Results 31 to 40 of about 30,346 (252)

Regulation of Nrf2 by Mitochondrial Reactive Oxygen Species in Physiology and Pathology

Biomolecules, 2020
Reactive oxygen species (ROS) are byproducts of aerobic respiration and signaling molecules that control various cellular functions. Nrf2 governs the gene expression of endogenous antioxidant synthesis and ROS-eliminating enzymes in response to various ...
Shuya Kasai, Sunao Shimizu, Yota Tatara, Junsei Mimura, Ken Itoh   +4 more
doaj   +1 more source

ATF4-sensitive genes and biological pathways.

, 2023
(A) Gene ontology biological process enrichment analysis for genes with a TSS-proximal ATF4 peak called in ≥4 cell types (out of the 7 analyzed). One ChIP-Seq library was used to represent each cell type (the library with the most peaks called).
Tõnis Örd (234737), Tiit Örd (551518), Daima Örd (234734), Priit Adler (260134)   +3 more
core   +1 more source

ATF4- and NeuN-positive neurons in the corticolimbic system.

, 2021
Representative immunofluorescent images of 8-week-old OLETF and LETO rats in the anterior cingulate cortex (ACC; A, B, C and D), basolateral amygdala (BLA; E, F, G, and H), and hippocampal cornu ammonis area 3 (CA3; I, J, K, and L.
Hisao Nishijo (303632), Ryosuke Ochi (11419784), Son Tien Nguyen (11324552), Naoto Fujita (677910), Takaya Oshima (11324550), Susumu Urakawa (354542), Kaho Takaishi (11324547), Natsuki Goto (11324541)   +7 more
core   +1 more source

ATF4- and PV-positive neurons in the corticolimbic system.

, 2021
Representative immunofluorescent images of 8-week-old OLETF and LETO rats in the prelimbic cortex (PL; A, B, C and D), basolateral amygdala (BLA; E, F, G, and H), and hippocampal cornu ammonis area 3 (CA3; I, J, K, and L).
Hisao Nishijo (303632), Ryosuke Ochi (11419784), Son Tien Nguyen (11324552), Naoto Fujita (677910), Takaya Oshima (11324550), Susumu Urakawa (354542), Kaho Takaishi (11324547), Natsuki Goto (11324541)   +7 more
core   +1 more source

ATF4- and CCK-positive neurons in the corticolimbic system.

, 2021
Representative immunofluorescent images of 8-week-old OLETF and LETO rats in the anterior cingulate cortex (ACC; A, B, C, and D), basolateral amygdala (BLA; E, F, G, and H), and hippocampal cornu ammonis area 3 (CA3; I, J, K, and L).
Hisao Nishijo (303632), Ryosuke Ochi (11419784), Son Tien Nguyen (11324552), Naoto Fujita (677910), Takaya Oshima (11324550), Susumu Urakawa (354542), Kaho Takaishi (11324547), Natsuki Goto (11324541)   +7 more
core   +1 more source

ATF4 and HIF-1α in bone: An intriguing relationship [PDF]

Journal of Bone and Mineral Research, 2013
As occurs in any other vascularized organ, one of the essential functions of blood vessels in bone is to be a source of O2, nutrients, hormones and growth factors (1). However, additional roles for bone blood vessels are emerging. For example, osteoblast precursors have been recently identified within their wall (2,3), which suggests that blood vessels
Schipani, Ernestina, Mangiavini, Laura, Merceron, Christophe   +2 more
openaire   +3 more sources

Dynamic induction of drug resistance through a stress-responsive enhancer in acute myeloid leukemia

Molecular & Cellular Oncology, 2020
The drug efflux pump ABCB1 (ATP binding cassette subfamily B member 1) confers chemotherapy resistance in acute myeloid leukemia (AML). We recently identified an ABCB1 enhancer that is activated in response to a range of cellular stressors, including ...
Mark S. Williams, Tim C. P. Somervaille
doaj   +1 more source

Hop2 Interacts with ATF4 to Promote Osteoblast Differentiation [PDF]

Journal of Bone and Mineral Research, 2019
ABSTRACT Activating transcription factor 4 (ATF4) is a member of the basic leucine zipper (bZip) transcription factor family required for the terminal differentiation of osteoblasts. Despite its critical importance as one of the three main osteoblast differentiation transcription factors, regulators of osteoblast terminal maturation ...
Yang Zhang, Tonghui Lin, Na Lian, Huan Tao, Cong Li, Lingzhen Li, Xiangli Yang   +6 more
openaire   +2 more sources

Elucidation of an mTORC2-PKC-NRF2 pathway that sustains the ATF4 stress response and identification of Sirt5 as a key ATF4 effector

Cell Death Discovery, 2022
AbstractProliferating cancer cells are dependent on glutamine metabolism for survival when challenged with oxidative stresses caused by reactive oxygen species, hypoxia, nutrient deprivation and matrix detachment. ATF4, a key stress responsive transcription factor, is essential for cancer cells to sustain glutamine metabolism when challenged with these
Ruizhi Li, Kristin F. Wilson, Richard A. Cerione   +2 more
openaire   +3 more sources

Functional contribution of the transcription factor ATF4 to the pathogenesis of amyotrophic lateral sclerosis. [PDF]

PLoS ONE, 2013
Endoplasmic reticulum (ER) stress represents an early pathological event in amyotrophic lateral sclerosis (ALS). ATF4 is a key ER stress transcription factor that plays a role in both adaptation to stress and the activation of apoptosis.
Soledad Matus, Estefanía Lopez, Vicente Valenzuela, Melissa Nassif, Claudio Hetz   +4 more
doaj   +1 more source