Results 31 to 40 of about 3,665 (185)

miR-424 targets AKT3 and PSAT1 and has a tumor-suppressive role in human colorectal cancer

open access: yesCancer Management and Research, 2018
Yifeng Fang,1 Xiao Liang,1 Junfen Xu,2 Xiujun Cai1 1Department of General Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China; 2Department of Gynecologic Oncology, Women’s Hospital, Zhejiang University School
Fang Y, Liang X, Xu J, Cai X
doaj   +1 more source

Protein post-translational modifications in serine synthetic pathway: functions and molecular mechanisms [PDF]

open access: yesCell Communication and Signaling
Serine is a non-essential amino acid, serving as a precursor for other amino acids, lipids, and nucleotide synthesis. Its supply is ensured by two main mechanisms: exogenous uptake and endogenous synthesis.
Mincong Shu, Yuhan Liu, Jianbin Wang
doaj   +2 more sources

Prognostic microRNAs associated with phosphoserine aminotransferase 1 in gastric cancer as markers of bone metastasis

open access: yesFrontiers in Genetics, 2022
This study analyzed PSAT1-targeted miRNAs as a prognostic predictor for gastric cancer. The relationship between the clinical manifestations of gastric cancer in patients and phosphoserine aminotransferase 1 (PSAT1) was analyzed using correlation ...
Jingwei Ma   +7 more
doaj   +1 more source

COMPUTER‐BASED VERBAL SCORE REPORTS: I. PSAT1 [PDF]

open access: yesETS Research Bulletin Series, 1967
ABSTRACTA system for analyzing PSAT score profiles and producing “conversational” interpretations in the form of letters to be sent to candidates is developed. The system utilizes a problem‐oriented computer language for the description of the analysis.
Stefan J. Harasymiw, Carl E. Helm
openaire   +1 more source

A PSAT1 buff of YBX1 transcriptionally sustains HLA-E-mediated evasion of NK immunity. [PDF]

open access: yesProc Natl Acad Sci U S A
Despite great success in certain cancers, immunotherapy made little progress in treating immune cold tumors, largely attributed to an immune-suppressive tumor microenvironment with elusive mechanisms. Here, we report in prostate cancer cells a positive feedback loop driven by phosphoserine aminotransferase 1 (PSAT1) that could be targeted to render ...
Zhang Y   +17 more
europepmc   +3 more sources

Hypoxia controls the expression of genes responsible for serine synthesis in U87MG cells on ERN1-dependent manner

open access: yesEndocrine Regulations, 2023
Objective. Serine synthesis as well as endoplasmic reticulum stress and hypoxia are important factors of malignant tumor growth including glioblastoma.
Sliusar Myroslava Y.   +8 more
doaj   +1 more source

Restored microRNA-133a-3p or Depleted PSAT1 Restrains Endothelial Cell Damage-Induced Intracranial Aneurysm Via Suppressing the GSK3β/β-Catenin Pathway

open access: yesNanoscale Research Letters, 2020
It is unclear about the functional role of microRNA-133a-3p (miR-133a-3p) in intracranial aneurysm (IA). Hence, the aim of the present study was to investigate the regulatory role of miR-133a-3p on the regulation of vascular endothelial injury-induced IA
Qiang Jia   +3 more
doaj   +1 more source

Investigating a novel function for phosphoserine aminotransferase 1 (PSAT1) in epidermal growth factor receptor (EGFR)-mediated lung tumorigenesis.

open access: yes, 2021
Phosphoserine aminotransferase 1 (PSAT1) catalyzes the second enzymatic step within the serine synthetic pathway (SSP) and its expression is elevated in numerous human cancers, including non-small cell lung cancer (NSCLC).
Biyik-Sit, Rumeysa
core   +2 more sources

Supplementary Table from Metabolic and Nonmetabolic Functions of PSAT1 Coordinate Signaling Cascades to Confer EGFR Inhibitor Resistance and Drive Progression in Lung Adenocarcinoma

open access: yes, 2022
Supplementary Table from Metabolic and Nonmetabolic Functions of PSAT1 Coordinate Signaling Cascades to Confer EGFR Inhibitor Resistance and Drive Progression in Lung ...
Hui-Min Lei (14956797)   +17 more
core   +3 more sources

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