Results 141 to 150 of about 31,889 (263)
Targeting ATF4 alters SOD1 aggregation in mutant SOD1 transgenic mice.
, 2013 Histological characterization of ATF4−/−/SOD1G86R spinal cord. (A) Immunofluorescence analysis of NeuN and Olig2 staining in spinal cord tissue derived from ATF4+/+, ATF4+/+/SOD1G86R and ATF4−/−/SOD1G86R at the late disease stage.
Vicente Valenzuela (434946) +4 more
core +1 more source
The Pathological Roles of Cationic Amino Acid Transporters (CATs) in Cancer
Cancer Science, EarlyView.CAT family transporters (SLC7A1–SLC7A4) coordinate arginine allocation within the tumor microenvironment, thereby regulating cancer metabolism, mTORC1 signaling, immune responses, and metastatic progression. Emerging evidence supports context‐dependent roles for SLC7A1–SLC7A3, whereas the physiological and pathological functions of SLC7A4 remain poorly
Thant Thant Myo Oo, Yasuhiro Saito
wiley +1 more source
ATF4 transcriptional activities during UPR are Siah1/2-dependent.
, 2014 (A) Siah2 expression augments ATF4 protein levels. WT MEFs were transfected either with control or Siah2 expression vectors, and 24 h later the cells were collected. Harvested proteins were analyzed for ATF4, Siah2 and β-actin.
Jaeseok Han (561532) +10 more
core +1 more source
The FEBS Journal, EarlyView.Proteostasis ensures proper protein folding, modification, and degradation, while its impairment triggers ER stress. Chronic ER stress and maladaptive UPR via the CHOP–ERO1 axis remodel ERMCs, altering calcium signaling and mitochondrial metabolism.
Giorgia Maria Renna +5 more
wiley +1 more source
Nature CommunicationsCells adapt to proteostatic and metabolic stresses, in part, through stress activated eIF2α kinases that stimulate the translation of ATF4. Stress-induced ATF4 translation is regulated through elements at ATF4 mRNA’s 5’ leader.
Kristoffer Walsh +5 more
doaj +1 more source
Proteostasis of organelles in aging and disease
The FEBS Journal, EarlyView.Cells rely on regulated proteostasis mechanisms to keep their internal compartments functioning properly. When these mechanisms fail, damaged proteins accumulate, disrupting organelles, such as the nucleus, mitochondria, endoplasmic reticulum, Golgi, and lysosomes, as well as membraneless organelles, such as stress granules, processing bodies, the ...
Yara Nabawi +5 more
wiley +1 more source
GCN2 in proteostasis: structural logic, signalling networks and disease
The FEBS Journal, EarlyView.Threats to protein synthesis activate the kinase GCN2, initiating the integrated stress response (ISR). GCN2 is triggered by stalled ribosomes and uncharged tRNAs, which accumulate when amino acids are scarce. The ISR adjusts cellular physiology by promoting redox balance, protein quality control, and mitochondrial optimisation.
JiaYi Zhu, Stefan J. Marciniak
wiley +1 more source
Overcoming Cancer Persister Cells by Stabilizing the ATF4 Promoter G‐quadruplex
Advanced SciencePersister cells (PS) selected for anticancer therapy have been recognized as a significant contributor to the development of treatment‐resistant malignancies.
Chengmei Xiao +9 more
doaj +1 more source
The integrated stress response effector ATF4: Characterization of a small molecule modulator of its expression and investigation of the role of ATF4 in metastasis [PDF]
, 2013 The Integrated Stress Response (ISR) and the Unfolded Protein Response (UPR) are signaling programs that enable cellular adaptation to stressful conditions like hypoxia and nutrient deprivation in the tumor microenvironment.
Sayers, Carly M
core
From hepatic to hematopoietic: LRH‐1's expanding cellular repertoire to the immune system
The FEBS Journal, EarlyView.The nuclear receptor LRH‐1 is a well‐characterized regulator of endodermal tissue. Yet, increasing evidence indicates that LRH‐1, although expressed at low levels, is also a critical regulator of the hematopoietic system. LRH‐1 regulates the immune system by contributing to immune cell‐specific functions.
Lukas Meisinger +3 more
wiley +1 more source