Results 181 to 190 of about 30,346 (252)

V̇O2max$\dot V_{\rm{O_{2max}}}$‐based all‐out aerobic exercise attenuates hexosamine biosynthetic pathway activity: Metabolomic insights in mice model

Experimental Physiology, Volume 111, Issue 7, Page 3253-3266, 1 July 2026.
Abstract Aerobic exercise enhances physiological performance by activating metabolic systems, including glucose oxidation and fat metabolism. Cellular glucose predominantly flows through glycolysis (95–98%), whereas a smaller fraction (2–5%) enters the hexosamine biosynthetic pathway (HBP), generating UDP‐N‐acetylglucosamine.
Gyumin Kang, Eui‐Cheol Shin, Jae Kyeom Kim, Young Jun Kim   +3 more
wiley   +1 more source

ATF4 participates in perfluorooctane sulfonate-induced neurotoxicity by regulating ferroptosis

Evidence from animal and human research suggests that perfluorooctane sulfonate (PFOS), a prevalent persistent organic pollutant (POP), exerts neurotoxic effects, but the precise mechanisms remain unclear.
Yun Chen, Xiaohua Su, Chengcheng Yu, Zhuoni Kuang, Yichao Xu, Linhua Liu, Yongdui Ruan, Nan Wang, Xiaoxuan Ling, Daifan Lin, Guanlin Chen, Ziliang Deng, Fangling Zhu   +12 more
core   +1 more source

ATF4 and CHOP coordinate endoplasmic reticulum stress-responsive gene programs through enhancer activation and chromatin looping. [PDF]

Nucleic Acids Res
Joo JS, Kim M, Kim S, Kim H, Kim HP.
europepmc   +1 more source

Targeting ATF4 overcomes dual resistance to chemo-immunotherapy in gastric cancer by disrupting the DNA damage response. [PDF]

J Immunother Cancer
Ye H, Zhang W, Cao H, Peng Z, Xu T, Xia Z, Li L, He N, Zhou Y, Qin J, Ma K, Ren W, Han H, Cai W, Qin L, Jiao Z.   +15 more
europepmc   +1 more source

Stress Responsive bZIP Transcription Factors ATF4 and BACH1 Cooperate With MAF-Family bZIP Protein NRL to Fine-Tune Rod Photoreceptor Gene Expression. [PDF]

Invest Ophthalmol Vis Sci
Preston K, Arya M, Kumari A, Nellissery J, Brooks MJ, Batz Z, Liang X, Tosini G, Swaroop A.   +8 more
europepmc   +1 more source

Mechanisms of ATF4-mediated neuronal apoptosis

, 2015
Abstract to be ...
openaire   +1 more source

ATF4 promotes immune evasion in oral squamous cell carcinoma by suppressing autophagic PD-L1 degradation. [PDF]

J Immunother Cancer
Wang KM, Zhang LZ, Liang JJ, Wang Z, Wang XL, Zhang J, Chen G, Zhang W.   +7 more
europepmc   +1 more source

HIF-2α drives osteoarthritis progression via suppression of the HDAC4-ATF4-CHOP signaling axis. [PDF]

PLoS One
Jiang P, Wang H, Li Y, Zhang Y, Huang J, Xu Y, Rong D, Ruan D, Wang Y, Yuan J, Li P.   +10 more
europepmc   +1 more source

ATF4: Orchestrating Cellular Stress Adaptation, Metabolism, and Immune Regulation in Health and Disease. [PDF]

Int J Mol Sci
Wang C, Jia F, He F.
europepmc   +1 more source

Lipiidide ainevahetusega seotud geeni GPAT3 ekspressiooni regulatsioon transkriptsioonifaktori ATF4 poolt

Lipiidid sünteesitakse endoplasmaatilises retiikulumis (ER). Toksilise toime vältimiseks säilitatakse üleliigseid lipiide rakus lipiiditilgakestena, mis samuti moodustuvad ER-is.
Gluboki, Elina
core