Results 51 to 60 of about 30,346 (252)
Cell Reports, 2015 Prior studies suggested that the transcription factor ATF4 negatively regulates synaptic plastic and memory. By contrast, we provide evidence from direct in vitro and in vivo knockdown of ATF4 in rodent hippocampal neurons and from ATF4-null mice that ...
Silvia Pasini +4 more
doaj +1 more source
Activating transcription factor 4 confers a multidrug resistance phenotype to gastric cancer cells through transactivation of SIRT1 expression. [PDF]
PLoS ONE, 2012 BACKGROUND: Multidrug resistance (MDR) in gastric cancer remains a major challenge to clinical treatment. Activating transcription factor 4 (ATF4) is a stress response gene involved in homeostasis and cellular protection.
Hongwu Zhu +13 more
doaj +1 more source
Drug Design, Development and Therapy, 2021 Ke Rong,1 Xiaoliu Li,2 Weimin Jiang,1 Xuhua Wu,1 Qingquan Xia,2 Jie Chen,1 Xiaofan Yin2 1Department of Orthopedics, The First Affiliated Hospital of Soochow University, Soochow, 215006, People’s Republic of China; 2Department of Orthopedics ...
Rong K +6 more
doaj
ATF4, a new player in fetal HSC expansion [PDF]
Blood, 2015 In this issue of Blood, Zhao et al have identified the basic region-leucine zipper transcription factor activating transcription factor 4 (ATF4) as a key molecule for the intrinsic and extrinsic regulation of the extensive expansion of fetal liver (FL) hematopoietic stem cells (HSCs) (see figure ...
openaire +2 more sources
Limited ATF4 Expression in Degenerating Retinas with Ongoing ER Stress Promotes Photoreceptor Survival in a Mouse Model of Autosomal Dominant Retinitis Pigmentosa. [PDF]
PLoS ONE, 2016 T17M rhodopsin expression in rod photoreceptors leads to severe retinal degeneration and is associated with the activation of ER stress related Unfolded Protein Response (UPR) signaling.
Yogesh Bhootada +6 more
doaj +1 more source
Role of ATF4 in regulation of autophagy and resistance to drugs and hypoxia [PDF]
Cell Cycle, 2009 Tumor hypoxia confers resistance to many modalities of anticancer therapy. The endoplasmic reticulum (ER) is highly sensitive to severe hypoxic stress and results in the activation of the unfolded protein response. ATF4 is the main transcriptional regulator of the cellular hypoxic response to the Unfolded Protein Response (UPR) and activates genes that
Rzymski, T +3 more
openaire +2 more sources
, 2016 Introduction: Endoplasmic reticulum (ER) stress has been considered to be an important regulator of airway inflammation in the pathogenesis of bronchial asthma, but the mechanism of ER stress involved in neutrophilic asthma remain not fully understood ...
Huixia Li (739049) +6 more
core +1 more source
The spliceosome inhibitor isoginkgetin activates an ATF4-dependent transcriptional response
, 2023 Gene expression is a highly regulated process that is essential to produce diverse proteins and RNAs required for life. The transfer of genetic information from gene to protein involves many steps including transcription of DNA to pre-mRNA, pre-mRNA ...
van Zyl, Erin Patricia
core +1 more source
Neural Regeneration ResearchSeveral studies have shown that activation of unfolded protein response and endoplasmic reticulum (ER) stress plays a crucial role in severe cerebral ischemia/reperfusion injury. Autophagy occurs within hours after cerebral ischemia, but the relationship
Ju Zheng +10 more
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The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source