Results 51 to 60 of about 31,889 (263)

The spliceosome inhibitor isoginkgetin activates an ATF4-dependent transcriptional response

, 2023
Gene expression is a highly regulated process that is essential to produce diverse proteins and RNAs required for life. The transfer of genetic information from gene to protein involves many steps including transcription of DNA to pre-mRNA, pre-mRNA ...
van Zyl, Erin Patricia
core   +1 more source

ATF4, a new player in fetal HSC expansion [PDF]

Blood, 2015
In this issue of Blood, Zhao et al have identified the basic region-leucine zipper transcription factor activating transcription factor 4 (ATF4) as a key molecule for the intrinsic and extrinsic regulation of the extensive expansion of fetal liver (FL) hematopoietic stem cells (HSCs) (see figure ...
openaire   +2 more sources

Role of ATF4 in regulation of autophagy and resistance to drugs and hypoxia [PDF]

Cell Cycle, 2009
Tumor hypoxia confers resistance to many modalities of anticancer therapy. The endoplasmic reticulum (ER) is highly sensitive to severe hypoxic stress and results in the activation of the unfolded protein response. ATF4 is the main transcriptional regulator of the cellular hypoxic response to the Unfolded Protein Response (UPR) and activates genes that
Rzymski, T, Milani, M, Singleton, D, Harris, A   +3 more
openaire   +2 more sources

Endoplasmic reticulum stress and autophagy in cerebral ischemia/reperfusion injury: PERK as a potential target for intervention

Neural Regeneration Research
Several studies have shown that activation of unfolded protein response and endoplasmic reticulum (ER) stress plays a crucial role in severe cerebral ischemia/reperfusion injury. Autophagy occurs within hours after cerebral ischemia, but the relationship
Ju Zheng, Yixin Li, Ting Zhang, Yanlin Fu, Peiyan Long, Xiao Gao, Zhengwei Wang, Zhizhong Guan, Xiaolan Qi, Wei Hong, Yan Xiao   +10 more
doaj   +1 more source

Profiles of Patients with ATF4-Positive or ATF4-Negative ESCCs.

, 2014
Profiles of Patients with ATF4-Positive or ATF4-Negative ESCCs.
Xiong Chen (555744), Yagang Zhao (606833), Bei Chen (202271), Dayong Sun (606832), Bin Chen (63682), Hongwu Zhu (183424), Weibing Song (606831)   +6 more
core   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Research Progress of Endoplasmic Reticulum Stress PERK-eIF2α-AFT4-CHOP Signaling Pathway in Hematological Malignancies

Zhongliu Fangzhi Yanjiu
The biosynthesis and maturation of proteins are primarily regulated by the endoplasmic reticulum in its physiological state. Thus, the disruption of physiological homeostasis initiates the buildup of unfolded and misfolded proteins in the endoplasmic ...
HE Mengke, XU Zizhen, LI Junmin
doaj   +1 more source

A KDM6 inhibitor potently induces ATF4 and its target gene expression through HRI activation and by UTX inhibition

Scientific Reports, 2021
UTX/KDM6A encodes a major histone H3 lysine 27 (H3K27) demethylase, and is frequently mutated in various types of human cancers. Although UTX appears to play a crucial role in oncogenesis, the mechanisms involved are still largely unknown.
Shojiro Kitajima, Wendi Sun, Kian Leong Lee, Jolene Caifeng Ho, Seiichi Oyadomari, Takashi Okamoto, Hisao Masai, Lorenz Poellinger, Hiroyuki Kato   +8 more
doaj   +1 more source

Axonally Synthesized ATF4 Transmits a Neurodegenerative Signal across Brain Regions [PDF]

, 2014
SummaryIn Alzheimer’s disease (AD) brain, exposure of axons to Aβ causes pathogenic changes that spread retrogradely by unknown mechanisms, affecting the entire neuron.
Crary, John F., Walker, Chandler A., Troy, Carol M., Baleriola, Jimena, Hengst, Ulrich, Jean, Ying Y., Nagy, Peter L.   +6 more
core   +1 more source