Results 131 to 140 of about 31,889 (263)

Activating transcription factor 4 plays a major role in shaping the transcriptional response to isoginkgetin in HCT116 cells

Scientific Reports
Activating transcription factor 4 (ATF4) plays a central role in the integrated stress response (ISR) and one overlapping branch of the unfolded protein response (UPR).
Erin van Zyl, John D. H. Stead, Claire Peneycad, Carole L. Yauk, Bruce C. McKay   +4 more
doaj   +1 more source

Overexpression of ATF4 promotes tumor cell invasion and metastasis.

, 2014
In vitro migration and invasion assays in TE-1LM (A) and Eca-109 (B) cells that were stably transfected with LV-vector or LV-ATF4. Inset, relative ATF4 protein expression levels as determined by Western blot. (C) Incidence of metastasis in mice implanted
Xiong Chen (555744), Yagang Zhao (606833), Bei Chen (202271), Dayong Sun (606832), Bin Chen (63682), Hongwu Zhu (183424), Weibing Song (606831)   +6 more
core   +1 more source

Hyperhomocysteinemia and Vitamin B Deficiency as Potential Aggravating Factors in Huntington's Disease: A Prospective Monocentric Study

Movement Disorders, EarlyView.
Abstract Background Although not confirmed, some studies have suggested that elevated homocysteine levels are common in patients with Huntington's disease (HD). Its clinical relevance remains unclear. Objectives We aimed to assess vitamin B and homocysteine levels in HD patients and explore the relationships among hyperhomocysteinemia, vitamin B ...
Salomé Puisieux, Elise Pourié, Céline Bonnet, Lucie Hopes, Solène Frismand, Myriam Bronner, Virginie Roth, Marion Wandzel, Natacha Sloboda, Laetitia Lambert, Abderrahim Oussalah, Amélia Julien, Irina Rotaru, Rosa‐Maria Guéant‐Rodriguez, Jean Louis Guéant, Carine Bossenmeyer‐Pourié, Mathilde Renaud   +16 more
wiley   +1 more source

ATF4 helps mitochondria pass the stress test

, 2017
The transcription factor ATF4 coordinates the mitochondrial stress response in mammalian cells.
Ben Short
core   +1 more source

Comparative Genomics and Functional Evidence for Convergent Adaptation to Hypoxia in Mammals

Integrative Zoology, EarlyView.
This study reveals convergent selection in mammals adapted to hypoxia. Functional assays demonstrate that amino acid mutations reduce oxidative stress, attenuate hypoxia‐induced injury, and modulate the hypoxia‐inducible transcription factor (HIF)‐driven hypoxic response.
Hao Dong, Chunxu Wang, Enqing Pei, Liang Zhao, Simin Chai, Ran Tian   +5 more
wiley   +1 more source

Resolving Endoplasmic Reticulum‐Protein Misfolding Restores Corticosteroid Sensitivity in Experimental Models of Severe Asthma

Allergy, EarlyView.
This study investigates the role of ER stress in steroid resistance in severe asthma. Results from advanced 3D models of human bronchial epithelial cells, steroid‐resistant severe asthma mouse models, and human severe asthma sputum samples show that treatment with ICS in combination with the ER stress inhibitor 4‐PBA significantly enhances steroid ...
Prabuddha S. Pathinayake, Alexandra C. Brown, Nikhil T. Awatade, Philip M. Hansbro, Katherine J. Baines, Richard Y. Kim, Nathan W. Bartlett, Jay C. Horvat, Peter A. B. Wark   +8 more
wiley   +1 more source

Transcriptional regulation of ATF4 is critical for controlling the Integrated Stress Response during eIF2 phosphorylation

, 2012
Indiana University-Purdue University Indianapolis (IUPUI)In response to different environmental stresses, phosphorylation of eIF2 (eIF2P) represses global translation coincident with preferential translation of ATF4.
Dey, Souvik
core   +1 more source

Histone deacetylase inhibitors as venetoclax‐sensitising partners in acute myeloid leukaemia: Mechanisms, pharmacology and translational perspectives

British Journal of Pharmacology, EarlyView.
Abstract Venetoclax combined with hypomethylating agents has improved treatment for older or unfit patients with acute myeloid leukaemia (AML), but resistance and relapse remain common. This review analyses the rationale for combining venetoclax with inhibitors of histone deacetylase (HDAC).
Jaebok Lee, Marc Diederich
wiley   +1 more source

Role of ATF4 in fibroblast proliferation and apoptosis induced by mechanical trauma through the miR−93-3p/Smad7 axis

Stress
Stress urinary incontinence (SUI) is a serious disease for females. This study attempts to explore the role of activating transcription factor 4 (ATF4) in mechanical trauma-induced SUI fibroblast cell proliferation and apoptosis, thereby finding a ...
Wei Li, Haitang Chen, Xueyan Hu, Peifan Yang, Mingmin Liu   +4 more
doaj   +1 more source

ATF4–histone 2‐hydroxyisobutyrylation feedback loop drives sepsis‐induced inflammation

Background and Purpose The role and mechanisms of lysine 2‐hydroxyisobutyrylation (Khib) in the acute inflammatory phase of sepsis remain unclear. We investigated the function and underlying
Yongling Lu, Lin Xia, Jiang Zheng, Xinhui Shi, Xiaoli Li, Hong Zhou, Hongmei Qiu, Qingsong Jiang, Wenjun Li, Junxia Yang, Sijia Liu, Xin Liu, Liang Zhang, Feng Cao, Ting Yang, Qian Chen   +15 more
core   +1 more source