Results 31 to 40 of about 31,889 (263)
Cell Death Discovery, 2022 AbstractProliferating cancer cells are dependent on glutamine metabolism for survival when challenged with oxidative stresses caused by reactive oxygen species, hypoxia, nutrient deprivation and matrix detachment. ATF4, a key stress responsive transcription factor, is essential for cancer cells to sustain glutamine metabolism when challenged with these
Ruizhi Li +2 more
openaire +3 more sources
Vitamin D receptor attenuate ischemia-reperfusion kidney injury via inhibiting ATF4
Cell Death Discovery, 2023 Activating transcription factor 4 (ATF4) is one of the key effectors of endoplasmic reticulum stress (ERS), ATF4/CHOP pathway-mediated ERS plays an important role in the progression of acute kidney disease (AKI).
Shiqi Tang +10 more
doaj +1 more source
Hop2 Interacts with ATF4 to Promote Osteoblast Differentiation [PDF]
Journal of Bone and Mineral Research, 2019 ABSTRACT Activating transcription factor 4 (ATF4) is a member of the basic leucine zipper (bZip) transcription factor family required for the terminal differentiation of osteoblasts. Despite its critical importance as one of the three main osteoblast differentiation transcription factors, regulators of osteoblast terminal maturation ...
Yang Zhang +6 more
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Functional contribution of the transcription factor ATF4 to the pathogenesis of amyotrophic lateral sclerosis. [PDF]
PLoS ONE, 2013 Endoplasmic reticulum (ER) stress represents an early pathological event in amyotrophic lateral sclerosis (ALS). ATF4 is a key ER stress transcription factor that plays a role in both adaptation to stress and the activation of apoptosis.
Soledad Matus +4 more
doaj +1 more source
Shared Gene Targets of the ATF4 and p53 Transcriptional Networks
Molecular and Cellular Biology, 2023 Abstract The master tumor suppressor p53 regulates multiple cell fate decisions, like cell cycle arrest and apoptosis, via transcriptional control of a broad gene network. Dysfunction in the p53 network is common in cancer, often through mutations that inactivate p53 or other members of the pathway.
Gabriele Baniulyte +3 more
openaire +3 more sources
Genetic variants that are located in ATF4 binding regions and alter ATF4 binding motifs.
, 2023 Genetic variants that are located in ATF4 binding regions and alter ATF4 binding motifs.
Tõnis Örd (234737) +3 more
core +1 more source
ATF4 DNA binding activity in nuclear extracts of ATF4-293 cells.
, 2023 Cells were untreated (-) or treated with tetracycline (+) to induce ATF4 overexpression from a stably integrated tetracycline-upregulated expression construct. (A) ATF4 protein level in nuclear extracts (20 μg per line) determined using Western blotting.
Tõnis Örd (234737) +3 more
core +1 more source
ATF4-mediated histone deacetylase HDAC1 promotes the progression of acute pancreatitis
Cell Death and Disease, 2021 Acute pancreatitis (AP), an acute inflammatory process, can be difficult to diagnose. Activating transcription factor 4 (ATF4) has been reported to participate in the pathogenesis of AP.
Xiaofeng Deng +3 more
doaj +1 more source
Investigation of Nrf2, AhR and ATF4 Activation in Toxicogenomic Databases [PDF]
Frontiers in Genetics, 2018 Toxicological responses to chemical insult are largely regulated by transcriptionally activated pathways that may be independent, correlated and partially or fully overlapping. Investigating the dynamics of the interactions between stress responsive transcription factors from toxicogenomic data and defining the signature of each of them is an ...
Zgheib +9 more
openaire +5 more sources
ATF4 links ER stress with reticulophagy in glioblastoma cells [PDF]
Autophagy, 2020 Selective degradation of the endoplasmic reticulum (ER; reticulophagy) is a type of autophagy involved in the removal of ER fragments. So far, amino acid starvation as well as ER stress have been described as inducers of reticulophagy, which in turn restores cellular energy levels and ER homeostasis.
Svenja Zielke +11 more
openaire +4 more sources