Results 141 to 150 of about 32,812 (263)
ATF4–histone 2‐hydroxyisobutyrylation feedback loop drives sepsis‐induced inflammation
Background and Purpose The role and mechanisms of lysine 2‐hydroxyisobutyrylation (Khib) in the acute inflammatory phase of sepsis remain unclear. We investigated the function and underlying
Yongling Lu +15 more
core +1 more source
Targeting ATF4 alters SOD1 aggregation in mutant SOD1 transgenic mice.
, 2013 Histological characterization of ATF4−/−/SOD1G86R spinal cord. (A) Immunofluorescence analysis of NeuN and Olig2 staining in spinal cord tissue derived from ATF4+/+, ATF4+/+/SOD1G86R and ATF4−/−/SOD1G86R at the late disease stage.
Vicente Valenzuela (434946) +4 more
core +1 more source
Proteostasis in the regulation of pancreatic islet cell plasticity
Journal of Diabetes Investigation, EarlyView.Adaptive proteostasis integrates protein synthesis, folding, trafficking, and degradation through ISR, UPR, ER stress responses, autophagy, and proteasomal degradation. In pancreatic islet cells, this coordinated network preserves protein quality, secretory function, proliferation, and survival, enabling adaptation to metabolic stress and aging while ...
Jun Shirakawa
wiley +1 more source
ATF4 transcriptional activities during UPR are Siah1/2-dependent.
, 2014 (A) Siah2 expression augments ATF4 protein levels. WT MEFs were transfected either with control or Siah2 expression vectors, and 24 h later the cells were collected. Harvested proteins were analyzed for ATF4, Siah2 and β-actin.
Jaeseok Han (561532) +10 more
core +1 more source
One day of environment‐induced heat stress causes injury to the murine kidney
Experimental Physiology, EarlyView.Abstract Environment‐induced heat stress (EIHS) results from sustained body temperature elevation owing to prolonged exposure to heat and humidity. We hypothesized that EIHS would cause kidney injury and cellular dysfunction. To test this hypothesis, female C57 mice were exposed to EIHS (n = 14; 37.6°C, 42.0% relative humidity) or thermoneutral (TN ...
Melissa Roths +3 more
wiley +1 more source
British Journal of Pharmacology, Volume 183, Issue 21, Page 6261-6290, November 2026.Abstract Venetoclax combined with hypomethylating agents has improved treatment for older or unfit patients with acute myeloid leukaemia (AML), but resistance and relapse remain common. This review analyses the rationale for combining venetoclax with inhibitors of histone deacetylase (HDAC).
Jaebok Lee, Marc Diederich
wiley +1 more source
Nature CommunicationsCells adapt to proteostatic and metabolic stresses, in part, through stress activated eIF2α kinases that stimulate the translation of ATF4. Stress-induced ATF4 translation is regulated through elements at ATF4 mRNA’s 5’ leader.
Kristoffer Walsh +5 more
doaj +1 more source
Molecular Oncology, Volume 20, Issue 10, Page 2424-2448, October 2026.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
StressStress urinary incontinence (SUI) is a serious disease for females. This study attempts to explore the role of activating transcription factor 4 (ATF4) in mechanical trauma-induced SUI fibroblast cell proliferation and apoptosis, thereby finding a ...
Wei Li +4 more
doaj +1 more source