported that stearate, a saturated fatty acid, promotes osteoblastic differentiation and mineralization of vascular smooth muscle cells (VSMC).
Masashi Masuda, Tabitha C. Ting, Moshe Levi, Sommer J. Saunders, Shinobu Miyazaki-Anzai, Makoto Miyazaki   +5 more
doaj   +1 more source

Spatiotemporal Targeting Randle Cycle and Immune Checkpoint for Potent Antitumor Therapy

Advanced Science, EarlyView.
A glucose oxidase‐based nanogel (GOX‐NG) system using catechol‐functionalized alginate, exhibits enhanced tumor penetration, prolonged retention, and sustained glucose depletion in the tumor microenvironment. When combined with a fatty acid oxidation inhibitor, it implements dual metabolic suppression, thereby enhancing ROS‐induced immunogenic cell ...
Yuan Gao, Zijian Gong, Yixuan Fu, Jianan Zheng, Xiao Sang, Binglin Chen, Qinzhi Su, Weiping Gao, Fei Duan, Jinqi Wei, Xuliang Deng, Xinyu Liu   +11 more
wiley   +1 more source

In vivo ATF4 reporter, tub-ATF4.5′UTR>dsRed responds to protein misfolding.

, 2015
(A) The structure of the ATF4 translational activation reporter, tub-ATF4.5′UTR>dsRed. The dsRed ORF replaces that of ATF4, thereby reporting ATF4′s translation. (B-E) Validation of the reporter response in vivo.
Hyung Don Ryoo (440989), Min-Ji Kang (464343), Jee-Hyun Yoon (491218), Kwonyoon Kang (740150), Jung-Eun Park (480566)   +4 more
core   +1 more source

Pre-print data on ATF4 paper

, 2023
BWA and MACS2 data from the article about ATF4 regulation of tracheal epithelial differentiation.
Angel Carlos Roman (12077375)
core   +1 more source