Results 31 to 40 of about 3,801 (180)
Communications BiologySerine is essential to maintain maximal growth and proliferation of cancer cells by providing adequate intermediate metabolites and energy. Phosphoserine aminotransferase 1 (PSAT1) is a key enzyme in de novo serine synthesis.
Yuhan Liu +8 more
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ΔNp63α drives serine synthesis to promote carboplatin resistance in NSCLC [PDF]
Cell Death and DiseaseSerine metabolism is a critical vulnerability in cancer; however, its role in mediating therapeutic resistance in non-small cell lung cancer (NSCLC) remains incompletely understood.
Liyuan Deng +6 more
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miR-424 targets AKT3 and PSAT1 and has a tumor-suppressive role in human colorectal cancer
Cancer Management and Research, 2018 Yifeng Fang,1 Xiao Liang,1 Junfen Xu,2 Xiujun Cai1 1Department of General Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China; 2Department of Gynecologic Oncology, Women’s Hospital, Zhejiang University School
Fang Y, Liang X, Xu J, Cai X
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Protein post-translational modifications in serine synthetic pathway: functions and molecular mechanisms [PDF]
Cell Communication and SignalingSerine is a non-essential amino acid, serving as a precursor for other amino acids, lipids, and nucleotide synthesis. Its supply is ensured by two main mechanisms: exogenous uptake and endogenous synthesis.
Mincong Shu, Yuhan Liu, Jianbin Wang
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PLoS ONEOvarian cancer, a formidable gynaecological malignancy, poses a significant global health challenge, and it is characterised by late-stage diagnosis and a high mortality rate. Even in its early stages, when treatment choices are scarce, ovarian cancer is
Jia Zhang +5 more
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Investigating a novel function for phosphoserine aminotransferase 1 (PSAT1) in epidermal growth factor receptor (EGFR)-mediated lung tumorigenesis. [PDF]
, 2021 Phosphoserine aminotransferase 1 (PSAT1) catalyzes the second enzymatic step within the serine synthetic pathway (SSP) and its expression is elevated in numerous human cancers, including non-small cell lung cancer (NSCLC).
Biyik-Sit, Rumeysa
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Frontiers in Genetics, 2022 This study analyzed PSAT1-targeted miRNAs as a prognostic predictor for gastric cancer. The relationship between the clinical manifestations of gastric cancer in patients and phosphoserine aminotransferase 1 (PSAT1) was analyzed using correlation ...
Jingwei Ma +7 more
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PSAT1 prompted cell proliferation and inhibited cell apoptosis in multiple myeloma through regulating PI3K/AKT pathway [PDF]
, 2020 Purpose: To identify the biological function of phosphoserine aminotransferase 1 (PSAT1) in regulating cell proliferation and apoptosis in multiple myeloma (MM).Methods: The mRNA and protein levels of PSAT1 were determined using quantitative real-time ...
Zhu, Hongqing +6 more
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COMPUTER‐BASED VERBAL SCORE REPORTS: I. PSAT1 [PDF]
ETS Research Bulletin Series, 1967 ABSTRACTA system for analyzing PSAT score profiles and producing “conversational” interpretations in the form of letters to be sent to candidates is developed. The system utilizes a problem‐oriented computer language for the description of the analysis.
Stefan J. Harasymiw, Carl E. Helm
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Endocrine Regulations, 2023 Objective. Serine synthesis as well as endoplasmic reticulum stress and hypoxia are important factors of malignant tumor growth including glioblastoma.
Sliusar Myroslava Y. +8 more
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