Results 151 to 160 of about 32,812 (263)

The integrated stress response effector ATF4: Characterization of a small molecule modulator of its expression and investigation of the role of ATF4 in metastasis [PDF]

, 2013
The Integrated Stress Response (ISR) and the Unfolded Protein Response (UPR) are signaling programs that enable cellular adaptation to stressful conditions like hypoxia and nutrient deprivation in the tumor microenvironment.
Sayers, Carly M
core  

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, Volume 20, Issue 10, Page 2533-2566, October 2026.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

The PERK-eIF2α-ATF4 pathway regulated rifampicin-induced GRP78 activation.

, 2014
(A) PC12 cells were treated with 150 μM rifampicin for indicated lengths of time, ranging from 3 to 24 h. Cell lysates were analyzed by western blotting using antibodies against phosphorylated PERK (p-PERK), PERK, phosphorylated eIF2a (p- eIF2a), eIF2a ...
Yanran Liang (322275), Songhua Xiao (322277), Xiuna Jing (322273), Xia Wu (203682), Wei Bi (322272), Lianhong Yang (322276), Qiaoyun Shi (322280), Jun Liu (42548), Enxiang Tao (322281), Zhifen Zeng (538151)   +9 more
core   +1 more source

QRICH1 Disrupts Endoplasmic Reticulum Homeostasis and Amplifies NF‐κB Signaling in Periodontal Ligament Stem Cells to Exacerbate Diabetic Periodontitis

Advanced Science, Volume 13, Issue 56, 9 October 2026.
QRICH1 has been established as a key factor contributing to impaired osteogenic potential and accelerated apoptosis of PDLSCs in diabetic periodontitis. QRICH1 not only significantly enhances UPR‐associated apoptotic signaling but also amplifies NF‐κB‐mediated inflammatory responses. Its inhibition restores osteogenic capacity and reduces alveolar bone
Han Li, Xiaoyu Yang, He Wang, Yunchun Kuang, Yiyao Hu, Houxuan Li, Shuhong Li, Deping Zeng, Jie Li, Jinlin Song   +9 more
wiley   +1 more source

ATF4 regulates mitochondrial dysfunction and mitophagy, contributing to corneal endothelial apoptosis

Scientific Reports
Endoplasmic reticulum (ER) stress, mitochondrial dysfunction, and mitophagy are known to contribute independently to corneal endothelial cell (CEnC) apoptosis in Fuchs’ endothelial corneal dystrophy (FECD).
Saba Qureshi, Stefan Y. Kim, Stephanie Lee, Lukas Ritzer, William Steidl, Gayle Joliet Krest, Anisha Kasi, Varun Kumar   +7 more
doaj   +1 more source

ATF4 ‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology
Chordoma, a rare primary bone malignancy, currently lacks effective targeted therapies. Despite surgical resection and adjuvant radiotherapy, prognosis remains poor. Recent preclinical studies have highlighted potential therapeutic targets, including the transcription factor T‐box transcription factor T (TBXT).
Cottone, L, Dunford, J, Calcutt, E, Gamble, V, Aksu, FS, Ligammari, L, Wherry, G, Gaeta, G, Christianson, JC, Flanagan, AM, Oppermann, U, Cribbs, AP   +11 more
openaire   +2 more sources

Aberrant GRP78 Phase Transition Sustains Endothelial IRE1α Signaling and Drives Blood–Brain Barrier Failure in Cerebral Amyloid Angiopathy

Advanced Science, Volume 13, Issue 58, 19 October 2026.
Vascular Aβ40 corrupts GRP78 phase behavior in brain endothelial cells, sustaining IRE1α–TRAF2–JNK signaling and driving apoptosis, tight junction loss, and blood–brain barrier failure in cerebral amyloid angiopathy. Pharmacological IRE1α inhibition restores vascular integrity, reduces leakage, and improves functional outcomes, revealing a targetable ...
Honglin Zheng, Qiang Li, Haiyang Luo, Yapei Yuan, Na Zhang, Yongting Lu, Suying Duan, Jieshi Zhong, Hang Zhang, Chenyang Liu, Yaochong Zhang, Wenzhuo Zhao, Yaxuan Song, Tuo Wang, Si Yan, Yapeng Li, Han Liu, Yuan Gao, Zongping Xia, Yuming Xu   +19 more
wiley   +1 more source

Short Communication: Activating Transcription Factor 4 (ATF4) Promotes HIV Type 1 Activation

, 2012
Activating Transcription Factor 4 (ATF4) is a central factor in the cellular response to multiple stresses, including altered metabolic conditions, anoxia and hypoxia, redox stress.
Jessica Grigolato, CASELLI, Elisabetta, GRIGOLATO, Jessica, DI LUCA, Dario, BENEDETTI, Sabrina, Elisabetta Caselli, Sabrina Benedetti, GENTILI, Valentina, Dario Di Luca, Valentina Gentili   +9 more
core   +1 more source

A Blood‐Derived Factor Rescues ALS: Platelet Factor 4 Activates OPTN‐Dependent Autophagy to Clear SOD1 Aggregates Independently of PINK1

Advanced Science, Volume 13, Issue 58, 19 October 2026.
Systemic platelet factor 4 (PF4) is significantly depleted in amyotrophic lateral sclerosis (ALS). Peripheral PF4 replenishment restores central proteostasis by driving OPTN‐dependent, PINK1‐independent selective autophagy in motor neurons. This intervention effectively clears toxic SOD1 aggregates, blunts glial activation, and preserves neuromuscular ...
Qingjian Xie, Yanbo Zhu, Wenhua Jiang, Haobo Xie, Yaojia Li, Mengjie Hu, Kezheng Li, Huan Yu, Yixuan Pan, Chaoyi Jiang, Xueqin Song, Dongsheng Fan, Binbin Deng   +12 more
wiley   +1 more source

Overcoming Cancer Persister Cells by Stabilizing the ATF4 Promoter G‐quadruplex

Advanced Science
Persister cells (PS) selected for anticancer therapy have been recognized as a significant contributor to the development of treatment‐resistant malignancies.
Chengmei Xiao, Yipu Li, Yushuang Liu, Ruifang Dong, Xiaoyu He, Qing Lin, Xin Zang, Kaibo Wang, Yuanzheng Xia, Lingyi Kong   +9 more
doaj   +1 more source