Results 151 to 160 of about 31,889 (263)
The PERK-eIF2α-ATF4 pathway regulated rifampicin-induced GRP78 activation.
, 2014 (A) PC12 cells were treated with 150 μM rifampicin for indicated lengths of time, ranging from 3 to 24 h. Cell lysates were analyzed by western blotting using antibodies against phosphorylated PERK (p-PERK), PERK, phosphorylated eIF2a (p- eIF2a), eIF2a ...
Yanran Liang (322275) +9 more
core +1 more source
Ubiquitin and ubiquitin‐like modifications in the endoplasmic reticulum stress response
The FEBS Journal, EarlyView.Endoplasmic reticulum (ER) stress activates various proteostasis control processes, including the unfolded protein response, ribosome‐associated quality control, and ER‐associated degradation. Ubiquitin and ubiquitin‐like modifications dynamically regulate these processes to determine cell fate, promoting adaptation or inducing cell death.
Tony Avril +2 more
wiley +1 more source
One day of environment‐induced heat stress causes injury to the murine kidney
Experimental Physiology, EarlyView.Abstract Environment‐induced heat stress (EIHS) results from sustained body temperature elevation owing to prolonged exposure to heat and humidity. We hypothesized that EIHS would cause kidney injury and cellular dysfunction. To test this hypothesis, female C57 mice were exposed to EIHS (n = 14; 37.6°C, 42.0% relative humidity) or thermoneutral (TN ...
Melissa Roths +3 more
wiley +1 more source
Molecular OncologyChordoma, a rare primary bone malignancy, currently lacks effective targeted therapies. Despite surgical resection and adjuvant radiotherapy, prognosis remains poor. Recent preclinical studies have highlighted potential therapeutic targets, including the transcription factor T‐box transcription factor T (TBXT).
Cottone, L +11 more
openaire +2 more sources
Scientific ReportsEndoplasmic reticulum (ER) stress, mitochondrial dysfunction, and mitophagy are known to contribute independently to corneal endothelial cell (CEnC) apoptosis in Fuchs’ endothelial corneal dystrophy (FECD).
Saba Qureshi +7 more
doaj +1 more source
Short Communication: Activating Transcription Factor 4 (ATF4) Promotes HIV Type 1 Activation
, 2012 Activating Transcription Factor 4 (ATF4) is a central factor in the cellular response to multiple stresses, including altered metabolic conditions, anoxia and hypoxia, redox stress.
Jessica Grigolato +9 more
core +1 more source
Acta Physiologica, Volume 242, Issue 10, October 2026.ABSTRACT Aim Skeletal muscle atrophy is tightly associated with maladaptive alterations in mitochondrial function and morphology. Itchy E3 ubiquitin‐protein ligase (ITCH) modulates mitochondria, and thrombospondin 1 (THBS1) positively regulates muscle atrophy, but their roles in muscle atrophy are unclear. Methods A muscle atrophy model was established
Wan Yu, Yanteng Wang, Na Li, Difei Wang
wiley +1 more source
FEBS Open Bio, Volume 16, Issue 9, Page 1766-1785, September 2026.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source