Results 151 to 160 of about 30,346 (252)

ATF4 helps mitochondria pass the stress test

, 2017
The transcription factor ATF4 coordinates the mitochondrial stress response in mammalian cells.
Ben Short
core   +1 more source

Metformin Partially Attenuates Simvastatin‐Induced Myotoxic Responses in C2C12 Myotubes Through Metabolic Adaptation

The FASEB Journal, Volume 40, Issue 13, 15 July 2026.
Simvastatin induces metabolic suppression, mitochondrial dysfunction, and atrophy‐related responses in skeletal muscle cells. In differentiated C2C12 myotubes, metformin partially attenuates these alterations by preserving myotube structural integrity, reducing cellular stress signaling, and maintaining mitochondrial network organization despite ...
Chuqi He, Mike Wesselink, Jelle Y. Huijts, Zhenjia Zhong, Moritz Eggelbusch, Richard T. Jaspers, Rob C. I. Wüst   +6 more
wiley   +1 more source

4EHP and NELF-E regulate physiological ATF4 induction and proteostasis in disease models of Drosophila

Nature Communications
Cells adapt to proteostatic and metabolic stresses, in part, through stress activated eIF2α kinases that stimulate the translation of ATF4. Stress-induced ATF4 translation is regulated through elements at ATF4 mRNA’s 5’ leader.
Kristoffer Walsh, Hidetaka Katow, Hannah Junn, Deepika Vasudevan, Christoph Dieterich, Hyung Don Ryoo   +5 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, Volume 20, Issue 7, Page 1857-1876, July 2026.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Quantitative Control of Transposable Elements: From Genome Plasticity to Immune Regulatory Circuits

Cell Biochemistry and Function, Volume 44, Issue 7, July 2026.
ABSTRACT Transposable elements (TEs) constitute nearly half of the human genome and are increasingly recognized as context‐dependent regulators of genome function rather than passive repetitive DNA. This Review synthesizes classical and recent evidence on TE biology, including TE classification, mechanisms of mobilization, host restriction pathways ...
Irving Jesús Reyes‐Barragán
wiley   +1 more source

Short Communication: Activating Transcription Factor 4 (ATF4) Promotes HIV Type 1 Activation

, 2012
Activating Transcription Factor 4 (ATF4) is a central factor in the cellular response to multiple stresses, including altered metabolic conditions, anoxia and hypoxia, redox stress.
Jessica Grigolato, CASELLI, Elisabetta, GRIGOLATO, Jessica, DI LUCA, Dario, BENEDETTI, Sabrina, Elisabetta Caselli, Sabrina Benedetti, GENTILI, Valentina, Dario Di Luca, Valentina Gentili   +9 more
core   +1 more source

Overcoming Cancer Persister Cells by Stabilizing the ATF4 Promoter G‐quadruplex

Advanced Science
Persister cells (PS) selected for anticancer therapy have been recognized as a significant contributor to the development of treatment‐resistant malignancies.
Chengmei Xiao, Yipu Li, Yushuang Liu, Ruifang Dong, Xiaoyu He, Qing Lin, Xin Zang, Kaibo Wang, Yuanzheng Xia, Lingyi Kong   +9 more
doaj   +1 more source

Remodelling the tumour microenvironment and beyond: ERO1A as a multifaceted regulator and emerging therapeutic target in cancer

Clinical and Translational Medicine, Volume 16, Issue 7, July 2026.
ERO1A exhibits oncogenic functions, including promoting tumour progression, metastasis, epithelial‒mesenchymal transition, angiogenesis, immune evasion and metabolic reprogramming. ERO1A is also identified as a diagnostic biomarker and a factor contributing to therapy resistance (chemotherapy and immunotherapy).
Jing Mao, Kai Wang
wiley   +1 more source

ATF4 Gene [PDF]

, 2020
openaire   +1 more source

ATF4 ‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology
Chordoma, a rare primary bone malignancy, currently lacks effective targeted therapies. Despite surgical resection and adjuvant radiotherapy, prognosis remains poor. Recent preclinical studies have highlighted potential therapeutic targets, including the transcription factor T‐box transcription factor T (TBXT).
Cottone, L, Dunford, J, Calcutt, E, Gamble, V, Aksu, FS, Ligammari, L, Wherry, G, Gaeta, G, Christianson, JC, Flanagan, AM, Oppermann, U, Cribbs, AP   +11 more
openaire   +2 more sources