Results 51 to 60 of about 32,812 (263)

ATF4, a new player in fetal HSC expansion [PDF]

Blood, 2015
In this issue of Blood, Zhao et al have identified the basic region-leucine zipper transcription factor activating transcription factor 4 (ATF4) as a key molecule for the intrinsic and extrinsic regulation of the extensive expansion of fetal liver (FL) hematopoietic stem cells (HSCs) (see figure ...
openaire   +2 more sources

Role of ATF4 in regulation of autophagy and resistance to drugs and hypoxia [PDF]

Cell Cycle, 2009
Tumor hypoxia confers resistance to many modalities of anticancer therapy. The endoplasmic reticulum (ER) is highly sensitive to severe hypoxic stress and results in the activation of the unfolded protein response. ATF4 is the main transcriptional regulator of the cellular hypoxic response to the Unfolded Protein Response (UPR) and activates genes that
Rzymski, T, Milani, M, Singleton, D, Harris, A   +3 more
openaire   +2 more sources

Tunicamycin aggravates endoplasmic reticulum stress and airway inflammation via PERK-ATF4-CHOP signaling in a murine model of neutrophilic asthma

, 2016
Introduction: Endoplasmic reticulum (ER) stress has been considered to be an important regulator of airway inflammation in the pathogenesis of bronchial asthma, but the mechanism of ER stress involved in neutrophilic asthma remain not fully understood ...
Huixia Li (739049), Lin Xu (94491), Bo Zhou (15092), Jiali Liu (327739), Lan Yang (457660), Qinyue Guo (2867816), Zhongmin Sun (1699048)   +6 more
core   +1 more source

The spliceosome inhibitor isoginkgetin activates an ATF4-dependent transcriptional response

, 2023
Gene expression is a highly regulated process that is essential to produce diverse proteins and RNAs required for life. The transfer of genetic information from gene to protein involves many steps including transcription of DNA to pre-mRNA, pre-mRNA ...
van Zyl, Erin Patricia
core   +1 more source

Endoplasmic reticulum stress and autophagy in cerebral ischemia/reperfusion injury: PERK as a potential target for intervention

Neural Regeneration Research
Several studies have shown that activation of unfolded protein response and endoplasmic reticulum (ER) stress plays a crucial role in severe cerebral ischemia/reperfusion injury. Autophagy occurs within hours after cerebral ischemia, but the relationship
Ju Zheng, Yixin Li, Ting Zhang, Yanlin Fu, Peiyan Long, Xiao Gao, Zhengwei Wang, Zhizhong Guan, Xiaolan Qi, Wei Hong, Yan Xiao   +10 more
doaj   +1 more source

Profiles of Patients with ATF4-Positive or ATF4-Negative ESCCs.

, 2014
Profiles of Patients with ATF4-Positive or ATF4-Negative ESCCs.
Xiong Chen (555744), Yagang Zhao (606833), Bei Chen (202271), Dayong Sun (606832), Bin Chen (63682), Hongwu Zhu (183424), Weibing Song (606831)   +6 more
core   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Research Progress of Endoplasmic Reticulum Stress PERK-eIF2α-AFT4-CHOP Signaling Pathway in Hematological Malignancies

Zhongliu Fangzhi Yanjiu
The biosynthesis and maturation of proteins are primarily regulated by the endoplasmic reticulum in its physiological state. Thus, the disruption of physiological homeostasis initiates the buildup of unfolded and misfolded proteins in the endoplasmic ...
HE Mengke, XU Zizhen, LI Junmin
doaj   +1 more source

O-GlcNAc regulates the mitochondrial integrated stress response by regulating ATF4

Frontiers in Aging Neuroscience, 2023
BackgroundAccumulation of mitochondrial dysfunctional is a hallmark of age-related neurodegeneration including Alzheimer’s disease (AD). Impairment of mitochondrial quality control mechanisms leading to the accumulation of damaged mitochondria and ...
Ibtihal M. Alghusen, Marisa S. Carman, Heather Wilkins, Heather Wilkins, Heather Wilkins, Sophiya John Ephrame, Amy Qiang, Wagner B. Dias, Halyna Fedosyuk, Aspin R. Denson, Russell H. Swerdlow, Russell H. Swerdlow, Russell H. Swerdlow, Chad Slawson, Chad Slawson   +14 more
doaj   +1 more source