Results 161 to 170 of about 32,812 (263)
Advanced Science, Volume 13, Issue 58, 19 October 2026.This review elucidates how cancer cell metabolic reprogramming—across glucose, lipid, amino acid, and nucleotide pathways—remodels the tumor microenvironment to suppress anti‐tumor immunity and promote immune escape. Targeting these metabolic axes offers promising strategies to overcome immunotherapy resistance and enhance cancer treatment.
Guoqing Xiang +5 more
wiley +1 more source
Nature CommunicationsCells rapidly and extensively remodel their transcriptome in response to stress to restore homeostasis, but the underlying mechanisms are not fully understood.
Peipei Jiang, Qian Bian
doaj +1 more source
CNS Neuroscience &Therapeutics, Volume 32, Issue 10, October 2026.We identified endoplasmic reticulum (ER) stress modulation as a convergent transcription signature across fentanyl and multiple substance use disorder (SUD)‐relevant treatments. Key ER stress genes, including TRIB3, XBP1, and DDIT3, were downregulated, while CEBPB emerged as a shared upstream regulator linked to ER stress–related proteins.
Cheng Zhang, Hu Li, Ming‐Fen Ho
wiley +1 more source
CNS Neuroscience &Therapeutics, Volume 32, Issue 10, October 2026.Traumatic brain injury (TBI) induces acute, sex‐specific activation of endoplasmic reticulum (ER) stress, inflammatory signaling, and ferroptotic mechanisms within brain microvascular endothelial cells (BMECs). Administration of dexmedetomidine (DEX) produces both sex‐dependent and sex‐independent modulatory effects on BMECs, prominently suppressing ...
Yara Mashal +6 more
wiley +1 more source
ATF4 participates in perfluorooctane sulfonate-induced neurotoxicity by regulating ferroptosis
Evidence from animal and human research suggests that perfluorooctane sulfonate (PFOS), a prevalent persistent organic pollutant (POP), exerts neurotoxic effects, but the precise mechanisms remain unclear.
Yun Chen +12 more
core +1 more source
Recalibrating the apoptotic threshold: Ubiquitin‐regulated ER stress signalling in colorectal cancer
Clinical and Translational Discovery, Volume 6, Issue 5, October 2026.Ubiquitin‐dependent turnover of ER‐stress sensors, proteostasis factors, and apoptotic regulators can recalibrate the apoptotic threshold in colorectal cancer, balancing adaptive survival against terminal cell death. Defining these context‐dependent vulnerabilities may enable strategies that overcome stress adaptation and restore apoptotic competence ...
Jing Hu, Shanliang Zheng, Ying Hu
wiley +1 more source
JDP2 is directly regulated by ATF4 and modulates TRAIL sensitivity by suppressing the ATF4-DR5 axis
JDP2 is directly regulated by ATF4 and modulates TRAIL sensitivity by suppressing the ATF4-DR5 axis掲載誌：FEBS open bio, 10(12):2771-2779 ...
openaire +1 more source
Food Science &Nutrition, Volume 14, Issue 10, October 2026.This graphical abstract illustrates the complete translational pipeline of Terminalia arjuna in modern phytomedicine and functional food development. It is rich in key bioactive compounds like arjunolic acid, arjungenin, flavonoids, and tannins which serve as the foundation for the plant's versatile medicinal uses and offers broad therapeutic benefits ...
Ishani Banerjee +5 more
wiley +1 more source
ATF4 Is a Fundamental Regulator of Nutrient Sensing and Protein Turnover [PDF]
The Journal of Nutrition, 2020 Blake B, Rasmussen, Christopher M, Adams
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