Results 181 to 190 of about 32,812 (263)
Elamipretide Rejuvenates Oocyte Quality and Restores Female Fertility During Reproductive Aging
Aging Cell, Volume 25, Issue 10, October 2026.We reported a novel peptide therapy showing that elamipretide restores the quality of aged oocytes for fertility by coordinately boosting oocyte nuclear and cytoplasmic maturation via activation of the VEGF signaling pathway. ABSTRACT Aging represents a major contributor to the deterioration of female fertility, with oocyte quality being the central ...
Hao‐Lin Zhang +12 more
wiley +1 more source
Acta Physiologica, Volume 242, Issue 10, October 2026.ABSTRACT Aim Skeletal muscle atrophy is tightly associated with maladaptive alterations in mitochondrial function and morphology. Itchy E3 ubiquitin‐protein ligase (ITCH) modulates mitochondria, and thrombospondin 1 (THBS1) positively regulates muscle atrophy, but their roles in muscle atrophy are unclear. Methods A muscle atrophy model was established
Wan Yu, Yanteng Wang, Na Li, Difei Wang
wiley +1 more source
Lipiidid sünteesitakse endoplasmaatilises retiikulumis (ER). Toksilise toime vältimiseks säilitatakse üleliigseid lipiide rakus lipiiditilgakestena, mis samuti moodustuvad ER-is.
Gluboki, Elina
core
The Pathological Roles of Cationic Amino Acid Transporters (CATs) in Cancer
Cancer Science, Volume 117, Issue 10, Page 2636-2643, October 2026.CAT family transporters (SLC7A1–SLC7A4) coordinate arginine allocation within the tumor microenvironment, thereby regulating cancer metabolism, mTORC1 signaling, immune responses, and metastatic progression. Emerging evidence supports context‐dependent roles for SLC7A1–SLC7A3, whereas the physiological and pathological functions of SLC7A4 remain poorly
Thant Thant Myo Oo, Yasuhiro Saito
wiley +1 more source
From hepatic to hematopoietic: LRH‐1's expanding cellular repertoire to the immune system
The FEBS Journal, Volume 293, Issue 20, Page 5996-6010, October 2026.The nuclear receptor LRH‐1 is a well‐characterized regulator of endodermal tissue. Yet, increasing evidence indicates that LRH‐1, although expressed at low levels, is also a critical regulator of the hematopoietic system. LRH‐1 regulates the immune system by contributing to immune cell‐specific functions.
Lukas Meisinger +3 more
wiley +1 more source
Journal of Cellular and Molecular Medicine, Volume 30, Issue 19, October 2026.ABSTRACT The tumour microenvironment (TME) comprises a dynamic network of structural, cellular, and signalling components that interact to influence tumour development. Immune cells play a key role in recognizing and eliminating cancer cells through detection of tumour‐derived membrane and secreted proteins processed in the endoplasmic reticulum (ER ...
Yew Hwang Chee +4 more
wiley +1 more source
ATF4 and FGFR4 cooperatively support thyroid cancer progression and CAF-associated tumor-promoting features. [PDF]
EndocrineZhang J, Cai J, Ruan W.
europepmc +1 more source
Journal of Cellular and Molecular Medicine, Volume 30, Issue 19, October 2026.ABSTRACT Knee osteoarthritis (KOA) is a degenerative joint disease primarily driven by the disruption of homeostasis in the chondrocyte extracellular matrix (CECM). This review systematically examines the central role of CECM homeostasis in KOA pathogenesis and summarizes recent advances in this field.
Chao Du +8 more
wiley +1 more source
Dissecting the cell biology of the ISR in cognitive disorders at the single-cell resolution. [PDF]
Proc Natl Acad Sci U S AKaang BK.
europepmc +1 more source