Results 131 to 140 of about 32,812 (263)

Protective Potentials of Natural Products Against Vascular Dementia: A Comprehensive Review of Experimental Studies

Phytotherapy Research, EarlyView.
ABSTRACT Vascular dementia (VaD), accounting for up to 20% of dementia cases globally, is primarily driven by chronic cerebral hypoperfusion (CCH), which leads to progressive cognitive impairment. Despite the increasing prevalence of VaD, effective treatments remain limited.
Jung‐Hoon Kim, Yongtaek Oh, Suin Cho
wiley   +1 more source

Correction to “Combined inhibition of de novo pyrimidine synthesis and ATR promotes ATF4‐mediated cell death in TP53‐deficient ALL” [PDF]

Hemasphere
HemaSphere, Volume 10, Issue 10, October 2026.
europepmc   +2 more sources

Overexpression of ATF4 promotes tumor cell invasion and metastasis.

, 2014
In vitro migration and invasion assays in TE-1LM (A) and Eca-109 (B) cells that were stably transfected with LV-vector or LV-ATF4. Inset, relative ATF4 protein expression levels as determined by Western blot. (C) Incidence of metastasis in mice implanted
Xiong Chen (555744), Yagang Zhao (606833), Bei Chen (202271), Dayong Sun (606832), Bin Chen (63682), Hongwu Zhu (183424), Weibing Song (606831)   +6 more
core   +1 more source

Mogroside V Promotes Brown Adipose Thermogenesis via FTO‐m6A‐LETMD1‐UCP1 Pathway to Combat Obesity

Phytotherapy Research, EarlyView.
Mogroside V (MV) alleviates high‐fat diet‐induced obesity and metabolic dysfunction. Mechanistically, MV suppresses FTO expression, thereby increasing m6A modification of Letmd1 mRNA and enhancing its YTHDC2‐dependent stabilization. Theincreased LETMD1 expression is associated with elevated PGC1α and UCP1 levels, contributing to brown adipocyte ...
Yuan‐hai Sun, Ling‐huan Li, Ya‐qian Feng, Teng‐jiao Zhao, Min‐you Qi, Han‐bing Li   +5 more
wiley   +1 more source

ATF4 helps mitochondria pass the stress test

, 2017
The transcription factor ATF4 coordinates the mitochondrial stress response in mammalian cells.
Ben Short
core   +1 more source

Comparative Genomics and Functional Evidence for Convergent Adaptation to Hypoxia in Mammals

Integrative Zoology, EarlyView.
This study reveals convergent selection in mammals adapted to hypoxia. Functional assays demonstrate that amino acid mutations reduce oxidative stress, attenuate hypoxia‐induced injury, and modulate the hypoxia‐inducible transcription factor (HIF)‐driven hypoxic response.
Hao Dong, Chunxu Wang, Enqing Pei, Liang Zhao, Simin Chai, Ran Tian   +5 more
wiley   +1 more source

Activating transcription factor 4 plays a major role in shaping the transcriptional response to isoginkgetin in HCT116 cells

Scientific Reports
Activating transcription factor 4 (ATF4) plays a central role in the integrated stress response (ISR) and one overlapping branch of the unfolded protein response (UPR).
Erin van Zyl, John D. H. Stead, Claire Peneycad, Carole L. Yauk, Bruce C. McKay   +4 more
doaj   +1 more source

Transcriptional regulation of ATF4 is critical for controlling the Integrated Stress Response during eIF2 phosphorylation

, 2012
Indiana University-Purdue University Indianapolis (IUPUI)In response to different environmental stresses, phosphorylation of eIF2 (eIF2P) represses global translation coincident with preferential translation of ATF4.
Dey, Souvik
core   +1 more source

Autophagy Regulates Foxo1 Protein Abundance to Control Hepatic Glucose Production in Glucagon Signalling

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aim During fasting, the liver undergoes coordinated metabolic adaptations to maintain systemic energy homeostasis. These adaptations are driven in part by glucagon, which promotes hepatic glucose production (HGP) and fatty acid oxidation (FAO) through mechanisms involving the transcription factor Foxo1.
Zheng Shen, Wanbao Yang, Quan Pan, Wen Jiang, Jeffrey Guo, Yuxiang Sun, Nicolaas Deutz, Bhimanagouda S. Patil, Pingwei Li, Shaodong Guo   +9 more
wiley   +1 more source

A comparative analysis of cell death signalling in RNA and DNA virus infections and potential inhibitory strategies

The FEBS Journal, EarlyView.
RNA and DNA viruses can manipulate host cell death through various mechanisms. RNA viruses (H1N1, SARS‐CoV‐2) induce acute apoptosis, necroptosis, and pyroptosis to promote rapid viral transmission and epithelial barrier damage. In contrast, DNA viruses (HSV‐1, EBV) regulate these mechanisms to sustain a lytic‐latency cycle, evade immune response and ...
Panagiotis Keramidas, Maria Pitou, Amalia Aggeli, Sotiris Varlamis, Theodora Choli‐Papadopoulou   +4 more
wiley   +1 more source