Results 161 to 170 of about 30,346 (252)
Food Frontiers, Volume 7, Issue 4, July 2026.Biosynthetic D‐calcium pantothenate and cyanocobalamin alleviate MPTP‐induced Parkinsonism in mice by modulating gut microbiota, restoring metabolic homeostasis, and inhibiting Endoplasmic Reticulum Stress. ABSTRACT Vitamin B5 (VB5) and Vitamin B12 (VB12) are essential micronutrients widely distributed in functional foods, yet their neuroprotective ...
Yaru Chen +6 more
wiley +1 more source
ATF4 Is a Fundamental Regulator of Nutrient Sensing and Protein Turnover [PDF]
The Journal of Nutrition, 2020 Blake B, Rasmussen, Christopher M, Adams
openaire +2 more sources
Altered expression of UPR-target genes in mutant SOD1 transgenic mice upon deletion of ATF4.
, 2013 (A) Expression levels of several ER stress-responsive proteins were monitored in spinal cord extracts derived from ATF4+/+, ATF4−/−, ATF4+/+/SOD1G86R and ATF4−/−/SOD1G86R symptomatic mice using Western blot analysis.
Vicente Valenzuela (434946) +4 more
core +1 more source
Scientific ReportsEndoplasmic reticulum (ER) stress, mitochondrial dysfunction, and mitophagy are known to contribute independently to corneal endothelial cell (CEnC) apoptosis in Fuchs’ endothelial corneal dystrophy (FECD).
Saba Qureshi +7 more
doaj +1 more source
Food Frontiers, Volume 7, Issue 4, July 2026.This review summarizes recent advances in acrylamide neurotoxicity mechanisms and highlights the multitarget neuroprotective effects of diverse natural products while also addressing current challenges and future translational research directions.
Wen Du +7 more
wiley +1 more source
The PERK-eIF2α-ATF4 pathway regulated rifampicin-induced GRP78 activation.
, 2014 (A) PC12 cells were treated with 150 μM rifampicin for indicated lengths of time, ranging from 3 to 24 h. Cell lysates were analyzed by western blotting using antibodies against phosphorylated PERK (p-PERK), PERK, phosphorylated eIF2a (p- eIF2a), eIF2a ...
Yanran Liang (322275) +9 more
core +1 more source
ATF4 Signaling in HIV-1 Infection: Viral Subversion of a Stress Response Transcription Factor
BiologyCellular integrated stress response (ISR), the mitochondrial unfolded protein response (UPRmt), and IFN signaling are associated with viral infections.
Adrien Corne +4 more
doaj +1 more source
Research on the Mechanism of Natural Products Acting on Chronic Obstructive Pulmonary Disease
Food Science &Nutrition, Volume 14, Issue 7, July 2026.This figure illustrates that approximately 80 natural compounds exert therapeutic effects against chronic obstructive pulmonary disease by targeting pathological mechanisms such as airway inflammation, oxidative stress, airway remodeling, mucus hypersecretion, emphysema, protease–antiprotease imbalance, apoptosis, and autophagy.
Shuna Wei, Xiaoju Liu
wiley +1 more source
, 2018 Ovulatory disorder is common in patients with hyperprolactinemia or polycystic ovary syndrome (PCOS). Previous studies have shown that ATF4 plays critical role in apoptosis and glucose homeostasis, but its role in regulating reproductive function was not
Weiping Li (43906) +7 more
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Nature CommunicationsCells rapidly and extensively remodel their transcriptome in response to stress to restore homeostasis, but the underlying mechanisms are not fully understood.
Peipei Jiang, Qian Bian
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