Results 131 to 140 of about 30,346 (252)
Neuropsychiatric Disease and TreatmentWentao Wu,1,* Fei Wen,1,* Jiaxin Hu,1 Leijun Li2 1Department of Psychiatry, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou City, Guangdong Province, People’s Republic of China; 2Department of Psychiatry, The Third ...
Wu W, Wen F, Hu J, Li L
doaj
The FEBS Journal, EarlyView.Proteostasis ensures proper protein folding, modification, and degradation, while its impairment triggers ER stress. Chronic ER stress and maladaptive UPR via the CHOP–ERO1 axis remodel ERMCs, altering calcium signaling and mitochondrial metabolism.
Giorgia Maria Renna +5 more
wiley +1 more source
Proteostasis of organelles in aging and disease
The FEBS Journal, EarlyView.Cells rely on regulated proteostasis mechanisms to keep their internal compartments functioning properly. When these mechanisms fail, damaged proteins accumulate, disrupting organelles, such as the nucleus, mitochondria, endoplasmic reticulum, Golgi, and lysosomes, as well as membraneless organelles, such as stress granules, processing bodies, the ...
Yara Nabawi +5 more
wiley +1 more source
, 2020 Presentation of poster 1003A at TAGC 2020 Online. Files include a PDF of the poster (TAGC2020_Poster_HMD_Final.pdf) and an 8-minute audio walkthrough of the poster material (TAGC2020_Audio_HMD_Final.mp3).
Dalton, Hans M. +3 more
openaire +1 more source
Scientific ReportsIn brown adipose tissue (BAT), short-term cold exposure induces the activating transcription factor 4 (ATF4), and its downstream target fibroblast growth factor 21 (FGF21).
Sarah H. Bjorkman +12 more
doaj +1 more source
Abstract 055 | The importance of mitochondrial stress response regulators in aged muscle
European Journal of Translational MyologyIn skeletal muscle, the health and adaptive capacity of the mitochondrial network is regulated by mitochondrial quality control (MQC) mechanisms (1). The Mitochondrial Integrated Stress Response (ISR) and Unfolded Protein Response (UPRmt) are conserved ...
Victoria C. Sanfrancesco
doaj +1 more source
GCN2 in proteostasis: structural logic, signalling networks and disease
The FEBS Journal, EarlyView.Threats to protein synthesis activate the kinase GCN2, initiating the integrated stress response (ISR). GCN2 is triggered by stalled ribosomes and uncharged tRNAs, which accumulate when amino acids are scarce. The ISR adjusts cellular physiology by promoting redox balance, protein quality control, and mitochondrial optimisation.
JiaYi Zhu, Stefan J. Marciniak
wiley +1 more source
Overexpression of ATF4 promotes tumor cell invasion and metastasis.
, 2014 In vitro migration and invasion assays in TE-1LM (A) and Eca-109 (B) cells that were stably transfected with LV-vector or LV-ATF4. Inset, relative ATF4 protein expression levels as determined by Western blot. (C) Incidence of metastasis in mice implanted
Xiong Chen (555744) +6 more
core +1 more source
From hepatic to hematopoietic: LRH‐1's expanding cellular repertoire to the immune system
The FEBS Journal, EarlyView.The nuclear receptor LRH‐1 is a well‐characterized regulator of endodermal tissue. Yet, increasing evidence indicates that LRH‐1, although expressed at low levels, is also a critical regulator of the hematopoietic system. LRH‐1 regulates the immune system by contributing to immune cell‐specific functions.
Lukas Meisinger +3 more
wiley +1 more source
Scientific ReportsActivating transcription factor 4 (ATF4) plays a central role in the integrated stress response (ISR) and one overlapping branch of the unfolded protein response (UPR).
Erin van Zyl +4 more
doaj +1 more source