Results 181 to 190 of about 31,889 (263)

Ageing stress signalling: metastatic plasticity and metabolic vulnerability in lung cancer. [PDF]

Signal Transduct Target Ther
Lee SJ, Bae J, Cheon YJ, Bak SG.
europepmc   +1 more source

Creb3l1 Overexpression Improves Flexor Tendon Repair in Aged Rats

Aging Cell, Volume 25, Issue 9, September 2026.
Aging impairs flexor tendon repair, with aged tendons showing reduced Col1a1 and Sparc expression and compromised mechanical properties. The transcription factor Creb3l1 binds both gene promoters and drives their expression; its overexpression restores Col1a1 and Sparc levels and improves the gliding function, healing strength, and elastic modulus of ...
Qian Qian Yang, Zhanghao Huang, Yan Xue, Jia Yu Shi, You Lang Zhou   +4 more
wiley   +1 more source

The dual role of ATF4 in neurons: from stress adaptation to therapeutic intervention. [PDF]

Front Mol Neurosci
Huang H, Xu Y, Li X, Li C, Peng W.
europepmc   +1 more source

CKAP4 Regulates ERS‐Induced Apoptosis in Osteoclasts Through FOXO3 in Periodontitis

Cell Proliferation, Volume 59, Issue 9, September 2026.
CKAP4 promotes the transcription of PERK via FOXO3 in OCs, thereby facilitating ER stress‐induced apoptosis. In periodontitis, the reduction of CKAP4 in OCs leads to decreased OC apoptosis, which exacerbates alveolar bone resorption. ABSTRACT Periodontitis is a prevalent oral disease characterised by chronic inflammation and irreversible alveolar bone ...
Jiayu Cheng, Dihao Tao, Wenzhe Wang, Huiyu Wang, Hanzhe Wang, Yufan Liang, Jia Guo, Wenhao Liu, Yiming Wang, Jianhua Yang, Xiaoning He, Ce Shan, Bei Li   +12 more
wiley   +1 more source

Context matters: role of ATF4 in hematopoiesis

Blood
Junhua Lyu, Jian Xu
openaire   +2 more sources

Bruno 1 remodels P-bodies to protect select mRNAs during the early ER stress response. [PDF]

Life Sci Alliance
Milano SN, Bayer LV, Ko JJ, Posner GS, Granovsky AH, Bratu DP.   +5 more
europepmc   +1 more source

Dissection of Mitochondrial Function via Chemical Perturbation and Single‐Cell Profiling

Cell Proliferation, Volume 59, Issue 9, September 2026.
We establish a systematic framework to dissect mitochondrial function at the module level by combining targeted chemical perturbations with scRNA‐seq. This approach reveals shared and module‐specific programs linking mitochondrial activity to mito‐nuclear communication, stress response, and cell cycle, highlighting the tight coupling between ...
Hao Luo, Xiaona Yin, Hongxin He, Yaning Wang, Hongbo Zhang   +4 more
wiley   +1 more source

Sodium butyrate induces mitochondrial pathway apoptosis in liver cancer via ATF4/SLC7A11-mediated ferroptosis. [PDF]

PLoS One
Meng X, Li Y, He M, Wang C, Shengsong H, Guo J, Zhang J, Zhao S, Zhu Y, Li B, Li Y, Sun H.   +11 more
europepmc   +1 more source

Lipiidide ainevahetusega seotud geeni GPAT3 ekspressiooni regulatsioon transkriptsioonifaktori ATF4 poolt

Lipiidid sünteesitakse endoplasmaatilises retiikulumis (ER). Toksilise toime vältimiseks säilitatakse üleliigseid lipiide rakus lipiiditilgakestena, mis samuti moodustuvad ER-is.
Gluboki, Elina
core  

Targeting m6A Modifications Regulating Ferroptosis Offers Novel Therapy in Diseases

Cell Proliferation, Volume 59, Issue 9, September 2026.
m6A RNA modification regulates ferroptosis by balancing iron metabolism, lipid peroxidation, and antioxidant defenses. Dysregulated m6A signaling disrupts pro‐ and anti‐ferroptotic factors, leading to excess ROS, Fe3+ accumulation, and lipid peroxidation–driven cell death. Targeting m6A‐mediated ferroptotic regulation represents a promising therapeutic
Lida Du, Joshua S. Fleishman, Shuang Wu, Yuan Zhou, Clara X. Wang, Haitong Wang, Yumin Wang, Hongquan Wang   +7 more
wiley   +1 more source